教育
Education
発表論文
Publications (2000 - 2023)
Dept. Molecular Biology (Biochemistry 1), Hamamatsu University School of Medicine
2023
1. Suzuki, T., *Sakai, S., Ota, K., Yoshida, M., Uchida, C., Niida, H., Suda, Y., Kitagawa, M. and *Ohhata, T.: Expression of tumor suppressor FHIT is regulated by the LINC00173-SNAIL axis in human lung adenocarcinoma. Int. J. Mol. Sci. 24: 17011, 2023.
2. Suzuki, M., Sakai, S., Ota, K., Bando, Y., Uchida, C., Niida, H., Kitagawa, M. and *Ohhata, T.: CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts with specified regions. Sci. Rep.13: 14807, 2023.
3. *Uchida, C., Niida, H., Sakai, S., Iijima, K, Kitagawa, K., Ohhata, T., Shiotani B. and Kitagawa, M.: p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. BBA-Mol Cell Res. 1870(6): 119484, 2023.
4. Ota, K., *Sakai, S., Ohhata, T., Suzuki, T., Uchida, C., Niida, H. and *Kitagawa, M.: APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway. Carcinogenesis 44: 1-14, 2023.
2022
1. *Ohhata, T., Suzuki, M., Sakai, S., Ota, K., Yokota, H., Uchida, C., Niida, H., and Kitagawa, M.: CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles. Sci. Rep. 12: 15525, 2022.
2. Sano,A., Inoue, Y., Kikuchi, H., Fukuchi, K., Funai, K., Imai, A., Matsushita, Y., Tamura, K., Kitagawa, M., *Miyake, H.:Development of a simple and objective prognostication model for patients with advanced solid malignant tumors treated with immune checkpoint inhibitors: A pan-cancer analysis. Targeted Oncology 17: 583-589, 2022.
3. Hirotsu, A., *Kikuchi, H., Yamada,H., Ozaki, Y., Haneda, R., Kawata, S., Murakami, T., Matsumoto T., Hiramatsu, Y., Kamiya, K., Yamashita, D., Fujimori, Y., Ueda, Y., Okazaki, S., Kitagawa, M., Konno, H. and Takeuchi, H. Artificial intelligence-based classification of peripheral blood nucleated cells using label-free imaging flow cytometry. Lab on a Chip,22:3464-3474, 2022.
4. Koyauchi, T., *Niida, H., Motegi, A., Sakai, S., Uchida, C., Ohhata, T., Iijima, K., Yokoyama, A., Suda, T., and Kitagawa, M.: Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1- dependent manner to facilitate nucleotide excision repair. BBA-Mol Cell Res. 1869:11932, 2022.
5. *Iizumi, Y., Sowa, Y., Goi, W., Aono, Y., Watanabe, M., Kurumida, Y., Kameda, T., Akaji, K., Kitagawa, M., Sakai, T.: Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol. Commun. Biol. 5(1):564, 2022.
2021
1.Tamura, Y., *Ohhata, T., Niida, H., Sakai, S., Uchida C., Masumoto, K., Kotou, F., Wuts, A. and *Kitagawa, M.: Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes. EMBO Reports. 22, e52190, 2021.
2. *Ohhata, T., Yamazawa, K., Kamio, M.A., Takahashi, S., Sakai, S., Tamura, Y., Uchida, C., Kitagawa, K., Niida, H., Hiratan,i I., Kobayashi, H., Kimura, H., Wuts, A. and *Kitagawa, M.: Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix. Cell Rep. 34(13):108912, 2021.
3. Inui, N*., Sakai, S., Kitagawa, M*: Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway Int. J. Mol. Sci. 22, 6107, 2021
2020
1. Kitagawa, K., Uchida, C., Horiguchi, R., Ohhata, T., Sakai, S., Niida, H., Yasumoto, S., Handa, Y., Suzuki, M., Hashimoto, M., Tazawa, T., Yokochi, Y., Tsuji, M., *Kitagawa, M.: Substitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation. Sci. Rep. 10(1):14381, 2020.
2. Nishimoto, K., *Niida, H., Uchida, C., Ohhata, T., Kitagawa, K., Motegi, A., Suda, T., Kitagawa, M.: HDAC3 is required for XPC recruitment to DNA damage sites after UV irradiation. Mol. Cancer Res. 18(9):1367-1378, 2020.
3. Kim C, Sung S, Kim JS, Lee H, Jung Y, Shin S, Kim E, Seo JJ, Kim J, Kim D, Niida H, Kim VN, Park D, Lee J.Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Nat Commun.12(1):1097, 2021.
4. Zhou X., Nakashima K., Ito M., Zhang X., Sakai S., Feng C., Sun H., Chen H., Li TC. and Suzuki T.: Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China. Sci Rep. 10 (1): 17066, 2020.
2019
1. Sakai, S., Ohhata, T., Kitagawa, K., Uchida, C., Aoshima, T., Niida, H., Suzuki, T., Inoue, Y., Miyazawa, K and *Kitagawa, M.: Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition: Cancer Res. 79, 2821-2838, 2019.
2. Ozaki, Y., Yamada, H., *Kikuchi, H., Hirotsu, A., Murakami, T., Matsumoto, T., Kawabata, T., Hiramatsu, Y., Kamiya, K., Yamauchi, T., Goto, K., Ueda, Y., Okazaki, S., Kitagawa, M., Takeuchi, H. and Hiroyuki Konno.: Label-free classification of cells based on supervised machine learning of subcellular structures. PLoS One, 14:e0211347, 2019.
2018
1. Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K.I., Inui, N., Suda, T., *Kitagawa, M.: Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis. Int. J. Mol. Sci. 19: pii: E474. 2018.
2017
1. Harada, M., Sakai, S., Ohhata, T., Kitagawa, K., Mikamo, M., Nishimoto, K., Uchida, C., Niida, H., Kotake, Y., Sugimura, H., Suda, T. and *Kitagawa, M.: Homeobox Transcription Factor NKX2-1 Promotes Cyclin D1 Transcription in Lung Adenocarcinomas: Mol Cancer Res,10, 1388-1397, 2017.
2. Murakami, T., *Kikuchi, H., Ishimatsu, H., Iino, I., Hirotsu, A., Matsumoto, T., Ozaki, Y., Kawabata, T., Hiramatsu, Y., Ohta, M., Kamiya, K., Fukushima, M., Baba, S., Kitagawa, K., Kitagawa, M. and Konno, H.: Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis. Br. J. Cancer, 117, 1360-1370, 2017.
3. *Niida, H., Matsunuma, R., Horiguchi, R., Uchida, C., Nakazawa, Y., Motegi, A., Nishimoto, K., Sakai, S., Ohhata, T., Kitagawa, K., Moriwaki, S., Nishitani, H., Ui, A., Ogi, T. and Kitagawa, M.: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair: Nature Commun., 8:16102, 2017.
4. *Dobashi, Y., Tsubochi, H., Minegishi, K., Kitagawa, M., Otani, S., Ooi, A.: Regulation of p27 by ubiquitin ligases and its pathological significance in human lung adenocarcinomas. Human Pathology, 66: 67-78, 2017.
2016
1 Johmura, Y., Sun, J., Kitagawa, K., Nakanishi, K., Kuno, T., Naiki-Ito, A., Sawada, Y., Miyamoto, T., Okabe, A., Aburatani, H., Li, SF., Miyoshi, I., Takahashi, S., Kitagawa, M. and *Nakanishi, M.: SCFFbxo22-KDM4A target methylated p53 for degradation and regulate senescence. Nat. Commun. 7, 10574, 2016.
2 Matsunuma, R., *Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K.I., Ogura, H., Shiiya, N. and Kitagawa, M.: UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation to Regulate Cell proliferation. Mol. Cell. Biol. 36: 394-406, 2016.
3 Kitagawa, K. and *Kitagawa, M.: The SCF-type E3 Ubiquitin Ligase as Cancer Targets. Curr. Cancer Drug Targets 16: 119-129, 2016.
4 *Uchida, C. and Kitagawa, M.: RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer. Curr. Cancer Drug Targets 16: 157-174, 2016.
5 *Masumoto, K. and Kitagawa, M.: E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers. Curr. Cancer Drug Targets 16: 130-135, 2016.
6. Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M.: Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. Anticancer Res. 36(4):1605-11, 2016.
7. *Kotake,Y., Naemura, M., Kitagawa, K., Niida, H., Tsunoda, T., Shirasawa, S. and Kitagawa, M.: Oncogenic Ras regulates the expression of multiple lncRNAs. Cytotechnology 68:1591-1596, 2016.
2015
1. Ohhata, T., Matsumoto, M., Leeb, M., Shibata, S., Sakai, S., Kitagawa, K., Niida, H., *Kitagawa, M. and *Wutz, A.: Histone H3 lysine 36 tri-methylation is established over the Xist promoter by antisense Tsix transcription and contributes to repressing Xist expression. Mol. Cell. Biol. 35: 3909-3920, 2015.
2. *Kotake, Y. and Kitagawa, M.: Regulation of pRB and p53 Pathways by the Long Noncoding RNAs ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA. Long Noncoding RNAs, edited by Kurokawa R., Springer, 175-189, 2015. doi:10.1007/s10616-014-9834-9
3. Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Matsumoto, A., Nakayama, KI., Masumoto, K., Katou, F., Niida, H. and *Kitagawa, M.: Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA binding protein 2. J. Biol. Chem. 29: 10370-10381, 2015.
2014
1. Kitagawa, K., Shibata, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, KI., Niida, H. and *Kitagawa, M.: Fbw7 targets GATA3 through CDK2-dependent proteolysis and contributes to regulation of T-cell development. Mol. Cell. Biol. 34: 2732-2744, 2014.
2. *Fukasawa, H., Furuya, R., Yasuda, H., Fujigaki Y., Yamamato, T., Hishida, A. and Kitagawa, M.: Anti-cancer agent-induced nephrotoxicity. Anti-Cancer Agents in Medicinal Chemistry 14: 921-927, 2014.
3. Harada, M., Kotake, Y., Ohhata, T., Kitagawa, K., Niida, H., Matsuura, S., Funai, K., Sugimura, H., Suda, T. and *Kitagawa, M.: YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers. Genes Cells 19: 504-516, 2014.
4. *Uchida, C., Hattori, T., Takahashi, H., Yamamoto, N., Kitagawa, M., Taya, Y.: Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules. Genes Cells 19: 89-96, 2014.
5. Miyazaki, S., *Kikuchi, H., Iino I., Uehara, T, Setoguchi, T., Fujita, T., Hiramatsu, Y., Ohta, M., Kamiya, K., Kitagawa, K., Kitagawa, M., Baba, S. and Konno, K.: Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int. J. Cancer 135: 295-307, 2014.
2013
1. *Kotake, Y., Ozawa, Y., Harada, M., Kitagawa, K., Niida, H., Morita, Y., Tanaka, K., Suda, T. and Kitagawa, M.: YB1 binds to and represses the p16 tumor suppressor gene. Genes Cells 18: 999-1006, 2013.
2. *Kitagawa, M., Kitagawa, K., Kotake, Y., Niida, H. and Ohhata, T.: Cell cycle regulation by long non-coding RNAs. Cell. Mol. Life Sci. 70: 4785-4794, 2013.
3. Suzuki, S., Ohashi, N. and *Kitagawa, M.: Roles of the Skp2/p27 axis in the progression of chronic nephropathy. Cell. Mol. Life Sci. 70: 3277-3289, 2013.
2012
1. Egawa, K., Kitagawa, K., Inoue K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M. and *Fukuda, A: Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. Sci. Transl. Med. 4: 163ra157, 1-10, 2012.
2. Liu, N., Matsumoto M., Kitagawa K., Kotake Y., Suzuki S., Shirasawa S., Nakayama KI., Nakanishi M., Niida H. and *Kitagawa M.: Chk1 phosphorylates the tumor suppressor Mig-6, regulating the activation of EGF signaling. EMBO J. 31: 2365-2377, 2012.
3. *Fukasawa, H., Fujigaki Y., Yamamato, T., Hishida, A. and Kitagawa, M.: Protein Degradation by the Ubiquitin-Proteasome Pathway and Organ Fibrosis. Curr. Medicinal Chemistry 19: 893-900, 2012.
2011
1. Suzuki, S., Fukasawa, H., Misaki, T., Togawa A., Ohashi, N., Kitagawa, K., Kotake, Y., Niida, H., Hishida, A., Yamamoto, T. and *Kitagawa M.: Up-regulation of Cks1 and Skp2 with TNFa/NFkB signaling in chronic progressive nephropathy. Genes Cells 16: 1110-1120, 2011.
2. Kotake, Y., Nakagawa, T., Kitagawa, K., Suzuki, S., Liu, N., *Kitagawa, M. and *Xiong, Y.: Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene. Oncogene 30:1956-1962, 2011.
3. Hung, T., Wang, Y., Lin, MF., Koegel, A.K., Kotake, Y., Grant, GD., Horlings, H.M., Shah, N., Umbricht, C., Wang, P., Wang, Y., Kong, B., Langerod, A., Borresen-Dale, AL., Kim, S.K., van de Vijver, M., Sukumar, S., Whitfield, M.L., Kellis, M., Xiong, Y., Wong, DJ. and Chang, HY.: Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43(7): 621-629. 2011.
4. Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Kojima, M., Kubota, K., Noda, M., Ogawa S., Shirato, H., Sato M., Suzuki-Migishima, R., Hino, T., Kitagawa, M. and *Takeuchi, T.: Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonnji (Jarid2)-cyclin D1 pathway. Development 138:1771-1782, 2011.
2010
1. Kitagawa, K., Kotake, Y., Hiramatsu, Y., Liu, N., Suzuki, S., Nakamura, S., Kikuchi, A. and *Kitagawa, M.: GSK3 regulates the expression of human and mouse c-Myb via different mechanisms. Cell Div. 5: 27, 2010.
2. *Suzuki, T., Isobe, T., Kitagawa, M. and Ueda, K.: Kaposi's sarcoma-associated herpesvirus- encoded LANA positively affects on ubiquitylation of p53. Biochem. Biophys. Res. Commun. 403: 194-197, 2010.
3. Yu, H.S., Oyama, T., Isse, T., Kitagawa, K., Pham, T.T., Tanaka, M. and *Kawamoto, T.: Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. Chem. Biol. Interact. 188:367-375, 2010.
4. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, M.P., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E. and *Nakanishi, M.: Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J. 29: 3558-3570, 2010.
5. *Togawa, A., Sfakianos, J., Ishibe, S., Suzuki, S., Fujigaki, Y., Kitagawa, M., Mellman, I. and Cantley, L.G.: Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent Tight Junction Disassembly. Biochem. Biophys. Res. Commun. 400: 271-277, 2010.
6. Sakai, S., Ohoka, N., Onozaki, K., Kitagawa, M., Nakanishi, M. and *Hayashi, H.: Dual mode of regulation of Cdc25A protein by TRB3. Biol. Pharm. Bull. 33: 1112-1116, 2010.
7. *Fukasawa, H., Yamamoto, T., Fujigaki, Y., Misaki, T., Ohashi, N., Takayama, T., Suzuki, S., Mugiya, S., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Hayashi, H., Ozono, S., Kitagawa, M. and Hishida, A.: Reduction of transforming growth factor-s type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma. Int. J. Cancer 127: 1517-1525, 2010.
8. Gao, Y., Gu, C., Li, S., Tokuyama, T., Yokota, N., Nakayama, K.I., Kitagawa, M. and *Namba, H.: p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp. Ther. Med. 1: 695-699, 2010.
9. Ma, H., Yu, L., Byra, E.A., Hu, N., Kitagawa, K., Nakayama, K.I., Kawamoto, T. and Ren, J.: Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J. Mol. Cell. Cardiol. 49: 322-329, 2010.
2009
1. Isobe, T., Hattori, T., Kitagawa, K., Uchida, C., Kotake, Y., Kosugi, I., Oda, T. and *Kitagawa, M.: Adenovirus E1A inhibits SCFFbw7 ubiquitin ligase. J. Biol. Chem. 284: 27766-27779, 2009.
2. Kitagawa, K., Hiramatsu, Y., Uchida, C., Isobe, T., Hattori, T., Oda, T., Shibata, K., Nakamura, S., Kikuchi, A. and *Kitagawa, M.: Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene 28: 2383-2405, 2009.
3. Kotake, Y., Zeng, Y. and *Xiong, Y.: DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res. 69: 1809-1814, 2009.
4. Kitagawa, K., Kotake, Y. and *Kitagawa, M.: Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100: 1374-1381, 2009.
5. Misaki, T., *Yamamoto, T., Suzuki, S., Fukasawa, H., Togawa, A., Ohashi, N., Suzuki, H., Fujigaki, Y., Oda, T, Uchida, C., Kitagawa, K., Hattori, T., Kitagawa, M. and Hishida, A.: Decrease in TRADD resulted from ubiquitin-dependent degradation in the obstructive renal injury in rats. Am. J. Pathol. 175: 74-83, 2009.
6. Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., Abe, K., Kotake, Y., Oda, T., Suzuki, H., Hashimoto, K. and *Kitagawa, M.: High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Sci. 100: 866-872, 2009.
7. Jamal, M., Ameno, K., Miki, T., Wang, W., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. and Kinoshita, H.: Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models. Brain Res. 1295: 37-43, 2009.
8. Yu, HS, Oyama, T, Isse, T, Kitagawa, K., Ogawa, M., Pham, T.T. and *Kawamoto, T.: Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. Toxicol. Mechanisms and Methods 19(9): 535-540, 2009.
9. Ameno, K., Wang, W., Jamal, M., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. and Kinoshita, H.: Ethanol metabolism in ALDH2 knockout mice Blood acetate levels. Legal Med. 11: 413-415, 2009.
2008
1. Yamamoto, M., Kikuchi, H., Ohta, M., Kawabata, T., Hiramatsu, Y., Kondo, K., Baba, M,. Kamiya, K., Tanaka, T., Kitagawa M. and Konno, H.: TSU68 prevents liver metastasis of colon cancer xenografts by modulating the pre-metastatic niche. Cancer Res. 68: 9754-9762, 2008.
2. *Ohashi, N., Yamamoto, T., Huang, Y., Misaki, T., Fukasawa, H., Suzuki, H., Togawa, A., Suzuki, S., Fujigaki, Y., Nakagawa, T., Nakamura, Y., Suzuki, F., Kitagawa, M. and Hishida, A.: Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats. Am. J. Physiol Renal Physiol. 295: F1512-1518, 2008.
3. *Hayakawa, M., Matsushima, M., Hagiwara, H., Oshima, T., Fujino, T., Ando, K., Kikugawa, K., Tanaka, H., Miyazawa,K. and Kitagawa, M.: Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF/βTrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Genes Cells 13: 329-442, 2008.
4. Abe, K., Hattori, T., Isobe, T., Kitagawa, K., Oda, T., Uchida, C., and *Kitagawa, M.: Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit. Biomed Res. 29:53-60, 2008.
5. Kurata, K., Yanagisawa, R., Ohira, M., Kitagawa, M., Nakagawara, A. and *Kamijo, T.: Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells. Oncogene 27: 741-754, 2008.
6. *Fukasawa, H., Yamamato, T., Kitagawa, M. and Hishida, A.: Regulation of TGF-beta signaling by Smads and its roles in tissue fibrosis. Curr. signal transduction therapy 3: 1-6, 2008.
7. Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K.I. and Ichiba, M.: Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenet. Genomics 18: 847-52, 2008.
8. Kunugita, N., Isse, T., Oyama, T., Kitagawa, K., Ogawa, M., Yamaguchi, T., Kinaga, T. and Kawamoto, T.: Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde. J. Toxicol. Sci. 33: 31-36, 2008.
2007
1. Hattori, T., Isobe, T., Abe, K., Kikuchi, H., Kitagawa, K., Oda, T., Uchida, C. and *Kitagawa, M.: Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip1. Cancer Res. 67: 10789-10795, 2007.
2. Ohoka, N., Hattori, T., Kitagawa, M., Onozaki, K. and *Hayashi H.: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J. Biol. Chem. 282: 35687-35694, 2007.
3. Arakawa, T., Yamamura, T., Hattori, T., Hayashi H., Mori, A., Yoshida, A., Uchida, C., Kitagawa, M. and *Onozaki, K.: Contribution of Extracellular Signal-Regulated Kinases to the IL-1-induced Growth Inhibition of Human Melanoma Cells A375. Int. Immunopharm. 8: 80-89, 2007.
4. *Kono, S., Suzuki, H., Oda, T., Takahashi, Y., Shirakawa, K., Takahashi, Y., Kitagawa, M. and Miyajima, H.: Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia. J. Hepatology 47: 844-850, 2007.
5. Kikuchi, H., Yamamoto, M., Hiramatsu, Y., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Sugimura, H., Kitagawa, M., Kanai, T., Kitayama, Y., Kanda, T., Nishikura, K. and Konno, H.: Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Cancer Sci. 98: 1734-1739, 2007.
6. Kikuchi, H., Uchida, C., Hattori, T., Isobe, T., Hiramatsu, Y., Kitagawa, K., Oda, T., Konno, H. and *Kitagawa, M.: ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. Carcinogenesis 28: 1752-1758, 2007.
7. Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T. and *Kitagawa, M.: Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice. Am. J. Pathol. 171: 473-483, 2007.
8. Inoue, Y., Kitagawa, M. and *Taya, Y.: Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 26: 2083-2093, 2007.
9. Li, S., Gao, Y., Tokuyama, T., Yamamoto, J., Yokota, N., Yamamoto, S., Terakawa, S., Kitagawa, M. and *Namba, H.: Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett. 251: 220-227, 2007.
10. Wang, R.S., Ohtani, K., Suda, M., Kitagawa, K., Nakayama, K., Kawamoto, T. and Nakajima, T.: Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. Ind. Health 45: 574-578, 2007.
11. Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R.A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K.I., Tomokuni, K. and Ichiba, M.: Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol. Carcinogenesis 28: 2363-2366, 2007.
2006
1. Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K.I., Tanaka, T., Konno, H. and *Kitagawa, M.: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66: 11623-11631, 2006.
2. *Kono, S., Suzuki, H., Oda, T., Miyajima, H., Takahashi, Y., Shirakawa, K., Ishikawa, K., and Kitagawa, M.: Biochemical features of ceruloplasmin gene mutations linked to aceruloplasminemia. Neuromolecular Med. 8: 361-374, 2006.
3. Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T. and *Kitagawa, M.: Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor. Hokkaido. J. Med. Sci. 81: 101-105, 2006.
4. Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama K.I., Yamamtoto, T., Konno, H. and *Kitagawa, M.: Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 66: 8477-8483, 2006.
5. *Takemura, M., Yoshida, S., Akiyama, T., Kitagawa, M. and Yamada, Y.: Role of the second-largest subunit of DNA polymerase a in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase. Biochem. Biophys. Acta 1764: 1447-1453, 2006.
6. Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda, T., Yasuda, H. and *Kitagawa, M.: Effect of MdmX on Mdm2-mediated downregulation of pRB. FEBS Lett. 580:1753-1758, 2006.
7. Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T. and *Kitagawa, M.: Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69. Biochem. Biophys. Res. Commun. 339: 367-374, 2006.
8. Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H. Chida K. and *Kitagawa, M.: Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner. Biochem. Biophys. Res. Commun. 340: 54-61, 2006.
9. Kikuchi, H., Yamashita, K., Kawabata, T., Yamamoto, M., Hiramatsu, Y., Kondo, K., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Kitagawa, K., Kitagawa, M., Sugimura, H. and Konno, H.:Immunohistochemical and genetic features of gastric and the metastatic liver GISTs, sequential analyses. Cancer Sci. 97: 127-132, 2006.
10. Fukasawa, H., Yamamoto, T., Togawa, A. Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M. and Hishida, A.: Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int. 69: 1733-1740, 2006.
2005
1. Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., Yasuda, H., and *Kitagawa, M.: Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24: 160-169, 2005.
2. Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A. and *Kitagawa, M.: Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta. FEBS Lett. 579: 2557-2563, 2005.
3. Takaki, T., Fukasawa, K., Suzuki-Takahashi, I., Semba, K., Kitagawa, M., Taya, Y. and *Hirai, H: Preferences for phosphorylation sites in the retinoblastoma protein of D-Type cyclin-dependent kinases, Cdk4 and Cdk6 in vitro. J. Biochem. 137: 381-386, 2005.
4. *Hayakawa, M., Kitagawa, H., Miyazawa, K., Kitagawa, M., and Kikugawa, K.: The FWD1/beta-TrCP-mediated degradation pathway establishes a turning off switch of a Cdc42 guanine nucleotide exchange factor, FGD1. Genes Cells 10: 241-251, 2005.
5. Isse, T., Matsuno, K., Oyama, T., Kitagawa, K. and Kawamoto, T.: Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin. Exp. Res. 29: 1959-1964, 2005.
6. Chen, Z., Foster, M.W., Zhang, J., Mao, L., Rockman, H.A., Kawamoto, T., Kitagawa, K., Nakayama, K.I., Hess, D.T. and Stamler, J.S.: An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc. Natl. Acad. Sci. USA. 102: 12159-12164, 2005.
7. Kim, Y.D., Oyama, T., Isse, T., Kitagawa, K., Ogawa, M., Yamaguchi, T., Suzuki, R., Kinaga, T., Kim, Y. H. and Kawamoto T.: Expression levels of hepatic cytochrome p450 enzymes in Aldh2 deficient mice following ethanol exposure; a pilot study. Archives of Toxicology 79: 192-195, 2005.
2004
1. Naito, M., Katayama, R., Ishioka, T., Suga, A., Takubo, K., Nanjyo, M., Hashimoto, C., Taira, M., Takada S., Takada, R., Kitagawa, M., Matsuzawa, S.-i., Reed, J. C. and Tsuruo, T.: Cellular FLIP inhibits b-catenin ubiquitylation and enhances Wnt signaling. Mol. Cell. Biol. 24: 8418-8427, 2004.
2. Fukasawa, H., Yamamoto, T., Togawa, A. Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M. and Hishida, A.: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in mice obstructive nephropathy. Proc. Natl. Acad. Sci. USA 101: 8687-8692, 2004.
3. Nakayama, K., Nagahama, H., Minamishima, Y. A., Miyake S., Matsumoto, M., Ishida, N., Hatakeyama S., Kitagawa, M., Iemura, S.-i., Natsume, T., and *Nakayama, K.-i.: Skp2-mediated degradation of p27 regulates progression into Mitosis. Dev. Cell 6: 661-672, 2004.
4. Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M. and *Nakayama K-I.: Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J. 23: 659-669, 2004.
5. Inoue, Y., Kitagawa, M., Onozaki, K, and *Hayashi, H.: Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-b signaling. J. Interferon Cytokine Res. 24: 43-54, 2004
6. Kimura, M., Uchida, C., Takano, Y., Kitagawa, M. and Okano, Y.: Cell cycle-dependent regulation of the human aurora B promoter. Biochem. Biophys. Res. Commun. 316: 930-6, 2004.
7. Fukasawa, H., Yamamoto, T., Suzuki, H., Togawa, A. Ohashi, N., Fujigaki, Y., Uchida, C., Aoki, M., Hosono, M., Kitagawa, M. and Hishida, A.: Treatment with anti-TGF-s antibody ameliorates progressive nephritis by inhibiting Smad/TGF-s signaling. Kidney Int. 65: 63-74, 2004.
8. Oyama, T., Kagawa, N., Kunugita, N., Kitagawa, K., Ogawa, M., Yamaguchi, T., Suzuki, R., Kinaga, T., Yashima, Y., Ozaki, S., Isse, T., Kim, Y.D., Kim, H. and Kawamoto, T.: Expression of cytochrome P450 in tumor tissues and its association with cancer development. Front. Biosci. 9: 1967-1976, 2004.
2003
1. Hattori, T., Kitagawa, K., Uchida, C., Oda, T., and *Kitagawa, M.: Cks1 is degraded via the ubiquitin-proteasome pathway in a cell cycle-dependent manner. Genes Cells 8: 889-896, 2003.
2. Togawa, A., Yamamoto, T., Suzuki, S., Fukasawa, H., Ohashi, N., Fujigaki, Y., Kitagawa, K., Hattori, T., Kitagawa, M. and Hishida, A.: Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis. Am. J. Pathol. 163: 1645-1652, 2003.
3. Natsume, H., Sasaki, S., Kitagawa, M., Kashiwabara, Y., Matsushita, A., Nakano, K., Nishiyama, K., Nagayama, K., Misawa, H., Masuda H. and Nakamura, H.: b-Catenin/Tcf-1-mediated transactivation of cyclin D1 promoter is negatively regulated by thyroid hormone. Biochem. Biophys. Res. Commun. 309: 408-413, 2003.
4. Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. and *Nakayama, K.-I.: Cell Cycle-dependent Regulation of the Skp2 Promoter by GA-binding Protein. Cancer Res. 63: 4607-4613, 2003.
5. Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M. and Kikugawa, K.: Evidence that reactive oxygen species do not mediate NF-kB activation. EMBO J. 22: 3356-3366, 2003.
6. Inui, N., Kitagawa, K., Miwa, S., Hattori, T., Chida, K., Nakamura, H. and *Kitagawa, M.: High expression of Cks1 in human non-small cell lung carcinomas. Biochem. Biophys. Res. Commun. 303: 978-984, 2003.
7. Tahara, K., Tsuchimoto, D., Tominaga, Y., Asoh, S., Ohta, S., Kitagawa, M., Horie, H., Kadoya, T. and *Nakabeppu, Y.: ΔFosB but not FosB induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line. Cell Death Diff. 10: 496-507, 2003.
8. Katayama, K., *Dobashi, Y., Kitagawa, M., Kawai, M., Kadoya, Y. and Kameya, T.: Cdk4/cyclin D1 kinase, a universal and critical regulator of apoptosis. Anticancer Res. 23: 235-244, 2003.
9. Matsumoto, A., Kunugita, N., Kitagawa, K., Isse, T., Oyama, T., Foureman, G.L., Morita, M. and Kawamoto, T.: Bisphenol A levels in human urine. Environ. Health Perspect. 111: 101-104, 2003.
2002
1. Uchida, C., Oda, T., Sugiyama, T., Otani, S., Kitagawa, M. and Ichiyama, A.: The role of Sp1 and AP-2 in basal and protein kinase A-induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. J. Biol. Chem. 277: 39082-39092, 2002.
2. Mizuno, T., Ito, K., Uchida, C., Kitagawa, M., Ichiyama, A., Miura, S., Fujita, K. and *Oda, T.: Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase. Histochem. Cell Biol. 118: 321-328 2002.
3. Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., Nakayama, K., Nakayama, K. and Kawamoto, T.: Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12: 621-626, 2002.
2001
1. Nishida, T., Kaneko, F., Kitagawa, M. and *Yasuda, H.: Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat Axam, which is an Axin-binding protein promoting b-catenin degradation. J. Biol. Chem. 276: 39060-39066, 2001.
2. Katayama, K., *Dobashi Y., Kitagawa, M., Kamekura, S., Kawai, M., Kadoya Y. and Kameya T.: Overexpression of Cdk4/Cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support. FEBS Lett. 509: 382-388, 2001.
3. Sugiyama, T., Uchida, C., Oda, T., Kitagawa, M., Hayashi, H. and Ichiyama, A.: Involvement of CCAAT/enhancer-binding protein in regulation of the rat serine:pyruvate/alanine:glyoxylate aminotransferase gene expression. FEBS Lett. 508: 16-22, 2001.
4. Takemura, M., Yamamoto, T., Kitagawa, M., Taya Y., Akiyama, T., Asahara, H., Linn S., Suzuki, S., Tamai, K. and Yoshida, S.: Stimulation of DNA polymerase a activity by cdk2-phosphorylated Rb Protein. Biochem. Biophys. Res. Commun. 282: 984-990, 2001.
5. Kitagawa, K., Kunugita, N., Kitagawa, M. and Kawamoto, T.: CYP2A6*6, a novel polymorphism in Cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. J. Biol. Chem. 276: 17830-17835, 2001.
6. Yang, M., Kunugita, N., Kitagawa, K., Kang, S.H., Coles, B., Kadlubar, F.F., Katoh, T., Matsuno, K. and Kawamoto, T.: Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes. Cancer Epidemiol. Biomarkers Prev. 10: 589-593, 2001.
7. Yamanaka, A., Hatakeyama, S., Kominami, K.-i., Kitagawa, M., Matsumoto, M. and *Nakayama, K.-i.: Cell-cycle dependent expression of mammalian E2-C regulated by the anaphase promoting complex/cyclosome. Mol. Biol. Cell 11: 2821-2831, 2000.
8. Ishida, N., Kitagawa, M., Hatakeyama, S. and *Nakayama, K.-i.: Phosphorylation at Ser10 a major phosphorylation site of p27Kip1 , increases its protein stability. J. Biol. Chem. 275: 25146-25154, 2000.
9. *Ishimi, Y., Komamura, Y., You, Z., Omori, A. and Kitagawa, M.: Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A-Cdk2. J. Biol. Chem. 275: 16235-16241, 2000.
10. Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., *Nakayama, K.-i., and Hatakeyama S.: Targeted disruption of Skp2 result in accumulation of Cyclin E and p27Kip1, polyploidy, and centrosome overdeplication. EMBO J. 19(9): 2069-2081, 2000.
11. *Dobashi, Y., Shoji, M., Kitagawa, M., Noguchi, T. and Kameya, T.: Simultaneous suppression of Cdc2/Cdk2 activity is necessary and sufficient for neuronal differentiation of PC12. J. Biol. Chem. 275: 12572-12580, 2000.
12. Tanaka, T., Tatsuno, I., Uchida, D., Moroo, I., Morio, H., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Saito, Y. and Hirai, A.: Geranylgeranyl-pyrophosphate (GGPP), an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by HMG-CoA reductase inhibition. J. Neurosci. 20: 2852-2859, 2000.
13. Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K. and Nakayama, K.: Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 476(3):306-311, 2000.
14. Katoh, T., Boissy, R., Nagata, N., Kitagawa, K., Kuroda, Y., Itoh, H., Kawamoto, T., and Bell, D.A.: Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genesand susceptibility to gastric and colorectal adenocarcinoma. Int J Cancer. 85(1):46-49, 2000.
Selected Paper (-1999)
Prof. Masatoshi Kitagawa
1 Kitagawa, M., Hatakeyama S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.-i. and *Nakayama, K. : An F-box protein FWD1 mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J. 18: 2401-2410, 1999.
2 Hatakeyama S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakao, H., Okumura, K., Onoe, K., Good, R. A. and *Nakayama, K.-i. (Hatakeyama, S. and Kitagawa, M. equally contributed to this report): Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1. Proc. Nathl. Acad. Sci. USA 96: 3859-3863, 1999.
3 Shirane, M., Harumiya, Y., Ishida, N., Miyamoto, C., Hirai, A., Hatakeyama, S., Nakayama, K.-i. and Kitagawa, M.: Down-regulation of p27Kip1 by two mechanizms, ubiquitin-mediated degradation and site-specific cleavage. J. Biol. Chem. 274(20): 13886-13893, 1999.
4 Noguchi, Y., Nakamura, S., Yasuda, T., Kitagawa, M., Kohn, L.D., Saito, Y. and Hirai, A.: Newly synthesized Rho A, not Ras is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth stimulated rat FRTL-5 cells. J. Biol. Chem. 273: 3649-3653, 1998.
5 Kawana, H., Tamaru, J.-i., Tanaka, T., Hirai, A., Saito, Y., Kitagawa, M., Mikata, A., Harigaya, K. and Kuriyama, T.: Role of p27Kip1 and cyclin-dependent kinase 2 in proliferation of non-small cell lung cancer. Am. J. Pathol. 153: 505-513, 1998.
6 Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y. and Hirai, A.: Activation of Cyclin dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. - Geranylgeranylated-Rho-small GTPase(s) are essential for the induction of cyclin E gene expression. J. Biol. Chem. 273: 26772-26778, 1998.
7 *Hirai, A., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Tatsuno, I., Oeda, T., Tahara, K., Terano,T., Narumiya, S., Kohn, L. D. and Saito, Y. : Geranylgeranylated Rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J. Biol. Chem. 272: 13-16, 1997.
8 *Kitagawa, M., Higashi, H., Jung, H.-K., Suzuki-Takahashi, I., Ikeda, M., Tamai, K., Kato, J., Segawa, K., Yoshida, E., Nishimura, S. and Taya, Y.: Consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15: 7060-7069, 1996.
9 *Furukawa, Y., Iwase, S., Terui, Y., Kikuchi, J., Nakamura, M., Kitagawa, S., and Kitagawa, M.: Transcriptional activation of the cdc2 gene is associated with Fas-induced apoptosis of human hematopoietic cells. J. Biol. Chem. 271: 28469-28477, 1996.
10 Yamamoto, K., Hirai, A., Ban, T., Saito, J., Tahara, K., Terano, T., Tamura, Y., Saito, Y. and Kitagawa, M.: Tyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells. Endocrinology 137: 2036-2042, 1996.
11 Higashi, H., Suzuki-Takahashi, I., Saitoh, S., Segawa, K., Taya, Y., Okuyama, A., Nishimura, S. and *Kitagawa, M.: Cyclin-depemdent kinase 2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur. J. Biochem. 237: 460-467, 1996.
12 *Kitagawa, M., Higashi, H., Takahashi, -S.I., Segawa, K. Hanks, S.K., Taya, Y., Nishimura, S. and Okuyama, A.: Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 10 : 229-236, 1995.
13 Suzuki-Takahashi, I., Kitagawa, M., Saijo, M., Higashi, H., Ogino, H., Matsumoto, H., Taya, Y., Nishimura, S. and Okuyama, A.: The interaction of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by cyclin-dependent kinases. Oncogene 10: 1691-1698, 1995.
14 *Kitagawa, M., Higashi, H., Takahashi, -S.I., Okabe, T., Ogino, H., Taya, Y., Nishimura, S. and Okuyama, A.: A cyclin dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression. Oncogene 9 : 2549-2557, 1994.
15 Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Takahashi, -S.I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., Ohba, Y., Nishimura, S. and *Okuyama, A. : Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene 8: 2425-2432, 1993.
16 *Kitagawa, M., Saitoh, S., Ogino, H., Okabe, T., Matsumoto, H., Okuyama, A., Tamai, K., Ohba, Y., Yasuda, H., Nishimura, S. and Taya, Y.: cdc2-like kinase is associated with the retinoblastoma protein. Oncogene 7 : 1067-1074, 1992.