Research Activities
The aim of Laboratory for Promotion of Advanced Research (LPAR) is to contribute to promoting the basic and clinical research through utilization of instruments in ARFS and inter-departmental collaboration. One of our collaborative topics is the dysfunction of the cell cycle regulators, which could cause several human diseases including cancers and chronic disorders.
- Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M*: Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition. Cancer Res. 79(11) 2821-2838, 2019, doi: 10.1158/0008-5472.CAN-18-3210.
- Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, Niida H, Suzuki S, Nakayama KI, Inui N, Suda T, Kitagawa M*: Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis. Int J Mol Sci 19(2): E474-491, 2018.
- Niida H*, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M.: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nat Commun. Jul 18;8:16102. doi: 10.1038/ncomms16102, 2017.
- Harada M, Sakai S, Ohhata T, Kitagawa K, Mikamo M, Nishimoto K, Uchida C, Niida H, Kotake Y, Sugimura H, Suda T, Kitagawa M.: Homeobox Transcription Factor NKX2-1 Promotes Cyclin D1 Transcription in Lung Adenocarcinomas. Mol Cancer Res. Oct;15(10):1388-1397, 2017.
- Uchida C: Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. Biomed Res. Int. Volume 2016, Article ID 5959721, 2016.
- Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M: Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. Anticancer Res. 36(4):1605-1611, 2016.
- Uchida C, Kitagawa M: RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer. Curr. Cancer Drug Targets 16(2):157-174, 2016.
- Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y: Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development. Curr. Cancer Drug Targets 16(2):147-156, 2016.
- Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M: UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol. 36(3): 394-406, 2015.
- Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, Minegishi N, Yumimoto K, Matsumoto A, Nakayama KI, Masumoto K, Katou F, Niida H, Kitagawa M: Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA binding protein 2. J. Biol. Chem. 290:10370-10381, 2015.
- Uchida C, Hattori T, Takahashi H, Yamamoto N, Kitagawa M, Taya Y: Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules. Genes Cells. 19: 89-96, 2014.
- Uchida C: The retinoblastoma protein: Functions beyond the G1-S regulator. Curr Drug Targets 13: 1622-1632, 2012.