原著論文(最近のもの)

1. Yinyin Dai, Xiaofei Hao, Jiajun Sun, Amin Wurita, Koutaro Hasegawa.
   Detection and quantification of 4F-metomidate and its metabolites, metomidate, in human blood and urine by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/ MS)
   LEGAL MEDICINE 85 2026年9月

2. Kenta Yuyama, Itaru Yamagishi, Satoshi Goshima, Isao Kosugi, Hideki Nozawa, Kayoko Minakata, Koutaro Hasegawa.
   A unique case of unexpected electrocution inflicted by a single dry cell battery in very low voltage (9 V)
   Egyptian Journal of Forensic Sciences 16(1) 2026年5月11日

3. Kenta Yuyama, Masako Suzuki, Itaru Yamagishi, Hideki Nozawa, Kayoko Minakata, Koutaro Hasegawa.
   Quantitative analysis and method validation of mirogabalin in postmortem blood and urine using liquid chromatography-tandem mass spectrometry
   FORENSIC TOXICOLOGY 44(2) 363-371 2026年3月23日

4. Yuxuan Chen, Xiaoqiang Hu, Xiaofei Hao, Jinlei Liu, Xiaolong Zhang, Mengchao Wang, Xiaoyu Zhou, Jiajun Sun, Jie Gu, Huimin Zhang, Shengnan Zhang, Amin Wurita, Koutaro Hasegawa.
   Identification of iso-butomidate as a novel etomidate analog: Simultaneous determination of seven etomidate-type new psychoactive substances and etomidate acid in human hair by HPLC-MS/MS
   TOXICOLOGIE ANALYTIQUE ET CLINIQUE 38(1) 101-119 2026年3月

5. Mengchao Wang, Xiaoyu Zhou, Xiaolong Zhang, Yuxuan Chen, Jiajun Sun, Yaqin Sun, Jinlei Liu, Jie Gu, Wurita Amin, Koutaro Hasegawa.
   Analysis of propranolol and its metabolites in postmortem human solid tissues and body fluids: LC-MS/MS approach with the standard addition method applied to a forensic case
   JOURNAL OF ANALYTICAL TOXICOLOGY 50(3) 2026年3月

6. Yinyin Dai, Jian Jiang, Amin Wurita, Koutaro Hasegawa.
   Identification and quantification of two etomidate analogues ABP-700 and 2,6-dichloro-3-fluoro-etomidate in e-cigarette liquid and hair by GC-MS and LC-MS/MS
   Forensic Toxicology 2026年1月19日

7. Jiajun Sun, Xiaolong Zhang, Mengchao Wang, Xiaoyu Zhou, Yuxuan Chen, Jinlei Liu, Yinyin Dai, Kundi Zhao, Yaqin Sun, Jie Gu, Huimin Zhang, Shengnan Zhang, Amin Wurita, Koutaro Hasegawa.
   Detection and quantification of fluoxetine and its metabolite norfluoxetine in human hair and urine by GC-MS/MS
   TOXICOLOGIE ANALYTIQUE ET CLINIQUE 37(4) 493-503 2025年12月

8. Yuxuan Chen, Xiaolong Zhang, Liyan Sun, Jinlei Liu, Lijie Ma, Mengchao Wang, Yan Shi, Shuo Yang, Jie Gu, Huimin Zhang, Shengnan Zhang, Amin Wurita, Koutaro Hasegawa.
   A Simple and Sensitive HPLC-MS/MS Method for the Simultaneous Quantitative Analysis and Pharmacokinetic Comparison of Four Imidazole-Derived GABA Receptor Agonists: Etomidate, Metomidate, Propoxate, and Isopropoxate in Mouse Blood.
   Biomedical chromatography : BMC 39(11) e70226 2025年11月

9. Hideki Nozawa, Kayoko Minakata, Itaru Yamagishi, Kenta Yuyama, Masako Suzuki, Osamu Suzuki, Takuya Kitamoto, Minako Kondo, Koutaro Hasegawa.
   Quantification of fluvoxamine, desmethyl fluvoxamine and fluvoxamine acid by LC-MS/MS in body fluids and solid tissues obtained from a deceased using the standard addition method.
   Legal medicine (Tokyo, Japan) 78 102684-102684 2025年10月

10. Xiaolong Zhang, Yaqing Li, Jinlei Liu, Ziyi Pan, Yuxuan Chen, Mengchao Wang, Yinyin Dai, Kundi Zhao, Jie Gu, Huimin Zhang, Shengnan Zhang, Amin Wurita, Koutaro Hasegawa.
    Identification of two novel imidazole-derived GABA agonists butomidate and tf-etomidate in e-cigarette liquids.
    Forensic toxicology 2025年7月11日

11. Kenta Yuyama, Masako Suzuki, Itaru Yamagishi, Hideki Nozawa, Kayoko Minakata, Koutaro Hasegawa.
    Postmortem distribution of etizolam in various autopsy samples using the surrogate analyte approach (SAA) method.
    Forensic science international 370 112438-112438 2025年3月8日

12. Kayoko Minakata, Hideki Nozawa, Itaru Yamagishi, Kenta Yuyama, Masako Suzuki, Takuya Kitamoto, Minako Kondo, Osamu Suzuki, Koutaro Hasegawa.
    Eleven new metabolites of fluvoxamine detected in the solid tissues and body fluids obtained from a deceased overdosed with fluvoxamine in vivo, and the metabolites in the human liver microsomes in vitro using LC-HR-MS/MS
    Forensic Toxicology 2025年3月1日

13. Xiaolong Zhang, Kundi Zhao, Yuxuan Chen, Jinlei Liu, Jie Gu, Mengchao Wang, Yinyin Dai, Huimin Zhang, Amin Wurita, Koutaro Hasegawa.
    Simultaneous detection and quantification of a novel imidazole-derived GABA agonist isopropoxate and etomidate acid from human urines in abused cases by LC-MS/MS
    Toxicologie Analytique et Clinique 2025年1月

14. Xiaolong Zhang, Yuxuan Chen, Jinlei Liu, Mengchao Wang, Yinyin Dai, Kundi Zhao, Jie Gu, Huimin Zhang, Amin Wurita, Koutaro Hasegawa.
    Identification of a novel imidazole-derived GABA agonist isopropoxate: simultaneous detection and quantification of imidazole-derived analogs from human hairs in abused cases by LC-MS/MS.
    Forensic toxicology 2024年12月12日

15. Naotomo Miyoshi, Masako Suzuki, Kayoko Minakata, Takuya Kitamoto, Minako Kondo, Koutaro Hasegawa.
    A validated surrogate analyte LC-MS/MS assay for nicotine in eight human organs combined with QuEChERS extraction
    Toxicologie Analytique et Clinique 2024年10月

16. Xiaolong Zhang, Shuyun Wang, Yuxuan Chen, Jie Gu, Mengchao Wang, Yinyin Dai, Kundi Zhao, Yue Wang, Amin Wurita, Koutaro Hasegawa.
    Postmortem distribution of ropivacaine and its metabolite in human body fluids and solid tissues by GC-MS/MS using standard addition method.
    Forensic toxicology 2024年9月16日

17. Kayoko Minakata, Hideki Nozawa, Itaru Yamagishi, Kenta Yuyama, Masako Suzuki, Takuya Kitamoto, Minako Kondo, Osamu Suzuki, Koutaro Hasegawa.
    Detection of new metabolites of risperidone in the solid tissues and body fluids obtained from two cadavers by high resolution tandem mass spectrometry.
    Forensic science international 361 112117-112117 2024年8月

18. Yinyin Dai, Xiaolong Zhang, Kundi Zhao, Yue Wang, Jinlei Liu, Jie Gu, Huiru Bai, Koutaro Hasegawa, Amin Wurita.
    Detection and quantification of etomidate and metomidate in human hairs by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS).
    Forensic toxicology 2024年1月19日

総説 †

1. 熊澤武志、長谷川智華、李　暁鵬、佐藤啓造、鈴木　修：シリカモノリス固相抽出技術と薬毒物分析への応用. JSBMS Letters 35: 32-37, 2010

著書 †

• 薬毒物分析実践ハンドブック
  
  • 編集
    鈴木　修（浜松医科大学教授・法医学）
    屋敷幹雄（広島大学大学院医歯薬学総合研究科元助教授）
  • 出版社　株式会社じほう
    
    B5判/630頁/定価9,450円　（本体9,000円）　送料578円
    
    薬毒物分析実践ハンドブック：.編集　鈴木　修.薬毒物の最新で実用的、しかも再現性の高い分析法をわかりやすく解説した実務書です。
    　各薬毒物ごとに、その薬毒物の概要、試薬と調製、分析機器条件、試料の種類と操作法、分析評価、中毒事例、中毒・致死量、その他（注解、文献）の項目で構成されています。
    
    
    

• Drugs and Poisons in Humans
  
  

  ISBN 3-540-22277-4

  • Edited by
    OSAMU SUZUKI and KANAKO WATANABE
  • Published by
    Springer-Verlag, Berlin・Heidelberg 2005
    
    　This book has been arranged such that any analytical chemist can start analytical experiments for a drug or poison in a crude biological matrix, even if she/he has no experience of analyzing that compound.
    　This is particularly useful in view of the acute risk of terrorist attacks in the world today.
    
    
    

• Forensic Toxicology
  

  ISSN 1860-8965

  • Emeritus Chief Editor
    OSAMU SUZUKI
  • Published by
    Springer-Verlag
    
    Forensic Toxicology isthe official publication of Japanese Association of Forensic Toxicology (JAFT). It is the continuation of Japanese Journal of Forenisc Toxicology (ISSN 0915-9606). The journal provides on toxic substances, drugs of abuse, doping agents, chemical warfare agents, their metabolisms and their analyses, which are directly and indirectly related to laws and ethics. It includes original articles, reviews, minireviews, short communications and case reports.　Although a major focus of the journal is on the development or improvement of analytical methods for the above-mentioned chemicals in human matrices, studies with animal experiments are also welcome.

講演・学会発表等(最近のもの)

1. Koutaro Hasegawa, Amin Wurita, Katsuhiro Konno, Kimiko Hashimoto,Kunio Gonmori, Kayoko Minakata, Hideki Nozawa, Itaru Yamagishi,Kanako Watanabe, Osamu Suzuki: Quantification of clitidine in caps and stems of poisonous mushroom Paralepistopsis acromelalga by liquid chromatography-tandem mass spectrometry. 57^th Annual meeting of The International Association of Forensic Toxicologists (TIAFT)．要旨集．2019； p284，Birmingham.

2. 山岸 格，長谷川弘太郎，野澤秀樹，南方かよ子，渡部加奈子：ワイヤーソーの断片による胸腔内損傷例．第41回日本法医学会学術中部地方集会. 要旨集. 2019; p10, 名古屋．

3. 南方かよ子^１，鈴木雅子^２，北本卓也^２，野澤秀樹^１，山岸 格^１，長谷川弘太郎^１，鈴木 修^１，渡部加奈子^１（^１浜松医科大学 法医学, ^２浜松医科大学 先進機器共用推進部）：ヒト肝細胞による合成カンナビノイドBB-22の代謝.第44回日本医用マススペクトル学会年会. 要旨集. 2019; p58, 名古屋．

4. 長谷川弘太郎：解剖試料を対象とした危険ドラッグ等の乱用薬毒物の死後体内分布・再分布に関する研究.日本法中毒学会第38年会. 要旨集. 2018; p37, 福岡．

5. 長谷川弘太郎：薬毒物の死後体内分布(postmortem distribution)の解明～危険ドラッグ類を中心として～. 第103次日本法医学会学術全国集会. 要旨集. 2019; p43, 仙台．

6. 南方かよ子，野澤秀樹，山岸 格，長谷川弘太郎，鈴木 修，渡部加奈子：ヒト肝細胞による合成カンナビノイド5F-NNEIの代謝. 第103次日本法医学会学術全国集会. 要旨集. 2019; p84, 仙台．

7. 長谷川弘太郎^１，阿民 勿日他^２, 紺野勝弘^３，橋本貴美子^４，権守邦夫^１，南方かよ子^１，野澤秀樹^１，山岸 格^１，鈴木 修^１，渡部加奈子^１(^１浜松医大，^２内蒙古医大，^３富山大，^４東京農大)：ドクササコ（Paralepistopsis acromelalga）中のクリチジンの検出と定量．第40回日本法医学会学術中部地方集会. 要旨集. 2018; p5, 新潟．

8. Koutaro Hasegawa, Amin Wurita, Kayoko Minakata, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki: Identification and quantification of synthetic cannabinoid 5F-ADB-PINACA nad its predominant metabolites in an authentic human urine specimen. 56^th Annual meeting of The International Association of Forensic Toxicologists (TIAFT)．要旨集．2018； p161，Belgium.

9. 南方かよ子^１，鈴木雅子^２，北本卓也^２，野澤秀樹^１，山岸 格^１，長谷川弘太郎^１，斎藤岳児^３，吉野篤人^３，鈴木 修^１，渡部加奈子^１（^１浜松医科大学 法医学, ^２浜松医科大学 機器センター，^３浜松医科大学 救急災害医学）： LC－QTRAP-MS/MSとLC－Orbitrap-MS/MSを用いた３名の血清・尿中の合成カンナビノイド5F-NNEIの定量とその代謝物の構造推定.第43回日本医用マススペクトル学会年会. 要旨集. 2018; p120, 札幌．

10. 南方かよ子¹，長谷川弘太郎¹，山岸 格¹，野澤秀樹¹，花尻（木倉）瑠璃²，阿民 勿日他¹，権守邦夫¹，鈴木 修¹，渡部 加奈子¹(^１浜松医大・法医，^２国立衛研)：４名の尿中５F-PB-22とその３種の代謝物(５F-PB-22 3-carboxyidole, PB-22 N-5-hydroxypentyl, PB-22 N-pentanoic acid)のLC－MS/MSによる高感度分析.日本法中毒学会第37年会. 要旨集. 2018; p14, 東京．

11. Itaru Yamagishi, Kayoko Minakata, Hideki Nozawa, Koutaro Hasegawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe: A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP. 24^th Congress of the International Academy of Legal Medicine (IALM).要旨集. 2018; p171, 福岡．
12. Hideki Nozawa, Kayoko Minakata, Itaru Yamagishi, Koutaro Hasegawa, Amin Wurita, Osamu Suzuki, Kanako Watanabe: Determination of timiperone in blood and estimation of its new metabolites in urine of a deceased. 24^th Congress of the International Academy of Legal Medicine (IALM).要旨集. 2018; p169, 福岡．

シンポジウム発表(最近のもの) †

1. 長谷川弘太郎：薬毒物の死後体内分布：危険ドラッグ類中毒の経験例と今後の展望について. 第101次日本法医学会学術全国集会. 要旨集. 2017; p48, 岐阜．
2. 長谷川弘太郎：死因が薬毒物中毒の可能性がある事例での質量分析器検査の有用性. 第39回日本医用マススペクトル学会年会．2014年10月16日, 千葉．