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ホーム > 教育 > 医学部看護学科 > 看護学科講座等紹介 > 健康科学 > 感染免疫学部門 > 研究活動 > 研究業績

研究業績

原著論文

2026年

  1. Masahiro Komeno, Rin Miyajima, Kanami Miyashita, Masato Suzuki, Toshinao Matoba, Ayuna Miwa, Shoo Katsumoto, Ryosuke Yasumura, Kenta Ko, Hitoshi Kotani, Shoma Tamori, Shoko Itakura, Kosuke Kusamori, Makiya Nishikawa, Kazunori Akimoto, Takashi Suda, Chiaki Takahashi, Nobuaki Higashi, Fuming Zhang, Toshihiko Toida, Kyohei Higashi. Auranofin Suppresses Cancer Cell Invasion by Inhibiting Heparanase-1 Expression via the aPKC-NF-κB Pathway. Int. J. Mol. Sci. 2026, 27(13), 5646
  2. Suzuki M, Komeno M, Yasumura R, Miwa A. Enomono M, Kotani H, Matsumoto K, Akimoto K, Takahashi C, Igarashi K, Higashi K. Identification of inhibitors for eIF5A2-dependent translation elongation by monitoring protein synthesis of the polyproline motif in mitochondrial fission regulator 1. Biological & Pharmaceutical Bulletin 49(2):355-363. 2026.

2025年以前

  1. Kotani H, Han W, Iida Y, Tanino R, Katakawa K, Okimoto T, Tsubata Y, Isobe T, Harada M. Therapeutic senolysis of axitinib-induced senescent human lung cancer cells. Cancers 16(16): 2782. 2024.
  2. Hoque MM, Iida Y, Kotani H, Harada M. Senolysis of gemcitabine-induced senescent human pancreatic cancer cells. Cancer Reports 7(4): e2075 2024.
  3. Harada M, Kotani H, Iida Y, Tanino R, Minami T, Komohara Y, Yoshikawa K, Uemura H. Hypoxia-related carbonic anhydrase 9 induces serpinB9 expression in cancer cells and apoptosis in T cells via acidosis. Cancer Sci. 115(5): 1405-1416. 2024.
  4. Watanabe M, Yahagi T, Kamikura R, Kotani H, Miyake K, Matsuzaki K. Methoxyflavones isolated from the whole plant of Scutellaria rubropunctata Hayata var. rubropunctata promote osteoblast differentiation in MC3T3-E1 cells. Jouranal of Natural Medicines. 77(4): 748-760. 2023.
  5. Ishitobi K, Kotani H, Iida Y, Taniura T, Notsu Y, Tajima Y, Harada M. A modulatory effect of L-arginine supplementation on anticancer effects of chemoimmunotherapy in colon cancer-bearing aged mice. International Immunopharmacology. 113(Part A):109423 2022.
  6. Watanabe M, Yahagi T, Shirayama T, Miyake K, Kotani H, Ogawa T, Matsuzaki K. Effects of a whole plant extract of Scutellaria rubropunctata var. rubropunctata on bone metabolism with estrogen receptor activation. Plants 11: 2075-2090. 2022.
  7. Koyanagi A, Kotani H, Iida Y, Tanino R, Kartika ID, Kishimoto K, Harada M. Protective roles of cytoplasmic p21Cip/Waf1 in senolysis and ferroptosis of lung cancer cells. Cell Proliferation.55(12). E13326. 2022.
  8. Hoque M. M, Iida Y, Kotani H, Irna D. K, Harada M. Hydroxychloroquine promotes Bcl-xL inhibition-induced apoptosis in BxPC-3 human pancreatic cancer cells.
  9. Harada M, Iida Y, Kotani H, Minami T, Komohara Y, Eto M, Yoshikawa K, Uemura H. T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.
  10. Kartika ID, Kotani H, Iida Y, Koyanagi A, Tanino R, Harada M. Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor-induced senescence in breast cancer cells.
  11. Taniura T, Iida Y, Kotani H, Ishitobi K, Tajima Y, Harada M. Immunogenic chemotherapy in two mouse colon cancer models.
  12. Iida Y, Yoshikawa R, Murata A, Kotani H, Kazuki Y, Oshimura M, Matsuzaki Y, Harada M. Local injection of CCL19-expressing mesenchymeal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltrateon of immune cells.
  13. Sato Y, Kotani H, Iida Y, Taniura T, Notsu Y, Harada M. Supplementation of L-arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy.
  14. Okimoto T, Kotani H, Iida Y, Koyanagi A, Tanino R, Tsubata Y, Isobe T, Harada M. Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells.
  15. Inao T, Kotani H, Iida Y, Kartika ID, Okimoto T, Tanino R, Shiba E, Hrada M. Different sensitiveties of senescent breast cancer cells to immune cell-mediated cytotoxicity.
  16. Inao T, Iida Y, Moritani T, Okimoto T, Tanino R, Kotani H, Hrada M. Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin.
  17. Asakawa M, Yoshida H, Sakai R, Saeki K, Okada M, Kanamori M, Kotani H, Wei X, Yoshimura A. A novel JAK-STAT inhibotor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl (2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen induced arthritis in vivo.
  18. Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.
  19. Tanabe H, Yasui T, Kotani H, Nagatsu A, Makishima M, Amagaya S, Inoue M. Retinoic Acid Receptor Agonist Activity of Naturally Occurring Diterpenes.
  20. Hayashi T#, Kotani H#, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ. (# The first authors contributed equally to this work.) Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.
  21. Muto G#, Kotani H#, Kondo T#, Morita R, Tsuruta S, Kobayashi T, Hervé Luche Hans Joerg Fehling, Walsh M, Choi Y, Yoshimura A. (# The first three authors contributed equally to this work.) TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.
  22. Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A. Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-Like Skin Inflammation.
  23. Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A. Smad2/3 and IRF4 Play a Cooperative Role in IL-9-Producing T Cell Induction.
  24. Yoshida H#, Kotani H#, Kondo T, Tani I, Wei X, Tsuruta S, Kimura A, Asakawa M, Ito M, Nagai S, Yoshimura A. (#The first authors contributed equally to this work.) CDK inhibitors suppress Th17 and promote iTreg differentiation, and ameliorate experimental autoimmune encephalomyelitis in mice.
  25. Yoshida H, Suzuki M, Sakaguchi R, Tani I, Kotani H, Shudo N, Yoshimura A. Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi).　
  26. Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M. A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid X receptor heterodimers.
  27. Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y. Dose-Dependent Modulatory Effects of Insulin on Glucose-induced Endothelial Senescence in vitro and in vivo: A Relationship between Telomeres and Nitric Oxide.
  28. Kotani H, Tanabe H, Mizukami H, Makishima M, and Inoue M. Identification of a naturally occurring rexinoid, honokiol, that activates retinoid X receptor (RXR).
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