Barrett CD, Suzuki Y, Moore EE, Moore HB, Maginot ER, White CM, Siddiqui H, GAwargi FI, Chandler JG, Sauala A, Urano T. A Novel Fibrinolysis Resistance Capacity Assay Can Detect Fibrinolytic Phenotypes in Trauma Patients. Thromb Haemost doi: https://doi.org/10.1055/a-2508-3424.
Mochizuki L, Sano H, Honkura N, Masumoto K, Urano T, Suzuki Y. Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis. Thromb Haemost. 2023 Jan;123(1):16-26. doi: 10.1055/s-0042-1757407. Epub 2022 Oct 28.PMID:36307100
Urano T, Yasumoto A, Yokoyama K, Horiuchi H, Morishita E, Suzuki Y. COVID-19 and Thrombosis: Clinical Aspects. Curr Drug Targets. 2022;23(17):1567-1572.
Kugo H, Enomoto H, Yanagimoto K, Tanaka H, Moriyama T, Zaima N Eicosapentaenoic acid is associated with the attenuation of dysfunctions of mesenchymal stem cells in the abdominal aortic aneurysm wall. Food Funct. 13:7540-7547. 2022
Tanaka A, Inami W, Suzuki Y, Kawata Y. Development of a direct point electron beam exposure system to investigate the biological functions of subcellular domains in a living biological cell.
Micron. Apr;155:103214. 2022
Kugo H, Tanaka H, Moriyama T, Zaima N. Characteristic distribution of eicosapentaenoic acid in human abdominal aortic aneurysm wall. J Lipid Res. Mar 18:100200. 2022
Ito T, Suzuki Y, Sano H, Honkura N, Castellino FJ, Urano T. Demonstration of Three Distinct High-Molecular-Weight Complexes between Plasminogen Activator Inhibitor Type 1 and Tissue-Type Plasminogen Activator. Thromb Haemost. Mar;122(3):336-343. 2022
Mathews NS, Suzuki Y, Honkura N, Sano H, Iwashita T, Urano T. Pre-administration of a carboxypeptidase inhibitor enhances tPA-induced thrombolysis in mouse microthrombi: Evidence from intravital imaging analysis. Thromb Res. Feb;210:78-86. 2022
Wendelboe AM, Langenfeld H, Ageno W, Castellucci L, Cesarman-Maus G, Ddungu H, De Paula EV, Dumantepe M, Forgo G, Guillermo Esposito MC, McLintock C, Ní Áinle F, Spyropoulos AC, Urano T, Barco S, Hunt BJ. Current practices of standardized risk assessment for venous thromboembolism: Results from a global survey from the World Thrombosis Day steering committee. J Thromb Haemost. Feb;20(2):532-535. 2022
Forgo G, Micieli E, Ageno W, Castellucci LA, Cesarman-Maus G, Ddungu H, De Paula EV, Dumantepe M, Guillermo Esposito MC, Konstantinides SV, Kucher N, McLintock C, Ní Áinle F, Spyropoulos AC, Urano T, Hunt BJ, Barco S. An update on the global use of risk assessment models and thromboprophylaxis in hospitalized patients with medical illnesses from the World Thrombosis Day steering committee: Systematic review and meta-analysis. J Thromb Haemost. Feb;20(2):409-421. 2022
2021
Takeda R, Islam A, Sato T, Kurita H, Kahyo T, Urano T, Setou M. The stability of the metabolic turnover of arachidonic acid in human unruptured intracranial aneurysmal walls is sustained.
Clin Neurol Neurosurg. Sep;208:106881. 2021
Tanaka H, Xu B, Xuan H, Ge Y, Wang Y, Li Y, Wang W, Guo J, Zhao S, Glover KJ, Zheng X, Liu S, Inuzuka K, Fujimura N, Furusho Y, Ikezoe T, Shoji T, Wang L, Fu W, Huang J, Unno N, Dalman RL. Recombinant Interleukin-19 Suppresses the Formation and Progression of Experimental Abdominal Aortic Aneurysms. J Am Heart Assoc. Sep 7;10(17):e022207. 2021
Barco S, Valerio L, Gallo A, Turatti G, Mahmoudpour SH, Ageno W, Castellucci LA, Cesarman-Maus G, Ddungu H, De Paula EV, Dumantepe M, Goldhaber SZ, Guillermo Esposito MC, Klok FA, Kucher N, McLintock C, Ní Áinle F, Simioni P, Spirk D, Spyropoulos AC, Urano T, Zhai ZG, Hunt BJ, Konstantinides SV. Global reporting of pulmonary embolism-related deaths in the World Health Organization mortality database: Vital registration data from 123 countries. Res Pract Thromb Haemost. Jun 15;5(5):e12520. 2021
Horiuchi H, Morishita E, Urano T, Yokoyama K; Questionnaire-survey Joint Team on The COVID-19-related thrombosis. COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020. J Atheroscler Thromb. Apr 1;28(4):406-416, 2021
2020
Suzuki Y, Tanaka H, Horinouchi T, Sano H, Honkura N, Unno N, Miwa S, Urano T. Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms. Sci Rep. Nov 26;10(1):20728, 2020
Suzuki Y, Sano H, Mochizuki L, Honkura N, Urano T. Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system. Blood Adv. Nov 10;4(21):5501-5511, 2020
Thachil J, Longstaff C, Favaloro EJ, Lippi G, Urano T, Kim PY; SSC Subcommittee on Fibrinolysis of the International Society on Thrombosis and Haemostasis. The need for accurate D-dimer reporting in COVID-19: Communication from the ISTH SSC on fibrinolysis. J Thromb Haemost. Sep;18(9):2408-2411, 2020
Sano M, Hirakawa S, Suzuki M, Sakabe JI, Ogawa M, Yamamoto S, Hiraide T, Sasaki T, Yamamoto N, Inuzuka K, Tanaka H, Saito T, Sugisawa R, Katahashi K, Yata T, Kayama T, Urano T, Tokura Y, Sato K, Setou M, Takeuchi H, Konno H, Unno N. Potential role of transforming growth factor-beta 1/Smad signaling in secondary lymphedema after cancer surgery. Cancer Sci. Jul;111(7):2620-2634, 2020
Moore HB, Gando S, Iba T, Kim PY, Yeh CH, Brohi K, Hunt BJ, Levy JH, Draxler DF, Stanworth S, Görlinger K, Neal MD, Schreiber MA, Barrett CD, Medcalf RL, Moore EE, Mutch NJ, Thachil J, Urano T, Thomas S, Scărlătescu E, Walsh M; Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and Hemostasis. Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. J Thromb Haemost. Mar;18(3):740-747, 2020
Tanaka H, Zaima N, Kugo H, Yata T, Iida Y, Hashimoto K, Miyamoto C, Sasaki T, Sano H, Suzuki Y, Moriyama T, Shimizu H, Inuzuka K, Urano T, Unno N. The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model. Ann Vasc Surg. Feb;63:382-390, 2020
2019
Urano T, Suzuki Y. Assessing plasminogen activation potential with global fibrinolytic assays. Res Pract Thromb Haemost. Dec 26;4(1):13-15, 2019
Hashimoto T, Mogami H, Tsuriya D, Morita H, Sasaki S, Kumada T, Suzuki Y, Urano T, Oki Y, Suda T. G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells. PLoS One. Sep 9;14(9):e0222179, 2019
Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ. Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis. Curr Drug Targets. ;20(16):1695-1701, 2019
2018
Tanaka H, Inuzuka K, Iida Y, Shimizu H, Unno N, Urano T. Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm. J Oleo Sci. Oct 11;67(10):1355-1360, 2018
Sugiura K, Ojima T, Urano T, Kobayashi T. The incidence and prognosis of thromboembolism associated with oral contraceptives: Age-dependent difference in Japanese population. J Obstet Gynaecol Res. Sep;44(9):1766-1772, 2018
Urano T, Castellino FJ, Suzuki Y. Regulation of plasminogen activation on cell surfaces and fibrin. J Thromb Haemost. 16:1487-1497, 2018
Tanaka H, Unno N, Suzuki Y, Sano H, Yata T, Urano T. Hypoperfusion of the aortic wall secondary to degeneration of adventitial vasa vasorum causes abdominal aortic aneurysms. Curr Drug Targets Jan 22, 2018
Hashimoto K, Kugo H, Tanaka H, Miyamoto C, Uranon T, Unno N, Zaima N, Moriyama T. The effect of high fat diet on development of abdominal aortic aneurysm in vascular hypoperfusion-induced animal model. J Vasc Res 55(2):63-74, 2018
Tanaka H, Iida Y, Iwaki T, Suzuki Y, Sano H, Miyajima C, Zaima N, Sasaki T, Sumioka A, Hakamata S, Shimizu H, Umemura K, Urano T. Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice. Ann Vasc Surg 48:204-213, 2018
Iida Y, Tanaka H, Sano H, Suzuki Y, Shimizu H, Urano T. Ectopic Expression of PCSK9 by Smooth Muscle Cells Contributes to Aortic Dissection. Ann Vasc Surg 48:195-203, 2018
2017
Wendelboe AM, Raskob GE, Angchaisuksiri P, Blanco AN, Büller H, Ddungu H, Dvorak JD, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, McLintock C, Urano T, Weitz JI. Global public awareness about atrial fibrillation. Res Pract Thromb Haemost. Oct 25;2(1):49-57, 2017
Brzoska T, Suzuki Y, Sano H, Suzuki A, Tanaka H, Urano T. Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor. Thromb Haemost 7. 682-690. doi.org/10.1160/TH16-09-0722, 2017
H Kugo, N Zaima, H Tanaka, T Urano, N Unno, T Moriyama The effects of nicotine administration on pathophysiology of rat vascular wall. Biotechnic & Histochemistry 92(2):141-148, 2017
Iwaki T, Nagahashi K, Takano K, Suzuki-Inoue K, Kanayama N, Umemura K, Urano T. Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerization. Thromb Haemost 117(5):860-869, 2017
Kugo H, Zaima N, Tanaka H, Hashimoto K, Miyamoto C, Sawaragi A, Urano T, Unno N, Moriyama T. Pathological Analysis of the Ruptured Vascular Wall of Hypoperfusion-induced Abdominal Aortic Aneurysm Animal Model. J Oleo Sci 66(5), 499-506, 2017
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N. Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression. J Vasc Res 54(4), 200-208, 2017
Wendelboe, Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Ddungu, H, Dvorak JD, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, McLintock C, Urano T, Weitz J. Global Public Awareness about Atrial Fibrillation. Res Pract Thromb Haemost. ;1-9. 2017
Iida Y, Tanaka H, Urano T, Unno N, Shimizu H. PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection. J Vasc Surg 65(6), 192S-193S, 2017
Takechi D, Kuroda N, Dote H, Kim E, Yonekawa O, Watanabe T, Urano T, Homma Y. Better documentation in electronic medical records would lead to an increased use of lower extremity venous ultrasound in the inpatient setting: a retrospective study. Acute Med Surg 4(4), 385-393, 2017
Tanaka H, Unno N, Yata T, Kugo H, Zaima N, Sasaki T, Urano T. Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion. J Vis Exp Nov 8;(129), 2017
2016
Suzuki Y, Sano H, Tomczyk M, Brzoska T, Urano T. Activities of wild-type and variant tissue-type plasminogen activators retained on vascular endothelial cells. FEBS Open Bio 6:469-76, 2016
Tanaka H, Yamamoto N, Suzuki M, Mano Y, Sano M, Zaima N, Sasaki T, Setou M, Unno N: Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration. Ann Vasc Dis 9(4):277-284, 2016
Tomczyk M, Suzuki Y, Sano H, Brzoska T, Tanaka H, Urano T.Bidirectional functions of thrombin on fibrinolysis: Evidence of thrombin-dependent enhancement of fibrinolysis provided by spontaneous plasma clot lysis. Thromb Res 143:28-33, 2016
Hosokawa K, Ohnishi-Wada T, Sameshima-Kaneko H, Nagasato T, Miura N, Kikuchi K, Koide T, Maruyama I, Urano T. Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model. Thromb Res 146:69-75, 2016
Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T. Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. Sci Rep 6:31268, 2016
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Konno H, Urano T, Setou M, Unno N. Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms. J Atheroscler Thromb 23(6):673-80, 2016
Kugo H, Zaima N, Mouri Y, Tanaka H, Yanagimoto K, Urano T, Unno N, Moriyama T. The preventive effect of fish oil on abdominal aortic aneurysm development. Biosci Biotechnol Biochem 80(6):1186-91, 2016
Asai J, Hirakawa S, Sakabe J, Kishida T, Wada M, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N. Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice. Am J Pathol 186(1):101-8, 2016
2015
Brzoska T, Tanaka-Murakami A, Suzuki Y, Sano Hideto, Kanayama N, Urano T. Endogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi. PloS One 10(3), e0122196, 2015
2013
Brzoska T, Suzuki Y, Mogami H, Sano H, Urano T. Binding of thrombin-activated platelets to a fibrin scaffold through α(IIb)β3 evokes phosphatidylserine exposure on their cell surface. PloS One 8(2), e55466, 2013
Yasui H, Suzuki Y, Sano H, Suda T, Chida K, Dan T, Miyata T, Urano T. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thrmob Res 132(1),100-105, 2013
2012
Iwaki T, Urano T, Umemura K. PAI-1 progress in understanding the clinical problem and its aetiology. Br J Haematol 157(3), 291-298, 2012
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, and Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood 119(8), 45-56, 2012
Kramkowski K, Leszczynska A, Mogielnicki A, Chlopicki S, Fedorowicz A, Grochal E, Mann B, Brzoska T, Urano T, Motterlini R, Buczko W. Anti-thrombotic properties of water-soluble carbon monoxide-releasing molecules (CO-RMS). ATVB, 32(9), 2149-57, 2012
2011
Suzuki Y, Yasui H, Brzoska T, Mogami H, Urano T. Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells. Blood 118(11), 3182-3185, 2011
Ryobaltowski M, Suzuki Y, Mogami H, Chlebinska I, Brzoska T, Tanaka A, Bannno F, Miyata T, Urano T. In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall. Pflugers Arch 461(6), 623-633, 2011
Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T,Kanayama N. Life-threatening hemorrhage and prolonged wound haeling are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans. J Thromb Haemost 9(6), 1200-1206, 2011
2009
Hoki S, Suzuki Y, Umemura K, Urano T.Enhancement of fibrinolysis by gel-filtered platelets and its quenching by cytochalasin B and GPIIb/IIIa antagonists.Pharmacological Reports 61(5),877-84, 2009
Tanaka A, Suzuki Y, Sugihara K, Kanayama N, Urano T. Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factorsin-vitro.Life Scineces 85(5/6), 220-225, 2009
Suzuki Y, Mogami H, Ihara Y, Urano T. Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells. Blood 113, 470-478, 2009
Yashiro K, Matsumoto Y, Ihara H, Suzuki Y, Kondo K,Urano T,Umemura K. Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice.Transplantation, 87(3), 660-667, 2009
Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, LohseMJ,Tominaga M, Mogami H.A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy Pflugers Arch - Eur J Physiol 459(1),227-34, 2009
2008
Hayashi T, Mogami H, Murakami Y, Nakamura T, Kanayama N, Konno K, UranoT. Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo.Pflugers Archiv-European Journal of Physiology 456(6), 1239-51, 2008
Suwa D, Konno H, Tanaka T, Urano T. Intraperitoneal Infusion of Recombinant Plasminogen Activator inhibitor Type 2 Induced Apoptosis in Implanted Human Colon Cancer and Inhibited its Growth and Liver Metastasis.Anticancer Research 28(2A), 693-698, 2008
2006
Nakamura R, Umemura K, Hashimoto H, Urano T.Less pronounced enhancement of thrombin-dependent inactivation of plasminogen activator inhibitor type 1 by low molecular weight heparin compared with unfractionated heparin. Thromb Haemost 95, 637-42, 2006
Hryszko T, Inaba K, Ihara H, Suzuki Y, Mogami H, Urano T. Nafamostat attenuated the impairment of fibrinolysis in animal sepsis model by suppressing the increase of plasminogen activator inhibitor type 1. The Journal of Trauma, Injury, Infection and Critical Care 60(4), 859-64, 2006
Suzuki Y, Zhang H, Saito N, Urano T, Kojima N, Mogami H.Glucagon-Like Peptide 1 Activates Protein Kinase C Through a Ca2+-Dependent Phospholipase C Activation in Insulin-Secreting Cells. J Biol Chem 281(39), 28499-28507, 2006
2005
Hryszko T, Suzuki Y, Mogami H, Urano T. Protein S attenuates the invasive potential of THP-1 cells by interfering with plasminogen binding on cell surface via a protein C-independent mechanism. FEBS Letters 579(27), 6023-6, 2005
Terada H, Urano T, Konno H. Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer.Eur. Surg. Res. 37, 166-172, 2005
Inaba K, Suzuki S, Ihara H, Sakaguchi T, Baba S, Urano T, Konno H, Nakamura S. Sexual dimorphism in endotoxin susceptibility after partial hepatectomy in rats. J Hepatol 42(5), 719-27, 2005
Takahashi H, Nagai N and Urano T. Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia. Neuroscience Letters 381, 189-193, 2005
TakahashiT, SuzukiK, IharaH, MogamiH, KazuiT and UranoT. Plasminogen activator inhibitor-1 promotes fibrosarcoma cell migration by modifying cellular attachment to vitronectin viaavb5integrin. Semin Thromb Hemost. 31(3), 356-363, 2005
2004
Hryszko T, and Urano T. Activated Protein C enhances tPA-catalyzed Glu-plasminogen activation in the presence of poly-D-lysine.Thrombosis & Haemostasis 92(4), 891-2, 2004
Zhao BQ, Ikeda Y, Ihara H, Urano T, Fan WY, Mikawa S, Suzuki Y, Kondo K, Sato K, Nagai N and Umemura K. Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice. Blood 103(7), 2610-2616, 2004
2003
Urano T, Castellino FJ, Ihara H, Suzuki Y, Ohta M, Suzuki K, Mogami H. Activated protein C attenuates coagulation-associated over expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1. Journal of Thrombosis and Hemostasis 1, 2615-2620, 2003
Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery.Life Sci 73(10), 1289-98, 2003
Mogami H, Zhang H, Suzuki Y, Urano T, Saito N, Kojima I, and Petersen OH. Decoding of short-lived Ca2+influx signals into long-term substrate phosphorylation through activation of two distinct classes of protein kinase C. J Biol Chem 278(11), 9896-9904, 2003
Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T and Umemura. K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 19 (3), 261-264, 2003
2002
Sakata K, Pawlak R, Urano T and Takada A Effects of a longterm pharmacological interruption of the rennin-angiotensin system on the fibrinolytic system in essential hypertension. Pathophysiology of Haemostasis and Thrombosis. 32, 67-75, 2002
YoshidaM, NaitoY, UranoT, TakadaA and Takada Y. L-158,809 and (D-Ala7)-angiotensin I/II (1-7) decrease PAI-1 release from human umbilical vein endothelial cells. Thromb. Res. 105(6), 531-536, 2002
Takahashi H, Takada Y, Urano T and Takada A. 5-HT4 receptors in the hippocampus modulate rat locomotor activity. Hippocampus 12, 304-310, 2002
Nagai N, Zhao BQ, Suzuki Y, Ihara H, Urano T, Takada A, Umemura K.Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice. J Cereb Blood Flow Metab. 22, 648-651, 2002
Pawlak R-, NagaiN, UranoT, Napiorkowska-PawlakD, IharaH, TakadaY , Collen D.and TakadaA. Rapid, specific and active site-catalyzed effect of tissue-plasminogen activator on hippocampus-dependent learning in mice. Neuroscience 113(4), 995-1001, 2002
Yoshino A, Suzuki K, Urano T, Aoki K, Takada Y and Takada A Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery. Life Sciences70, 1461-1470, 2002
2001
Urano T., Ihara H., Umemura K., Suzuki Y., Oike M., Akita S., Tsukamoto Y., Suzuki I. and Takada A. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1.J Biol Chem 276(27): 24690-24696, 2001
Konno H, Abe J, Kaneko T, Baba M, Shoji A, Sunayama K, Kamiya K, Tanaka T, Suzuki S, Nakamura S, Urano T. Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer.Jpn J Cancer Res. 92(5): 516-523, 2001
Aoki K, Aikawa N, Sekine K, Yamazaki M, Mimura T, Urano T and Takada A. Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burs. Burns 27, 569-575, 2001
Ihara, H., Urano, T., Takada, A. and Loskutoff D. J. Induction of plasminogen activator inhibitor-1 (PAI-1) gene expression in adipocytes by thiazolidinediones. FASEB J.15(7):1233-1235, 2001
Urano T., Suzuki Y., Arakida M., Kanamori M. and Takada A. The expression of exercise-induced tPA activity in blood is regulated by the basal level of PAI-1. Thromb. Haemost. 85, 751-752, 2001
Pawlak R, Napiorkowska-Pawlak D, Takada Y, Urano T, Nagai N, Ihara H, Takada A. The differential effect of angiotensin II and angiotensin 1-7 on norepinephrine, epinephrine, and dopamine concentrations in rat hypothalamus: the involvement of angiotensin receptors. Brain Res Bull. 54(6): 689-694, 2001
Takahashi H, Takada Y, Urano T, Takada A. Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors. Neurosci Res. 40(1): 97-103, 2001
Nagai N., YamamotoS., TsuboiT., IharaH., UranoT., TakadaY., TerakawaS. and TakadaA. Tissue-type plasminogen activator enhances neuronal death induced by oxygen-glucose-deprivation in culture. J Cereb Blood Flow Metab. 21(6): 631-634. 2001
~2000
Urano, T., Ihara, H., Takada, Y., Fujie, M. and Takada, A.The cleavage and inactivation of plasminogen activator inhibitor type 1 and a2-antiplasmin by reptilase, a thrombin-like venom enzyme.Blood Coagulation & Fibrinolysis 11(2), 145-153, 2000
Takahashi, H., Urano, T., Takada, Y., Nagai, N. and Takada, A. Neutrophil Elastase May Play a Key Role in the Development of Symptomatic DIC and Multiple Organ Failure in Patients with Head Injury. J. Trauma 49, 86-91, 2000
Urano, T., Ihara, H., Suzuki, Y., Takada, Y. and Takada. A. Coagulation Associated Enhancement of Fibrinolytic Activity Via a Neutralization of PAI-1 Activity. Semin. Thromb. Hemost. 26(1), 39-42, 2000
Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A. Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during treatment of hypertension with cilnidipine. Pharmaclogical Research 41(1), 81-84, 2000
Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A. Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during amlodipine treatment of hypertension in Japanese. Pharmaclogical Research 41(1), 75-79, 2000
Fujii, M., Hayakawa, H., Urano, T., Sato, A., Chida, K., Nakamura, H. and Takada, A. Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis. Thromb. Res. 99, 111-117, 2000
Urano, T., Ihara, H., Suzuki, Y., Nagai, N., Takada, Y. and Takada, A. Soluble thrombomodulin quenches thrombin-mediated neutralization of PAI-1 activity and inhibits fibrinolysis through a TAFI independent mechanism.Fibrinolysis & Proteolysis 13(6), 264-271, 1999
Abe, J., Urano, T., Konno, H., Erhan, Y., Tanaka, T., Nishino, N., Takada, A. and Nakamura, S. Larger and more invasive colo-rectal cancer contained larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlated well with tumor size. Cancer 86(12), 2602-2611, 1999
Sakata, K., Shirotani, M., Yoshida, H., Urano, T., Takada, Y. and Takada, A. Differential effects of analapril and nitrendipine on the fibrinolytic system in essential hypertension. Am. Heart J. 137 (6), 1094-1099, 1999
Endo A, Hashimoto K, Takada Y, Takada A. The activation of the tissue plasminogen activator-plasmin system induced in the mouse hippocampus after injection of trimethyltin: Poosible proteolysis of highly polysialated NCAM.Jpn. J. Physiol. 49(5): 463-466 , 1999
Endo, A., Nagai, N., Urano, T., Takada, Y., Hashimoto, K. and Takada, Y. Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus.Neuroscience Research 33, 1-8, 1999
Nagai, N., Urano, T., Endo, A., Takahashi, H., Takada, Y. and Takada, A. Neuronal degeneration and a decrease in laminin-like immunoreactivity is associated with elevated tissue-type plasminogen activator in the rat hippocampus after kainic acid injection.Neuroscience Research 33, 147-154, 1999
Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A. Progressive expansion of hypertensive intracerebral hemorrhage by coagulopathy.Am. J. Hematology 59, 110-114, 1998
Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A. Hyperfibrinolytic Activity After Head Injury Is Induced By Elevated tPA Activity. Fibrinolysis and Proteolysis 12(2), 113-118, 1998
Urano, T., Nagai, N., Matsuura, M., Ihara, H., Takada Y. and Takada, A. Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity. Thromb Haemost 80, 161-166, 1998
Morita, S., Sato, A., Hayakawa, H., Ihara, H., Urano, T., Takada, Y. and Takada A. Cancer Cells Overexpress mRNA of Urokinase-Type Plasminogen Activator, Its Receptor And Inhibitors In Human Non-Small-Cell Lung Cancer Tissue: Analysis By Northern Blotting And In Situ Hybridization. Int J Cancer 78, 286-292, 1998
Takada, Y., Urano, T., Takahashi, H., Nagai, N. and Takada, A. Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats. Thromb. Res. 89, 107-114, 1998.
Nagai, N., Urano, T., Takada, Y. and Takada, A. Reperfusion after venous occlusion caused transient increase in plasminogen activator inhibitor-1 in systemic circulation.Clinical and Applied Thrombosis/Hemostasis, 4(2), 133-137, 1998
Takahashi, H., Urano, T., Takada, Y., Nagai, N. and Takada. Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate. J. Neurosurgery 86, 768-772, 1997
Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T., Takada, A. Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. American Journal of Respiratory & Critical Care Medicine, 156(2 Pt1):631-6, 1997
Rydzewski, A., Urano, T., Nagai, N., Takada, Y., Katoh-Oishi, Y., Taminato, T., Yoshimi, T. and Takada, A. Diurnal variation in serum remnant-loke lipoproteins, platelet aggregation and fibrinolysis in healthy volunteers.Haemostasis, 27, 305-314, 1997
Urano, T., Nishikawa, T., Nagai, N., Takada, Y. and Takada, A. Amounts of tPA and PAI-1 in the euglobulin fraction obtained at different pH: Their relation to the euglobulin clot lysis time. Thromb. Res. 88(1), 75-80, 1997
Urano T., Ihara H., Takada Y., Nagai N. and Takada A. The inhibition of human factor Xa by plasminogen activator inhibitor type 1 in the presence of calcium ion, and its enhancement by heparin and vitronectin. Biochim. Biophys. Acta 1298, 199-208, 1996
Mochizuki M., Takada Y., Urano T., Nagai N., Nakano T., Nakajima K. and Takada A. The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons. Thromb Res. 81(5), 583-593, 1996
Malyszko J., Urano T., Knofler R., Takada Y. and Takada A. Effects of short term treatment with mevalotin on platelet aggregation, fibrinolysis, peripheral serotonergic system and serum lipids in Japanese monkeys.Thromb. Res. 81(2), 397-402, 1996
Wu, K., Urano, T., Ihara, H., Takada, Y., Fujie, M., Shikimori, M., Hashimoto, K. and Takada, A. The Cleavage and Inactivation of Plasminogen Activator Inhibitor Type 1 by Neutrophil Elastase: The Evaluation of Its Physiological Relevance in Fibrinolysis. Blood 86, 1056-1061, 1995
Urano, T., Serizawa, K., Takada, Y., Ny, T. and Takada, A.Heparin and heparan sulphate enhancement of the inhibitory activity of plasminogen activator inhibitor type 1 toward urokinase type plasminogen activator.Biochim. Byophys. Acta 1201, 217-222, 1994
Kojima, Y., Urano, T., Kojima, K., Serizawa, K., Takada, Y. and Takada, A.The Significant Enhancement of Fibrinolysis by Calcium Ion in a Cell Free System. : The Shortening of Euglobulin Clot Lysis Time by Calcium Ion.Thromb. Haemostas.72(1), 113-118, 1994
Takada, Y., Urano, T. and Takada, A.Effect of heparan sulfate analogue or other sulfated polysaccharides on the activation of plasminogen by t-PA or u-PA.Thromb. Res.73(5), 301-311, 1994
Nagayama, M., Sato, A., Hayakawa, H., Urano, T., Takada, Y. and Takada, A. Plasminogen activators and their inhibitors in non-small cell lung cancer: Low content of type 2 plasminogen activator inhibitor associated with tumor dissemination. Cancer 73(5), 1398-1405, 1994
Aoki, K., Nishino, N., Baba, S., Urano, T. and Takada, A. Postoperative changes in plasma tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. Surg Today Jpn J Surg 24, 1039-1043, 1994
Malyszko, J., Urano, T., Knofler, R., Ihara, H., Shimoyama, I., Uemura, K., Takada, Y. and Takada, A. Correlation between platelet aggregation, fibrinolysis, peripheral and central serotonergic measures in subhuman primates.Atherosclerosis 110, 63-68, 1994
Malyszko, J., Urano, T., Knofler, R., Ihara, H., Takada, Y. and Takada, A. Relationships between serum lipids, serotonin, platelet aggregation and some fibrinolytic parameters in humans. Life Sciences 55(21), 1619-1623, 1994
Malyszko, J., Urano, T., Knofler, R., Taminato, A., Yoshimi, T., Takada, Y. and Talkada, A. Daily variations of platelet aggregation in relation to blood and plasma serotonin in diabetes. Thromb. Res. 75(5), 569-576, 1994
Malyszko, J., Urano, T., Takada, Y. and Takada, A. Stress dependent changes in fibrinolysis, serotonin and platelet aggregation in rats.Life Sci. 54(17): 1275-1280, 1994
Malyszko, J., Urano, T., Takada, Y. and Takada, A. Time-dependent changes in platelet aggregation, fibrinolytic activity, and peripheral serotnergic measures in rats subjected to water-immersion restraint stress. Haemostasis 24, 236-242, 1994
Urano T., Malyszko J., Serizawa K., Kozima Y., Takada Y. and Takada A. Electric-foot-shock induced the supression of fibrinolytic activity in rats. Thromb. Res. 74(6): 595-603, 1994
Takada, Y., Urano, T. and Takada, A.Conformational change of plasminogen: Effects of N-terminal peptides of Glu-plasminogen.Thromb. Res.70; 151-159, 1993
Takada, Y., Urano, T., Watanabe, I., Taminato, A., Yoshimi, T., Takada, A. Changes in fibrinolytic parameters in male patients with type 2 (non insulin dependent) diabetes mellitus. Thromb. Res. 71, 405-415, 1993.
Urano, T., Kojima, Y., Takahashi, M., Serizawa, K., Sakakibara, K., Takada, Y. and Takada, A. Impaired fibrinolysis in hypertension and obesity due to high plasminogen activator inhibitor-1 level in plasma. Jpn. J. Physiol. 43, 221-228, 1993
Urano T., Strandberg L., Johansson L. B-A., Ny T.A substrate-like form of plasminogen activator inhibitor type 1: Conversions between different forms by sodium dodecyl sulphate.Eur. J. Biochem.209, 985-992, 1992
Sumiyoshi, K. Serizawa, T. Urano, Y. Takada, A. Takada and S. Baba. Plasminogen activator system in human breast cancer. Int. J. Cancer 50, 345-348, 1992.
Nakamura, M., Konnno, H., Tanaka, T., Maruo, Y., Nishino, N., Aoki, K., Baba, S., Sakaguchi, S., Takada, Y. and Takada, A. Possible role of plasminogen activator inhibitor 2 in the prevention of the metastasis of gastric cancer tissues. Thromb. Res. 65: 709-719, 1992
Sakata, K., Hoshino, T., Yoshida, H., Ono, N., Ohtani, S., Yokoyama, S., Mori, N., Kaburagi, T., Kurata, C., Urano, T., Takada, Y. and Takada, A. Circadian fluctuations of tissue plasminogen activator antigen and plasminogen activator inhibitor-1 antigens in vasospastic angina. Am. Heart J. 124(4): 854-860, 1992
Kawamura, I. Watanabe, T. Urano, Y. Takada and A. Takada.The effects of polysaccharides on plasminogen activation by single chain-tissue plasminogen activator.Thromb. Res.62, 481-490, 1991
T. Urano, Y. Takada and A. Takada.Stimulation of the amidolytic activity of single chain tissue-type of plasminogen activator by fibrinogen degradation products : possible binding sites on single chain tissue plasminogen activator molecule.Biochim. Biophys. Acta 1077; 245-252, 1991.
Urano, T. Sumiyoshi, K. Pietraszek, M. H. Takada, Y. and Takada, A. PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA.Thrombos. Haemostas. 66(4) 474-478, 1991
Sumiyoshi, S. Baba, S. Sakaguchi, T. Urano, Y. Takada and A. Takada. Increase in levels of plasminogen activator and type-1 plasminogen activator inhibitor in human breast cancer: possible roles in tumor progression and metastasis. Thromb. Res. 63, 59-71, 1991
Urano T., Sakakibara K., Rydzewski A., Urano S., Takada Y. and Takada A. Relationships between euglobulin clot lysis time and the plasma levels of tissue plasminogen activator inhibitor 1. Thrombos. Haemostas. 63; 82-86, 1990
Urano, T., de Serrano, V. S., Urano, S. and Castellino, F. J.Stimulation by fibrinogen of the amidolytic activity of single-chain tissue plasminogen activator.Arch Biochem. Biophys.270(1): 356-362, 1989
Urano, T., de Serrano, V. S. Gaffney, P. J. and Castellino F. J.Effectors of the activation of human [Glu1] plasminogen by human tissue plasminogen activator.Biochemistry 27:6522-6528, 1988.
Urano, T., de Serrano, V. S., Chibber, B. A. K. and Castellino, F. J.The control of the urokinase-catalyzed activation of human glutamic acid 1-plasminogen by positive and negative effectors.J. Biol. Chem.262(33): 15959-15964, 1987.
Urano, T., Chibber, B. A. K. and Castellino, F. J.The reciprocal effects of e-aminohexanoic acid and chloride ion on the activation of human (Glu1) plasminogen by human urokinase.Proc. Natl. Acad. Sci. USA84: 4031-4034, 1987.
Urano, T., Kamiya, T., Sakaguchi, S., Takada, Y. and Takada, A. Fibrinogenolysis and fibrinolysis in normal volunteers and patients with thrombosis after infusion of urokinase. Thromb. Res. 39(2): 145-155, 1985.
Urano, T. Takada, Y. and Takada, A. The enhanced activation of Glu- and Lys-plasminogen by urokinase in the presence of fibrin or Des A Fibrin as measured by the release of Ba peptide and FDP. Thromb. Res. 36(5): 429-435, 1984.
Takada A. and Takada Y. Effects of w-aminoacids and clot formation on the activation by urokinase of various plasminogen preparations.Thromb. Res. 18(1/2): 167-176, 1980
Takada, A., Urano, T. and Takada, Y. Influence of coagulation on the activation of plasminogen by streptokinase and urokinase.Thrombos. Haemostas. 42(3): 901-908, 1979
Takada A. and Takada Y. Studies on SK-potentiator of plasminogen in human plasma. Thrombos. Res. 13(2): 325-335, 1978
Iwaki T, Urana T, Umemura K. PAI-1, progress in understanding the clinical problem and its aetiology. Br J Haematol 157(3), 291-8, 2012
Urano T, Suzuki Y. Accelated fibriolysis and its propagation on vascular endothelial cells by secreted and retained tPA. J Biomed Biotechnol 2012, 208108, 2012
2011
Suzuki Y, Urano T. Novel situations of endothelial injury in stroke: mechanisms of stroke and strategy of drug development: novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis. J Pharmacol Sci 116(1), 19-24, 2011
Nagai N and Urano T. Role of tPA in the neural system. In Recent Advances in Thrombosis and Hemostasis. Edited by K. Tanaka and E.W. Davie. Springer, Tokyo pp. 314-327, 2008