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ホーム > 教育 > 医学部医学科 > 医学科講座等紹介 > 微生物学・免疫学講座 > 研究活動 > 研究業績

研究業績

発表論文（2010〜2023年）

2023年

原著論文（英文）
  1. Xiaofang Li, Kenji Nakashima, Masahiko Ito, Mami Matsuda, Takeshi Chida, Kazumasa Sekihara, Hirotaka Takahashi, Takanobu Kato, Tatsuya Sawasaki, Tetsuro Suzuki, SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection. Antiviral Res. (in press).
  2. Malabika Ghosh, Keita Isago, Uddipan Dasgupta, Horoyuki Shimizu, Tetsuro Suzuki, Jasmina Vidic, Ankan Dutta Chowdhury, Enoch Y. Park, Duplex-specific nuclease assisted magnetic nanoprobe for cyclic amplified RNA detection. Sensors and Actuators B: Chemical (in press).
  3. Ohta K, Ito M, Chida T, Nakashima K, Sakai S, Kanegae Y, Kawasaki H, Aoshima T, Takabayashi S, Takahashi H, Kawata K, Shoji I, Sawasaki T, Suda T, Suzuki T. Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. PLOS Pathog. doi.org/10.1371/journal.ppat.1011591 (2023).
  4. Adi Ariffianto, Lin Deng, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizokami, Yoshiharu Matsuura, Ikuo Shoji. Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication. J Virol. 97: e01287-23 (2023).

2022年

原著論文（英文）
  1. Nerome K, Imagawa T, Sugita S, Arasaki Y, Maegawa K, Kawasaki K, Tanaka T, Watanabe S, Nishimura H, Suzuki T, Kuroda K, Kosugi I, Kajiura Z. The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine. Life Sci Alliance. 2022 Nov 7;6(1):e202201548. doi: 10.26508/lsa.202201548.
  2. Shirasago Y, Fukazawa H, Nagase S, Shimizu Y, Mizukami T, Wakita T, Suzuki T, Tani H, Kondoh M, Kuroda T, Yasuda S, Sato Y, Hanada K, Fukasawa M. A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection. Sci Rep. 2022 Nov 24;12(1):20243. doi: 10.1038/s41598-022-23824-3.
  3. Horikawa M, Koizumi S, Oishi T, Yamamoto T, Ikeno M, Ito M, Yamasaki T, Amano S, Sameshima T, Mitani Y, Otani Y, Yan Y, Suzuki T, Namba H, Kurozumi K. Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth. Cancer Gene Ther. (2022) Sep 8. doi: 10.1038/s41417-022-00527-5.
  4. Li X, Ito M, Aoyagi H, Murayama A, Aizaki H, Fukasawa M, Kato T, Wakita T, Suzuki T. Development and Use of a Kinetical and Real-Time Monitoring System to Analyze the Replication of Hepatitis C Virus. Int J Mol Sci. 23: 8711 (2022). doi: 10.3390/ijms23158711.
  5. Oishi T, Ito M, Koizumi S, Horikawa M, Yamamoto T, Yamagishi S, Yamasaki T, Sameshima T, Suzuki T, Sugimura H, Namba H, Kurozumi K. Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases. Mol Ther Methods Clin Dev. 26; 253-265 (2022) doi: 10.1016/j.omtm.2022.07.001.
  6. Yoshida Y, Zheng Ti, Tanabe W, Tomoike F, Hashiya F, Suzuki T, Hirota S, Saiki Y, Horii A, Hirayama A, Soga T, Kimura Y, Abe H. Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs. ChemMedChem. e202200188 (2022). doi: 10.1002/cmdc.202200188.

2021年

原著論文（英文）
  1. Imagawa T, Ito M, Matsuda M, Nakashima K, Tokunaga Y, Ohta I, Li TC, Suzuki R, Suzuki T. Virus-like particles with FLAG-tagged envelope protein as a tetravalent dengue vaccine candidate. Sci Rep.11;17542 (2021). doi: 10.1038/s41598-021-97038-4.
  2. Achadu OJ, Abe F, Hossain F, Nasrin F, Yamazaki M, Suzuki T, Park EY. Sulfur-doped carbon dots@polydopamine-functionalized magnetic silver nanocubes for dual-modality detection of norovirus. Biosens Bioelectron. 193;113540 (2021). doi: 10.1016/j.bios.2021.113540.
  3. Hosoi H, Murata S, Suzuki T, Li TC, Hatanaka K, Tanaka-Taya K, Mushino T, Kuriyama K, Tamura S, Hanaoka N, Sonoki T. A cluster of BK polyomavirus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. e13736 (2021). doi: 10.1111/tid.13736. Epub 2021 Oct 4.
  4. Achadu OJ, Abe F, Li TC, Khoris IM, Lee D, Lee J, Suzuki T, Park EY. Molybdenum Trioxide Quantum Dot-Encapsulated Nanogels for Virus Detection by Surface-Enhanced Raman Scattering on a 2D Substrate. ACS Appl Mater Interfaces.13; 27836-27844 (2021). doi: 10.1021/acsami.1c04793.
  5. Bawono RG, Abe T, Qu M, Kuroki D, Deng L, Matsui C, Ryo A, Suzuki T, Matsuura Y, Sugiyama M, Mizokami M, Shimotohno K, Ikuo Shoji. HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication. J Gen Virol. (2021) Oct;102(10). doi: 10.1099/jgv.0.001668.
  6. Ibrahim MK, Abdelhafez TH, Takeuchi JS, Wakae K, Sugiyama M, Tsuge M, Ito M, Watashi K, El Kassas M, Kato T, Murayama A, Suzuki T, Chayama K, Shimotohno K, Muramatsu M, Aly HH, Wakita T. MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter. J Virol. 95:e0076721 (2021). doi: 10.1128/JVI.00767-21.
  7. Shimoyama S, Kawata K, Ohta K, Chida T, Suzuki T, Tsuneyama K, Shimoda S, Kurono N, Leung PSC, Gershwin ME, Suda T, Kobayashi Y. Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-gamma and CX3CL1 production in primary biliary cholangitis. European journal of immunology (2021). doi:10.1002/eji.202048589.
  8. Murayama A, Yamada N, Osaki Y, Shiina M, Aly HH, Iwamoto M, Tsukuda S, Watashi K, Matsuda M, Suzuki R, Tanaka T, Moriishi K, Suzuki T, Nishitsuji H, Sugiyama M, Mizokami M, Shimotohno K, Wakita T, Muramatsu M, Liang TJ, Kato T. N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus. Hepatology 73 (2);520-532 (2021). doi:10.1002/hep.31308. Epub 2020 Oct 31.
  9. Takemori A, Ishizaki J, Nakashima K, Shibata T, Kato H, Kodera Y, Suzuki T, Hasegawa H, Takemori N. BAC-DROP: Rapid Digestion of Proteome Fractionated via Dissolvable Polyacrylamide Gel Electrophoresis and Its Application to Bottom-Up Proteomics Workflow. Journal of proteome research 20 (3):1535-1543 (2021). doi:10.1021/acs.jproteome.0c00749. Epub 2020 Dec 24.
  10. Shimizu Y, Shinoda T, Shirasago Y, Kondoh M, Shinya N, Hanada K, Yagi K, Suzuki T, Wakita T, Kimura-Someya T, Shirouzu M, Fukasawa M. Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection. FEBS letters 595 (2):220-229 (2021). doi:10.1002/1873-3468.13975.
  11. Khoris IM, Ganganboina AB, Suzuki T, Park EY. Self-assembled chromogen-loaded polymeric cocoon for respiratory virus detection. Nanoscale 13 (1):388-396 (2021). doi:10.1039/d0nr06893d.

2020年

原著論文（英文）
  1. Zhou X, Nakashima K, Ito M, Zhang X, Sakai S, Feng C, Sun H, Chen H, Li T-C, Suzuki T. Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China. Scientific Reports 10; 17066 (2020). doi: 10.1038/s41598-020-74244-0
  2. Ogata M, Onoda T, Koizumi A, Tokunaga Y, Ohta I, Nukuzuma S, Park EY, Usui T, Suzuki T. Agglutination of human polyomaviruses by using a tetravalent glycocluster as a cross-linker. ACS Omega 5 (34);21940-21947 (2020). doi:10.1021/acsomega.0c03269.
  3. Ganganboina AB, Chowdhury AD, Khoris IM, Doong RA, Li TC, Hara T, Abe F, Suzuki T, Park EY. Hollow magnetic-fluorescent nanoparticles for dual-modality virus detection. Biosens Bioelectron 170:112680 (2020). doi:10.1016/j.bios.2020.112680. Epub 2020 Oct 2.PMID: 33032196.
  4. Ganganboina AB, Chowdhury AD, Khoris IM, Nasrin F, Takemura K, Hara T, Abe F, Suzuki T, Park EY. Dual modality sensor using liposome-based signal amplification technique for ultrasensitive norovirus detection. Biosens Bioelectron 157:112169 (2020). doi:10.1016/j.bios.2020.112169. Epub 2020 Mar 26.PMID: 32250939.
  5. Chowdhury AD, Nasrin F, Gangopadhyay R, Ganganboina AB, Takemura K, Kozaki I, Honda H, Hara T, Abe F, Park S, Suzuki T, Park EY. Controlling distance, size and concentration of nanoconjugates for optimized LSPR based biosensors. Biosens Bioelectron 170:112657 (2020). doi:10.1016/j.bios.2020.112657
  6. Kuroda G, Sasaki S, Matsushita A, Ohba K, Sakai Y, Shinkai S, Nakamura HM, Yamagishi S, Sato K, Hirahara N, Oki Y, Ito M, Suzuki T, Suda T. G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor beta2 in the rat hypothalamic paraventricular nucleus. PloS one 15 (11):e0242380 (2020). doi:10.1371/journal.pone.0242380.
  7. Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T. Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. Respiratory research 21 (1):282 (2020). doi:10.1186/s12931-020-01555-1.
  8. Ganganboina AB, Chowdhury AD, Khoris IM, Nasrin F, Takemura K, Hara T, Abe F, Suzuki T, Park EY. Dual modality sensor using liposome-based signal amplification technique for ultrasensitive norovirus detection. Biosens Bioelectron. 157: (2020). doi:10.1016/J.Bios.2020.112169.
  9. Khoris IM, Chowdhury AD, Li TC, Suzuki T, Park EY. Advancement of capture immunoassay for real-time monitoring of hepatitis E virus-infected monkey. Analytica chimica acta. 1110: 64-71 (2020). doi:10.1016/j.aca.2020.02.020.
  10. Shimoyama H, Shibata TK, Ito M, Oda T, Itoh T, Mukai M, Matsuya-Ogawa M, Adachi M, Murakami H, Nakayama T, Sugihara K, Itoh H, Suzuki T, Kanayama N. Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer. Biochemistry and biophysics reports. 22: 100740 (2020). doi:10.1016/j.bbrep.2020.100740.

2019年

原著論文（英文）
  1. Takemura K, Lee J, Suzuki T, Hara T, Abe F, Park EY. Ultrasensitive detection of norovirus using a magnetofluoroimmunoassay based on synergic properties of gold/magnetic nanoparticle hybrid nanocomposites and quantum dots. Sensor Actuat B-Chem. 296: (2019). doi:10.1016/J.Snb.2019.126672.
  2. Kong L, Aoyagi H, Yang Z, Ouyang T, Matsuda M, Fujimoto A, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Suzuki T, Muramatsu M, Wakita T, Aizaki H. Surfeit 4 contributes to the replication of hepatitis C virus using double membrane vesicles. J. Virol. pii: JVI.00858-19. doi: 10.1128/JVI.00858-19 (2019).
  3. Zhou X, Bai H, Kataoka M, Ito M, Muramatsu M, Suzuki T, Li TC. Characterization of the self-assembly of New Jersey polyomavirus VP1 into virus-like particles and the virus seroprevalence in Japan. Sci Rep. 9: 13085 (2019). doi: 10.1038/s41598-019-49541-y.
  4. Chowdhury AD, Takemura K, Li TC, Suzuki T, Park EY. Electrical pulse induced electrochemical biosensor for hepatitis E virus detection. Nat Commun. 10: 3737 (2019). Doi: 10.1038/s41467-019-11644-5
  5. Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M. Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-beta/Smad signaling and promote epithetial-mesenchymal transition. Cancer Res. 79: 2821-2838 (2019). doi: 10.1158/0008-5472.CAN-18-3210.
  6. Shirasago Y, Inamori Y, Suzuki T, Tanida I, Suzuki T, Sugiyama K, Wakita T, Hanada K, Fukasawa M. Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid and Tannic Acid. Biol Pharm Bull. 42: 770-777 (2019). doi: 10.1248/bpb.b18-00970.
  7. Shimizu Y, Yoneda K, Shirasago Y, Suzuki T, Tada M, Ishii-Watabe A, Sugiyama K, Suzuki T, Wakita T, Yagi K, Kondoh M, Fukasawa M. Human-rat chimeric anti-occludin monoclonal antibodies inhibit hepatitis C virus infection. Biochem Biophys Res Commun. 514: 785-790 (2019). doi: 10.1016/j.bbrc.2019.05.019.
  8. Takemura K, Adegoke O, Suzuki T, Park EY. A localized surface plasmon resonance-amplified immunofluorescence biosensor for ultrasensitive and rapid detection of nonstructural protein 1 of Zika virus. PLoS ONE. 14: e0211517 (2019). doi:10.1371/journal.pone.0211517.
  9. Suzuki R, Matsuda M, Shimoike T, Watashi K, Aizaki H, Kato T, Suzuki T, Muramatsu M, Wakita T. Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase. Virology. 529: 226-233 (2019). doi:10.1016/j.virol.2019.01.024.
  10. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y. USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. J. Virol. 93: e01708-18 (2019). doi:10.1128/JVI.01708-18.
  11. Khoris IM, Takemura K, Lee J, Hara T, Abe F, Suzuki T, Park EY. Enhanced colorimetric detection of norovirus using in-situ growth of Ag shell on Au NPs. Biosens. Bioelectron. 126: 425-432 (2019). doi:10.1016/j.bios.2018.10.067.
  12. Ito N, Nakashima K, Sun S, Ito M, Suzuki T. Cell Type Diversity in Hepatitis B Virus RNA Splicing and Its Regulation. Front Microbiol. 10: 207 (2019). doi:10.3389/fmicb.2019.00207.
  13. Shimizu Y, Shirasago Y, Suzuki T, Hata T, Kondoh M, Hanada K, Yagi K, Fukasawa M. Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin. J Biochem. 166: 297-308 (2019). doi: 10.1093/jb/mvz037.
  14. Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C, Abe T, Watashi K, Wakita T, Suzuki T, Okamoto T, Matsuura Y, Mizokami M, Shoji I, Hotta H. Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA. J. Virol. 93: e02203-18 (2019). doi:10.1128/JVI.02203-18.

2018年

原著論文（英文）
  1. Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S. The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. Sci Rep. 8: 13143 (2018). doi:10.1038/s41598-018-31421-6.
  2. Shirasago Y, Fukazawa H, Aizaki H, Suzuki T, Sugiyama K, Wakita T, Hanada K, Abe R, Fukasawa M. Thermostable hepatitis C virus JFH1-derived variant isolated by adaptation to Huh7.5.1 cells. J. Gen. Virol. 99: 1407-1417 (2018). doi:10.1099/jgv.0.001117.
  3. Shimizu Y, Shirasago Y, Kondoh M, Suzuki T, Wakita T, Hanada K, Yagi K, Fukasawa M. Monoclonal antibodies against occludin completely prevented hepatitis C virus infection in a mouse model. J. Virol. 92: e02258-17 (2018). doi:10.1128/JVI.02258-17.
  4. Niwa M, Fujisawa T, Mori K, Yamanaka K, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suzuki T, Maekawa M, Suda T. IL-17A Attenuates IFN-lambda Expression by Inducing Suppressor of Cytokine Signaling Expression in Airway Epithelium. J. Immunol. 201: 2392-2402 (2018). doi:10.4049/jimmunol.1800147.
  5. Nasrin F, Chowdhury AD, Takemura K, Lee J, Adegoke O, Deo VK, Abe F, Suzuki T, Park EY. Single-step detection of norovirus tuning localized surface plasmon resonance-induced optical signal between gold nanoparticles and quantum dots. Biosens. Bioelectron. 122: 16-24 (2018). doi:10.1016/j.bios.2018.09.024.
  6. Kato T, Hasegawa M, Yamamoto T, Miyazaki T, Suzuki R, Wakita T, Suzuki T, Park EY. Expression of a functional intrabody against hepatitis C virus core protein in Escherichia coli and silkworm pupae. Protein Expr. Purif. 150: 61-66 (2018). doi:10.1016/j.pep.2018.05.009.
  7. Chida T, Kawata K, Ohta K, Matsunaga E, Ito J, Shimoyama S, Yamazaki S, Noritake H, Suzuki T, Suda T, Kobayashi Y. Rapid Changes in Serum Lipid Profiles during Combination Therapy with Daclatasvir and Asunaprevir in Patients Infected with Hepatitis C Virus Genotype 1b. Gut Liver. 12: 201-207 (2018). doi:10.5009/gnl17179.
総説論文（英文）
  1. Shi G, Suzuki T. Molecular Basis of Encapsidation of Hepatitis C Virus Genome. Front Microbiol. 9: 396 (2018). doi:10.3389/fmicb.2018.00396.

2017年

原著論文（英文）
  1. Tsutsumi T, Okushin K, Enooku K, Fujinaga H, Moriya K, Yotsuyanagi H, Aizaki H, Suzuki T, Matsuura Y, Koike K. Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver. PLoS ONE. 12: e0170461 (2017). doi:10.1371/journal.pone.0170461.
  2. Takemura K, Adegoke O, Takahashi N, Kato T, Li TC, Kitamoto N, Tanaka T, Suzuki T, Park EY. Versatility of a localized surface plasmon resonance-based gold nanoparticle-alloyed quantum dot nanobiosensor for immunofluorescence detection of viruses. Biosens. Bioelectron. 89: 998-1005 (2017). doi:10.1016/j.bios.2016.10.045.
  3. Suzuki M, Kondo S, Yamasaki M, Matsuda N, Nomoto A, Suzuki T, Saito I, Kanegae Y. Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit. Sci Rep. 7: 41851 (2017). doi:10.1038/srep41851.
  4. Sun S, Nakashima K, Ito M, Li Y, Chida T, Takahashi H, Watashi K, Sawasaki T, Wakita T, Suzuki T. Involvement of PUF60 in Transcriptional and Post-transcriptional Regulation of Hepatitis B Virus Pregenomic RNA Expression. Sci Rep. 7: 12874 (2017). doi:10.1038/s41598-017-12497-y.
  5. Lee J, Takemura K, Kato CN, Suzuki T, Park EY. Binary Nanoparticle Graphene Hybrid Structure-Based Highly Sensitive Biosensing Platform for Norovirus-Like Particle Detection. ACS Appl Mater Interfaces. 9: 27298-27304 (2017). doi:10.1021/acsami.7b07012.
  6. Kato J, Mori T, Suzuki T, Ito M, Li TC, Sakurai M, Yamane Y, Yamazaki R, Koda Y, Toyama T, Hasegawa N, Okamoto S. Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation. Am. J. Transplant. 17: 2428-2433 (2017). doi:10.1111/ajt.14271.
  7. Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, Nakashima K, Tagawa YI, Okazaki S, Matsuura Y, Wakita T, Suzuki T. Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation. Oncotarget. 8: 53899-53915 (2017). doi:10.18632/oncotarget.19108.
  8. Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T. Critical role of CREBH-mediated induction of transforming growth factor beta2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells. Hepatology. 66: 1430-1443 (2017). doi:10.1002/hep.29319.
  9. Ahmed SR, Takemeura K, Li TC, Kitamoto N, Tanaka T, Suzuki T, Park EY. Size-controlled preparation of peroxidase-like graphene-gold nanoparticle hybrids for the visible detection of norovirus-like particles. Biosens. Bioelectron. 87: 558-565 (2017). doi:10.1016/j.bios.2016.08.101.
  10. Ahmed SR, Kim J, Tran VT, Suzuki T, Neethirajan S, Lee J, Park EY. In situ self-assembly of gold nanoparticles on hydrophilic and hydrophobic substrates for influenza virus-sensing platform. Sci Rep. 7: 44495 (2017). doi:10.1038/srep44495.
  11. Adegoke O, Morita M, Kato T, Ito M, Suzuki T, Park EY. Localized surface plasmon resonance-mediated fluorescence signals in plasmonic nanoparticle-quantum dot hybrids for ultrasensitive Zika virus RNA detection via hairpin hybridization assays. Biosens. Bioelectron. 94: 513-522 (2017). doi:10.1016/j.bios.2017.03.046.
総説論文（英文）
  1. Suzuki T. Hepatitis C Virus Replication, in Tagaya M, Simmen T (Eds). Organelle contact sites : from molecular mechanism to disease, Advances in Experimental Medicine and Biology. Springer. Singapore. pp 199-209 (2017),

2016年

原著論文（英文）
  1. Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T. Single-domain intrabodies against hepatitis C virus core inhibit viral propagation and core-induced NFkappaB activation. J. Gen. Virol. 97: 887-892 (2016). doi:10.1099/jgv.0.000423.
  2. Shirasago Y, Shimizu Y, Tanida I, Suzuki T, Suzuki R, Sugiyama K, Wakita T, Hanada K, Yagi K, Kondoh M, Fukasawa M. Occludin-Knockout Human Hepatic Huh7.5.1-8-Derived Cells Are Completely Resistant to Hepatitis C Virus Infection. Biol. Pharm. Bull. 39: 839-848 (2016). doi:10.1248/bpb.b15-01023.
  3. Shi G, Ando T, Suzuki R, Matsuda M, Nakashima K, Ito M, Omatsu T, Oba M, Ochiai H, Kato T, Mizutani T, Sawasaki T, Wakita T, Suzuki T. Involvement of the 3' Untranslated Region in Encapsidation of the Hepatitis C Virus. PLoS Pathog. 12: e1005441 (2016). doi:10.1371/journal.ppat.1005441.
  4. Li Y, Ito M, Sun S, Chida T, Nakashima K, Suzuki T. LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity. Sci Rep. 6: 36741 (2016). doi:10.1038/srep36741.
  5. Kong L, Fujimoto A, Nakamura M, Aoyagi H, Matsuda M, Watashi K, Suzuki R, Arita M, Yamagoe S, Dohmae N, Suzuki T, Sakamaki Y, Ichinose S, Wakita T, Aizaki H. Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B. J. Virol. 90: 3093-3111 (2016). doi:10.1128/JVI.01540-15.
  6. Ahmed SR, Kim J, Suzuki T, Lee J, Park EY. Detection of influenza virus using peroxidase-mimic of gold nanoparticles. Biotechnol. Bioeng. 113: 2298-2303 (2016). doi:10.1002/bit.25982.
  7. Ahmed SR, Kim J, Suzuki T, Lee J, Park EY. Enhanced catalytic activity of gold nanoparticle-carbon nanotube hybrids for influenza virus detection. Biosens. Bioelectron. 85: 503-508 (2016). doi:10.1016/j.bios.2016.05.050.
総説論文（英文）
  1. Suzuki T, Suzuki R. Role of Nonstructural Proteins in HCV Replication, in Miyamura T, Lemon SM, Walker CM, Wakita T (Eds). Hepatitis C virus I:Cellular and Molecular Virology.Springer. Tokyo. pp 129-148 (2016),

2015年

原著論文（英文）
  1. Shirasago Y, Sekizuka T, Saito K, Suzuki T, Wakita T, Hanada K, Kuroda M, Abe R, Fukasawa M. Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus. Jpn. J. Infect. Dis. 68: 81-88 (2015). doi:10.7883/yoken.JJID.2014.231.
  2. Saito K, Shirasago Y, Suzuki T, Aizaki H, Hanada K, Wakita T, Nishijima M, Fukasawa M. Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus. J. Virol. 89: 2220-2232 (2015). doi:10.1128/JVI.03385-14.
  3. Park C, Min S, Park EM, Lim YS, Kang S, Suzuki T, Shin EC, Hwang SB. Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry. J. Virol. 89: 10073-10086 (2015). doi:10.1128/JVI.01707-15.
  4. Okuyama-Dobashi K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K. Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide. Sci Rep. 5: 17047 (2015). doi:10.1038/srep17047.
  5. Li TC, Iwasaki K, Katano H, Kataoka M, Nagata N, Kobayashi K, Mizutani T, Takeda N, Wakita T, Suzuki T. Characterization of self-assembled virus-like particles of Merkel cell polyomavirus. PLoS ONE. 10: e0115646 (2015). doi:10.1371/journal.pone.0115646.
  6. Lee J, Ahmed SR, Oh S, Kim J, Suzuki T, Parmar K, Park SS, Park EY. A plasmon-assisted fluoro-immunoassay using gold nanoparticle-decorated carbon nanotubes for monitoring the influenza virus. Biosens. Bioelectron. 64: 311-317 (2015). doi:10.1016/j.bios.2014.09.021.
  7. Fukumoto H, Li TC, Kataoka M, Hasegawa H, Wakita T, Saeki H, Suzuki T, Katano H. Seroprevalence of trichodysplasia spinulosa-associated polyomavirus in Japan. J. Clin. Virol. 65: 76-82 (2015). doi:10.1016/j.jcv.2015.02.014.
  8. Fukasawa M, Nagase S, Shirasago Y, Iida M, Yamashita M, Endo K, Yagi K, Suzuki T, Wakita T, Hanada K, Kuniyasu H, Kondoh M. Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model. J. Virol. 89: 4866-4879 (2015). doi:10.1128/JVI.03676-14.
総説論文（英文）
  1. Masaki T, Suzuki T. NS5A phosphorylation: its functional role in the life cycle of hepatitis C virus. Future Virology. 10: 751-762 (2015). doi:10.2217/fvl.15.33.

2014年

原著論文（英文）
  1. Murakami Y, Fukasawa M, Kaneko Y, Suzuki T, Wakita T, Fukazawa H. Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling. Microbes Infect. 16: 114-122 (2014). doi:10.1016/j.micinf.2013.10.016.
  2. Matsuda M, Suzuki R, Kataoka C, Watashi K, Aizaki H, Kato N, Matsuura Y, Suzuki T, Wakita T. Alternative endocytosis pathway for productive entry of hepatitis C virus. J. Gen. Virol. 95: 2658-2667 (2014). doi:10.1099/vir.0.068528-0.
  3. Masaki T, Matsunaga S, Takahashi H, Nakashima K, Kimura Y, Ito M, Matsuda M, Murayama A, Kato T, Hirano H, Endo Y, Lemon SM, Wakita T, Sawasaki T, Suzuki T. Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-alpha in infectious virus production. J. Virol. 88: 7541-7555 (2014). doi:10.1128/JVI.03170-13.
  4. Fang L, Wang Z, Song S, Kataoka M, Ke C, Suzuki T, Wakita T, Takeda N, Li TC. Characterization of human bocavirus-like particles generated by recombinant baculoviruses. J. Virol. Methods. 207: 38-44 (2014). doi:10.1016/j.jviromet.2014.06.007.
  5. Ahn S, Tamai M, Nakashima K, Ito M, Suzuki T, Tagawa Y. An in vitro liver model consisting of endothelial vascular networks surrounded by human hepatoma cell lines allows for improved hepatitis B virus replication. J Biosci Bioeng. 118: 107-111 (2014). doi:10.1016/j.jbiosc.2013.12.016.
  6. Ahmed SR, Hossain MA, Park JY, Kim SH, Lee D, Suzuki T, Lee J, Park EY. Metal enhanced fluorescence on nanoporous gold leaf-based assay platform for virus detection. Biosens. Bioelectron. 58: 33-39 (2014). doi:10.1016/j.bios.2014.02.039.

2013年

原著論文（英文）
  1. Suzuki R, Matsuda M, Watashi K, Aizaki H, Matsuura Y, Wakita T, Suzuki T. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. PLoS Pathog. 9: e1003589 (2013). doi:10.1371/journal.ppat.1003589.
  2. Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S. HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor. Sci Rep. 3: 3243 (2013). doi:10.1038/srep03243.
  3. Saeed M, Gondeau C, Hmwe S, Yokokawa H, Date T, Suzuki T, Kato T, Maurel P, Wakita T. Replication of hepatitis C virus genotype 3a in cultured cells. Gastroenterology. 144: 56-58 e57 (2013). doi:10.1053/j.gastro.2012.09.017.
  4. Pei Z, Shi G, Kondo S, Ito M, Maekawa A, Suzuki M, Saito I, Suzuki T, Kanegae Y. Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication. Sci Rep. 3: 3575 (2013). doi:10.1038/srep03575.
  5. Murakami Y, Fukasawa M, Kaneko Y, Suzuki T, Wakita T, Fukazawa H. Selective estrogen receptor modulators inhibit hepatitis C virus infection at multiple steps of the virus life cycle. Microbes Infect. 15: 45-55 (2013). doi:10.1016/j.micinf.2012.10.003.
  6. Mawatari S, Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H. Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4. PLoS ONE. 8: e82094 (2013). doi:10.1371/journal.pone.0082094.
  7. Matsumoto Y, Matsuura T, Aoyagi H, Matsuda M, Hmwe SS, Date T, Watanabe N, Watashi K, Suzuki R, Ichinose S, Wake K, Suzuki T, Miyamura T, Wakita T, Aizaki H. Antiviral activity of glycyrrhizin against hepatitis C virus in vitro. PLoS ONE. 8: e68992 (2013). doi:10.1371/journal.pone.0068992.

2012年

原著論文（英文）
  1. Suzuki R, Saito K, Kato T, Shirakura M, Akazawa D, Ishii K, Aizaki H, Kanegae Y, Matsuura Y, Saito I, Wakita T, Suzuki T. Trans-complemented hepatitis C virus particles as a versatile tool for study of virus assembly and infection. Virology. 432: 29-38 (2012). doi:10.1016/j.virol.2012.05.033.
  2. Fukazawa H, Suzuki T, Wakita T, Murakami Y. A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus. Biol. Pharm. Bull. 35: 1320-1327 (2012).
  3. Ando T, Imamura H, Suzuki R, Aizaki H, Watanabe T, Wakita T, Suzuki T. Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA. PLoS Pathog. 8: e1002561 (2012). doi:10.1371/journal.ppat.1002561.
総説論文（英文）
  1. Suzuki T. Morphogenesis of infectious hepatitis C virus particles. Front Microbiol. 3: 38 (2012). doi:10.3389/fmicb.2012.00038.

2011年

原著論文（英文）
  1. Yamamoto M, Aizaki H, Fukasawa M, Teraoka T, Miyamura T, Wakita T, Suzuki T. Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus. J. Gen. Virol. 92: 2082-2087 (2011). doi:10.1099/vir.0.032391-0.
  2. Wen X, Abe T, Kukihara H, Taguwa S, Mori Y, Tani H, Kato N, Suzuki T, Tatsumi M, Moriishi K, Matsuura Y. Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules. PLoS ONE. 6: e15967 (2011). doi:10.1371/journal.pone.0015967.
  3. Watanabe N, Aizaki H, Matsuura T, Kojima S, Wakita T, Suzuki T. Hepatitis C virus RNA replication in human stellate cells regulates gene expression of extracellular matrix-related molecules. Biochem. Biophys. Res. Commun. 407: 135-140 (2011). doi:10.1016/j.bbrc.2011.02.125.
  4. Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H. Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses. Gastroenterology. 141: e1-5 (2011). doi:10.1053/j.gastro.2011.05.027.
  5. Saeed M, Suzuki R, Watanabe N, Masaki T, Tomonaga M, Muhammad A, Kato T, Matsuura Y, Watanabe H, Wakita T, Suzuki T. Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particles. J. Biol. Chem. 286: 37264-37273 (2011). doi:10.1074/jbc.M111.259085.
  6. Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T. In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis. Hepatology. 54: 425-433 (2011). doi:10.1002/hep.24399.
  7. Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K. Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. J. Hepatol. 54: 432-438 (2011). doi:10.1016/j.jhep.2010.07.039.
  8. Iwasaki Y, Mori K, Ishii K, Maki N, Iijima S, Yoshida T, Okabayashi S, Katakai Y, Lee YJ, Saito A, Fukai H, Kimura N, Ageyama N, Yoshizaki S, Suzuki T, Yasutomi Y, Miyamura T, Kannagi M, Akari H. Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets. Front Microbiol. 2: 240 (2011). doi:10.3389/fmicb.2011.00240.
  9. Inoue Y, Aizaki H, Hara H, Matsuda M, Ando T, Shimoji T, Murakami K, Masaki T, Shoji I, Homma S, Matsuura Y, Miyamura T, Wakita T, Suzuki T. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. Virology. 410: 38-47 (2011). doi:10.1016/j.virol.2010.10.026.
  10. Honda M, Takehana K, Sakai A, Tagata Y, Shirasaki T, Nishitani S, Muramatsu T, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Nakamura M, Shimakami T, Yi M, Lemon SM, Suzuki T, Wakita T, Kaneko S. Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. Gastroenterology. 141: 128-140, 140 e121-122 (2011). doi:10.1053/j.gastro.2011.03.051.
  11. Akazawa D, Morikawa K, Omi N, Takahashi H, Nakamura N, Mochizuki H, Date T, Ishii K, Suzuki T, Wakita T. Production and characterization of HCV particles from serum-free culture. Vaccine. 29: 4821-4828 (2011). doi:10.1016/j.vaccine.2011.04.069.
総説論文（英文）
  1. Suzuki T. Assembly of hepatitis C virus particles. Microbiol. Immunol. 55: 12-18 (2011). doi:10.1111/j.1348-0421.2010.00274.x.

2010年

原著論文（英文）
  1. Tanaka Y, Mori Y, Tani H, Abe T, Moriishi K, Kojima H, Nagano T, Okabe T, Suzuki T, Tatsumi M, Matsuura Y. Establishment of an indicator cell system for hepatitis C virus. Microbiol. Immunol. 54: 206-220 (2010). doi:10.1111/j.1348-0421.2010.00209.x.
  2. Tanaka N, Mamemura T, Abe S, Imabayashi K, Kashiwada Y, Takaishi Y, Suzuki T, Takebe Y, Kubota T, Kobayashi J. Biyouxanthones A-D, prenylated xanthones from roots of Hypericum chinense. Heterocycles. 80: 613-621 (2010).
  3. Takahashi H, Akazawa D, Kato T, Date T, Shirakura M, Nakamura N, Mochizuki H, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Suzuki T, Wakita T. Biological properties of purified recombinant HCV particles with an epitope-tagged envelope. Biochem. Biophys. Res. Commun. 395: 565-571 (2010). doi:10.1016/j.bbrc.2010.04.081.
  4. Nasu J, Murakami K, Miyagawa S, Yamashita R, Ichimura T, Wakita T, Hotta H, Miyamura T, Suzuki T, Satoh T, Shoji I. E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1. J. Cell. Biochem. 111: 676-685 (2010). doi:10.1002/jcb.22752.
  5. Murayama A, Weng L, Date T, Akazawa D, Tian X, Suzuki T, Kato T, Tanaka Y, Mizokami M, Wakita T, Toyoda T. RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells. PLoS Pathog. 6: e1000885 (2010). doi:10.1371/journal.ppat.1000885.
  6. Moriishi K, Shoji I, Mori Y, Suzuki R, Suzuki T, Kataoka C, Matsuura Y. Involvement of PA28gamma in the propagation of hepatitis C virus. Hepatology. 52: 411-420 (2010). doi:10.1002/hep.23680.
  7. Masaki T, Suzuki R, Saeed M, Mori K, Matsuda M, Aizaki H, Ishii K, Maki N, Miyamura T, Matsuura Y, Wakita T, Suzuki T. Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription. J. Virol. 84: 5824-5835 (2010). doi:10.1128/JVI.02397-09.
  8. Ito M, Murakami K, Suzuki T, Mochida K, Suzuki M, Ikebuchi K, Yamaguchi K, Mizuochi T. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Clin. Immunol. 135: 459-465 (2010). doi:10.1016/j.clim.2010.02.002.
  9. Hmwe SS, Aizaki H, Date T, Murakami K, Ishii K, Miyamura T, Koike K, Wakita T, Suzuki T. Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin. Antiviral Res. 85: 520-524 (2010). doi:10.1016/j.antiviral.2009.12.008.
  10. Braconi C, Valeri N, Gasparini P, Huang N, Taccioli C, Nuovo G, Suzuki T, Croce CM, Patel T. Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes. Clin. Cancer Res. 16: 957-966 (2010). doi:10.1158/1078-0432.CCR-09-2123.
総説論文（英文）
↑
  1. Suzuki T. A Hepatitis C virus-host interaction involved in viral replication: toward the identification of antiviral targets. Jpn. J. Infect. Dis. 63: 307-311 (2010).