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研究業績

原著論文

  1. Nakayama T, Ouchi Y, Yoshikawa E, Sugihara G, Torizuka T, Tanaka K. Striatal D2 receptor availability after shunting in idiopathic normal pressure hydrocephalus. J Nucl Med　2008;48:1981-1986
  2. Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara GI, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N,Yoshikawa T, Mori N. Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism.Am J Med Genet B Neuropsychiatr Genet. 2008; 147B:1019-27
  3. Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N. Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. Int J Neuropsychopharmacol. 2008;11:1073-84
  4. Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, Iwata Y, Tsuchiya K, Suda S, Suzuki K, Kawai M, Takebayashi K, Yamamoto S, Matsuzaki H, Ueki T, Mori N, Gold MS, Mark, Cadet JL. Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci 2008;28:5756-5761
  5. Uchiyama T, Ikeuchi T, Ouchi Y, Sakamoto M, Kasuga K, Shiga A, Suzuki M, Ito M, Atsumi T, Shimizu T, Ohashi T. Prominent psychiatric symptoms and glucose hypometabolism in a family with a SNCA duplication. Neurology. 2008;71:1289-91
  6. Ogawa M, Tsukada H, Hatano K, Ouchi Y, Saji H, Magata Y. Central in vivo nicotinic acetylcholine receptor imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT). Biol Pharm Bull. 2009;32:337-40
  7. Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Naitou K, Ueda Y, Ouchi Y. Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer. Am J Roentgenol. 2009 Apr;192(4):W156-60
  8. Ouchi Y, Yoshikawa E, Futatsubashi M, Yagi S, Ueki T, Nakamura K. Altered brain serotonin transporter and associated glucose metabolism in Alzheimer's disease. J Nucl Med 2009;50:1260-1266
  9. Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Yoshikawa E, Okada H, Ouchi Y. Single 20-second acquisition of deep-inspiration breath-hold PET/CT: clinical feasibility for Lung cancer. J Nucl Med. 2009 Oct;50:1579-84
  10. 尾内康臣　11C-CFTによるドパミントランスポーターイメージングRADIOISOTOPES、 2009;58:781-8
  11. Ouchi Y. Imaging of brain microgliosis by PET. Rinsho Shinkeigaku. 2009;49:925-8. Japanese
  12. Ouchi Y, Yagi S, Yokokura M, Sakamoto M. Neuroinflammation in the living brain of Parkinson's disease. Parkinsonism Relat Disord 2009;15:S200-4.
  13. 寺田達弘, 小尾智一, 杉浦明, 山崎公也, 溝口功一: Frontal Assessment Batteryの年齢による効果, 神経心理学 25: 51-56, 2009.
  14. 寺田達弘, 小尾智一, 吉住美保, 村井俊哉, 溝口功一: Frontal Systems Behavior Scale (FrSBe)によるパーキンソン病の前頭葉機能評価, 神経心理学 25: 281-289, 2009.
  15. Nakamura K, Sekine Y, Ouchi Y, Tsujii M Yoshikawa E, Futatsubashi M, Tsuchiya KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Sugiyama T, Takei N, Mori N. Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Arch Gen Psychiatry 2010;67:59-68
  16. Yagi S, Yoshikawa E, Futatsubashi M, Yokokura M, Yoshihara Y, Torizuka T, Ouchi Y. Progression from unilateral to bilateral parkinsonism in early Parkinson disease: implication of mesocortical dopamine dysfunction by PET. J Nucl Med. 2010;51:1250-7
  17. Kono S, Ouchi Y, Terada T, Ida H, Suzuki M, Miyajima H. Functional brain imaging in glucocerebrosidase mutation carriers with and without Parkinsonism. Mov Disord. 2010;25:1823-9
  18. Tajima S, Yamamoto S, Tanaka M, Kataoka Y, Iwase M, Yoshikawa E, Okada H, Onoe H, Tsukada H, Kuratsune H, Ouchi Y, Watanabe Y. Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation. Neurology Research International 671421:1-5, 2010
  19. 寺田達弘, 小尾智一, 宮嶋裕明, 溝口功一: 筋萎縮側索硬化症におけるFrontal Assessment Batteryによる前頭葉機能評価, 臨床神経学 50: 379-384, 2010.
  20. Yokokura M, Mori N, Yagi S, Yoshikawa E, Kikuchi M, Yoshihara Y, Wakuta T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y. In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease. Eur J Nucl Med Mol Imaging 38(2):343-51, 2011
  21. Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N. Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders. Arch Gen Psychiatry.2011 68:306-13.
  22. Sun W, Sugiyama K, Asakawa T, Yamaguchi H, Akamine S, Ouchi Y, Magata Y, Namba H. Dynamic changes of striatal dopamine D(2) receptor binding at later stages after unilateral lesions of the medial forebrain bundle in Parkinsonian rat models. Neurosci Lett. 2011 496(3):157-62
  23. Kono S, Ouchi Y, Terada T, Suzuki M, Yagi S, Miyajima H. Combined FDG and raclopride PET study in a case of ALS with the R521C FUS gene mutation. J Neurol. 2011 Jul 15
  24. Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi. Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging. J Neurosci. 2011 31(31):11193-9
  25. Terada T, Obi T, Yoshizumi M, Murai T, Miyajima H, Mizoguchi K. Frontal lobe-mediated behavioral changes in amyotrophic lateral sclerosis: Are they independent of physical disabilities. J Neurol Sci. 2011 309.136-140
  26. Okada H, *Ouchi Y, Ogawa M, Futatsubashi M, Saito Y, Yoshikawa E, Terada T, Oboshi Y, Tsukada H, Ueki T, Watanabe M, Yamashita T, Magata Y. Alterations inα4β2 nicotinic receptors in cognitive decline in Alzheimer's etiopathology. Brain 136 (Pt 10):3004-17, 2013
  27. Omata, K., Hanakawa, T., Morimoto, M., & Honda, M. Spontaneous Slow Fluctuation of EEG Alpha Rhythm Reflects Activity in Deep-Brain Structures: A Simultaneous EEG-fMRI Study. PLOS ONE,8(6), e66869. 2013
  28. Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, *Mori N. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry. 70(1):49-58, 2013
  29. Nozaki T, Sugiyama K, Yagi S, Yoshikawa E, Kanno T, Asakawa T, Ito T, Terada T, Namba H, *Ouchi Y. Molecular Imaging in the Default Mode Network. Effect of subthalamic nucleus stimulation during exercise on the mesolimbocorital dopaminergic region in Parkinson's disease: A positron Emission Tomography Study. J Cereb Blood Flow Metab. 2013,33:415-421, 2013
  30. Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, *Ouchi Y. Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging. J Neurosci. 31(31):11193-9, 2011
  31. Terada T, Kono S, Ouchi Y, Yoshida K, Hamaya Y, Kanaoka S, Miyajima H.SPG3A-linked hereditary spastic paraplegia associated with cerebral glucose hypometabolism.Ann Nucl Med. 2013 Apr;27(3):303-8.
  32. Hosoi Y, Suzuki-Sakao M, Terada T, Konishi T, Ouchi Y, Miyajima H, Kono S.GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies. J Neurol. 2013 Dec;260(12):3086-92.
  33. Terada T, Kono S, Konishi T, Miyajima H, Ouchi Y.Altered GABAergic system in the living brain of a patient with spinocerebellar ataxia type 8.J Neurol. 2013 Dec;260(12):3164-6
  34. Oboshi Y, Kikuchi M, Shimizu Y, Yoshimura Y, Hiraishi H, Okada H, Magata Y, Ouchi Y. Pre-task prefrontal activation during cognitive processes in aging: A near-infrared spectroscopy study. PLoS One. 9(6):e98779,2014
  35. Shimizu Y, Yamamoto S, Fukumoto D, Ohba H, Kakiuchi T, Nishiyama S, Yoshikawa E, Tsukada H, Okada H, Ouchi Y. Loud noise exposure during activity and neurogenesis in the living rat brain: a preliminary study. J Neurol Neurophysiol 5:6,2014
  36. Kono S, Terada T, Ouchi Y, Miyajima H. An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation. BBA Clin. 28;2:56-61, 2014
  37. Ito K, Fukuyama H, Senda M, Ishii K, Maeda K, Yamamoto Y, Ouchi Y, Ishii K, Okumura A, Fujiwara K, Kato T, Arahata Y, Washimi Y, Mitsuyama Y, Meguro K, Ikeda M. Prediction of Outcomes in Mild Cognitive Impairment by Using 18F-FDG-PET: A Multicenter Study. J Alzheimers Dis. 45(2):543-52,2015
  38. Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Senda K, Murayama S, Ishii K, Takao M, Beach TG, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Catafau AM, Stephens AW, Mueller A, Koglin N, Hoffmann A, Roth K, Reininger C, Schulz-Schaeffer WJ; Florbetaben Phase 3 Study Group. Florbetaben PET imaging to detect amyloid plaques in Alzheimer disease: Phase 3 study. Alzheimers Dement. 11(8):964-74,2015
  39. Ouchi Y. [PET imaging of α7 nicotinic receptor]. Nihon Yakurigaku Zasshi. 145(5):266-7,2015
  40. Terada T, Kakimoto A, Yoshikawa E, Kono S, Bunai T, Hosoi Y, Sakao-Suzuki M, Konishi T, Miyajima H, Ouchi Y. The Possible Link between GABAergic Dysfunction and Cognitive Decline in a Patient with Idiopathic Hypoparathyroidism. Intern Med. 54(17): 2245-50,2015
  41. Kakimoto A, Ito S, Okada H, Nishizawa S, Minoshima S, Ouchi Y. Age-related gender-specific changes in the brain metabolism and morphology. J Nucl Med. 57(2):221-5, 2016
  42. Oboshi Y, Kikuchi M, Terada T, Yoshikawa E, Bunai T, *Ouchi Y. Alterations in phase-related prefrontal activation during cognitive tasks and nicotinic α4β2 receptor availability in Alzheimer's disease. J Alzheimers Dis. 53,817-830,2016
  43. Terada T, Yokokura M, Yoshikawa E, Futatsubashi M, Kono S, Konishi T, Miyajima H, Hashizume T, Ouchi Y. Extrastriatal spreading of microglial activation in Parkinson's disease: a positron emission tomography study. Ann Nucl Med. 30,579-587,2016
  44. Yokokura M, Terada T, Bunai T, Nakaizumi K, Takebayashi K, Iwata Y, Yoshikawa E, Futatsubashi M, Suzuki K, Mori N, Ouchi Y. Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195. J Cereb Blood Flow Metab. 37(3):877-889, 2017
  45. Hirosawa T, Kikuchi M, Ouchi Y, Takahashi T, Yoshimura Y, Kosaka H, Furutani N, Hiraishi H, Fukai M, Yokokura M, Yoshikawa E, Bunai T, Minabe Y. A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder. Autism Res. 10(5):821-828, 2017
  46. Hosoya T, Fukumoto D, Kakiuchi T, Nishiyama S, Yamamoto S, Ohba H, Tsukada H, Ueki T, Sato K, Ouchi Y. In vivo TSPO and cannabinoid receptor type 2 availability early in poststroke neuroinflammation in rats: a positron emission tomography study. J Neuroinflammation. 29;14: 69-78, 2017
  47. Kikuchi, M, Takahashi T, Hirosawa T, Oboshi Y, Yoshikawa E, Minabe Y, Ouchi Y. The lateral occipito-temporal cortex is involved in the mental manipulation of body part imagery. Front Hum Neurosci., 11 (11): 181, 2017
  48. Fukai M, Hirosawa T, Kikuchi M, Ouchi Y, Takahashi T, Yoshimura Y, Miyagishi Y, Kosaka H, Yokokura M, Yoshikawa E, Bunai T, Minabe Y. Oxytocin effects on emotional response to others' faces via serotonin system in autism: A pilot study. Psychiatry Res. 2017 267:45-50
  49. Matsudaira T, Omote Y, Terada T, Kondo A, Obi T, Ouchi Y, Inoue Y. Reversible amygdala enlargement: a longitudinal observation of a patient with elderly onset temporal lobe epilepsy. J Neurol. 2017 Dec;264(12):2487-2490
  50. Yoshimura Y, Kikuchi M, Hayashi N, Hiraishi H, Hasegawa C, Takahashi T, Oi M, Remijn GB, Ikeda T, Saito DN, Kumazaki H, Minabe Y. Altered human voice processing in the frontal cortex and a developmental language delay in 3- to 5-year-old children with autism spectrum disorder. Sci Rep. 2017;7(1):17116. Published 2017 Dec 7. doi:10.1038/s41598-017-17058-x
  51. Takahashi T, Yamanishi T, Nobukawa S, Kasakawa S, Yoshimura Y, Hiraishi H, Hasegawa C, Ikeda T, Hirosawa T, Munesue T, Higashida H, Minabe Y, Kikuchi M. Band-specific atypical functional connectivity pattern in childhood autism spectrum disorder. Clin Neurophysiol. 2017;128(8):1457-1465. doi:10.1016/j.clinph.2017.05.010
  52. Ouchi Y. Imaging neuroinflammation to monitor α-synucleinopathy. Lancet Neurol. 16(10):763-764,2017
  53. Nakaizumi K, Ouchi Y, Terada T, Yoshikawa E, Kakimoto A, Isobe T, Bunai T, Yokokura Y, Suzuki K, Magata Y. In vivo depiction of α7 nicotinic receptor loss for cognitive decline in Alzheimer's disease. J Alzheimers Dis. 2018;61(4):1355-1365
  54. Bunai T, Terada T, Kono S, Yokokura M, Yoshikawa E, Futatsubashi M, Miyajima H, Ouchi Y. Neuroinflammation following disease modifying therapy in multiple sclerosis A pilot positron emission tomography study. J Neurol Sci. 2018 Feb 15; 385:30-33.
  55. Omata K, Ito S, Takata Y, Ouchi Y. Similar neural correlates of planning and execution to inhibit continuing actions. Front Neurosci. 2018 Dec 12;12:951.
  56. Yoshimura Y, Kikuchi M, Hiraishi H, Hasegawa C, Hirosawa T, Takahashi T, Munesue T, Kosaka H, Hiagashida H, Minabe Y. Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder. Psychiatry Res Neuroimaging. 2018;281:117-122. doi:10.1016/j.pscychresns.2018.05.003
  57. Fukai M, Bunai T, Hirosawa T, Kikuchi M, Ito S, Minabe Y, Ouchi Y. Endogenous dopamine release under transcranial direct-current stimulation governs enhanced attention: a study with positron emission tomography. Transl Psychiatry. 2019 9(1):115-125.
  58. Bunai T, Kakimoto A, Yoshikawa E, Terada T, Ouchi Y. Biopathological significance of early-phase amyloid imaging in the spectrum of Alzheimer's disease. J Alzheimers Dis 62(2):529-538, 2019
  59. Terada T, Yokokura M, Obi T, Bunai T, Yoshikawa E, Ando I, Shimada H, Suhara T, Higuchi M, Ouchi Y. In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer's disease. J Neurol. 266(9):2186-2196, 2019 doi: 10.1007/s00415-019-09400-2
  60. Yokokura M, Terada T, Bunai T, Nakaizumi K, Kato Y, Yoshikawa Futatsubashi M, Suzuki K, Yamasue H, Ouchi Y. Alterations in serotonin transporter and body image-related cognition in anorexia nervosa. Neuroimage Clinical. 23:101928, 2019 doi.org/10.1016/j.nicl.2019.101928.
  61. Yamagishi S, Iga Y, Nakamura M, Takizawa C, Fukumoto D, Kakiuchi T, Nishiyama S, Ohba H, Tsukada H, Sato K, Ouchi Y. Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. J Neuroinflamm. 10;16(1):208, 2019 doi: 10.1186/s12974-019-1604
  62. Ikeda T, Takahashi T, Hiraishi H, Saito DN, Kikuchi M. Anodal transcranial direct current stimulation induces high gamma-band activity in the left dorsolateral prefrontal cortex during a working memory task: A double-blind, randomized, crossover study. Front Hum Neurosci. 2019 Apr 24;13:136. doi: 10.3389/fnhum.2019.00136
  63. Terada T, Obi T, Bunai T, Matsudaira T, Yoshiksawa E, Ando I, Futatsubashi M, Tsukada H, Ouchi Y. In vivo depiction of mitochondrial and glycolytic impairments in Alzheimer's disease. Neurology. Apr 14;94(15):e1592-e1604, 2020. doi: 10.1212/WNL.0000000000009249
  64. Matsudaira T, Terada T, Obi T, Yokokura M, Takahashi Y, Ouchi Y. Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome. EJNMMI Res. Mar 20;10(1):29, 2020. doi: 10.1186/s13550-020-00617-1
  65. Yokokura M, Takebayashi K, ATakao A, Nakaizumi K, Yoshikawa E, Futatsubashi M, Suzuki K, Nakamura K, Yamasue H, Ouchi Y. In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: A positron emission tomography study. Mol Psychiatry 2020 May 21. doi.org/10.1038/s41380-020-0784-7
  66. Yoshimura Y, Kikuchi M, Saito DN, Hirosawa T, Takahashi T, Munesue T, Kosaka H, Naito N, Ouchi Y, Minabe Y. Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder. Sci Rep. 2020 Sep 3;10(1):14558. doi: 10.1038/s41598-020-71254-w
  67. Mori Y, Yoshikawa E, Futatsubashi M, Ouchi Y. Neural correlates of standing imagery and execution in Parkinsonian patients: the relevance to striatal dopamine dysfunction. PLOS ONE. 2020 Oct 28;15(10):e0240998. doi: 10.1371/journal.pone.0240998. eCollection 2020
  68. Hashimoto F, Ohba H, Ote K, Kakimoto A, Tsukada H, Ouchi Y.4D Deep Image Prior: Dynamic PET Image Denoising Using an Unsupervised Four-Dimensional Branch Convolutional Neural Network. Physics in Medicine and Biology 2020 Nov 23. doi: 10.1088/1361-6560/abcd1a
  69. Bunai T, Hirosawa T, Kikuchi M, Fukai M, Yokokura M, Ito S, Takata Y, Terada T, Ouchi Y. tDCS-induced modulation of GABA concentration and dopamine release in the human brain: A combination study of magnetic resonance spectroscopy and positron emission tomography. Brain Stimul. 2020 Dec 28;14(1):154-160. doi: 10.1016/j.brs.2020.12.010
  70. Yoshimura Y, Hasegawa C, Ikeda T, Saito DN, Hiraishi H, Takahashi T, Kumazaki H, Kikuchi M. The maturation of the P1m component in response to voice from infancy to 3 years of age: A longitudinal study in young children. Brain and behavior 10(8) e01706. 2020 doi.org/10.1002/brb3.1706
  71. Furutani N, Nariya Y, Takahashi T, Ito H, Yoshimura Y, Hiraishi H, Hasegawa C, Ikeda T, Kikuchi M. Neural Decoding of Multi-Modal Imagery Behavior Focusing on Temporal Complexity. Frontiers in Psychiatry 11 2020. doi.10.3389/fpsyt.2020.00746
  72. Inubushi T, Ito M, Mori Y, Futatsubashi M, Sato K, Ito S, Yokokura M, Shinke T, Kameno Y, Kakimoto A, Kanno T, Okada H, Ouchi Y, Yoshikawa E. Neural correlates of head restraint: unsolicited neuronal activation and dopamine release. Neuroimage. 2021 Jan 1;224: 117434. doi: 10.1016/j.neuroimage.2020.117434
  73. Hiraishi H, Ikeda T, Saito D, Hasegawa C, Kitagawa S, Takahashi T, Kikuchi M, Ouchi Y. Regional and temporal differences in brain activity with morally good or bad judgments in men: a magnetoencephalography study. Front. Neurosci. 15:596711. doi.org/10.3389/fnins.2021.596711
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講演・学会発表等 †

1998 国際ヒト機能画像学会研究優秀賞
2001 浜松市医療奨励賞
2017　第51回日本てんかん学会学術集会　京都　『高齢発症の側頭葉てんかん患者における臨床症状・脳波特徴』　優秀ポスター賞