ヒトの固形腫瘍（肺がん、消化管がんを中心）を対象として、中心体・一次繊毛、DNA修復・DNA付加体、遺伝性腫瘍症候群などをkeywordに、その遺伝・環境要因の研究、発がんと進展機構に関する研究、translational research、などを行なっています。

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Publication list

2023年３月までのものは、新村の欧文論文（原著論文及び総説）の中でIF４以上のものを挙げます。

1. Shinmura K*, Kato H, Kawasaki H, Hariyama T, Yoshimura K, Tsuchiya K, Watanabe H, Asahina E, Sumiyoshi F, Hamada K, Kawanishi Y, Kawase A, Funai K, Sugimura H: Primary cilia are frequently present in small cell lung carcinomas, but not in non-small cell lung carcinomas or lung carcinoids, Lab Invest 103: 100007, 2023. (IF:5.515)
2. Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H*: m⁶A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer. Cancer Gene Ther 29: 1355-1372, 2022. (IF:5.854)
3. Tsuchiya K, Yoshimura K, Inoue Y, Iwashita Y, Yamada H, Kawase A, Watanabe T, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H*: YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer. Oncoimmunology 10: 1962656, 2021. (IF:7.723)
4. Shinmura K*, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H. Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation. J Pathol 254: 519-530, 2021. (IF:9.883)
5. Yoshimura K, Suzuki Y, Inoue Y, Tsuchiya K, Karayama M, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Sugimura H, Suda T: CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. Oncoimmunology 9: 1746554, 2020. (IF:7.723)
6. Yoshimura K, Inoue Y, Tsuchiya K, Karayama M, Yamada H, Iwashita Y, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H*: Elucidation of the relationships of MET protein expression and gene copy number status with PD-L1 expression and the immune microenvironment in non-small cell lung cancer. Lung Cancer 141: 21-31, 2020. (IF:6.081)
7. Yoshimura K, Inoue Y, Karayama M, Tsuchiya K, Mori K, Suzuki Y, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Yokomura K, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H*: Heterogeneity analysis of PD-L1 expression and copy number status in EBUS-TBNA biopsy specimens of non-small cell lung cancer: Comparative assessment of primary and metastatic sites. Lung Cancer 134: 202-209, 2019. (IF:6.081)
8. Shinmura K*, Kato H, Kawanishi Y, Yoshimura K, Tsuchiya K, Takahara Y, Hosokawa S, Kawase A, Funai K, Sugimura H: POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma. Cancers (Basel) 11: E722. 2019. (IF:6.575)
9. Misawa K*, Kanazawa T, Mochizuki D, Imai A, Mima M, Yamada S, Morita K, Misawa Y, Shinmura K, Mineta H: Genes Located on 18q23 Are Epigenetic Markers and Have Prognostic Significance for Patients with Head and Neck Cancer. Cancers (Basel) 11: E401, 2019. (IF:6.575)
10. Shinmura K*, Kato H, Kawanishi Y, Goto M, Tao H, Yoshimura K, Nakamura S, Misawa K, Sugimura H: Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine. Free Radic Biol Med 131: 264-273, 2019. (IF:8.101)
11. Hosokawa S*, Takebayashi S, Sasaki Y, Nakamura Y, Shinmura K, Takahashi G, Mineta H: Clinical analysis of false-negative fine needle aspiration cytology of head and neck cancers. Postgrad Med 18: 1-5, 2019. (IF:4.379)
12. Kanazawa T*, Misawa K, Shinmura K, Misawa Y, Kusaka G, Maruta M, Sasaki T, Watanabe Y, Carey TE: Promoter methylation of galanin receptors as epigenetic biomarkers for head and neck squamous cell carcinomas. Expert Rev Mol Diagn 19: 137-148, 2019. (IF:5.67)
13. Shinmura K*, Kato H, Goto M, Tao H, Inoue Y, Nakamura S, Yoshida H, Tsuzaki E, Sugimura H: Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, in Human Cells. Oxid Med Cell Longev 2017, 7308501, 2017. (IF:7.31)
14. Inoue Y, Matsuura S, Yoshimura K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Maeda M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H*: Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells. Cancer Sci 108: 1701-1714, 2017. (IF:6.518)
15. Yoshimura K, Inoue Y, Mori K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H*: Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer. Genes Chromosomes Cancer 56: 570-581, 2017. (IF:4.263)
16. Shinmura K*, Kato H, Kawanishi Y, Igarashi H, Inoue Y, Yoshimura K, Nakamura S, Fujita H, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H: WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma. Mol Carcinog 56: 1984-1991, 2017. (IF:5.139)
17. Misawa K, Mochizuki D, Endo S, Mima M, Misawa Y, Imai A, Shinmura K, Kanazawa T, Carey TE, Mineta H: Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis. Mol Carcinog 56: 1107-1116, 2017. (IF:5.139)
18. Shinmura K*, Kato H, Kawanishi Y, Yoshimura K, Igarashi H, Goto M, Tao H, Inoue Y, Sugiyama T, Furuse H, Ozono S, Sugimura H: Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma. Mol Carcinog 56: 781-788, 2017. (IF:5.139)
19. Shinmura K*, Kato H, Kawanishi Y, Igarashi H, Goto M, Tao H, Inoue Y, Nakamura S, Misawa K, Mineta H, Sugimura H: Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer. Oxid Med Cell Longev 2016: 1546392, 2016. (IF:7.31)
20. Sekine S, Yamashita S, Tanabe T, Hashimoto T, Yoshida H, Taniguchi H, Kojima M, Shinmura K, Saito Y, Hiraoka N, Ushijima T, Ochiai A: Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma. J Pathol 239: 133-138, 2016. (IF:9.883)
21. Shinmura K*, Kato H, Goto M, Yamada H, Tao H, Nakamura S, Sugimura H: Functional Evaluation of 9 Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population. Hum Mutat 37: 350-353, 2016. (IF:4.7)
22. Inoue Y, Matsuura S, Kurabe N, Kahyo T, Mori H, Kawase A, Karayama M, Inui N, Funai K, Shinmura K, Suda T, Sugimura H*: Clinicopathological and survival analysis of Japanese patients with resected non-small-cell lung cancer harboring NKX2-1, SETDB1, MET, HER2, SOX2, FGFR1, or PIK3CA gene amplification. J Thorac Oncol 10: 1590-1600, 2015. (IF:20.121)
23. Nakamura S*, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H: Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation. Sci Rep 5: 13474, 2015. (IF:4.996)
24. Shinmura K*, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M, Kurachi K, Nakamura T, Sugimura H: SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer. Oncol Rep 34: 727-738, 2015. (IF:4.136)
25. Du C, Kurabe N, Matsushima Y, Suzuki M, Kahyo T, Ohnishi I, Tanioka F, Tajima S, Goto M, Yamada H, Tao H, Shinmura K, Konno H, Sugimura H*: Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer. Gastric Cancer 18: 516-525, 2015. (IF:7.708)
26. Goto M, Shinmura K*, Matsushima Y, Ishino K, Yamada H, Totsuka Y, Matsuda T, Nakagama H, Sugimura H*: Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts. Free Radic Biol Med 76: 136-146, 2014. (IF:8.101)
27. Shinmura K*, Goto M, Tao H, Kato H, Suzuki R, Nakamura S, Matsuda T, Yin G, Morita M, Kono S, Sugimura H: Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer. Oxid Med Cell Longev 2014: 627351, 2014. (IF:7.31)
28. Shinmura K*, Kato H, Matsuura S, Inoue Y, Igarashi H, Nagura K, Nakamura S, Maruyama K, Tajima M, Funai K, Ogawa H, Tanahashi M, Niwa H, Sugimura H: A novel somatic FGFR3 mutation in primary lung cancer. Oncol Rep 31: 1219-1224, 2014. (IF:4.136)
29. Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H, Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, Sugimura H*: SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Sci Rep 3: 3012, 2013. (IF:4.996)
30. Kahyo T, Tao H, Shinmura K, Yamada H, Mori H, Funai K, Kurabe N, Suzuki M, Tanahashi M, Niwa H, Ogawa H, Tanioka F, Yin G, Morita M, Matsuo K, Kono S, Sugimura H*: Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus. Carcinogenesis 34: 2531-2538, 2013. (IF:4.741)
31. Kurabe N, Hayasaka T, Ogawa M, Masaki N, Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H*: Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4. Cancer Sci 104: 1295-1302, 2013. (IF:6.518)
32. Matsuura S, Shinmura K*, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, Funai K, Kohno T, Suda T, Sugimura H: CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. Oncol Rep, 30: 1675-1680, 2013. (IF:4.136)
33. Matsuda T*, Tao H, Goto M, Yamada H, Suzuki M, Wu Y, Xiao N, He Q, Guo W, Cai Z, Kurabe N, Ishino K, Matsushima Y, Shinmura K, Konno H, Maekawa M, Wang Y, Sugimura H*: Lipid peroxidation-induced DNA adducts in human gastric mucosa. Carcinogenesis 34: 121-127, 2013. (IF:4.741)
34. Shinmura K*, Goto M, Tao H, Matsuura S, Matsuda T, Sugimura H: Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis. World J Gastroenterol 18: 6935-6942, 2012. (IF:5.374)
35. Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H, Nakamura S, Sugimrua H*: The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer. J Transl Med 10: 97, 2012. (IF:8.459)
36. Yamada H, Shinmura K, Ito H, Kasami M, Sasaki N, Shima H, Ikeda M, Tao H, Goto M, Ozawa T, Tsuneyoshi T, Tanioka F, Sugimura H*: Germline alterations of the CDH1 gene in familial gastric cancer in the Japanese population. Cancer Sci 102: 1782-1788, 2011. (IF:6.518)
37. Shinmura K*, Goto M, Suzuki M, Tao H, Yamada H, Igarashi H, Matsuura S, Maeda M, Konno H, Matsuda T, Sugimura H*: Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer. J Pathol 225: 414-423, 2011. (IF:9.883)
38. Kahyo T, Iwaizumi M, Shinmura K, Matsuura S, Nakamura T, Watanabe Y, Yamada H, Sugimura H*: A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Oncogene 30: 4453-4463, 2011. (IF:8.756)
39. Shinmura K*, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Tajima M, Matsuda T, Yamane A, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H: Aberrant expression and mutation-inducing activity of AID in human lung cancer. Ann Surg Oncol 18: 2084-2092, 2011. (IF:4.339)
40. Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H*: Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer 71: 19-27, 2011. (IF:6.081)
41. Goto M, Shinmura K*, Nakabeppu Y, Tao H, Yamada H, Tsuneyoshi T, Sugimura H*: Adenine DNA glycosylase activity of 14 Human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer. Hum Mutat 31: E1861-1874, 2010. (IF:4.7)
42. Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H*: Secreted form of EphA7 in the lung cancer. Int J Oncol 36: 635-640, 2010. (IF:5.884)
43. Yamada H, Shinmura K, Goto M, Iwaizumi M, Konno H, Kataoka H, Yamada M, Ozawa T, Tsuneyoshi T, Tanioka F, Sugimura H*: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. Mol Cancer 8: 63, 2009. (IF:41.444)
44. Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi T, Tsugane S, Sugimura H*: Altered expression of the human base excision repair gene NTH1 in gastric cancer. Carcinogenesis 30: 1345-1352, 2009. (IF:4.741)
45. Yamada H, Shinmura K, Yamamura Y, Kurachi K, Nakamura T, Tsuneyoshi T, Yokota N, Maekawa M and Sugimura H: Identification and characterization of a novel germline p53 mutation in a patient with glioblastoma and colon cancer. Int J Cancer 125: 973-976, 2009. (IF:7.316)
46. Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H: Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut 58: 249-260, 2009. (IF:31.84)
47. Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M Fukasawa K, Sugimura H*: Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol 216: 365-374, 2008. (IF:9.883)
48. Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H*: EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer 61: 163-169, 2008. (IF:6.081)
49. Tao H, Shinmura K, Suzuki M, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N, Sugimura H*: Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population. Cancer Sci 99: 355-360, 2008. (IF:6.518)
50. Yamada H, Shinmura K, Okudela K, Goto M, Suzuki M, Kuriki K, Tsuneyoshi T, Sugimura H*: Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population. Carcinogenesis 28: 2013-2018, 2007. (IF:4.741)
51. Liu X, Liu Z, Jang SW, Ma Z, Shinmura K, Kang S, Dong S, Chen J, Fukasawa, K, Ye K*: Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival. Proc Natl Acad Sci USA 104: 9679-9684, 2007. (IF:12.779)
52. Shinmura K, Bennett RA, Tarapore P, Fukasawa K*: Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene 26: 2939-2944, 2007. (IF:8.756)
53. Wang J, Kataoka H, Suzuki M, Sato N, Nakamura R, Tao H, Maruyama K, Isogaki J, Kanaoka S, Ihara M, Tanaka M, Kanamori M, Nakamura T, Shinmura K, Sugimura H*: Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene 24: 5637-5647, 2005. (IF:8.756)
54. Nakamura R, Kataoka H, Sato N, Kanamori M, Ihara M, Igarashi H, Ravshanov S, Wang Y-J, Li Z, Shimamura T, Kobayashi T, Konno H, Shinmura K, Tanaka M, Sugimura H*: EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci 96: 42-47, 2005. (IF:6.518)
55. Shinmura K, Goto M, Tao H, Shimizu S, Otsuki Y, Kobayashi H, Ushida S, Suzuki K, Tsuneyoshi T, Sugimura H*: A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer. Clin Genet 67: 81-86, 2005. (IF:4.296)
56. Shinmura K, Tao H, Goto M, Igarashi H, Taniguchi T, Maekawa M, Takezaki T, Sugimura H*: Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. Carcinogenesis 25: 2311-2317, 2004. (IF:4.741)
57. Tao H, Shinmura K, Hanaoka T, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Ozawa T, Tsujinaka T, Li Z, Yamaguchi S, Yokota J, Sugimura H*, Tsugane S: A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus. Carcinogenesis 25: 1859-1866, 2004. (IF:4.741)
58. Shinmura K, Tao H, Yamada H, Kataoka H, Sanjar R, Wang J, Yoshimura K, Sugimura H*: Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. Hum Mutat 24: 273-274, 2004. (IF:4.7)
59. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R and Sugimura H*: Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J 23: 1075-1088, 2004. (IF:14.012)
60. Yabuta T, Shinmura K, Yamane A, Yamaguchi S, Takenoshita S, Yokota J*: Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1. Int J Oncol 24: 697-702, 2004. (IF:5.884)
61. Li ZY, Tanaka M, Kataoka H, Nakamura R, Sanjar R, Shinmura K, Sugimura H*: EphA2 Up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53 independense: J Cancer Res Clin Oncol 129: 703-708, 2003. (IF:4.322)
62. Yamane A, Shinmura K, Sunaga N, Saitoh T, Yamaguchi S, Shinmura Y, Yoshimura K, Murakami H, Nojima Y, Kohno T, Yokota J*: Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo. Carcinogenesis 24: 1031-1037, 2003. (IF:4.741)
63. Liu Y, Yoshimura K, Yamaguchi N, Shinmura K, Yokota J, Katai H*: Causation of Borrmann type 4 gastric cancer: heritable factors or environmental factors? Gastric Cancer 6: 17-23, 2003. (IF:7.708)
64. Yabuta T, Shinmura K, Tani M, Yamaguchi S, Yoshimura K, Katai H, Nakajima T, Mochiki E, Tsujinaka T, Takami M, Hirose K, Yamaguchi A, Takenoshita S,Yokota J*: E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. Int J Cancer 101: 434-441, 2002. (IF:7.316)
65. Sunaga N, Kohno T, Shinmura K, Saitoh T, Matsuda T, Saito R, Yokota J*: OGG1 protein suppresses G:C-->T:A mutation in a shuttle vector containing 8-hydroxyguanine in human cells. Carcinogenesis 22: 1355-1362, 2001. (IF:4.741)
66. Saitoh T, Shinmura K, Yamaguchi S, Tani M, Seki S, Murakami H, Nojima Y and Yokota J: Enhancement of OGG1 protein AP lyase activity by increase of APEX protein. Mutation Research - DNA repair (Now: DNA Repair) 486: 31-40, 2001. (IF:4.354)
67. Shinmura K, Yamaguchi S, Saitoh T, Kohno T, Yokota J*: Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA. Cancer Lett 166: 65-69, 2001. (IF:9.756)
68. Shinmura K, Yokota J*: The OGG1 gene encodes a repair enzyme for oxidatively damaged DNA and is involved in human carcinogenesis. Antioxid Redox Signal 3: 597-609, 2001. (IF:7.468)
69. Shinmura K, Yamaguchi S, Saitoh T, Takeuchi-Sasaki M, Kim S-R, Nohmi T, Yokota J*: Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA. Nucleic Acids Res 28: 4912-4918, 2000. (IF:19.16)
70. Kimura K, Shinmura K, Yoshimura K, Shimizu K, Katai H, Beppu Y, Moriya H, Yokota J*: Absence of germline CHK2 mutations in familial gastric cancer. Jap J Cancer Res (Present title: Cancer Sci) 91: 875-879, 2000. (IF:6.518)
71. Shinmura K, Kohno T, Takeuchi-Sasaki M, Maeda M, Segawa T, Kamo T, Sugimura H and Yokota J: Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells. Int J Oncol 16: 701-707, 2000. (IF:5.884)
72. Li XJ, Wang D-Y, Zhu Y, Guo R-J, Wang XD, Lubomir K, Mukai K, Sasaki H, Yoshida H, Oka T, Machinami R, Shinmura K, Tanaka M, Sugimura H*: Mxi1 mutations in human neurofibrosarcomas. Jap J Cancer Res (Present title: Cancer Sci) 90: 740-746, 1999. (IF:6.518)
73. Sugimura H, Kohno T, Wakai K, Nagura K, Genka K, Igarashi H, Morris BJ, Baba S, Ohno Y, Gao C, Li Z, Wang J, Takezaki T, Tajima K, Varga T, Sawaguchi T, Lum JK, Martinson JJ, Tsugane S, Iwamasa T, Shinmura K, Yokota J*: hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 8: 669-674, 1999. (IF:4.09)
74. Shinmura K, Kohno T, Takahashi M, Sasaki A, Ochiai A, Guilford P, Hunter A, Reeve AE, Sugimura H, Yamaguchi N, Yokota J*: Familial gastric cancer: clinicopathological characteristics, RER phenotype, and germ-line p53 and E-cadherin mutations. Carcinogenesis 20: 1127-1131, 1999. (IF:4.741)
75. Wang Y, Shinmura K, Guo R-J, Isogaki J, Wang D-Y, Kino I, Sugimura H*: Mutational analysis of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability. Jap J Cancer Res (Present title: Cancer Sci) 89: 1284-1291, 1998. (IF:6.518)
76. Shinmura K, Kohno T, Kasai H, Koda K, Sugimura H, Yokota J*: Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jap J Cancer Res (Present title: Cancer Sci) 89: 825-828, 1998. (IF:6.518)
77. Kohno T, Shinmura K, Tosaka M, Tani M, Kim S-R, Sugimura H, Nohmi T, Kasai H, Yokota J*: Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene 16: 3219-3225, 1998. (IF:8.756)
78. Shinmura K, Tani M, Isogaki J, Wang Y, Sugimura H, Yokota J*: RER phenotype and its associated mutations in familial gastric cancer. Carcinogenesis 19: 247-251, 1998. (IF:4.741)
79. Shinmura K, Kasai H, Sasaki A, Sugimura H, Yokota J*: 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity. Mutation Research - DNA repair (Now: DNA Repair) 385: 75-82. 1997. (IF:4.354)
80. Shinmura K, Wang Y, Isogaki J, Saitoh K, Kanazawa K, Kohda K, Yokota J, Kino I, Arai T, Sugimura H*: Stage-dependent evaluation of microsatellite instability in gastric carcinoma with familial clustering. Cancer Epidemiol Biomarkers Prev 6: 693-697, 1997. (IF:4.09)
81. Arai K, Morishita K, Shinmura K, Kohno T, Kim S-R, Nohmi T, Taniwaki M, Ohwada S, Yokota J*: Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene 14: 2857-2861, 1997. (IF:8.756)
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