原著論文(2013-2000)

2013

1. Kotake, Y., Ozawa, Y., Harada, M., Kitagawa, K., Niida, H., Morita, Y., Tanaka, K., Suda, T. and Kitagawa, M.: YB1 binds to and represses the p16 tumor suppressor gene. Gene Cells, in press.
2. Kitagawa, M., Kitagawa, K., Kotake, Y., Niida, H. and Ohhata, T.: Cell cycle regulation by long non-coding RNAs. Cell Mol Life Sci. 2013, DOI: 10.1007/s00018-013-1423-0.
3. Suzuki, S., Ohashi, N. and Kitagawa, M: Roles of the Skp2/p27 axis in the progression of chronic nephropathy. . Cell Mol Life Sci. 70:3277-3289, 2013.

2012

1. Liu, N., Matsumoto M., Kitagawa K., Kotake Y., Suzuki S., Shirasawa S., Nakayama KI., Nakanishi M., Niida H., Kitagawa M.: Chk1 phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling.　EMBO J. 31:2365-2377, 2012.
2. Egawa, K., Kitagawa, K., Inoue K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M., Fukuda, A: Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. Sci Transl Med. 4, 163ra157,1-10, 2012.
3. Kitagawa, M., Kotake, Y. and Ohhata, T.: Long noncoding RNA involved in cancer development and cell fate determination. Curr. Drug Targets 13:1616-1621, 2012.
4. Kitagawa, K. and Kitagawa, M.: The SCF ubiquitin ligases involved in hematopoietic linage. Curr. Drug Targets 13:1641-1648, 2012.
5. Niida, H. and Kitagawa, M.: Regulation of DNA replication licensing. Curr. Drug Target 13:1588-1592, 2012.
6. Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., Kitagawa, K., Kotake, Y., Niida, H., Liu, N., Nakayama. K., Nakayama, K.I., Yamamoto, T. and Kitagawa, M.: The amelioration of renal damage in Skp2-deficient mice is canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice. PLoS ONE, 7: e31249, 2012.
7. Fukasawa, H., Fujigaki Y., Yamamato, T., Hishida, A. and Kitagawa, M.: Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis. Current Medicinal Chemistry (review article) 19 893-900, 2012.

2011

1. Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., Kitagawa, K., Kotake, Y., Niida, H., Hishida, A., Yamamoto, T. and Kitagawa M.: Up-regulation of Cks1 and Skp2 with TNF-α/NF-κB signaling in chronic progressive nephropathy. Genes Cells 16: 1110-1120, 2011.
2. Kotake, Y., Nakagawa, T., Kitagawa, K., Suzuki, S., Liu, N., Kitagawa, M. and Xiong, Y.: Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene. Oncogene 30:1956-1962, 2011.
3. Hung, T., Wang, Y., Lin, MF., Koegel, A.K., Kotake, Y., Grant, GD., Horlings, H.M., Shah, N., Umbricht, C., Wang, P., Wang, Y., Kong, B., Langerod, A., Borresen-Dale, AL., Kim, S.K., van de Vijver, M., Sukumar, S., Whitfield, M.L., Kellis, M., Xiong, Y., Wong, DJ., Chang, HY.: Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43(7):621-629. 2011
4. Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Kojima, M., Kubota, K., Noda, M., Ogawa S., Shirato, H., Sato M., Suzuki-Migishima, R., Hino, T., Kitagawa, M. and Takeuchi, T.: Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonnji (Jarid2)-cyclin D1 pathway. Development 138:1771-1782, 2011.

2010

1. Kitagawa, K., Kotake, Y., Hiramatsu, Y., Liu, N., Suzuki, S., Nakamura, S., Kikuchi, A. and Kitagawa, M.: GSK3 regulates the expression of human and mouse c-Myb via different mechanisms. Cell Div. 5: 27, 2010.
2. Suzuki, T., Isobe, T., Kitagawa, M. and Ueda, K.: Kaposi's sarcoma-associated herpesvirus- encoded LANA positively affects on ubiquitylation of p53. Biochem. Biophys. Res. Commun. 403: 194-197, 2010.
3. Yu, H.S., Oyama, T., Isse, T., Kitagawa, K., Pham, T.T., Tanaka, M. and Kawamoto, T.: Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem. Biol. Interact. 188:367-375, 2010.
4. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, M.P., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E. and Nakanishi, M.: Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J. 29: 3558-3570, 2010.
5. Togawa, A., Sfakianos, J., Ishibe, S., Suzuki, S., Fujigaki, Y., Kitagawa, M., Mellman, I. and Cantley, L.G.: Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly. Biochem. Biophys. Res. Commun. 400: 271-277, 2010.
6. Sakai, S., Ohoka, N., Onozaki, K., Kitagawa, M., Nakanishi, M. and Hayashi, H.: Dual mode of regulation of Cdc25A protein by TRB3. Biol. Pharm. Bull. 33: 1112-1116, 2010.
7. Fukasawa, H., Yamamoto, T., Fujigaki, Y., Misaki, T., Ohashi, N., Takayama, T., Suzuki, S., Mugiya, S., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Hayashi, H., Ozono, S., Kitagawa, M. and Hishida, A.: Reduction of transforming growth factor-s type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma. Int. J. Cancer 127: 1517-1525, 2010.
8. Gao, Y., Gu, C., Li, S., Tokuyama, T., Yokota, N., Nakayama, K.I., Kitagawa, M. and Namba, H.: p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp. Ther. Med. 1: 695-699, 2010.
9. Ma, H., Yu, L., Byra, E.A., Hu, N., Kitagawa, K., Nakayama, K.I., Kawamoto, T. and Ren, J.: Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J. Mol. Cell. Cardiol. 49: 322-329, 2010.

2009

1. Isobe, T., Hattori, T., Kitagawa, K., Uchida, C., Kotake, Y., Kosugi, I., Oda, T. and Kitagawa, M.: Adenovirus E1A inhibits SCFFbw7 ubiquitin ligase. J. Biol. Chem. 284: 27766-27779, 2009.
2. Kitagawa, K., Hiramatsu, Y., Uchida, C., Isobe, T., Hattori, T., Oda, T., Shibata, K., Nakamura, S., Kikuchi, A. and Kitagawa, M.: Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene 28: 2383-2405, 2009.
3. Kotake, Y., Zeng, Y. and Xiong, Y.: DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res. 69: 1809-1814, 2009.
4. Kitagawa, K., Kotake, Y. and Kitagawa, M.: Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100: 1374-1381, 2009.
5. Misaki, T., Yamamoto, T., Suzuki, S., Fukasawa, H., Togawa, A., Ohashi, N., Suzuki, H., Fujigaki, Y., Oda, T, Uchida, C., Kitagawa, K., Hattori, T., Kitagawa, M. and Hishida, A.: Decrease in TRADD resulted from ubiquitin-dependent degradation in the obstructive renal injury in rats. Am. J. Pathol. 175: 74-83, 2009.
6. Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., Abe, K., Kotake, Y., Oda, T., Suzuki, H., Hashimoto, K. and Kitagawa, M.: High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Sci. 100: 866-872, 2009.
7. Jamal, M., Ameno, K., Miki, T., Wang, W., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. and Kinoshita, H.: Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models. Brain Res. 1295: 37-43, 2009.
8. Yu, HS, Oyama, T, Isse, T, Kitagawa, K., Ogawa, M., Pham, T.T. and Kawamoto, T.: Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. Toxicol. Mechanisms and Methods 19(9): 535-540, 2009.
9. Ameno, K., Wang, W., Jamal, M., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. and Kinoshita, H.: Ethanol metabolism in ALDH2 knockout mice Blood acetate levels Legal Med. 11: 413-415, 2009.

2008

1. Yamamoto, M., Kikuchi, H., Ohta, M., Kawabata, T., Hiramatsu, Y., Kondo, K., Baba, M,. Kamiya, K., Tanaka, T., Kitagawa M. and Konno, H.: TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche. Cancer Res. 68: 9754-9762, 2008.
2. Ohashi, N., Yamamoto, T., Huang, Y., Misaki, T., Fukasawa, H., Suzuki, H., Togawa, A., Suzuki, S., Fujigaki, Y., Nakagawa, T., Nakamura, Y., Suzuki, F., Kitagawa, M. and Hishida, A.: Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats. Am. J. Physiol Renal Physiol. 295: F1512-1518, 2008.
3. Hayakawa, M., Matsushima, M., Hagiwara, H., Oshima, T., Fujino, T., Ando, K., Kikugawa, K., Tanaka, H., Miyazawa,K. and Kitagawa, M.: Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF/b-TrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Genes to Cells 13: 329-442, 2008.
4. Abe, K., Hattori, T., Isobe, T., Kitagawa, K., Oda, T., Uchida, C., and Kitagawa, M.: Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit. Biomed Res. 29:53-60, 2008.
5. Kurata, K., Yanagisawa, R., Ohira, M., Kitagawa, M., Nakagawara, A. and Kamijo, T.: Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells. Oncogene 27: 741-754, 2008.
6. Fukasawa, H., Yamamato, T., Kitagawa, M. and Hishida, A.: Regulation of TGF-beta signaling by Smads and its roles in tissue fibrosis. Current signal transduction therapy (review article) 3: 1-6, 2008.
7. Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K.I. and Ichiba, M.: Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenet. Genomics 18: 847-52, 2008.
8. Kunugita, N., Isse, T., Oyama, T., Kitagawa, K., Ogawa, M., Yamaguchi, T., Kinaga, T. and Kawamoto, T.: Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde. J. Toxicol. Sci. 33: 31-36, 2008.

2007

1. Hattori, T., Isobe, T., Abe, K., Kikuchi, H., Kitagawa, K., Oda, T., Uchida, C. and Kitagawa, M.: Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip1. Cancer Res. 67: 10789-10795, 2007.
2. Ohoka, N., Hattori, T., Kitagawa, M., Onozaki, K. and Hayashi H.: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J. Biol. Chem. 282: 35687-35694, 2007.
3. Arakawa, T., Yamamura, T., Hattori, T., Hayashi H., Mori, A., Yoshida, A., Uchida, C., Kitagawa, M. and Onozaki, K.: Contribution of Extracellular Signal-Regulated Kinases to the IL-1-induced Growth Inhibition of Human Melanoma Cells A375. Int. Immunopharm. 8: 80-89, 2007.
4. Kono, S., Suzuki, H., Oda, T., Takahashi, Y., Shirakawa, K., Takahashi, Y., Kitagawa, M. and Miyajima, H.: Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia. J. Hepatology 47: 844-850, 2007.
5. Kikuchi, H., Yamamoto, M., Hiramatsu, Y., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Sugimura, H., Kitagawa, M., Kanai, T., Kitayama, Y., Kanda, T., Nishikura, K. and Konno, H.: Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Cancer Sci. 98: 1734-1739, 2007.
6. Kikuchi, H., Uchida, C., Hattori, T., Isobe, T., Hiramatsu, Y., Kitagawa, K., Oda, T., Konno, H. and Kitagawa, M.:　 ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. Carcinogenesis 28: 1752-1758, 2007.
7. Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T. and Kitagawa, M.: Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice. Am. J. Pathol. 171: 473-483, 2007.
8. Inoue, Y., Kitagawa, M. and Taya, Y.: Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 26: 2083-2093, 2007.
9. Li, S., Gao, Y., Tokuyama, T., Yamamoto, J., Yokota, N., Yamamoto, S., Terakawa, S., Kitagawa, M. and Namba, H.: Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett. 251: 220-227, 2007.
10. Wang, R.S., Ohtani, K., Suda, M., Kitagawa, K., Nakayama, K., Kawamoto, T. and Nakajima, T.: Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. Ind. Health 45: 574-578, 2007.
11. Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R.A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K.I., Tomokuni, K. and Ichiba, M.: Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol. Carcinogenesis 28: 2363-2366, 2007.

2006

1. Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H. and Kitagawa, M.: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66: 11623-11631, 2006.
2. Kono, S., Suzuki, H., Oda, T., Miyajima, H., Takahashi, Y., Shirakawa, K., Ishikawa, K., and Kitagawa, M.: Biochemical features of ceruloplasmin gene mutations linked to aceruloplasminemia. Neuromolecular Med. 8: 361-374, 2006.
3. Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T. and Kitagawa, M.: Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor. Hokkaido. J. Med. Sci. 81: 101-105, 2006.
4. Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama K.I., Yamamtoto, T., Konno, H. and Kitagawa, M.: Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 66: 8477-8483, 2006.
5. Takemura, M., Yoshida, S., Akiyama, T., Kitagawa, M. and Yamada, Y.: Role of the second-largest subunit of DNA polymerase a in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase. Biochem. Biophys. Acta 1764: 1447-1453, 2006.
6. Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda, T., Yasuda, H. and Kitagawa, M.: Effect of MdmX on Mdm2-mediated downregulation of pRB. FEBS Lett. 580:1753-1758, 2006.
7. Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T. and Kitagawa, M.: Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69. Biochem. Biophys. Res. Commun. 339: 367-374, 2006.
8. Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H. Chida K. and Kitagawa, M.: Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner. Biochem. Biophys. Res. Commun. 340: 54-61, 2006.
9. Kikuchi, H., Yamashita, K., Kawabata, T., Yamamoto, M., Hiramatsu, Y., Kondo, K., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Kitagawa, K., Kitagawa, M., Sugimura, H. and Konno, H.:Immunohistochemical and genetic features of gastric and the metastatic liver GISTs, sequential analyses. Cancer Sci. 97: 127-132, 2006.
10. Fukasawa, H., Yamamoto, T., Togawa, A. Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M. and Hishida, A.: Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int. 69: 1733-1740, 2006.

2005

1. Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., Yasuda, H., and Kitagawa, M.: Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24: 160-169, 2005.
2. Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A. and Kitagawa, M.: Transcriptional induction of Smurf2 ubiquitin ligase by TGF-?. FEBS Lett. 579: 2557-2563, 2005.
3. Takaki, T., Fukasawa, K., Suzuki-Takahashi, I., Semba, K., Kitagawa, M., Taya, Y. and Hirai, H: Preferences for phosphorylation sites in the retinoblastoma protein of D-Type cyclin-dependent kinases, Cdk4 and Cdk6 in vitro. J. Biochem. 137: 381-386, 2005.
4. Hayakawa, M., Kitagawa, H., Miyazawa, K., Kitagawa, M., and Kikugawa, K.: The FWD1/b-TrCP-mediated degradation pathway establishes a turning off switch of a Cdc42 guanine nucleotide exchange factor, FGD1. Genes to Cells 10: 241-251, 2005.
5. Isse, T., Matsuno, K., Oyama, T., Kitagawa, K. and Kawamoto, T.: Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin. Exp. Res. 29: 1959-1964, 2005.
6. Chen, Z., Foster, M.W., Zhang, J., Mao, L., Rockman, H.A., Kawamoto, T., Kitagawa, K., Nakayama, K.I., Hess, D.T. and Stamler, J.S.: An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc. Natl. Acad. Sci. U S A. 102: 12159-12164, 2005.
7. Kim, Y.D., Oyama, T., Isse, T., Kitagawa, K., Ogawa, M., Yamaguchi, T., Suzuki, R., Kinaga, T., Kim, Y. H. and Kawamoto T.: Expression levels of hepatic cytochrome p450 enzymes in Aldh2 deficient mice following ethanol exposure; a pilot study. Archives of Toxicology 79: 192-195, 2005.

2004

1. Naito, M., Katayama, R., Ishioka, T., Suga, A., Takubo, K., Nanjyo, M., Hashimoto, C., Taira, M., Takada S., Takada, R., Kitagawa, M., Matsuzawa, S.-i., Reed, J. C. and Tsuruo, T.: Cellular FLIP inhibits b-catenin ubiquitylation and enhances Wnt signaling. Mol. Cell. Biol. 24: 8418-8427, 2004.
2. Fukasawa, H., Yamamoto, T., Togawa, A. Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M. and Hishida, A.: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in mice obstructive nephropathy. Proc. Natl. Acad. Sci. USA 101: 8687-8692, 2004.
3. Nakayama, K., Nagahama, H., Minamishima, Y. A., Miyake S., Matsumoto, M., Ishida, N., Hatakeyama S., Kitagawa, M., Iemura, S.-i., Natsume, T., and Nakayama, K.-i.: Skp2-mediated degradation of p27 regulates progression into Mitosis. Dev. Cell 6: 661-672, 2004.
4. Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M. and Nakayama K-I.: Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J. 23: 659-669, 2004.
5. Inoue, Y., Kitagawa, M., Onozaki, K, and Hayashi, H.: Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-b signaling. J. Interferon Cytokine Res. 24: 43-54, 2004
6. Kimura, M., Uchida, C., Takano, Y., Kitagawa, M. and Okano, Y.: Cell cycle-dependent regulation of the human aurora B promoter. Biochem. Biophys. Res. Commun. 316: 930-6, 2004.
7. Fukasawa, H., Yamamoto, T., Suzuki, H., Togawa, A. Ohashi, N., Fujigaki, Y., Uchida, C., Aoki, M., Hosono, M., Kitagawa, M. and Hishida, A.: Treatment with anti-TGF-s antibody ameliorates progressive nephritis by inhibiting Smad/TGF-s signaling. Kidney Int. 65: 63-74, 2004.
8. Oyama, T., Kagawa, N., Kunugita, N., Kitagawa, K., Ogawa, M., Yamaguchi, T., Suzuki, R., Kinaga, T., Yashima, Y., Ozaki, S., Isse, T., Kim, Y.D., Kim, H. and Kawamoto, T.: Expression of cytochrome P450 in tumor tissues and its association with cancer development. Front. Biosci. 9: 1967-1976, 2004.

2003

1. Hattori, T., Kitagawa, K., Uchida, C., Oda, T., and Kitagawa, M.: Cks1 is degraded via the ubiquitin-proteasome pathway in a cell cycle-dependent manner. Genes to Cells 8: 889-896, 2003.
2. Togawa, A., Yamamoto, T., Suzuki, S., Fukasawa, H., Ohashi, N., Fujigaki, Y., Kitagawa, K., Hattori, T., Kitagawa, M. and Hishida, A.: Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis. Am. J. Pathol. 163: 1645-1652, 2003.
3. Natsume, H., Sasaki, S., Kitagawa, M., Kashiwabara, Y., Matsushita, A., Nakano, K., Nishiyama, K., Nagayama, K., Misawa, H., Masuda H. and Nakamura, H.: b-Catenin/Tcf-1-mediated transactivation of cyclin D1 promoter is negatively regulated by thyroid hormone. Biochem. Biophys. Res. Commun. 309: 408-413, 2003.
4. Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. and Nakayama, K.-I.: Cell Cycle-dependent Regulation of the Skp2 Promoter by GA-binding Protein. Cancer Res. 63: 4607-4613, 2003.
5. Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M. and Kikugawa, K.: Evidence that reactive oxygen species do not mediate NF-kB activation. EMBO J. 22: 3356-3366, 2003.
6. Inui, N., Kitagawa, K., Miwa, S., Hattori, T., Chida, K., Nakamura, H. and Kitagawa, M.: High expression of Cks1 in human non-small cell lung carcinomas. Biochem. Biophys. Res. Commun. 303: 978-984, 2003.
7. Tahara, K., Tsuchimoto, D., Tominaga, Y., Asoh, S., Ohta, S., Kitagawa, M., Horie, H., Kadoya, T. and Nakabeppu, Y.: ΔFosB but not FosB induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line. Cell Death and Diff. 10: 496-507, 2003.
8. Katayama, K., Dobashi, Y., Kitagawa, M., Kawai, M., Kadoya, Y. and Kameya, T.: Cdk4/cyclin D1 kinase, a universal and critical regulator of apoptosis. Anticancer Res. 23: 235-244, 2003.
9. Matsumoto, A., Kunugita, N., Kitagawa, K., Isse, T., Oyama, T., Foureman, G.L., Morita, M. and Kawamoto, T.: Bisphenol A levels in human urine. Environ. Health Perspect. 111: 101-104, 2003.

2002

1. Uchida, C., Oda, T., Sugiyama, T., Otani, S., Kitagawa, M. and Ichiyama, A.: The role of Sp1 and AP-2 in basal and protein kinase A-induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. J. Biol. Chem. 277: 39082-39092, 2002.
2. Mizuno, T., Ito, K., Uchida, C., Kitagawa, M., Ichiyama, A., Miura, S., Fujita, K. and Oda, T.: Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase. Histochem. Cell Biol. 118: 321-328 2002.
3. Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., Nakayama, K., Nakayama, K. and Kawamoto, T.: Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12: 621-626, 2002.

2001

1. Nishida, T., Kaneko, F., Kitagawa, M. and Yasuda, H.: Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat Axam, which is an Axin-binding protein promoting b-catenin degradation. J. Biol. Chem. 276: 39060-39066, 2001.
2. Katayama, K., Dobashi Y., Kitagawa, M., Kamekura, S., Kawai, M., Kadoya Y. and Kameya T.: Overexpression of Cdk4/Cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support. FEBS Lett. 509: 382-388, 2001.
3. Sugiyama, T., Uchida, C., Oda, T., Kitagawa, M., Hayashi, H. and Ichiyama, A.: Involvement of CCAAT/enhancer-binding protein in regulation of the rat serine:pyruvate/alanine:glyoxylate aminotransferase gene expression. FEBS Lett. 508: 16-22, 2001.
4. Takemura, M., Yamamoto, T., Kitagawa, M., Taya Y., Akiyama, T., Asahara, H., Linn S., Suzuki, S., Tamai, K. and Yoshida, S.: Stimulation of DNA polymerase a activity by cdk2-phosphorylated Rb Protein. Biochem. Biophys. Res. Commun. 282: 984-990, 2001.
5. Kitagawa, K., Kunugita, N., Kitagawa, M. and Kawamoto, T.: CYP2A6*6, a novel polymorphism in Cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. J. Biol. Chem. 276: 17830-17835, 2001.
6. Yang, M., Kunugita, N., Kitagawa, K., Kang, S.H., Coles, B., Kadlubar, F.F., Katoh, T., Matsuno, K. and Kawamoto, T.: Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes. Cancer Epidemiol. Biomarkers Prev. 10: 589-593, 2001.
7. Yamanaka, A., Hatakeyama, S., Kominami, K.-i., Kitagawa, M., Matsumoto, M. and Nakayama, K.-i.: Cell-cycle dependent expression of mammalian E2-C regulated by the anaphase promoting complex/cyclosome. Mol. Biol. Cell 11: 2821-2831, 2000.
8. Ishida, N., Kitagawa, M., Hatakeyama, S. and Nakayama, K.-i.: Phosphorylation at Ser10 a major phosphorylation site of p27Kip1 , increases its protein stability. J Biol. Chem. 275: 25146-25154, 2000.
9. Ishimi, Y., Komamura, Y., You, Z., Omori, A. and Kitagawa, M.: Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A-Cdk2. J. Biol. Chem. 275: 16235-16241, 2000.
10. Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K.-i., and Hatakeyama S.: Targeted disruption of Skp2 result in accumulation of Cyclin E and p27Kip1, polyploidy, and centrosome overdeplication. EMBO J. 19(9): 2069-2081, 2000.
11. Dobashi, Y., Shoji, M., Kitagawa, M., Noguchi, T. and Kameya, T.: Simultaneous suppression of Cdc2/Cdk2 activity is necessary and sufficient for neuronal differentiation of PC12. J. Biol. Chem. 275: 12572-12580, 2000.
12. Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y. and Hirai, A.: Geranylgeranyl-pyrophosphate (GGPP), an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by HMG-CoA reductase inhibition. J. Neurosci. 20: 2852-2859, 2000.
13. Kitagawa K, Kawamoto T, Kunugita N, Tsukiyama T, Okamoto K, Yoshida A, Nakayama K, Nakayama K. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 2000 Jul 7;476(3):306-11.
14. Katoh T, Boissy R, Nagata N, Kitagawa K, Kuroda Y, Itoh H, Kawamoto T, Bell DA. Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genesand susceptibility to gastric and colorectal adenocarcinoma. Int J Cancer. 2000 Jan 1;85(1):46-9.

Selected Paper (-1999）

1. Kitagawa, M., Hatakeyama S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.-i. and Nakayama, K. : An F-box protein FWD1 mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J. 18: 2401-2410, 1999.
2. Hatakeyama S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakao, H., Okumura, K., Onoe, K., Good, R. A. and Nakayama, K.-i. (Hatakeyama, S. and Kitagawa, M. equally contributed to this report): Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1. Proc. Nathl. Acad. Sci. USA 96: 3859-3863, 1999.
3. Shirane, M., Harumiya, Y., Ishida, N., Miyamoto, C., Hirai, A., Hatakeyama, S., Nakayama, K.-i. and Kitagawa, M.: Down-regulation of p27Kip1 by two mechanizms, ubiquitin-mediated degradation and site-specific cleavage. J. Biol. Chem. 274(20): 13886-13893, 1999.
4. Noguchi, Y., Nakamura, S., Yasuda, T., Kitagawa, M., Kohn, L.D., Saito, Y. and Hirai, A.: Newly synthesized Rho A, not Ras is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth stimulated rat FRTL-5 cells. J. Biol. Chem. 273: 3649-3653, 1998.
5. Kawana, H., Tamaru, J.-i., Tanaka, T., Hirai, A., Saito, Y., Kitagawa, M., Mikata, A., Harigaya, K. and Kuriyama, T.: Role of p27Kip1 and cyclin-dependent kinase 2 in proliferation of non-small cell lung cancer. Am. J. Pathol. 153: 505-513, 1998.
6. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y. and Hirai, A.: Activation of Cyclin dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. - Geranylgeranylated-Rho-small GTPase(s) are essential for the induction of cyclin E gene expression. J. Biol. Chem. 273: 26772-26778, 1998.
7. Hirai, A., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Tatsuno, I., Oeda, T., Tahara, K., Terano,T., Narumiya, S., Kohn, L. D. and Saito, Y. : Geranylgeranylated Rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J. Biol. Chem. 272: 13-16, 1997.
8. Kitagawa, M., Higashi, H., Jung, H.-K., Suzuki-Takahashi, I., Ikeda, M., Tamai, K., Kato, J., Segawa, K., Yoshida, E., Nishimura, S. and Taya, Y.: Consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15: 7060-7069, 1996.
9. Furukawa, Y., Iwase, S., Terui, Y., Kikuchi, J., Nakamura, M., Kitagawa, S., and Kitagawa, M.: Transcriptional activation of the cdc2 gene is associated with Fas-induced apoptosis of human hematopoietic cells. J. Biol. Chem. 271: 28469-28477, 1996.
10. Yamamoto, K., Hirai, A., Ban, T., Saito, J., Tahara, K., Terano, T., Tamura, Y., Saito, Y. and Kitagawa, M.: Tyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells. Endocrinology 137: 2036-2042, 1996.
11. Higashi, H., Suzuki-Takahashi, I., Saitoh, S., Segawa, K., Taya, Y., Okuyama, A., Nishimura, S. and Kitagawa, M.: Cyclin-depemdent kinase 2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur. J. Biochem. 237: 460-467, 1996.
12. Kitagawa, M., Higashi, H., Takahashi, -S.I., Segawa, K. Hanks, S.K., Taya, Y., Nishimura, S. & Okuyama, A.: Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene, 10 : 229-236, 1995.
13. Suzuki-Takahashi, I., Kitagawa, M., Saijo, M., Higashi, H., Ogino, H., Matsumoto, H., Taya, Y., Nishimura, S. & Okuyama, A.: The interaction of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by cyclin-dependent kinases. Oncogene, 10 : 1691-1698, 1995.
14. Kitagawa, M., Higashi, H., Takahashi, -S.I., Okabe, T., Ogino, H., Taya, Y., Nishimura, S. & Okuyama, A.: A cyclin dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression. Oncogene, 9 : 2549-2557, 1994.
15. Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Takahashi, -S.I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., Ohba, Y., Nishimura, S. & Okuyama, A. : Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene, 8: 2425-2432, 1993.
16. Kitagawa, M., Saitoh, S., Ogino, H., Okabe, T., Matsumoto, H., Okuyama, A., Tamai, K., Ohba, Y., Yasuda, H., Nishimura, S. & Taya, Y.: cdc2-like kinase is associated with the retinoblastoma protein. Oncogene, 7 : 1067-1074, 1992.

総説、著書（2000-2012） †

1. Fukasawa, H., Fujigaki Y., Yamamato, T., Hishida, A. and Kitagawa, M.: Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis. Current Medicinal Chemistry in press (review article).
   
   
2. 神武洋二郎、北川雅敏　長鎖ncRNAによるクロマチン修飾因子のリクルートメント機構、実験医学 29, 1716-1721, 2011.
   
   
3. 神武洋二郎、北川雅敏　長鎖ノンコーディングRNAと細胞老化、細胞工学 30, 729-733, 2011
   
   
4. Kitagawa, K., Kotake, Y. and Kitagawa, M. Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100, 1374-1381, 2009 (review article).
   
   
5. Fukasawa, H., Yamamato, T., Kitagawa, M. and Hishida, A.: Regulation of TGF-beta signaling by Smads and its roles in tissue fibrosis. Current signal transduction therapy 3: 1-6, 2008 (review article).
   
   
6. 北川雅敏（訳）分担　癌の細胞周期　中山敬一、中山啓子監訳「カラー図説　細胞周期　-細胞増殖の制御メカニズム」　メディカル･サイエンス･インターナショナル社　東京　2008年
   
   
7. 北川雅敏　「細胞周期調節機構とその新しい概念」血液フロンティア　血液疾患と細胞周期～基礎から臨床まで～　11月号　2007　
   
   
8. 北川雅敏　ユビキチン-プロテアソームと細胞周期　ニューサイエンス社「細胞」40、42-46　　105-113、2006
   
   
9. 北川雅敏 「p53およびRB蛋白質のプロテアソーム依存的分解機構」ユビキチンプロテアソーム系とオートファジー　作動機構と病態生理　（田中啓二、大隅良典　 編）共立出版　8月号増刊　Vol.51 No.10　1376-1381、2006
   
   
10. 北川雅敏編集　「細胞周期集中マスター」羊土 社: 2006
    
    
11. 北川雅敏　「2大癌抑制経路　RB経路とp53経路」　キーワードで理解する細胞周期イラストマップ（中山敬一編）羊土社: 162-169、2005
    
    
12. 北川雅敏　「p53・RBファミリーのユビキチン依存性代謝機構」　医学のあゆみ　211: 43-48、2004
    
    
13. 内田千晴　北川雅敏　「細胞周期制御分子の分解機構とがん化」　実験医学　22: 1800-1807、2004
    
    
14. 北川雅敏　「多様な生命現象の分子基盤としての細胞周期制御機構」　実験医学　22: 1782-1786、2004
    
    
15. 北川雅敏　「細胞周期制御分子の分解とがん」　分子細胞治療　3: 3-11、2004
    
    
16. 北川雅敏　「がん抑制遺伝子産物p53とRBファミリーの分解制御機構」　現代医療　36（4）: 147-153、2004
    
    
17. 北川雅敏　「細胞周期メカニズムの解明に向けて」　ポストゲノムの分子生物学　（村上康文 編）化学同人　95-106、2003
    
    
18. 北川雅敏（2001）β- カテニンの分解と癌「タンパク質分解の最前線2001」実験医学増刊19：83-89
    
    
19. 松本雅志，北川雅敏 (2000) ユビキチンープロテアソームによるシグナル伝達分子の量的制御機構 シグナル伝達がわかる 羊土社 110-116
    
    
20. 北川雅敏 (2000) RB 経路による細胞周期の制御機構 実験医学増刊 細胞周期研究のフロンティア18: 27-32