教育

Education

研究業績

2017年

  1. Furuta T, Sugimoto S, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Iwaizumi M, Hamaya Y, Osawa S, Sugimoto K, Umemura K. Infruence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel. J Thromb Thrombolysis 2017 43: 333-342  
  2. Nagahashi K, Umemura K, Kanayama N, Iwaki T. Successful synthesis of active human coagulation factor VII by co-expression of mammalian gamma-glutamyl carboxylase and modification of vit.K cycle in Drosophila Schneider S2 cells. Cytotechnology. 2017 69, 317-327
  3. Iwaki T, Nagahashi K, Takano K, Suzuki-Inoue K, Kanayama N, Umemura K, Urano T. Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation. Thromb Haemost. 2017 117, 860-869. 
  4. Tanaka H, Zaimad N, Sasakie T, Yamamotoa N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N. Lysophosphatidylcholine acyltransferase-3 expression is associated with atherosclerosis progression. J Vasc Res 2017 54, 200-208. 
  5. Kagami T, Yamade M, Suzuki T, Uotani T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T. Comparative study of effects of vonoprazan and esomeprazole on anti-platelet function of clopidogrel or prasugrel in relation to CYP2C19 genotype. Clin Pharmacol Ther 2017 in press
  6. Tanaka H, Iida Y, Iwaki T, Suzuki Y, Sano H, Miyajima C, Zaima N, Sasaki T, Sumioka A, Hakamata S, Shimizu H, Umemura K, Urano T. Elevated plasma level of LDL-cholesterol promotes thoracic aortic aneurysm and dissection in angiotensin II-induced mice. Ann Vasc Surg 2017 in press

2016年

  1. Umemura K, Iwaki T, Kimura T, Ogawa C, Fukuda T, Taniguchi S, Horibe K, Goto H, Yoshimura K, Watanabe Y, Nitani C, and Kikuta A. Pharmacokinetics and safety of defibrotide in healthy Japanese subjects. Clin Pharmacol Drug Dev 2016 5: 548-551
  2. Umemura K, Iwaki T, The pharmacokinetics and pharmacodynamics of prasugrel and clipidogrel in healthy Japanese volunteers. Clin Pharmacol Drug Dev 2016 5: 480-487
  3. Umemura K, Ikeda Y, Kondo K, Pharmacokinetics and pharmacodynamics of presugrel in healthy Japanese subjects. DMPK 2016. 31:285-91
  4. Umemura K, Ikeda Y, Matsushima N, ond Kondo K, Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects. Clin Pharmacol Drug Dev 2016 doi: 10.1002/cpdd.308.
  5. Iwaki T, Mizuma H, Hokamura K, Onoe H, Umemura K. [18F]FDG uptake in the aortic wall smooth muscle of atherosclerotic plaques in the simian atherosclerosis model. Biomed Res. Int. 2016 dol: 10.1155/2016/8609274
  6. Furuta T, Sugimoto S, Kodaira C, Nishino M, Uotani T, Sahara S, Ichikawa H, Kagami T, Iwaizumi M, Hamaya y, Osawa S, SugimotoK, Umemura K, Infruence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel. J Thromb Thrombolysis 2016 doi: 10.1007/s11239-016-1460-2. 
  7. Suzuki Y, Nagai N, Umemura K, A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia. Front Cell Neurosci. 2016. doi: 10.3389 

2015年

  1. Suzuki Y, Nagai N, Yamakawa K, Muranaka Y, Hokamura K, Umemura K. Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice. J Cereb Blood Flow Metab. 2015 35: 2021-31 
  2. Makino H, Hokamura K, Natsume T, Kimura T, Kamio Y, Magata Y, Namba H, Katoh T, Sato S, Hashimoto T, Umemura K. Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging. J Cereb Blood Flow Metab. 2015 35: 1523-7
  3. Inoue O, Hokamura K, Shirai T, Osada M, Tsukiji N, Hatakeyama K, Umemura K, Asada Y, Suzuki-Inoue K, Ozaki Y. Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis. PLoS One. 2015.10: e0139357.
  4. Arai H, Umemura K, Ichimiya Y, Iseki E, Eto K, Miyakawa K, Kirino E, Shibata N, Baba H, Tsuchiwata S. Safety and pharmacokinetics of bapineuzumab in a single ascending-dose study in Japanese patients with mild to moderate Alzheimer's disease. Geriatr Gerontol Int. 2015 35: 2021-31.
  5. Matsumoto Y and Umemura K. Chapter 4. Photochemically Induced Endothelial Injury. Mouse Models of Vascular Diseases (Editors: Sata, Masataka). pp.69-86

2014年

  1. Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Osawa S, Sugimoto K, Watanabe H, Umemura K. Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan. J Gastroen Hepatol. 29, 487-93, 2014
  2. Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K. Effect of Dosing Schemes of Amoxicillin on Eradication Rates of Helicobacter pylori With Amoxicillin Based Triple Therapy. J Clin Pharcol 54, 258-66. 2014 
  3. Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Osawa S, Sugimoto K, Watanabe H, Umemura K. Eradication of H. pylori Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin. Internal Med 53, 571-5. 2014.
  4. Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine. J Clin Pharmacol. 54, 858-64, 2014
  5. Iwaki S, Hokamura K, Ogawa M Takehara Y, Muramatsu Y Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirat Y, Arita M, Arai H, Umemura K, Nagano T and Hanaoka K. Design Strategy for Small Molecule-based Targeted MRI Contrast Agents: Application for Detection of Atherosclerotic Plaques. Org Biomol Chem 12, 8564-8784. 2014

2013年

  1. Kawano k, Umemura k. Oral Intake of Beet Extract Provides Protection Against Skin Barrier Impairment in Hairless Mice. Phytother Res. 27, 775-83, 2013 
  2. Nagahashi K, Umemura K, Kanayama N, Iwaki T. Fusion of fluorescent protein to puromycin N-acetyltransferase is useful in Drosophila Schneider S2 cells expressing heterologous proteins. Cytotechnology 65; 173-8, 2013
  3. Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K. Rapid Automated Genotyping of CYP2C19 and Helicobacter pylori 23S rRNA Gene in Gastric Juice. J Gastroen Hepatol 21; 508-512. 2013
  4. Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Antiplatelet drugs are a risk factor for esophageal mucosal injury. Digestion. 87; 281-9. 2013
  5. Nishino M, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment. Digestion. 88, 79-86. 2013
  6. Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T. Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolizers compared with twice-daily omeprazole, rabeprazole, or lansoprazole. Alimentary Pharmacology & Therapeutics 38, 1129-37. 2013
  7. Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Osawa S, Sugimoto K, Watanabe H, Umemura K. Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan. J Gastroen Hepatol 2013