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ホーム > 教育 > 医学部医学科 > 医学科講座等紹介 > 生活習慣関連疾患重症化予防医学講座（寄附講座） > 研究活動

研究活動

研究業績

  1. Iwakura T. SGLT2 inhibitors and acute kidney injury: renoprotective effects and mechanisms across diverse etiologies. Curr Opin Physiol. In press.

  2. Iwakura T, Fujigaki Y, Muraishi Y, Shiozaki Y, Kitamura A, Aoki T, Ohashi N, Yasuda H. A case of developing podocyte infolding glomerulopathy-like features and endothelial changes associated with an immune-mediated mechanism. Kidney Int Case Rep. In press.
  3. Takeuchi K, Mii A, Katafuchi R, Fujigaki Y, Honma S, Iwakura T, Kitamura M, Matsukuma Y, Abe M, Sakaguchi R, Morinaga H, Tanaka M, Nishi S, Ohno N, Mamorita N, Shimizu A, Joh K. Morphological subtypes and clinicopathological features of podocyte infolding glomerulopathy: retrospective nationwide Japanese cohort study of 93 cases. Clin Exp Nephrol. 2026. Online ahead of print.
  4. Uchiyama Y, Ohashi N, Iwakura T, Isobe S, Fujikura T, Fujigaki Y, Shimizu A, Yasuda H. An atypical case of proliferative glomerulonephritis with monoclonal immunoglobulin G1 κ deposits with organized structural deposits. CEN Case Rep. 2025;15(1):2.
  5. Iwakura T. Patient's view on: "Low-protein diet with personalized support in advanced chronic kidney disease: association with disease progression, dialysis delay, and mortality". Clin Kidney J. 2026;19(1):sfaf385.
  6. Ema C, Iwakura T, Tsuji N, Nakayama Y, Tsujda M, Katahashi N, Ishigaki S, Isobe S, Fujikura T, Ohashi N, Kato A, Sugimoto K, Yasuda H. Teneligliptin and empagliflozin attenuate ferroptosis-mediated acute tubular injury. Nephrol Dial Transplant. Nephrol Dial Transplant. 2026 Mar 31;41(4):750-765
  7. Asai Y, Iwakura T, Ishigaki S, Isobe S, Fujikura T, Ohashi N, Kato A, Yasuda H. Diagnostic Pitfalls of the Bleeding Origin after a Percutaneous Renal Biopsy. Intern Med. 64:881-885, 2025
  8. Iwakura T. Patient's View on: "Changes in body composition and handgrip strength during dapagliflozin administration in patients with chronic kidney disease". Clin Kidney J.18:sfaf121.2025
  9. Iwakura T, Huuskes BM. Reflections on our role as patient representatives for CKJ. Clin Kidney J. 18: sfaf202,2025
  10. Shida R, Iwakura T, Ohashi N, Ema C, Aoki T, Tashiro T, Ishigaki S, Isobe S, Fujikura T, Kato A, Nakamura T, Fujigaki Y, Shimizu A, Yasuda H. Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies. Intern Med.63:699-705,2024
  11. Yamashiro Y, Ohashi N, Iwakura T, Isobe S, Fujikura T, Fujigaki Y, Shimizu A, Yasuda H. A Rare Case of Sporadic Medullary Cystic Kidney Disease with Rapidly Progressive Renal Dysfunction and Renal Enlargement Complicated by Idiopathic Nodular Glomerulosclerosis. Intern Med.63:2439-2444, 2024
  12. Zhao ZB, Marschner JA, Iwakura T, Li C, Motrapu M, Kuang M, Popper B, Linkermann A, Klocke J, Enghard P, Muto Y, Humphreys BD, Harris HE, Romagnani P, Anders HJ. Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery. J Am Soc Nephrol. 34:394-411,2023
  13. Iwakura T, Ema C, Isobe S, Fujikura T, Ohashi N, Kato A, Yasuda H. Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan. Sci Rep. 12:2967, 2022
  14. Ishibuchi K, Iwakura T, Ema C, Nakagami D, Uchiyama Y, Kaneko M, Fukasawa H, Matsuyama T, Yasuda H, Furuya R. A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium Clin Med Insights Case Rep.15:11795476221078635, 2022
  15. Iwakura T, Ema C, Sato T, Isobe S, Fujikura T, Ohashi N, Kato A, Yasuda H. Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases. Kidney Med. 3:669-673, 2021
  16. Iwakura T, Marschner JA, Zhao ZB, Świderska MK, Anders HJ. Electric cell-substrate impedance sensing in kidney research. Nephrol Dial Transplant. 36:216-223, 2021
  17. Iwakura T, Fukasawa H, Kitamura A, Ishibuchi K, Yasuda H, Furuya R. Effect of dipeptidyl peptidase-4 inhibitors on cisplatin-induced acute nephrotoxicity in cancer patients with diabetes mellitus: A retrospective study. PLoS One. 15: e0229377, 2020
  18. Ishibuchi K, Iwakura T, Kaneko M, Fukasawa H, Furuya R. Pembrolizumab-associated nephrotic syndrome recovered from transient hemodialysis in a patient with lung cancer. CEN Case Rep. doi: 10.1007/s13730-020-00462-0, 2020
  19. Iwakura T, Zhao Z, Marschner JA, Devarapu SK, Yasuda H, Anders HJ. Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration. Nephrol Dial Transplant. 34: 1669-1680, 2019
  20. Kundert F, Platen L, Iwakura T, Zhao Z, Marschner JA, Anders HJ. Immune mechanisms in the different phases of acute tubular necrosis. Kidney Res Clin Pract. 2018; 37: 185-196
  21. Iwakura T, Fujigaki Y, Fujikura T, Tsuji T, Ohashi N, Kato A, Yasuda H. Cytoresistance after acute kidney injury is limited to the recovery period of proximal tubule integrity and possibly involves Hippo-YAP signaling. Physiol Rep. 5: e13310, 2017
  22. Iwakura T, Fujigaki Y, Fujikura T, Ohashi N, Kato A, Yasuda H. Acquired Resistance to Rechallenge Injury After Acute Kidney Injury in Rats Is Associated With Cell Cycle Arrest in Proximal Tubule Cells. Am J Physiol Renal Physiol. 310: F872-84, 2016
  23. Iwakura T, Fujigaki Y, Katahashi N, Sato T, Ishigaki S, Tsuji N, Naito Y, Isobe S, Ono M, Sakao Y, Tsuji T, Ohashi N, Kato A, Miyajima H, Yasuda H. Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman. Intern Med. 55: 2663-8, 2016
  24. Iwakura T, Ohashi N, Kato A, Baba S, Yasuda H. Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. PLoS One. 10:e0138841, 2015
  25. Iwakura T, Namikawa A, Tsuji N, Ishigaki S, Isobe S, Ono M, Sakao Y, Tsuji T, Ohashi N, Kato A, Goto M, Yasuda H. Tubulointerstitial Nephritis Caused by Peritubular Capillaritis Accompanied by Cryoglobulinemia. Intern Med. 54: 2885-91, 2015
  26. Iwakura T, Fujigaki Y, Fujikura T, Ohashi N, Kato A, Yasuda H. A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule. Physiol Rep. 2014; 2: pii: e12173, 2014
  27. Iwakura T, Ohashi N, Tsuji N, Naito Y, Isobe S, Ono M, Fujikura T, Tsuji T, Sakao Y, Yasuda H, Kato A, Fujiyama T, Tokura Y, Fujigaki Y. Calcitriol-induced hypercalcemia in a patient with granulomatous mycosis fungoides and end-stage renal disease. World J Nephrol. 2: 44-8, 2013
  28. Iwakura T, Fujigaki Y, Matsuyama T, Fujikura T, Ohashi N, Yasuda H, Kato A, Baba S. Tubulointerstitial nephritis and primary biliary cirrhosis with a T cell-dominant profile of infiltrating cells and granulomas in both organs. Intern Med. 2013; 52: 467-71