これまでの主な論文

原著論文 (*Corresponding)

1. KA Skorupka, K Matsuoka, B Hassan, R Ghirlando, V Balachandran, T Chen, KJ Walters, CA Schiffer, M Wolf, Y Iwatani*, H Matsuo*. HIV-1 Vif Mediates Ubiquitination of the Proximal Protomer in the APOBEC3H Dimer to Induce Degradation. Nature Communications. 2025; 16: 5879.
2. Y Iwatani*, K Matsuoka, H Ode, M Kubota, Y Nakata, Y Setoyama, K Kojima, M Imahashi, Y Yokomaku. The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces. mBio. 2025; 16: e0333224.
3. M Komori, T Nogimori, AL Morey, T Sekida, K Ishimoto, M Hassett, Y Masuta, H Ode, T Tamura, R Suzuki, J Alexander, Y Kido, K Matsuda, T Fukuhara, Y Iwatani, T Yamamoto, JF Smith, W Akahata* saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern. Nature Communications. 2023; 14: 2810.
4. Y Nakata, H Ode, M Kubota, T Kasahara, K Matsuoka, A Sugimoto, M Imahashi, Y Yokomaku, Y Iwatani*. The cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome. Nucleic Acids Research. 2023; 51:783-.
5. S Ozono, Y Zhang, H Ode, K Sano, TS Tan, K Imai, K Miyoshi, S Kishigami, T Ueno, Y Iwatani, T Suzuki, K Tokunaga. SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity. Nature Communications. 2021; 12:848.
6. T Kondo, Y Iwatani, K Matsuoka, T Fujino, S Umemoto, Y Yokomaku, K Ishizaki, S Kito, T Sezaki, G Hayashi, H Murakami*. Antibody-like proteins that capture and neutralize SARS-CoV-2. Science Advances. 2020; 6: eabd3916.
7. T Matsuoka, T Nagae, H Ode, H Awazu, T Kurosawa, A Hamano, K Matsuoka, A Hachiya, M Imahashi, Y Yokomaku, N Watanabe, Y Iwatani*. Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA. Nucleic Acids Research. 2018; 46: 10368-.
8. KR Chaurasiya, MJ McCauley, W Wang, DF Qualley, T Wu, S Kitamura, H Geertsema, DS Chan, A Hertz, Y Iwatani, JG Levin, K Musier-Forsyth, I Rouzina, MC Williams*. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein. Nature Chemistry. 2014; 6: 28-.
9. S Kitamura, H Ode, M Nakashima, M Imahashi, Y Naganawa, T Kurosawa, Y Yokomaku, T Yamane, N Watanabe, A Suzuki, W Sugiura, Y Iwatani*. The APOBEC3C crystal structure and the interface for HIV-1 Vif binding. Nature Structural & Molecular Biology. 2012; 19: 1005-
10. Y Iwatani*, DS Chan, L Liu, H Yoshii, J Shibata, N Yamamoto, JG Levin, AM Gronenborn, W Sugiura. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proceedings of the National Academy Sciences of the U S A. 2009; 106: 19539-.
11. Y Iwatani, DS Chan, F Wang, KS Maynard, W Sugiura, AM Gronenborn, I Rouzina, MC Williams, K Musier-Forsyth, JG Levin* (selected as "Fast Breaking Paper" by Thomson Reuters). Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. Nucleic Acids Research. 2007; 35: 7096-.
12. Y Iwatani, H Takeuchi, K Strebel, JG Levin*. Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect. Journal of Virology. 2006; 80: 5992-.

発表論文（2020〜2025年）

2025年

原著論文

1. J Taira, T Kubo, H Nagano, R Tsuda, T Ogi, K Nakashima and T Suzuki. Effect of Nrf2 Activators in Hepatitis B Virus-Infected Cells Under Oxidative Stress. Marine drugs. 2025; 23: 155. 10.3390/md23040155
2. KA Skorupka, K Matsuoka, B Hassan, R Ghirlando, V Balachandran, TH Chen, KJ Walters, CA Schiffer, M Wolf, Y Iwatani and H Matsuo. HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation. Nature communications. 2025; 16: 5879. 10.1038/s41467-025-60984-y
3. H Niida, M Ito, K Iijima, A Motegi, R Ogihara, H Akiyama, C Uchida, S Sakai, T Ohhata, A Hatano, M Hirose, A Ogura, M Matsumoto, NQ McDonald and M Kitagawa. CARM1/PRMT4 facilitates XPF-ERCC1 heterodimer assembly and maintains nucleotide excision repair activity. Nucleic acids research. 2025; 53: gkaf355. 10.1093/nar/gkaf355
4. Y Morita, K Oda, A Matsumoto, S Ida, R Kitajima, S Furuhashi, M Takeda, H Kikuchi, Y Hiramatsu, J Ito, T Chida, H Noritake, K Kawata, Y Nagakura, M Goto, S Baba and H Takeuchi. Intrahepatic Cholangiocarcinoma with BRCA Mutation Achieved Pathological Complete Response after Neoadjuvant Gemcitabine, Cisplatin, and S-1 Therapy: A Case Report. Surgical case reports. 2025; 11: 24-0042. 10.70352/scrj.cr.24-0042
5. M Kidiga, M Murata, P Grover, H Ode, Y Iwatani, Y Seki, M Kuramitsu, M Morimoto, T Natsume, A Kaneko, S Hayashi, JI Yasunaga, M Matsuoka, T Mizukami and H Akari. Identification of Occult Simian T-Cell Leukemia Virus Type 1 Infection in Japanese Macaques. Journal of infectious diseases. 2025; 232: 510-. 10.1093/infdis/jiaf120
6. Y Iwatani, K Matsuoka, H Ode, M Kubota, Y Nakata, Y Setoyama, K Kojima, M Imahashi and Y Yokomaku. The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces. mBio. 2025; 16: e0333224. 10.1128/mbio.03332-24
7. M Ito, J Liu, M Fukasawa, K Tsutsumi, Y Kanegae, M Setou, M Kohara and T Suzuki. Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation. JHEP reports. 2025; 7: 101225. 10.1016/j.jhepr.2024.101225
8. T Imagawa, K Tanaka, M Ito, M Matsuda, T Suzuki, T Ando, C Yaguchi, K Miyamoto, S Takabayashi, R Suzuki, T Takasaki, H Itoh and I Kosugi. Pathological characterization of female reproductive organs prior to miscarriage induced by Zika virus infection in the pregnant common marmoset. Microbiology spectrum. 2025; 13: e0228224. 10.1128/spectrum.02282-24
9. P Grover, M Murata, M Kidiga, S Hayashi, H Ode, Y Iwatani, M Morimoto, T Natsume, A Kaneko, JI Yasunaga, M Matsuoka, M Kuramitsu, Y Seki, T Mizukami and H Akari. Identification of Natural Remission of Mother-to-Child Retroviral Transmission. Journal of infectious diseases. 2025; 232: 203-. 10.1093/infdis/jiaf064
10. J Fujimoto, K Kawahara, K Takeda, S Takeo, K Sato, K Nakashima, N Mase, M Yokoyama, T Suzuki and T Narumi. Identification of peptide-based hepatitis B virus capsid inhibitors based on the viral core protein. Bioorganic & medicinal chemistry letters. 2025; 117: 130054. 10.1016/j.bmcl.2024.130054
11. 重見麗, 松田昌和, 大出裕高, 山村喜美, 今橋真弓, 横幕能行, 岩谷靖雅. ナノポアシーケンサーによるHIV-1近全長遺伝子配列の決定と薬剤耐性検査. 日本エイズ学会誌. 2025, 27, 166-

2024年

原著論文

1. M Umemura, A Honda, M Yamashita, T Chida, H Noritake, K Yamamoto, T Honda, M Ichimura-Shimizu, K Tsuneyama, T Miyazaki, N Kurono, PSC Leung, ME Gershwin, T Suda and K Kawata. High-fat diet modulates bile acid composition and gut microbiota, affecting severe cholangitis and cirrhotic change in murine primary biliary cholangitis. Journal of autoimmunity. 2024; 148: 103287. 10.1016/j.jaut.2024.103287
2. Y Tanaka, T Fujisawa, S Yazawa, I Ohta, Y Takaku, M Ito, Y Inoue, H Yasui, H Hozumi, M Karayama, Y Suzuki, K Furuhashi, N Enomoto, M Setou, N Inui, T Suzuki and T Suda. Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium. American journal of physiology. Lung cellular and molecular physiology. 2024; 327: L406-. 10.1152/ajplung.00114.2024
3. R Suzuki and T Suzuki. Reverse Genetics of Hepatitis C Virus Using an RNA Polymerase I-Mediated Transcription. Methods in molecular biology. 2024; 2733: 175-. 10.1007/978-1-0716-3533-9_11
4. H Ode, M Matsuda, U Shigemi, M Mori, Y Yamamura, Y Nakata, R Okazaki, M Kubota, Y Setoyama, M Imahashi, Y Yokomaku and Y Iwatani. Population-based nanopore sequencing of the HIV-1 pangenome to identify drug resistance mutations. Scientific reports. 2024; 14: 12099. 10.1038/s41598-024-63054-3
5. S Miyata, L Fan, J Kambe, MI Qasimi, S Takemoto, M Ito, C Li, Y Yamamoto and K Nagaoka. Influence of repeated mastitis on the milk production and metabolic status in the subsequent lactation period of dairy cattle. Heliyon. 2024; 10: e29789. 10.1016/j.heliyon.2024.e29789
6. M Matsuda, TC Li, A Nakanishi, K Nakamichi, M Saito, T Suzuki, T Matsuura, M Muramatsu, Y Miura and R Suzuki. Generation of JC Polyoma Pseudovirus for High-Throughput Measurement of Neutralizing Antibodies. Diagnostics. 2024; 14: 311. 10.3390/diagnostics14030311
7. L Liu, M Ito, S Sakai, J Liu, K Ohta, K Saito, K Nakashima, S Satoh, A Konno and T Suzuki. FGF21 upregulation by hepatitis C virus via the eIF2alpha-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation. Frontiers in microbiology. 2024; 15: 1456108. 10.3389/fmicb.2024.1456108
8. J Liu, M Ito, L Liu, K Nakashima, S Satoh, A Konno and T Suzuki. Involvement of ribosomal protein L17 and Y-box binding protein 1 in the assembly of hepatitis C virus potentially via their interaction with the 3' untranslated region of the viral genome. Journal of virology. 2024; 98: e0052224. 10.1128/jvi.00522-24
9. K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, B Ulmasov, BA Neuschwander-Tetri, T Suda and K Kawata. Inhibition of integrin binding to ligand arg-gly-asp motif induces AKT-mediated cellular senescence in hepatic stellate cells. Molecular and cellular biochemistry. 2024; 479: 2697-. 10.1007/s11010-023-04883-0
10. K Kitsugi, K Kawata, H Noritake, T Chida, K Ohta, J Ito, S Takatori, M Yamashita, T Hanaoka, M Umemura, M Matsumoto, Y Morita, M Takeda, S Furuhashi, R Kitajima, R Muraki, S Ida, A Matsumoto and T Suda. Prognostic value of neutrophil to lymphocyte ratio in patients with advanced pancreatic ductal adenocarcinoma treated with systemic chemotherapy. Annals of medicine. 2024; 56: 2398725. 10.1080/07853890.2024.2398725
11. K Kitsugi, T Chida, T Hanaoka, M Umemura, M Yamashita, J Ito, K Ohta, H Noritake, T Suda and K Kawata. Elevated serum neprilysin levels in patients with chronic hepatitis C and metabolic dysfunction-associated steatotic liver disease: hepatic oxidative stress as an underlying mechanism. Molecular biology reports. 2024; 52: 81. 10.1007/s11033-024-10152-0
12. J Kambe, K Usuda, R Inoue, K Hirayama, M Ito, K Suenaga, S Masukado, H Liu, S Miyata, C Li, I Kimura, Y Yamamoto and K Nagaoka. Hydrogen peroxide in breast milk is crucial for gut microbiota formation and myelin development in neonatal mice. Gut Microbes. 2024; 16: 2359729. 10.1080/19490976.2024.2359729
13. CY Chung, CP Sun, MH Tao, HL Wu, SH Wang, SH Yeh, QB Zheng, Q Yuan, NS Xia, K Ogawa, K Nakashima, T Suzuki and PJ Chen. Major HBV splice variant encoding a novel protein important for infection. Journal of hepatology. 2024; 80: 858-. 10.1016/j.jhep.2024.01.037
14. T Chida, S Watanabe, K Ohta, H Noritake, M Ito, T Suzuki, T Suda and K Kawata. Impact of amino acid substitutions in hepatitis C virus core region on the severe oxidative stress. Free radical biology & medicine. 2024; 212: 199-. 10.1016/j.freeradbiomed.2023.12.014
15. T Chida, K Ohta, H Noritake, M Matsushita, G Murohisa, F Kageyama, Y Sasada, T Oyaizu, M Tsugiki, K Tamakoshi, T Nakajima, T Suda and K Kawata. Lysyl oxidase-like 2 as a predictor of hepatocellular carcinoma in patients with hepatitis C virus after sustained virological response. Scientific reports. 2024; 14: 10864. 10.1038/s41598-024-61366-y
16. M Aboshi, K Matsuda, D Kawakami, K Kono, Y Kazami, T Sekida, M Komori, AL Morey, S Suga, JF Smith, T Fukuhara, Y Iwatani, T Yamamoto, N Sato and W Akahata. Safety and immunogenicity of VLPCOV-02, a SARS-CoV-2 self-amplifying RNA vaccine with a modified base, 5-methylcytosine. iScience. 2024; 27: 108964. 10.1016/j.isci.2024.108964

レポート

1. 鈴木信弘, 岩谷靖雅, 松野啓太, 西村秀一, 渡辺登喜子, 山田雅夫. ウイルス命名作業部会報告2024：背景、活動内容、役割. ウイルス. 2024, 74, 141-

2023年

原著論文

1. M Yamashita, A Honda, S Shimoyama, M Umemura, K Ohta, T Chida, H Noritake, N Kurono, M Ichimura-Shimizu, K Tsuneyama, T Miyazaki, A Tanaka, PSC Leung, ME Gershwin, T Suda and K Kawata. Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis. Journal of autoimmunity. 2023; 136: 103027. 10.1016/j.jaut.2023.103027
2. S Uno, H Gatanaga, T Hayashida, M Imahashi, R Minami, M Koga, S Samukawa, D Watanabe, T Fujii, M Tateyama, H Nakamura, S Matsushita, Y Yoshino, T Endo, M Horiba, T Taniguchi, H Moro, H Igari, S Yoshida, T Teshima, H Nakajima, M Nishizawa, Y Yokomaku, Y Iwatani, A Hachiya, S Kato, N Hasegawa, K Yoshimura, W Sugiura and T Kikuchi. Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study. Journal of antimicrobial chemotherapy. 2023; 78: 2859-. 10.1093/jac/dkad319
3. K Takamure, Y Iwatani, H Amano, T Yagi and T Uchiyama. Inactivation characteristics of a 280 nm Deep-UV irradiation dose on aerosolized SARS-CoV-2. Environment international. 2023; 177: 108022. 10.1016/j.envint.2023.108022
4. A Sugimoto, T Watanabe, K Matsuoka, Y Okuno, Y Yanagi, Y Narita, S Mabuchi, H Nobusue, E Sugihara, M Hirayama, T Ide, T Onouchi, Y Sato, T Kanda, H Saya, Y Iwatani, H Kimura and T Murata. Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy. Microbiology spectrum. 2023; 11: e0044023. 10.1128/spectrum.00440-23
5. Y Sasano, A Konno, M Nakamura, A Henmi, M Mayanagi, MC Yang and I Yao. Visualization of the localization of phospholipids in developing rat teeth by matrix-assisted laser desorption/ionization imaging mass spectrometry. Biomedical research. 2023; 44: 173-. 10.2220/biomedres.44.173
6. K Ohta, M Ito, T Chida, K Nakashima, S Sakai, Y Kanegae, H Kawasaki, T Aoshima, S Takabayashi, H Takahashi, K Kawata, I Shoji, T Sawasaki, T Suda and T Suzuki. Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. PLoS pathogens. 2023; 19: e1011591. 10.1371/journal.ppat.1011591
7. K Nerome, T Imagawa, S Sugita, Y Arasaki, K Maegawa, K Kawasaki, T Tanaka, S Watanabe, H Nishimura, T Suzuki, K Kuroda, I Kosugi and Z Kajiura. The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine. Life science alliance. 2023; 6: e202201548. 10.26508/lsa.202201548
8. Y Nakata, H Ode, M Kubota, T Kasahara, K Matsuoka, A Sugimoto, M Imahashi, Y Yokomaku and Y Iwatani. Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome. Nucleic acids research. 2023; 51: 783-. 10.1093/nar/gkac1238
9. X Li, K Nakashima, M Ito, M Matsuda, T Chida, K Sekihara, H Takahashi, T Kato, T Sawasaki and T Suzuki. SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection. Antiviral research. 2023; 220: 105756. 10.1016/j.antiviral.2023.105756
10. M Komori, T Nogimori, AL Morey, T Sekida, K Ishimoto, MR Hassett, Y Masuta, H Ode, T Tamura, R Suzuki, J Alexander, Y Kido, K Matsuda, T Fukuhara, Y Iwatani, T Yamamoto, JF Smith and W Akahata. saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern. Nature communications. 2023; 14: 2810. 10.1038/s41467-023-38457-x
11. K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, T Suda and K Kawata. Simvastatin inhibits hepatic stellate cells activation by regulating the ferroptosis signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. 2023; 1869: 166750. 10.1016/j.bbadis.2023.166750
12. K Kitsugi, K Kawata, H Noritake, T Chida, K Ohta, J Ito, S Takatori, M Yamashita, T Hanaoka, M Umemura, M Matsumoto and T Suda. Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation. Journal of clinical medicine. 2023; 12: 2210. 10.3390/jcm12062210
13. K Kitsugi, K Kawata, M Matsumoto, M Umemura, T Hanaoka, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, H Noritake and T Suda. Hepatic Angiosarcoma with Peliosis Hepatis. Internal medicine. 2023; 62: 1157-. 10.2169/internalmedicine.0315-22
14. Y Ito, H Lu, M Kitajima, H Ishikawa, Y Nakata, Y Iwatani and T Hoshino. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. Journal of natural products. 2023; 86: 2487-. 10.1021/acs.jnatprod.3c00662
15. M Horikawa, S Koizumi, T Oishi, T Yamamoto, M Ikeno, M Ito, T Yamasaki, S Amano, T Sameshima, Y Mitani, Y Otani, Y Yan, T Suzuki, H Namba and K Kurozumi. Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth. Cancer gene therapy. 2023; 30: 85-. 10.1038/s41417-022-00527-5
16. H Hamada, M Futamura, H Ito, R Yamamoto, K Yata, Y Iwatani, H Inoue, N Fukatsu, H Nagai and Y Hasegawa. Association of a third vaccination with antibody levels and side reactions in essential workers: A prospective cohort study. Vaccine. 2023; 41: 1632-. 10.1016/j.vaccine.2023.01.050
17. A Ariffianto, L Deng, T Abe, C Matsui, M Ito, A Ryo, HH Aly, K Watashi, T Suzuki, M Mizokami, Y Matsuura and I Shoji. Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication. Journal of virology. 2023; 97: e0128723. 10.1128/jvi.01287-23
18. W Akahata, T Sekida, T Nogimori, H Ode, T Tamura, K Kono, Y Kazami, A Washizaki, Y Masuta, R Suzuki, K Matsuda, M Komori, AL Morey, K Ishimoto, M Nakata, T Hasunuma, T Fukuhara, Y Iwatani, T Yamamoto, JF Smith and N Sato. Safety and immunogenicity of SARS-CoV-2 self-amplifying RNA vaccine expressing an anchored RBD: A randomized, observer-blind phase 1 study. Cell reports. Medicine. 2023; 4: 101134. 10.1016/j.xcrm.2023.101134
19. 重見麗, 山村喜美, 岡﨑玲子, 松田昌和, 笠原嵩翔, 今橋真弓, 横幕能行, 蜂谷敦子, 岩谷靖雅. HIV-1感染急性期の症例に対するGeenius HIV-1/2 Confirmatory Assayによる判定結果と考察. 感染症学雑誌. 2023, 97, 90-
20. 後藤勇也,　澤野智哉,　重見麗,　岡崎玲子,　山村喜美,　大出裕高,　松田昌和,　矢田啓二,　今橋真弓,　横幕能行,　岩谷靖雅. 東海地域のHIV-1感染症例におけるLenacapavir標的部位の配列保存性に関する研究. 日本エイズ学会誌. 2023, 25, 129-

2022年

原著論文

1. Y Yoshida, T Zheng, W Tanabe, F Tomoike, F Hashiya, T Suzuki, S Hirota, Y Saiki, A Horii, A Hirayama, T Soga, Y Kimura and H Abe. Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs. ChemMedChem. 2022; 17: e202200188. 10.1002/cmdc.202200188
2. TS Tan, M Toyoda, H Ode, G Barabona, H Hamana, M Kitamatsu, H Kishi, C Motozono, Y Iwatani and T Ueno. Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike. Journal of virology. 2022; 96: e0116222. 10.1128/jvi.01162-22
3. K Takamure, Y Sakamoto, Y Iwatani, H Amano, T Yagi and T Uchiyama. Characteristics of collection and inactivation of virus in air flowing inside a winding conduit equipped with 280 nm deep UV-LEDs. Environment international. 2022; 170: 107580. 10.1016/j.envint.2022.107580
4. Y Shirasago, H Fukazawa, S Nagase, Y Shimizu, T Mizukami, T Wakita, T Suzuki, H Tani, M Kondoh, T Kuroda, S Yasuda, Y Sato, K Hanada and M Fukasawa. A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection. Scientific reports. 2022; 12: 20243. 10.1038/s41598-022-23824-3
5. U Shigemi, Y Yamamura, M Matsuda, R Okazaki, M Kubota, S Ibe, M Nemoto, M Maejima-Kitagawa, S Sukegawa, M Imahashi, T Kikuchi, W Sugiura, Y Iwatani, A Hachiya, Y Yokomaku and HIVSN Japanese Drug Resistance. Evaluation of the Geenius HIV 1/2 confirmatory assay for HIV-2 samples isolated in Japan. Journal of clinical virology. 2022; 152: 105189. 10.1016/j.jcv.2022.105189
6. T Oishi, M Ito, S Koizumi, M Horikawa, T Yamamoto, S Yamagishi, T Yamasaki, T Sameshima, T Suzuki, H Sugimura, H Namba and K Kurozumi. Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases. Molecular therapy. Methods & clinical development. 2022; 26: 253-. 10.1016/j.omtm.2022.07.001
7. H Ode, A Saito, A Washizaki, Y Seki, T Yoshida, S Harada, H Ishii, T Shioda, Y Yasutomi, T Matano, T Miura, H Akari and Y Iwatani. Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques. Journal of general virology. 2022; 103: 001790. 10.1099/jgv.0.001790
8. H Ode, Y Nakata, M Nagashima, M Hayashi, T Yamazaki, H Asakura, J Suzuki, M Kubota, K Matsuoka, M Matsuda, M Mori, A Sugimoto, M Imahashi, Y Yokomaku, K Sadamasu and Y Iwatani. Molecular epidemiological features of SARS-CoV-2 in Japan, 2020-1. Virus evolution. 2022; 8: veac034. 10.1093/ve/veac034
9. M Mori, H Ode, M Kubota, Y Nakata, T Kasahara, U Shigemi, R Okazaki, M Matsuda, K Matsuoka, A Sugimoto, A Hachiya, M Imahashi, Y Yokomaku and Y Iwatani. Nanopore Sequencing for Characterization of HIV-1 Recombinant Forms. Microbiology spectrum. 2022; 10: e0150722. 10.1128/spectrum.01507-22
10. N Matsumoto, K Watanabe, A Konno, T Inoue and S Okazaki. Complex-Amplitude-Modulation Vectorial Excitation Beam for High-Resolution Observation of Deep Regions in Two-Photon Microscopy. Frontiers in neuroscience. 2022; 16: 880178. 10.3389/fnins.2022.880178
11. X Li, M Ito, H Aoyagi, A Murayama, H Aizaki, M Fukasawa, T Kato, T Wakita and T Suzuki. Development and Use of a Kinetical and Real-Time Monitoring System to Analyze the Replication of Hepatitis C Virus. International journal of molecular sciences. 2022; 23: 8711. 10.3390/ijms23158711
12. T Kondo, K Matsuoka, S Umemoto, T Fujino, G Hayashi, Y Iwatani and H Murakami. Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern. Life science alliance. 2022; 5: e202101322. 10.26508/lsa.202101322
13. K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, B Ulmasov, BA Neuschwander-Tetri, T Suda and K Kawata. Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway. Cellular signalling. 2022; 99: 110437. 10.1016/j.cellsig.2022.110437
14. K Kawata, M Atsukawa, K Ohta, T Chida, H Noritake, T Arai, K Iwakiri, S Yasuda, H Toyoda, T Okubo, A Hiraoka, T Watanabe, H Uojima, A Nozaki, J Tani, A Morishita, F Kageyama, Y Sasada, M Nagasawa, M Matsushita, T Oyaizu, S Mikami, T Ikegami, H Abe, K Matsuura, Y Tanaka and A Tsubota. Mac-2-binding protein glycan isomer predicts all malignancies after sustained virological response in chronic hepatitis C. Hepatology communications. 2022; 6: 1855-. 10.1002/hep4.1941
15. A Hachiya, M Kubota, U Shigemi, H Ode, Y Yokomaku, KA Kirby, SG Sarafianos and Y Iwatani. Specific mutations in the HIV-1 G-tract of the 3'-polypurine tract cause resistance to integrase strand transfer inhibitors. Journal of antimicrobial chemotherapy. 2022; 77: 574-. 10.1093/jac/dkab448
16. Y Fujisawa, H Ono, A Konno, I Yao, H Itoh, T Baba, K Morohashi, Y Katoh-Fukui, M Miyado, M Fukami and T Ogata. Intrauterine Hyponutrition Reduces Fetal Testosterone Production and Postnatal Sperm Count in the Mouse. Journal of the Endocrine Society. 2022; 6: bvac022. 10.1210/jendso/bvac022
17. K Takamure, Y Sakamoto, T Yagi, Y Iwatani, H Amano, T Uchiyama. Blocking effect of desktop air curtain on aerosols in exhaled breath. AIP Advances. 2022; 12: 055323. 10.1063/5.0086659

2021年

原著論文

1. N Urata, T Watanabe, N Hirashima, Y Yokomaku, J Imamura, Y Iwatani, M Shimada and Y Tanaka. Cytokines and Chemokines Involved in Hepatitis B Surface Antigen Loss in Human Immunodeficiency Virus/Hepatitis B Virus Coinfected Patients. Journal of clinical medicine. 2021; 10: 833. 10.3390/jcm10040833
2. Y Takeuchi, H Noritake, M Matsumoto, M Umemura, M Yamashita, K Kitsugi, S Takatori, K Ohta, J Ito, S Shimoyama, A Kaysuya, C Maruyama, K Fukuchi, S Dohtan, H Sakata and K Kawata. Azathioprine-induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report. Clinical case reports. 2021; 9: e04696. 10.1002/ccr3.4696
3. A Takemori, J Ishizaki, K Nakashima, T Shibata, H Kato, Y Kodera, T Suzuki, H Hasegawa and N Takemori. BAC-DROP: Rapid Digestion of Proteome Fractionated via Dissolvable Polyacrylamide Gel Electrophoresis and Its Application to Bottom-Up Proteomics Workflow. Journal of proteome research. 2021; 20: 1535-. 10.1021/acs.jproteome.0c00749
4. A Sugimoto, Y Abe, T Watanabe, K Hosokawa, J Adachi, T Tomonaga, Y Iwatani, T Murata and M Fujimuro. The FAT10 post-translational modification is involved in the lytic replication of Kaposi's sarcoma-associated herpesvirus. Journal of virology. 2021; 95: e0219420. 10.1128/JVI.02194-20
5. S Shimoyama, K Kawata, K Ohta, T Chida, T Suzuki, K Tsuneyama, S Shimoda, N Kurono, PSC Leung, ME Gershwin, T Suda and Y Kobayashi. Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-gamma and CX3CL1 production in primary biliary cholangitis. European journal of immunology. 2021; 51: 1519-. 10.1002/eji.202048589
6. Y Shimizu, T Shinoda, Y Shirasago, M Kondoh, N Shinya, K Hanada, K Yagi, T Suzuki, T Wakita, T Kimura-Someya, M Shirouzu and M Fukasawa. Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection. FEBS letters. 2021; 595: 220-. 10.1002/1873-3468.13975
7. S Ozono, Y Zhang, H Ode, K Sano, TS Tan, K Imai, K Miyoshi, S Kishigami, T Ueno, Y Iwatani, T Suzuki and K Tokunaga. SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity. Nature communications. 2021; 12: 848. 10.1038/s41467-021-21118-2
8. A Murayama, N Yamada, Y Osaki, M Shiina, HH Aly, M Iwamoto, S Tsukuda, K Watashi, M Matsuda, R Suzuki, T Tanaka, K Moriishi, T Suzuki, H Nishitsuji, M Sugiyama, M Mizokami, K Shimotohno, T Wakita, M Muramatsu, TJ Liang and T Kato. N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus. Hepatology. 2021; 73: 520-. 10.1002/hep.31308
9. IM Khoris, AB Ganganboina, T Suzuki and EY Park. Self-assembled chromogen-loaded polymeric cocoon for respiratory virus detection. Nanoscale. 2021; 13: 388-. 10.1039/d0nr06893d
10. K Kawata, S Joshita, S Shimoda, Y Yamashita, M Yamashita, K Kitsugi, S Takatori, K Ohta, J Ito, S Shimoyama, H Noritake, T Suda and K Harada. The ursodeoxycholic acid response score predicts pathological features in primary biliary cholangitis. Hepatology research. 2021; 51: 80-. 10.1111/hepr.13584
11. T Kasahara, M Imahashi, C Hashiba, M Mori, A Kogure, Y Yokomaku, N Hashimoto, Y Iwatani and Y Hasegawa. Retrospective Analysis of the Efficacy of Early Antiretroviral Therapy in HIV-1-Infected Patients Coinfected with Pneumocystis jirovecii. AIDS research and human retroviruses. 2021; 37: 754-. 10.1089/AID.2021.0025
12. M Ito, M Unou, T Higuchi, S So and K Yogo. Dysregulation of intracellular pH is a cause of impaired capacitation in Slc22a14-deficient mice. Reproduction. 2021; 163: 23-. 10.1530/REP-21-0135
13. M Imahashi, H Ode, A Kobayashi, M Nemoto, M Matsuda, C Hashiba, A Hamano, Y Nakata, M Mori, K Seko, M Nakahata, A Kogure, Y Tanaka, W Sugiura, Y Yokomaku and Y Iwatani. Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients. Scientific reports. 2021; 11: 960. 10.1038/s41598-020-80247-8
14. T Imagawa, M Ito, M Matsuda, K Nakashima, Y Tokunaga, I Ohta, TC Li, R Suzuki and T Suzuki. Virus-like particles with FLAG-tagged envelope protein as a tetravalent dengue vaccine candidate. Scientific reports. 2021; 11: 17542. 10.1038/s41598-021-97038-4
15. MK Ibrahim, TH Abdelhafez, JS Takeuchi, K Wakae, M Sugiyama, M Tsuge, M Ito, K Watashi, M El Kassas, T Kato, A Murayama, T Suzuki, K Chayama, K Shimotohno, M Muramatsu, HH Aly and T Wakita. MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter. Journal of virology. 2021; 95: e0076721. 10.1128/JVI.00767-21
16. H Hosoi, S Murata, T Suzuki, TC Li, K Hatanaka, K Tanaka-Taya, T Mushino, K Kuriyama, S Tamura, N Hanaoka and T Sonoki. A cluster of BK polyomavirus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Transplant infectious disease. 2021; 23: e13736. 10.1111/tid.13736
17. W Gu, Y Ueda, H Dansako, S Satoh and N Kato. Antiviral mechanism of preclinical antimalarial compounds possessing multiple antiviral activities. FASEB bioAdvances. 2021; 3: 356-. 10.1096/fba.2020-00107
18. H Dansako, Y Ueda, S Satoh and N Kato. Extracellular vesicles activate ATM-Chk2 signaling pathway through the intercellular transfer of mitochondrial DNA in HBV-infected human hepatocytes. FASEB journal. 2021; 35: e21680. 10.1096/fj.202002678R
19. S Chiba, M Kiso, N Nakajima, S Iida, T Maemura, M Kuroda, Y Sato, M Ito, M Okuda, S Yamada, K Iwatsuki-Horimoto, T Watanabe, M Imai, T Armbrust, RS Baric, PJ Halfmann, T Suzuki and Y Kawaoka. Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model. mBio. 2021; 13: e0304421. 10.1128/mbio.03044-21
20. RG Bawono, T Abe, M Qu, D Kuroki, L Deng, C Matsui, A Ryo, T Suzuki, Y Matsuura, M Sugiyama, M Mizokami, K Shimotohno and I Shoji. HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication. Journal of general virology. 2021; 102: 001668. 10.1099/jgv.0.001668
21. OJ Achadu, F Abe, TC Li, IM Khoris, D Lee, J Lee, T Suzuki and EY Park. Molybdenum Trioxide Quantum Dot-Encapsulated Nanogels for Virus Detection by Surface-Enhanced Raman Scattering on a 2D Substrate. ACS applied materials & interfaces. 2021; 13: 27836-. 10.1021/acsami.1c04793
22. OJ Achadu, F Abe, F Hossain, F Nasrin, M Yamazaki, T Suzuki and EY Park. Sulfur-doped carbon dots@polydopamine-functionalized magnetic silver nanocubes for dual-modality detection of norovirus. Biosensors & bioelectronics. 2021; 193: 113540. 10.1016/j.bios.2021.113540
23. 中田佳宏, 大出裕高, 久保田舞、松岡和弘, 松田昌和, 中筋美穂, 森美喜子, 今橋真弓, 横幕能行, 岩谷靖雅. SARS-CoV-2ゲノム配列に基づく分子疫学的動向とその特徴に関する考察 (2020年3-10月). 感染症学雑誌. 2021, 95, 293-
24. 加藤万理, 平野淳, 松岡梨恵, 福島直子, 今橋真弓, 岩谷靖雅, 高橋昌明, 中井正彦, 横幕能行. テノホビルジソプロキシルフマル酸塩からテノホビルアラフェナミドフマル酸塩への抗HIV療法の変更が, 日本人HIV陽性男性の体重および脂質検査値に及ぼす影響. 日本エイズ学会誌. 2021, 23, 144-

2020年

原著論文

1. X Zhou, K Nakashima, M Ito, X Zhang, S Sakai, C Feng, H Sun, H Chen, TC Li and T Suzuki. Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China. Scientific reports. 2020; 10: 17066. 10.1038/s41598-020-74244-0
2. H Shimoyama, TK Shibata, M Ito, T Oda, T Itoh, M Mukai, M Matsuya-Ogawa, M Adachi, H Murakami, T Nakayama, K Sugihara, H Itoh, T Suzuki and N Kanayama. Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer. Biochemistry and biophysics reports. 2020; 22: 100740. 10.1016/j.bbrep.2020.100740
3. A Saito, T Sultana, H Ode, K Nohata, Y Samune, EE Nakayama, Y Iwatani and T Shioda. The 4th and 112th Residues of Viral Capsid Cooperatively Modulate Capsid-CPSF6 Interactions of HIV-1. AIDS research and human retroviruses. 2020; 36: 513-. 10.1089/AID.2019.0250
4. D Onomura, S Satoh, Y Ueda, H Dansako and N Kato. Identification of ribavirin-responsive cis-elements for GPAM suppression in the GPAM genome. Biochemical and Biophysical Research Communications. 2020; 533: 148-. 10.1016/j.bbrc.2020.08.112
5. M Ogata, T Onoda, A Koizumi, Y Tokunaga, I Ohta, S Nukuzuma, EY Park, T Usui and T Suzuki. Agglutination of Human Polyomaviruses by Using a Tetravalent Glycocluster as a Cross-Linker. ACS Omega. 2020; 5: 21940-. 10.1021/acsomega.0c03269
6. G Kuroda, S Sasaki, A Matsushita, K Ohba, Y Sakai, S Shinkai, HM Nakamura, S Yamagishi, K Sato, N Hirahara, Y Oki, M Ito, T Suzuki and T Suda. G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor beta2 in the rat hypothalamic paraventricular nucleus. PLoS One. 2020; 15: e0242380. 10.1371/journal.pone.0242380
7. A Konno, N Matsumoto, Y Tomono and S Okazaki. Pathological application of carbocyanine dye-based multicolour imaging of vasculature and associated structures. Scientific reports. 2020; 10: 12613. 10.1038/s41598-020-69394-0
8. A Konno and K Inaba. Region-Specific Loss of Two-Headed Ciliary Dyneins in Ascidian Endostyle. Zoological science. 2020; 37: 512-. 10.2108/zs200095
9. T Kondo, Y Iwatani, K Matsuoka, T Fujino, S Umemoto, Y Yokomaku, K Ishizaki, S Kito, T Sezaki, G Hayashi and H Murakami. Antibody-like proteins that capture and neutralize SARS-CoV-2. Science advances. 2020; 6: eabd3916. 10.1126/sciadv.abd3916
10. IM Khoris, AD Chowdhury, TC Li, T Suzuki and EY Park. Advancement of capture immunoassay for real-time monitoring of hepatitis E virus-infected monkey. Analytica chimica acta. 2020; 1110: 64-. 10.1016/j.aca.2020.02.020
11. N Kato, Y Ueda, H Sejima, W Gu, S Satoh, H Dansako, M Ikeda and K Shimotohno. Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture. Archives of virology. 2020; 165: 331-. 10.1007/s00705-019-04461-0
12. Y Kamiya, T Fujisawa, M Katsumata, H Yasui, Y Suzuki, M Karayama, H Hozumi, K Furuhashi, N Enomoto, Y Nakamura, N Inui, M Setou, M Ito, T Suzuki, K Ikegami and T Suda. Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. Respiratory research. 2020; 21: 282. 10.1186/s12931-020-01555-1
13. AB Ganganboina, AD Chowdhury, IM Khoris, F Nasrin, K Takemura, T Hara, F Abe, T Suzuki and EY Park. Dual modality sensor using liposome-based signal amplification technique for ultrasensitive norovirus detection. Biosensors & bioelectronics. 2020; 157: 112169. 10.1016/j.bios.2020.112169
14. AB Ganganboina, AD Chowdhury, IM Khoris, RA Doong, TC Li, T Hara, F Abe, T Suzuki and EY Park. Hollow magnetic-fluorescent nanoparticles for dual-modality virus detection. Biosensors & bioelectronics. 2020; 170: 112680. 10.1016/j.bios.2020.112680
15. K Furukawa, T Suzuki, H Ishiguro, H Morikawa, K Sonoda, K Iijima, M Ito, O Hanyu and H Sone. Prevention of postprandial hypotension-related syncope by caffeine in a patient with long-standing diabetes mellitus. Endocrine journal. 2020; 67: 585-. 10.1507/endocrj.EJ19-0370
16. AD Chowdhury, F Nasrin, R Gangopadhyay, AB Ganganboina, K Takemura, I Kozaki, H Honda, T Hara, F Abe, S Park, T Suzuki and EY Park. Controlling distance, size and concentration of nanoconjugates for optimized LSPR based biosensors. Biosensors & bioelectronics. 2020; 170: 112657. 10.1016/j.bios.2020.112657