代表的論文

1. Yohei Okubo et al. Inositol 1,4,5-trisphosphate receptor type 2-independent Ca²⁺ release from the endoplasmic reticulum in astrocytes. Glia 67:113-124 (2019)
2. Yohei Okubo et al. Visualization of Ca²⁺ filling mechanisms upon synaptic inputs in the endoplasmic reticulum of cerebellar Purkinje cells. J Neurosci 35:15837-15846 (2015)
3. Yohei Okubo et al. Imaging extrasynaptic glutamate dynamics in the brain. Proc Nat Acad Sci USA 107:6526-6531 (2010)
4. Yohei Okubo et al. Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells. J Neurosci 24:9513-9520 (2004)
5. Yohei Okubo et al. Visualization of IP₃ dynamics reveals a novel AMPA receptor-triggered IP₃ production pathway mediated by voltage-dependent Ca²⁺ influx in Purkinje cells. Neuron 32:113-122 (2001)

原著論文†

1. Hiroyuki J Kanaya, Ken Kuwajima, Yuko Ito, Yuta Shinohara, Yohei Okubo, Shinnosuke Shiono, Fumiya Tatsuki, Rei-Ichiro Ohno, Hideki Ukai, Maki Ukai-Tadenuma Kenta Sumiyama, Hiroshi Fujishima, Rikuhiro G Yamada, Daisuke Tone, Hiroshi Kiyonari, Masaki Kikuchi, Takashi Umehara, Takashi Murayama, Kazunori Kanemaru, Masamitsu Iino, Koji L Ode, Takatsugu Hirokawa, Hiroki R Ueda. Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice. PLoS Biol 23:e3003172 (2025)
2. Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Yohei Okubo, Takashi Sakurai, Taku Amo, Ikuko Aiba, Yufuko Saito, Yuko Saito, Shigeo Murayama, Naoki Atsuta, Ryoichi Nakamura, Genki Tohnai, Yuishin Izumi, Mitsuya Morita, Asako Tamura, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Toru Yamashita, Jun Sone, Ryuji Kaji, Gen Sobue, Yuzuru Imai, Nobutaka Hattori. CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca²⁺ homeostasis. PNAS nexus 3:pgae319 (2024)
3. Shodai Takahashi, Kenjiro Hanaoka, Yohei Okubo, Honami Echizen, Takayuki Ikeno, Toru Komatsu, Tasuku Ueno, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano and Yasuteru Urano. Rational design of a near-infrared fluorescence probe for Ca²⁺ based on phosphorus-substituted rhodamines utilizing photoinduced electron transfer. Chem. Asian J. 15:524-530 (2020)
4. Yohei Okubo, Masamitsu Iino and Kenzo Hirose. Store-operated Ca²⁺ entry-dependent Ca²⁺ refilling in the endoplasmic reticulum in astrocytes. Biochem. Biophys. Res. Commun. 522:1003-1008 (2020)
5. Yohei Okubo, Kazunori Kanemaru, Junji Suzuki, Kenta Kobayashi, Kenzo Hirose and Masamitsu Iino. Inositol 1,4,5-trisphosphate receptor type 2-independent Ca²⁺ release from the endoplasmic reticulum in astrocytes. Glia 67:113-124 (2019)
6. Yoshinori Mikami, Kazunori Kanemaru, Yohei Okubo, Takuya Nakaune, Junji Suzuki, Kazuki Shibata, Hiroki Sugiyama, Ryuta Koyama, Takashi Murayama, Akihiro Ito, Toshiko Yamazawa, Yuji Ikegaya, Takashi Sakurai, Nobuhito Saito, Sho Kakizawa and Masamitsu Iino. Nitric oxide-induced activation of the type 1 ryanodine receptor is critical for epileptic seizure-induced neuronal cell death. EBioMedicine 11:253-261 (2016)
7. Jun Kubota, Yoshinori Mikami, Kazunori Kanemaru, Hiroshi Sekiya, Yohei Okubo and Masamitsu Iino. Whisker experience-dependent mGluR signaling maintains synaptic strength in the mouse a­doles­cent cortex. Eur. J. Neurosci. 44:2004-2014 (2016)
8. Yohei Okubo, Junji Suzuki, Kazunori Kanemaru, Naotoshi Nakamura, Tatsuo Shibata and Masamitsu Iino. Visualization of Ca²⁺ filling mechanisms upon synaptic inputs in the endoplasmic reticulum of cerebellar Purkinje cells. J. Neurosci. 35:15837-15846 (2015)
9. Daisuke Ino, Hiroshi Sagara, Junji Suzuki, Kazunori Kanemaru, Yohei Okubo and Masamitsu Iino. Neuronal regulation of Schwann cell mitochondrial Ca²⁺ signaling during myelination. Cell Rep. 12:1951-1959 (2015)
10. Kazunori Kanemaru, Hiroshi Sekiya, Ming Xu, Kaname Satoh, Nami Kitajima, Keitaro Yoshida, Yohei Okubo, Takuya Sasaki, Satoru Moritoh, Hidetoshi Hasuwa, Masaru Mimura, Kazuki Horikawa, Ko Matsui, Takeharu Nagai, Masamitsu Iino and Kenji F. Tanaka. In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca²⁺ indicator. Cell Rep. 8:311-318 (2014)
11. Junji Suzuki, Kazunori Kanemaru, Kuniaki Ishii, Masamichi Ohkura, Yohei Okubo and Masamitsu Iino. Imaging intraorganellar Ca²⁺ at subcellular resolution using CEPIA. Nat. Commun. 5:4153 (2014)
12. Kazunori Kanemaru, Jun Kubota, Hiroshi Sekiya, Kenzo Hirose, Yohei Okubo and Masamitsu Iino. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury. Proc. Nat. Acad. Sci. U.S.A. 110:11612-11617 (2013)
13. Masato Mashimo, Yohei Okubo, Toshiko Yamazawa, Miwako Yamasaki, Masahiko Watanabe, Toshihiko Murayama and Masamitsu Iino. Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia. Eur. J. Neurosci. 32:1668-1677 (2010)
14. Yohei Okubo, Hiroshi Sekiya, Shigeyuki Namiki, Hirokazu Sakamoto, Sho Iinuma, Miwako Yamasaki, Masahiko Watanabe, Kenzo Hirose and Masamitsu Iino. Imaging extrasynaptic glutamate dynamics in the brain. Proc. Nat. Acad. Sci. U.S.A. 107:6526-6531 (2010)
15. Naotoshi Nakamura, Toshiko Yamazawa, Yohei Okubo and Masamitsu Iino. Temporal switching and cell-to-cell variability in Ca²⁺ release activity in mammalian cells. Mol. Syst. Biol. 5:247 (2009)
16. Kazunori Kanemaru, Yohei Okubo, Kenzo Hirose and Masamitsu Iino. Regulation of neurite growth by spontaneous Ca²⁺ oscillations in astrocytes. J. Neurosci. 27:8957-8966 (2007)
17. Kazuharu Furutani, Yohei Okubo, Sho Kakizawa and Masamitsu Iino. Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. Proc. Nat. Acad. Sci. U.S.A. 103:8528-8533 (2006)
18. Yohei Okubo, Sho Kakizawa, Kenzo Hirose and Masamitsu Iino. Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells. J. Neurosci. 24:9513-9520 (2004)
19. Yohei Okubo, Sho Kakizawa, Kenzo Hirose and Masamitsu Iino. Visualization of IP₃ dynamics reveals a novel AMPA receptor-triggered IP₃ production pathway mediated by voltage-dependent Ca²⁺ influx in Purkinje cells. Neuron 32:113-122 (2001)

総説（英文）

1. Yohei Okubo. Investigation of brain functions with fluorescence imaging techniques. Juntendo Medical Journal 68:157-162 (2022)
2. Yohei Okubo. Astrocytic Ca²⁺ signaling mediated by the endoplasmic reticulum in health and disease. J. Pharmacol. Sci. 144:83-88 (2020)
3. Yohei Okubo and Masamitsu Iino. Visualization of astrocytic intracellular Ca²⁺ mobilization. J. Physiol. 598:1671-1681 (2020)
4. Yohei Okubo, Yoshinori Mikami, Kazunori Kanemaru and Masamitsu Iino. Role of endoplasmic reticulum-mediated Ca²⁺ signaling in neuronal cell death. Antioxid. Redox Signal. 29:1147-1157 (2018)
5. Yohei Okubo, Kazunori Kanemaru and Masamitsu Iino. Imaging of Ca²⁺ and related signaling molecules and investigation of their functions in the brain. Antioxid. Redox Signal. 14:1303-1314 (2011)
6. Yohei Okubo and Masamitsu Iino. Visualization of glutamate as a volume transmitter. J. Physiol. 589:481-488 (2011)

総説（和文）

1. 大久保洋平「カルシウムチャネル」クリニカルニューロサイエンス 41:902-906 (2023)　
2. 大久保洋平「滑面小胞体」脳科学辞典　DOI: 10.14931/bsd.504 (2022)　
3. 大久保洋平「小胞体Ca²⁺シグナリングの変調による神経細胞死」日本薬理学雑誌 153:155-160 (2019)
4. 三上義礼、大久保洋平「細胞内カルシウムストア」脳科学辞典　DOI: 10.14931/bsd.7107 (2016)　
5. 大久保洋平「オルガネラ内腔Ca²⁺イメージングの最前線」日本薬理学雑誌 144:192 (2014)　
6. 大久保洋平「代謝型グルタミン酸受容体シグナリングの可視化解析」日本薬理学雑誌 144:76-80 (2014)　
7. 大久保洋平「グリア細胞は脳血流制御に関与するか？」日本薬理学雑誌 143:314 (2014)
8. 大久保洋平「カルシウム」脳科学辞典　DOI: 10.14931/bsd.1795 (2013)
9. 大久保洋平「グルタミン酸スピルオーバーの可視化解析」日本薬理学雑誌 142:178-183 (2013)
10. 大久保洋平「グルタミン酸による非シナプス性伝達の可視化解析」BRAIN and NERVE 65:651-658 (2013)
11. 大久保洋平、飯野正光「二光子励起顕微鏡を用いた脳スライス標本における蛍光イメージング」バイオテクノロジージャーナル　5(3):282-286 (2005)

著書

1. 大久保洋平「神経細胞における細胞内カルシウムストアの機能解析」ブレインサイエンス・レビュー2021 廣川信隆、坂東武彦／編　アドスリー　111-128 (2021)
2. 大久保洋平、飯野正光「二光子励起顕微鏡」染色・バイオイメージング実験ハンドブック　高田邦昭、斎藤尚亮、川上速人／編　羊土社　262-267 (2006)