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研究活動

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細胞分子解剖学分野は質量顕微鏡法などの空間オミクス手法を開発して臨床各科や製薬会社とがんや炎症、中枢神経疾患のヒト試料やモデル動物の解析、特に薬物動態解析に応用してきました。そうした研究からUBL3化という新しい翻訳後修飾を発見し、UBL３化を分子標的にした認知症やがんの創薬にも挑戦しています。

    研究内容

  1. 質量顕微鏡法などの空間オミクス手法を用いた人体組織や病理組織の観察
  2. 新しい翻訳後修飾UBL3化をターゲットにした中枢神経疾患創薬
  3. UBL3化によるタンパク質分解やエクソソーム排出の研究

    研究業績

  1. Yan J, Kahyo T, Zhang H, Ping Y, Zhang C, Jiang S, Ji Q, Ferdous R, Islam MS, Oyama S, Aramaki S, Sato T, Mimi MA, Hasan MM, Setou M. Alpha-Synuclein Interaction with UBL3 Is Upregulated by Microsomal Glutathione S-Transferase 3, Leading to Increased Extracellular Transport of the Alpha-Synuclein under Oxidative Stress.Int J Mol Sci. 2024
  2. Tasaki E, Mitaka Y, Takahashi Y, Waliullah ASM, Tamannaa Z, Sakamoto T, Islam A, Kamiya M, Sato T, Aramaki S, Kikushima K, Horikawa M, Nakamura K, Kahyo T, Takata M, Setou M, Matsuura K. The royal food of termites shows king and queen specificity. PNAS Nexus. 2023.
  3. Chen B, Hasan MM, Zhang H, Zhai Q, Waliullah ASM, Ping Y, Zhang C, Oyama S, Mimi MA, Tomochika Y, Nagashima Y, Nakamura T, Kahyo T, Ogawa K, Kaneda D, Yoshida M, Setou M. UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib. Biomedicines. 2023.
  4. Chi DH, Kahyo T, Islam A, Mahmudul Hasan M, Waliullah A.S.M. , Al Mamun M, Nakajima M, Ikoma T, Akita K, Maekawa Y, Sato T, Setou M. NAD+ Levels are Augmented in Aortic Tissue of ApoE-/- Mice by Dietary Omega-3 Fatty Acids Arteriosclerosis, Thrombosis, and Vascular Biology.2022.
  5. Yamada T, Horikawa M, Sato T, Kahyo T, Takanashi Y, Ushirozako H, Kurosu K, Al Mamun M, Mihara Y, Oe S, Arima H, Banno T, Yosida G, Hasegawa T, Yamato Y, Matsuyama Y, Setou M.Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with abnormal accumulation of specific lipids.Sci Rep. 2021.
  6. Sato T, Horikawa M, Takei S, Yamazaki F, Ito TK, Kondo T, Sakurai T, Kahyo T, Ikegami K, Sato S, Sato R, Jinno Y, Kawano H, Naoe S, Arita M, Kashiwagi Y, Setou M.Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques.Arterioscler Thromb Vasc Biol. 2019.
  7. Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.UBL3 modification influences protein sorting to small extracellular vesicles.Nat Commun. 2018.
  8. Phua SC, Chiba S, Suzuki M, Su E, Elle RC, Ganesh PV, Setou M, Rohatgi R, Jeremy RF, Ikegami K, Inoue T.Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.Cell.2017.
  9. Masaki N, Ishizaki I, Hayasaka T, Fisher GL, Sanada N, Yokota H, Setou M.Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry.Sci Rep. 2015.
  10. Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M.Visualization of volatile substances in different organelles with an atmospheric-pressure Mass Microscope.Anal Chem. 2009.
  11. Konishi Y, Setou M.Tubulin tyrosination navigates the kinesin-1 motor domain to axons.Nat Neurosci. 2009.
  12. Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, MacGregor GR, Tanaka K, Setou M.SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.Cell. 2007.
  13. Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N.Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.Nature. 2002.
  14. Setou M, Nakagawa T, Seog DH, Hirokawa N.Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.Science. 2000.