細胞分子解剖学分野は老化関連疾患の病態と治療法を明らかにする事をテーマとしています。 私達は2つの異なるアプローチで老化の分子解剖を理解しようとしています。 1つ目のアプローチは自分たちで開発した質量顕微鏡法を使用した研究です。 質量顕微鏡法を使う事により、老化で体内に貯まってしまう物質や薬物動態の可視化が可能です。 2つ目のアプローチは、タンパク質の翻訳後修飾となる分子生物学及び細胞生物学です。 特に自分たちで発見したUBL3化によるエクソソームへの老廃物の廃棄に注目しており、疾患モデルマウスを作成し解析しています。

研究内容

1. 質量顕微鏡法関連の新技術開発
2. 質量顕微鏡法を使用して疾患の分子メカニズムを特定
3. 質量顕微鏡法による動物の分子解剖
4. 分子生物学または細胞生物学的アプローチによるマウスの分子解剖
   
   

研究業績

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