Hamamatsu University School of Medicine

About us

Research Activities

The aim of Laboratory for Promotion of Advanced Research (LPAR) is to contribute to promoting the basic and clinical research through utilization of instruments in ARFS and inter-departmental collaboration. One of our collaborative topics is the dysfunction of the cell cycle regulators, which could cause several human diseases including cancers and chronic disorders.

  1. Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M*: Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-╬▓/Smad signaling and promote epithelial-mesenchymal transition. Cancer Res. 79(11) 2821-2838, 2019, doi: 10.1158/0008-5472.CAN-18-3210.
  2. Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, Niida H, Suzuki S, Nakayama KI, Inui N, Suda T, Kitagawa M*: Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis. Int J Mol Sci 19(2): E474-491, 2018.
  3. Niida H*, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M.: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nat Commun. Jul 18;8:16102. doi: 10.1038/ncomms16102, 2017.
  4. Harada M, Sakai S, Ohhata T, Kitagawa K, Mikamo M, Nishimoto K, Uchida C, Niida H, Kotake Y, Sugimura H, Suda T, Kitagawa M.: Homeobox Transcription Factor NKX2-1 Promotes Cyclin D1 Transcription in Lung Adenocarcinomas. Mol Cancer Res. Oct;15(10):1388-1397, 2017.
  5. Uchida C: Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. Biomed Res. Int. Volume 2016, Article ID 5959721, 2016.
  6. Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M: Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. Anticancer Res. 36(4):1605-1611, 2016.
  7. Uchida C, Kitagawa M: RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer. Curr. Cancer Drug Targets 16(2):157-174, 2016.
  8. Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y: Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development. Curr. Cancer Drug Targets 16(2):147-156, 2016.
  9. Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M: UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol. 36(3): 394-406, 2015.
  10. Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, Minegishi N, Yumimoto K, Matsumoto A, Nakayama KI, Masumoto K, Katou F, Niida H, Kitagawa M: Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA binding protein 2. J. Biol. Chem. 290:10370-10381, 2015.
  11. Uchida C, Hattori T, Takahashi H, Yamamoto N, Kitagawa M, Taya Y: Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules. Genes Cells. 19: 89-96, 2014.
  12. Uchida C: The retinoblastoma protein: Functions beyond the G1-S regulator. Curr Drug Targets 13: 1622-1632, 2012.