Overview of study

Themes: cancer chemotherapy, early and late phase projects, colorectal cancer, gastric cancer, translational research, personalized medicine, respiratory organ, chemotherapy.

We are propelling basic and clinical researches related to cancer from the viewpoints of clinical and molecular genetics and a transorgan perspective.

Research activities

• Development of novel anticancer agent, especially early phase trials and translational research
• Late phase projects and clinical trials for digestive cancer
• Effects, adverse reactions and the correlation analysis of genetic polymorphism of drug-metabolizing enzyme, declines in organ function and other factors on the pharmacokinetics of anticancer agent
• Development of sequencing technology for practice of genomic medicine
• Development of early diagnosis markers via analysis of metabolome, microRNA, etc.
• Quest for immune marker related to effect and prognosis predictions of immune checkpoint inhibitor
• Development of a novel evaluation method using MRI in immune checkpoint inhibitor treatment
• Analysis of peripheral blood immune cell profile in immune checkpoint inhibitor treatment
• Planning, execution and data analysis by multi-institutional clinical research collaboration toward development of new systemic chemotherapy against advanced non-small-cell lung cancer
• Planning, execution and data analysis by multi-institutional clinical research collaboration toward development of novel supportive therapy against side effect accompanying use of anticancer agent
• Clinical research on drug-induced pulmonary disorder accompanying use of anticancer agent
• Clinical research on lung cancer complicated by interstitial pneumonitis
• Study on the effects of angiogenic inhibitor used against lung cancer on existing pulmonary vessel
• Elucidating the mechanisms of resistance to anticancer agent based on lipid analysis
• Mass microscopic analysis of malignant tumors of digestive organs