Hamamatsu University School of Medicine

About us

Research Activities

Center members and students conduct researches on various aspects of child mental development including cognitive neuroscience, etiology of developmental disorders, social support on children with disability, epidemiological studies, and evidence synthesis.

Research Topics

  1. Cognitive neuroscience studies: We promote research aimed at elucidating human social cognition, language, emotion, and decision-making by combining psychological experiments with physiological and neuroscientific measures.
  2. Large-scale epidemiological studies: We work with large numbers of children, closely observing and recording how and when they grow by employing longitudinal study approaches (i.e., Hamamatsu Birth Cohort Study), and using the recorded data to identify factors that promote or regulate their growth. We conduct research on clarification of aetiology in developmental disorders (such as ASD and ADHD)

  3. Social support and social implementation: Based on the research results obtained through surveys conducted mainly at schools, various efforts are made to solve problems such as bullying and truancy.

Recent Publications (selected)


Acharya A, Rahman MS(co-first author), Islam MR, Gilmour S, Dhungel B, Parajuli RP, Nishimura T, Senju A, Tsuchiya KJ. Socioeconomic and education-based inequality in suspected developmental delays among Nepalese children: a subnational level assessment. Scientific Reports. 2023 Mar 21; 13:4750. Doi: https://doi.org/10.1038/s41598-023-31629-1

Sugiyama M, Tsuchiya KJ, Okubo Y, Rahman MS, Uchiyama S, Harada T, Iwabuchi T, Okumura A, Nakayasu C, Amma Y, Suzuki H, Takahashi N, Kinsella-Kammerer B, Nomura Y, Itoh H, Nishimura T. Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes. JAMA Pediatrics. 2023 Jan 23; 177(3):303-310. Doi: https://doi.org/10.1001/jamapediatrics.2022.5356

Rahman MS, Chowdhury MRK, Islam MR, Krull Abe S, Hossain K, Iwabuchi T, Tsuchiya KJ, Gilmour S. Determinants and Projections of Minimum Acceptable Diet among Children Aged 6-23 Months: A National and Subnational Inequality Assessment in Bangladesh. International Journal of Environmental Research and Public Health. 2023 Jan 21; 20(3):2010. Doi: https://doi.org/10.3390/ijerph20032010 

Nishimura T, Takahashi N, Okumura A, Harada T, Iwabuchi T, Nakayasu C, Rahman S, Uchiyama S, Wakuta M, Nomura Y, Takei N. Sex Differences in Neurodevelopmental Trajectories in Children with Different Levels of Autistic Traits. Psychiatry and Clinical Neurosciences. 2023 Jan 9; Online ahad of print. Doi: https://doi.org/10.1111/pcn.13529 

Yoshioka A, Tanabe HC, Nakagawa E, Sumiya M, Koike T, Sadato N. The Role of the Left Inferior Frontal Gyrus in Introspection during Verbal Communication. Brain Sciences. 2023 January 7; 13(1):111. https://doi.org/10.3390/brainsci13010111

Ishikawa M, Senju A. Action value calculations in social context from infancy. Trends in Cognitive Sciences. 2023 Jan 5. Online first. Doi: https://doi.org/10.1016/j.tics.2022.12.005


Lockwood Estrin G, Aseervatham V, De Barros CM, Chapple T, Churchard A, Harper M, Jones EJ, Mandy W, Milner V, O'Brien S, Senju A, Smith C, Smith J. Homelessness in autistic women: Defining the research agenda. Women's Health. 2022 Dec 14;18. Doi: https://doi.org/10.1177/17455057221141291

Harada T, Iwabuchi T, Senju A, Nakayasu C, Nakahara R, Tsuchiya KJ, Hoshi Y. Neural mechanisms underlying rule selection based on response evaluation: a near-infrared spectroscopy study. Scientific Reports. 2022 Nov 30; 12:20696. Doi: https://doi.org/10.1038/s41598-022-25185-3

Kubo T, Matsumoto S, Izawa S, Ikeda H, Nishimura Y, Kawakami S, Tamaki M, Masuda S. Shift-Work Schedule Intervention for Extending Restart Breaks after Consecutive Night Shifts: A Non-randomized Controlled Cross-Over Study. International Journal of Environmental Research and Public Health. 2022 Nov 15;19(22):15042. Doi: https://doi.org/10.3390/ijerph192215042

Kasai C, Sumiya M, Koike T, Yoshimoto T, Maki H, Sadato N. Neural underpinning of Japanese particle processing in non-native speakers. Scientific Reports. 2022 Nov 5;12(1):18740. Doi: https://doi.org/10.1038/s41598-022-23382-8

Tautvydaitė D, Mares I, Rahman MS, Burra N, Senju A. Effect of perceived eye gaze on the N170 component - A systematic review. Neuroscience & Biobehavioral Reviews. 2022 October 17; 143: 104913. Doi: https://doi.org/10.1016/j.neubiorev.2022.104913

Ichinose D, Nishimura T, Senju A, Okumura A, Iwabuchi T, Harada T, Rahman MS, Takahashi N, Tsuchiya KJ, Takei N. Influence of maternal pre-pregnancy and children's body mass index on cognitive functions. Journal of Child & Brain Development. 2022 Oct 15; 13(1), 70-80. Doi: https://doi.org/10.34572/jcbd.13.1_70

Oba Y, Ninomiya T, Iwabuchi T, Tsuchiya KJ. Long-term Absenteeism in School and Unemployment in Young Adulthood: A Longitudinal Study of Social Participation among Youths in Hamamatsu. Journal of Child & Brain Development. 2022 Oct 15; 13(1), 60-69. Doi: https://doi.org/10.34572/jcbd.13.1_60

Dhungel B, Rahman MS, Rahman MM, Bhandari AKC, Le PM, Biva NA, Gilmour S. Reliability of early estimates of basic reproduction number of COVID-19: a systematic review and meta-analysis. International Journal of Environmental Research and Public Health. 2022 Sept 15; 19(18): 11613. Doi: https://doi.org/10.3390/ijerph191811613

Kato Y, Yokokura M, Iwabuchi T, Murayama C, Harada T, Goto T, Tamayama T, Kameno Y, Wakuda T, Kuwabara H, Benner S, Senju A, Tsukada H, Nishizawa S, Ouchi Y, Yamasue H. Lower Availability of Mitochondrial Complex I in Anterior Cingulate Cortex in Autism: A Positron Emission Tomography Study. American Journal of Psychiatry. 2022 Sep 7:appiajp22010014. Doi: https://doi.org/10.1176/appi.ajp.22010014.

Jang J, Lee S, Ko KP, Abe SK, Rahman MS, Saito E et al. Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants. Cancer Epidemiology, Biomarkers & Prevention. 2022 Sep 2;31(9):1727-1734. Doi: https://doi.org/10.1158/1055-9965.EPI-22-0051

Umeda N, Hirai T, Ohto-Nakanishi T, Tsuchiya KJ, Matsuzaki H. Linoleic acid and linoleate diols in neonatal cord blood influence birth weight. Frontiers in Endocrinology. 2022 Aug 22; 13: 986650. Doi: https://doi.org/10.3389/fendo.2022.986650

Chowdhury MRK, Rahman MS, Billah B, Kabir R, Nirmala KPP, Kader M. The prevalence and socio-demographic risk factors of coexistence of stunting, wasting, and underweight among children under five years in Bangladesh: a cross-sectional study. BMC Nutrition. 2022 Aug 22; 8: 84. Doi: https://doi.org/10.1186/s40795-022-00584-x

Ishikawa M, Senju A, Kato M, Itakura S. Physiological arousal explains infant gaze following in various social contexts. Royal Society Open Science. 2022 Aug 17; 9:220592. Doi: https://doi.org/10.1098/rsos.220592

Li M, Wang Y, Tachibana M, Rahman S, Kagitani-Shimono K. Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies. Autism Research. 2022 Aug 13; 1-18. Doi: https://doi.org/10.1002/aur.2789

Morisaki N, Obara T, Piedvache A, Kobayashi S, Miyashita C, Nishimura T, Ishikuro M, Sata F, Horikawa R, Mori C, Metoki H, Tsuchiya KJ, Kuriyama S, Kishi R. Association between smoking and hypertension in pregnancy among Japanese women: a meta-analysis of birth cohort studies in the Japan Birth Cohort Consortium (JBiCC) and JECS. Journal of Epidemiology. 2022 Aug 6; JE20220076. Doi: https://doi.org/10.2188/jea.JE20220076

Anik AI, Islam MR, Rahman MS. Association between socioeconomic factors and unmet need for modern contraception among the young married women: A comparative study across the low-and lower-middle-income countries of Asia and Sub-Saharan Africa. PLOS Global Public Health. 2022 Jul 27;2(7):e0000731. Doi: https://doi.org/10.1371/journal.pgph.0000731

Takahashi M, Adachi M, Hirota T, Nishimura T, Shinkawa H, Mori H, Nakamura K. Longitudinal association between addictive internet use and depression in early adolescents over a 2-year period: A study using a random intercept cross-lagged model. Computers in Human Behavior. 2022 July; 132:107251. Doi: https://doi.org/10.1016/j.chb.2022.107251

Hirota T, Nishimura T, Mikami M, Saito M, Nakamura K. The Role of the Maternal and Child Health Handbook in Developmental Surveillance: The Exploration of Milestone Attainment Trajectories. Frontiers in Psychiatry. 2022 Jun 17;13:902158. Doi: https://doi.org/10.3389/fpsyt.2022.902158

Haensel JX, Smith TJ, Senju A. Cultural differences in face looking and mutual gaze: a dual head-mounted eye-tracking study. Visual Cognition. 2022 May 21; 30: 100-115. Doi: https://doi.org/10.1080/13506285.2021.1928354

Tainaka H, Takahashi N, Nishimura T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Nomura Y, Tsuchiya KJ. Long-term effect of persistent postpartum depression on children's psychological problems in childhood. Journal of Affective Disorders. 2022 May 15; 305:71-76. Doi: https://doi.org/10.1016/j.jad.2022.02.061

Leung CY, Huang HL, Abe SK, Saito E, Islam MR, Rahman MS, Ikeda A, Sawada N, Tamakoshi A, Gao YT, Koh WP et al. Association of Marital Status With Total and Cause-Specific Mortality in Asia. JAMA Network Open. 2022 May 2;5(5):e2214181. Doi: https://doi.org/10.1001/jamanetworkopen.2022.14181

Sutskova O, Senju A, Smith TJ. Impact of Video-Mediated Online Social Presence and Observance on Cognitive Performance. Technology, Mind, and Behavior. 2022 Apr 22; 3(2): 1-15. Doi: https://doi.org/10.1037/tmb0000023

Oh J, Shin H-M, Nishimura T, Rahman MS, Takahashi N, Tsuchiya KJ. Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Environment International. 2022 Mar 28. Online first. Doi: https://doi.org/10.1016/j.envint.2022.107215

Nishimura T, Kato T, Okumura A, Harada T, Iwabuchi T, Rahman MS, Hirota T, Takahashi M, Adachi M, Kuwabara H, Takagai S, Nomura Y, Takahashi N, Senju A, Tsuchiya KJ. Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population. Frontiers in Psychiatry. 2022 Mar 23. 13: 817383. Doi: https://doi.org/10.3389/fpsyt.2022.817383

Kato T, Nishimura T, Takahashi N, Harada T, Okumura A, Iwabuchi T, Nomura Y, Senju A, Tsuchiya KJ, Takei N. Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition. Scientific Reports. 2022 Mar 21;12(1):4822. Doi: https://doi.org/10.1038/s41598-022-08827-4

Lee S, Jang J, Abe SK, Rahman S, Saito E, Islam R, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP. Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with> 800 000 individuals in the Asia Cohort Consortium. International Journal of Epidemiology. 2022 Mar 1. dyac023. Doi: https://doi.org/10.1093/ije/dyac023

Cabañas C, Senju A, Smith TJ. Dramatic Irony: A case study in the potential mutual benefit of combining social neuroscience with film theory. Projection. 2022 Mar 1; 16(1): 84-104. Doi: https://doi.org/10.3167/proj.2022.160106

Murayama C, Iwabuchi T, Kato Y, Yokokura M, Harada T, Goto T, Tamayama T, Kameno Y, Wakuda T, Kuwabara H, Senju A, Nishizawa S, Ouchi Y, Yamasue H. Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study. Molecular Psychiatry. 2022 Feb 18; 27, 2106-2113. Doi: https://doi.org/10.1038/s41380-022-01464-3

Ueda M, Tsuchiya KJ, Yaguchi C, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Suzuki M, Oda T, Kawai K, Itoh T, Matsuya M, Narumi M, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H. Placental pathology predicts infantile neurodevelopment. Scientific Reports. 2022 Feb 16;12(1):2578. Doi: https://doi.org/10.1038/s41598-022-06300-w

Rahman MM, Taniguchi H, Nsashiyi RS, Islam R, Mahmud SR, Rahman MS, Jung J, Khan S. Trend and projection of skilled birth attendants and institutional delivery coverage for adolescents in 54 low-and middle-income countries, 2000-2030. BMC Medicine. 2022 Feb 4;20(46). Doi: https://doi.org/10.1186/s12916-022-02255-x

Iwabuchi T, Takahashi N, Nishimura T, Rahman MS, Harada T, Okumura A, Kuwabara H, Takagai S, Nomura Y, Matsuzaki H, Ozaki N, Tsuchiya KJ. Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children. Frontiers in Psychiatry. 2022 Feb 3; 12:816196. Doi: https://doi.org/10.3389/fpsyt.2021.816196

Adachi M, Takahashi M, Shinkawa H, Mori H, Nishimura T, Nakamura K. Longitudinal association between smartphone ownership and depression among schoolchildren under COVID-19 pandemic. Social Psychiatry and Psychiatric Epidemiology. 2022 Feb; 57(2):239-243. Doi: https://doi.org/10.1007/s00127-021-02196-5

Kikuchi Y, Akechi H, Senju A, Tojo Y, Osanai H, Saito A, Hasegawa T. Attention to live eye contact in adolescents with autism spectrum disorder. Autism Research. 2022 Jan 25; 15(4), 702-711. Doi: https://doi.org/10.1002/aur.2676

Yamasue H, Kojima M, Kuwabara H, Kuroda M, Matsumoto K, Kanai C, Inada N, Owada K, Ochi K, Ono N, Benner S, Wakuda T, Kameno Y, Inoue J, Harada T, Tsuchiya K, Umemura K, Yamauchi A, Ogawa N, Kushima I, Ozaki N, Suyama S, Saito T, Uemura Y, Hamada J, Kano Y, Honda N, Kikuchi S, Seto M, Tomita H, Miyoshi N, Matsumoto M, Kawaguchi Y, Kanai K, Ikeda M, Nakamura I, Isomura S, Hirano Y, Onitsuka T, Kosaka H, Okada T. Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial. Brain. 2022 Jan 24:awab291. Doi: https://doi.org/10.1093/brain/awab291

Ishikawa-Omori Y, Nishimura T, Nakagawa A, Okumura A, Harada T, Nakayasu C, Iwabuchi T, Amma Y, Suzuki H, Rahman MS, Nakahara R, Takahashi N, Nomura Y, Tsuchiya KJ. Early temperament as a predictor of language skills at 40 months. BMC Pediatrics. 2022 Jan 21;22(1):56. Doi: https://doi.org/10.1186/s12887-022-03116-5

Mori H, Takahashi M, Adachi M, Shinkawa H, Hirota T, Nishimura T, Nakamura K. The association of social capital with depression and quality of life in school-aged children. PLoS One. 2022 Jan 13;17(1):e0262103. Doi: https://doi.org/10.1371/journal.pone.0262103

Shin A, Cho S, Jang D, Abe SK, Saito E, Rahman MS, Islam MR, Sawada N, Shu XO, Koh WP, Sadakane A, Tsuji I, Sugawara Y, Ito H, Nagata C, Park SK, Yuan JM, Kim J, Tsugane S, Cai H, Wen W, Ozasa K, Matsuyama S, Kanemura S, Oze I, Wada K, Wang R, Yoo KY, Potter JD, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D. Body Mass Index and Thyroid Cancer Risk: A Pooled Analysis of Half a Million Men and Women in the Asia Cohort Consortium. Thyroid. 2022 Jan 11. Doi: https://doi.org/10.1089/thy.2021.0445

Rahman MM, Islam MR, Rahman MS, Hossain F, Alam A, Rahman MO, Jung J, Akter S. Forgone healthcare and financial burden due to out-of-pocket payments in Bangladesh: a multilevel analysis. Health Economics Review. 2022 Jan 10;12(1):5. Doi: https://doi.org/10.1186/s13561-021-00348-6

Yang JJ, Yu D, Shu XO, Wen W, Rahman S, Abe S, Saito E, Gupta PC, He J, Tsugane S, Gao YT, Yuan JM, Koh WP, Sadakane A, Tomata Y, Tsuji I, Sugawara Y, Matsuo K, Ahn YO, Park SK, Chen Y, Inoue M, Kang D, Zheng W. Reduction in total and major cause-specific mortality from tobacco smoking cessation: a pooled analysis of 16 population-based cohort studies in Asia. International Journal of Epidemiol. 2022 Jan 6;50(6):2070-2081. Doi: https://doi.org/10.1093/ije/dyab087

Takahashi N, Okumura A, Nishimura T, Harada T, Iwabuchi T, Rahman MS, Tsuchiya KJ. Exploration of Sleep Parameters, Daytime Hyperactivity/Inattention, and Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores of Children in a Birth Cohort in Japan. JAMA Network Open. 2022 Jan 4;5(1):e2141768. Doi: https://doi.org/10.1001/jamanetworkopen.2021.41768


Kim S, Senju A, Sodian B, Paulus M, Itakura S, Okuno A, Ueno M, Proust J. Memory Monitoring and Control in Japanese and German Preschoolers. Memory & Cognition. 2021 Dec 17. Doi: https://doi.org/10.3758/s13421-021-01263-1

Horikoshi T, Nishimura T, Nomura Y, Iwabuchi T, Itoh H, Takizawa T, Tsuchiya KJ. Umbilical cord serum concentrations of perfluorooctane sulfonate, perfluorooctanoic acid, and the body mass index changes from birth to 5 1/2 years of age. Scientific Report. 2021 Oct 5;11(1):19789. Doi: https://doi.org/10.1038/s41598-021-99174-3

Rahman MS, Takahashi N, Iwabuchi T, Nishimura T, Harada T, Okumura A, Takei N, Nomura Y, Tsuchiya KJ. Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g. BMC Medicine. 2021 Sep 24;19(1):229. Doi: https://doi.org/10.1186/s12916-021-02093-3

Takahashi N, Nishimura T, Harada T, Okumura A, Iwabuchi T, Rahman MS, Kuwabara H, Takagai S, Nomura Y, Takei N, Tsuchiya KJ. Association Between Genetic Risks for Obesity and Working Memory in Children. Frontiers in Neuroscience. 2021 Sep 22;15:749230. Doi: https://doi.org/10.3389/fnins.2021.749230

Shin S, Lee JE, Loftfield E, Shu XO, Abe SK, Rahman MS, Saito E, Islam MR, Tsugane S, Sawada N, Tsuji I, Kanemura S, Sugawara Y, Tomata Y, Sadakane A, Ozasa K, Oze I, Ito H, Shin MH, Ahn YO, Park SK, Shin A, Xiang YB, Cai H, Koh WP, Yuan JM, Yoo KY, Chia KS, Boffetta P, Ahsan H, Zheng W, Inoue M, Kang D, Potter JD, Matsuo K, Qiao YL, Rothman N, Sinha R. Coffee and tea consumption and mortality from all causes, cardiovascular disease and cancer: a pooled analysis of prospective studies from the Asia Cohort Consortium. International Journal of Epidemiology. 2021 Sep 1:dyab161. Doi: https://doi.org/10.1093/ije/dyab161

Svensson T, Saito E, Svensson AK, Melander O, Orho-Melander M, Mimura M, Rahman S, Sawada N, Koh WP, Shu XO, Tsuji I, Kanemura S, Park SK, Nagata C, Tsugane S, Cai H, Yuan JM, Matsuyama S, Sugawara Y, Wada K, Yoo KY, Chia KS, Boffetta P, Ahsan H, Zheng W, Kang D, Potter JD, Inoue M. Association of Sleep Duration With All- and Major-Cause Mortality Among Adults in Japan, China, Singapore, and Korea. JAMA Network Open. 2021 Sep 1;4(9):e2122837. Doi: https://doi.org/10.1001/jamanetworkopen.2021.22837

Taniguchi H, Rahman MM, Swe KT, Islam MR, Rahman MS, Parsell N, Hussain A, Shibuya K, Hashizume M. Equity and determinants in universal health coverage indicators in Iraq, 2000-2030: a national and subnational study. International Journal for Equity in Health. 2021 Aug 30;20(1):196. Doi: https://doi.org/10.1186/s12939-021-01532-0

Nguyen PT, Rahman MS, Le PM, Nguyen HV, Vu KD, Nguyen HL, Dao ATM, Khuong LQ, Hoang MV, Gilmour S. Trends in, projections of, and inequalities in reproductive, maternal, newborn and child health service coverage in Vietnam 2000-2030: A Bayesian analysis at national and sub-national levels. The Lancet Regional Health - Western Pacific. 2021 Jul 30;15:100230. Doi: https://doi.org/10.1016/j.lanwpc.2021.100230

Anik AI, Islam MR, Rahman MS. Do women's empowerment and socioeconomic status predict the adequacy of antenatal care? A cross-sectional study in five South Asian countries. BMJ Open. 2021 Jun 3;11(6):e043940. Doi: http://dx.doi.org/10.1136/bmjopen-2020-043940

Islam MR, Hossain MS, Khan MMA, Rahman MS. Trends in body mass index among ever-married Bangladeshi women, 2004-14: evidence from nationally representative population-based surveys. Journal of Nutritional Science. 2021 Apr 22;10:e28. Doi: https://doi.org/10.1017/jns.2021.1

Swe KT, Rahman MM, Rahman MS, Teng Y, Abe SK, Hashizume M, Shibuya K. Impact of poverty reduction on access to water and sanitation in low- and lower-middle-income countries: country-specific Bayesian projections to 2030. Tropical Medicine & International Health. 2021 Apr 4; 26(7):760-774. Doi: https://doi.org/10.1111/tmi.13580

Wojcicki JM, Tsuchiya KJ, Murakami K, Ishikuro M, Obara T, Morisaki N. Limited consumption of 100% fruit juices and sugar sweetened beverages in Japanese toddler and preschool children. Preventive Medicine Reports. 2021 May 30;23:101409. Doi: https://doi.org/10.1016/j.pmedr.2021.101409

Yang JJ, Yu D, Shu XO, Freedman ND, Wen W, Rahman MS et al. Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in Asia. Tobacco Control. 2021 Apr 23; 30:328-335. Doi: http://dx.doi.org/10.1136/tobaccocontrol-2019-055412

Inoue J, Matsuo K, Iwabuchi T, Takehara Y, Yamasue H. How Memory Switches Brain Responses of Patients with Post-traumatic Stress Disorder. Cerebral Cortex Communications. 2021 Mar 20;2(2):tgab021. Doi: https://doi.org/10.1093/texcom/tgab021

Kato Y, Kuwabara H, Okada T, Munesue T, Benner S, Kuroda M, Kojima M, Yassin W, Eriguchi Y, Kameno Y, Murayama C, Nishimura T, Tsuchiya K, Kasai K, Ozaki N, Kosaka H, Yamasue H. Oxytocin-induced increase in N, N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms. Molecular Autism. 2021 Feb 21;12(1):1-3. Doi: https://doi.org/10.1186/s13229-021-00423-z

Iwabuchi T, Makuuchi M. When a sentence loses semantics: Selective involvement of a left anterior temporal subregion in semantic processing. European Journal of Neuroscience. 2021 Feb;53(3):929-42. Doi: https://doi.org/10.1111/ejn.15022

Ishikawa M, Haensel JX, Smith TJ, Senju A, Itakura S. Affective priming enhances gaze cueing effect. Journal of Experimental Psychology: Human Perception and Performance. 2021 Feb; 47(2): 189-199. Doi: https://doi.org/10.1037/xhp0000880


Hirayama A, Wakusawa K, Fujioka T, Iwata K, Usui N, Kurita D, Kameno Y, Wakuda T, Takagai S, Hirai T, Nara T, Ito H, Nagano Y, Oowada S, Tsujii M, Tsuchiya KJ, Matsuzaki H. Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children. Scientific Reports. 2020 Nov 26; 10(1):20602. Doi: https://doi.org/10.1038/s41598-020-77328-z

Ibara Y, Nishimura T, Nakahara R, Iwabuchi T, Harada T, Okumura A, Nakayasu C, Takei N, Tsuchiya, KJ. Specific components of child gestures at 14 months are associated with preschoolers' language skills. Journal of Brain Science. 2020 Oct 30; 49: 5-31. Doi: https://doi.org/10.20821/jbs.49.0_5

Sagawa Y, Nishimura T, Nomura Y, Iwabuchi T, Harada T, Okumura A, Nakayasu C, Takahashi N, Takei N, Tsuchiya KJ. Mixed associations of postnatal body mass index change with cognitive function at 4 years: Hamamatsu Birth Cohort for Mothers and Children Study. Journal of Brain Science. 2020 Oct 30; 49: 32-62. Doi: https://doi.org/10.20821/jbs.49.0_32

Chowdhury MR, Khan MM, Khan HT, Rahman MS, Islam MR, Islam MM, Billah B. Prevalence and risk factors of childhood anemia in Nepal: A multilevel analysis. PLoS ONE. 2020 Oct 6; 15(10):e0239409. Doi: https://doi.org/10.1371/journal.pone.0239409

Maekawa M, Ohnishi T, Toyoshima M, Shimamoto-Mitsuyama C, Hamazaki K, Balan S, Wada Y, Esaki K, Takagai S, Tsuchiya KJ, Nakamura K, Iwata Y, Nara T, Iwayama Y, Toyota T, Nozaki Y, Ohba H, Watanabe A, Hisano Y, Matsuoka S, Tsujii M, Mori N, Matsuzaki H, Yoshikawa T. A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder. Brain Communications. 2020 Sep 10; 2(2):fcaa145. Doi: https://doi.org/10.1093/braincomms/fcaa145

Takahashi N, Nishimura T, Harada T, Okumura A, Choi D, Iwabuchi T, Kuwabara H, Takagai S, Nomura Y, Newcorn JH, Takei N, Tsuchiya KJ. Polygenic risk score analysis revealed shared genetic background in attention deficit hyperactivity disorder and narcolepsy. Translational Psychiatry. 2020 Aug 17;10(1):284. Doi: https://doi.org/10.1038/s41398-020-00971-7

Usui N, Iwata K, Miyachi T, Takagai S, Wakusawa K, Nara T, Tsuchiya KJ, Matsumoto K, Kurita D, Kameno Y, Wakuda T, Takebayashi K, Iwata Y, Fujioka T, Hirai T, Toyoshima M, Ohnishi T, Toyota T, Maekawa M, Yoshikawa T, Maekawa M, Nakamura K, Tsujii M, Sugiyama T, Mori N, Matsuzaki H. VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction. EBioMedicine. 2020 Aug; 58:102917. Doi: https://doi.org/10.1016/j.ebiom.2020.102917

Iwabuchi T, Ohba M, Ogawa K, Inui T. Incongruence of grammatical subjects activates brain regions involved in perspective taking in a sentence-sentence verification task. Journal of Neurolinguistics. 2020 Aug; 55: 100893. Doi: https://doi.org/10.1016/j.jneuroling.2020.100893

Nishimura T, Wakuta M, Tsuchiya KJ, Osuka Y, Tamai H, Takei N, Katayama T. Measuring School Climate among Japanese Students-Development of the Japan School Climate Inventory (JaSC). International Journal of Environmental Research and Public Health. 2020 June 19; 17(12):4426. Doi: https://doi.org/10.3390/ijerph17124426

Fujioka T, Fujisawa TX, Inohara K, Okamoto Y, Matsumura Y, Tsuchiya KJ, Katayama T, Munesue T, Tomoda A, Wada Y, Kosaka H. Attenuated relationship between salivary oxytocin levels and attention to social information in adolescents and adults with autism spectrum disorder: a comparative study. Annals of General Psychiatry. 2020 Jun 5; 19:38. Doi: https://doi.org/10.1186/s12991-020-00287-2

Fujioka T, Tsuchiya KJ, Saito M, Hirano Y, Matsuo M, Kikuchi M, Maegaki Y, Choi D, Kato S, Yoshida T, Yoshimura Y, Ooba S, Mizuno Y, Takiguchi S, Matsuzaki H, Tomoda A, Shudo K, Ninomiya M, Katayama T, Kosaka H. Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study. Molecular Autism. 2020 Apr 9; 11(1):24. Doi: https://doi.org/10.1186/s13229-020-00321-w

Matsumoto M, Tsuchiya KJ, Yaguchi C, Horikoshi Y, Furuta-Isomura N, Oda T, Kohmura-Kobayashi Y, Tamura N, Uchida T, Itoh H. The fetal/placental weight ratio is associated with the incidence of atopic dermatitis in female infants during the first 14 months: The Hamamatsu Birth Cohort for Mothers and Children (HBC Study). International Journal of Women's Dermatology. 2020 Mar 5; 6(3):176-181. Doi: https://doi.org/10.1016/j.ijwd.2020.02.009

Kuno-Fujita A, Iwabuchi T, Wakusawa K, Ito H, Suzuki K, Shigetomi A, Kosaka H, Tsujii M, Tsuchiya KJ. Sensory processing patterns and fusiform activity during face processing in autism spectrum disorder. Autism Research. 2020 Feb 14; 13(5): 741-750. Doi: https://doi.org/10.1002/aur.2283

Takahashi N, Harada T, Nishimura T, Okumura A, Choi D, Iwabuchi T, Kuwabara H, Takagai S, Nomura Y, Takei N, Tsuchiya KJ. Association of genetic risks with autism spectrum disorder and early neurodevelopmental delays among children without intellectual disability. JAMA Network Open. 2020 Feb 7; 3(2):e1921644. Doi: https://doi.org/10.1001/jamanetworkopen.2019.21644

Zhang W, Ham J, Li Q, Deyssenroth MA, Lambertini L, Huang Y, Tsuchiya KJ, Chen J, Nomura Y. Moderate prenatal stress may buffer the impact of Superstorm Sandy on placental genes: Stress in Pregnancy (SIP) Study. PLoS One. 2020 Jan 29; 15(1):e0226605. Doi: https://doi.org/10.1371/journal.pone.0226605

Tsuchiya KJ, Hakoshima S, Hara T, Ninomiya M, Saito M, Fujioka T, Kosaka H, Hirano Y, Matsuo M, Kikuchi M, Maegaki Y, Harada T, Nishimura T, Katayama T. Diagnosing Autism Spectrum Disorder Without Expertise: A Pilot Study of 5- to 17-Year-Old Individuals Using Gazefinder. Frontiers in Neurology. 2021 Jan 28; 11:603085. Doi: https://doi.org/10.3389/fneur.2020.603085

Huang Y, Zhang W, Go K, Tsuchiya KJ, Hu J, Skupski DW, Sie SY, Nomura Y. Altered growth trajectory in children born to mothers with gestational diabetes mellitus and preeclampsia. Archives of Gynecology and Obstetrics. 2020 Jan 21; 301(1):151-159. Doi: https://doi.org/10.1007/s00404-020-05436-2


Aoyagi SS, Tsuchiya KJ. Does maternal postpartum depression affect children's developmental outcomes? Journal of Obstetrics and Gynaecology Research. 2019 Sep;45(9):1809-1820. Doi: https://doi.org/10.1111/jog.14064

Osuka Y, Nishimura T, Wakuta M, Takei N, Tsuchiya KJ. Reliability and validity of the Japan Ijime Scale and estimated prevalence of bullying among 4th through 9th graders: a large-scale school-based survey. Psychiatry & Clinical Neuroscience. 2019 Sep;73(9):551-559. Doi: https://doi.org/10.1111/pcn.12864

Iwabuchi T, Nakajima Y, Makuuchi M. Neural architecture of human language: Hierarchical structure building is independent from working memory. Neuropsychologia. 2019 Sep; 132: 107137. Doi: https://doi.org/10.1016/j.neuropsychologia.2019.107137

Nishimura T, Takei N, Tsuchiya KJ. Neurodevelopmental trajectory during infancy and diagnosis of autism spectrum disorder as an outcome at 32 months of age. Epidemiology. 2019 July; 30 (Suppl 1), S9-S14. Doi: https://doi.org/10.1097/EDE.0000000000000996

Choi D, Tsuchiya KJ, Takei N. Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. Scientific Reports. 2019 May 22;9(1):7685. Doi: https://doi.org/10.1038/s41598-019-44175-6

Suzuki K, Takagai S, Tsujii M, Ito H, Nishimura T, Tsuchiya KJ. Sensory processing in children with autism spectrum disorder and the mental health of primary caregivers. Brain and Development. 2019 Apr;41(4):341-351. Doi: https://doi.org/10.1016/j.braindev.2018.11.005

Aoyagi SS, Takei N, Nishimura T, Nomura Y, Tsuchiya KJ. Association of late-onset postpartum depression of mothers with expressive language development during infancy and early childhood: the HBC study. Peer J. 2019 Mar 6; 7:e6566. Doi: https://doi.org/10.7717/peerj.6566

Nomura Y, Davey K, Pehme PM, Finik J, Glover V, Zhang W, Huang Y, Buthmann J, Dana K, Yoshida S, Tsuchiya KJ, Li XB, Ham J. Influence of in utero exposure to maternal depression and natural disaster related stress on infant temperament at 6 months: The children of Superstorm Sandy. Infant Mental Health Journal. 2019 Feb 5; 40(2): 204-216. Doi: https://doi.org/10.1002/imhj.21766


Murakami T, Abe M, Wiratman W, Fujiwara J, Okamoto M, Mizuochi-Endo T, Iwabuchi T, Makuuchi M, Yamashita A, Tiksnadi A, Chang FY, Kubo H, Matsuda N, Kobayashi S, Eifuku S, Ugawa Y. The motor network reduces multisensory illusory perception. Journal of Neuroscience. 2018 Nov 7; 38(45): 9679-9688. Doi: https://doi.org/10.1523/JNEUROSCI.3650-17.2018

Harada T, Tsuruno M, Shirokawa T. Developmental trajectory of rule management system in children. Scientific Reports. 2018 Aug 24; 8: 12798. Doi: https://doi.org/10.1038/s41598-018-31235-6

Yaguchi C, Itoh H, Tsuchiya KJ, Furuta-Isomura N, Horikoshi Y, Matsumoto M, Jeenat FU, Keiko MK, Kohmura-Kobatashi Y, Tamura N, Sugihara K, Kanayama N. Placental pathology predicts infantile physical development during first 18 months in Japanese population: Hamamatsu birth cohort for mothers and children (HBC Study). PLoS One. 2018 Apr 10;13(4):e0194988. Doi: https://doi.org/10.1371/journal.pone.0194988

Nakamura K, Makuuchi M, Oga T, Mizuochi-Endo T, Iwabuchi T, Nakajima Y, Dehaene S. Neural capacity limits during unconscious semantic processing. European Journal of Neuroscience. 2018 Mar 7;47(8):929-937. Doi: https://doi.org/10.1111/ejn.13890

Zhang W, Qian L, Deyssenroth M, Lambertini L, Finik J, Ham J, Huang Y, Tsuchiya KJ, Pehme P, Buthmann J, Yoshida S, Chen J, Nomura Y. Timing of prenatal exposure to trauma and altered placental expressions of HPA-axis genes and genes driving neurodevelopment. Journal of Neuroendocrinology. 2018 Feb 9; 30(4):e12581. Doi: https://doi.org/10.1111/jne.12581

Engelke C, Lange-Asschenfeldt C, Peter S, Kahl KG, Frasch K, Larsen JI, Bickel GG, Bork B, Jacobsen BA, Wallenstein-Jensen SO, Lauber C, Mogensen B, Nielsen JA, Rössler W, Tsuchiya KJ, Toftegaard KL, Andersen UA, Uwakwe R, Munk-Jørgensen P, Cordes J. A cross-continental analysis of weight gain, psychiatric diagnoses and medication use during inpatient psychiatric treatment. The international study on physical illness in mentally ill. European Psychiatry. 2018 Feb; 48:65-70. Doi: https://doi.org/10.1016/j.eurpsy.2017.11.004

Wakusawa K, Nara C, Kubota Y, Tomizawa Y, Taki Y, Sassa Y, Kobayashi S, Suzuki-Muromoto S, Hirose S, Yokoyama H, Nara T, Kure S, Mori N, Takei N, Kawashima R. Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development. Brain and Development. 2018 Jan; 40(1):16-25. Doi: https://doi.org/10.1016/j.braindev.2017.07.002


Kishi R, Zhang JJ, Ha EH, Chen PC, Tian Y, Xia Y, Tsuchiya KJ, Nakai K, Kim S, Hong SJ, Hong YC, Lee JR, Jan Mohamed HJB, Parajuli RP, Adair LS, Chong YS, Guo YL, Wang SL, Nishijo M, Kido T, Tai PT, Nandasena S. Birth Cohort Consortium of Asia: Current and Future Perspectives. Epidemiology. 2017 Oct ;28 (Suppl 1):S19-S34. Doi: https://doi.org/10.1097/EDE.0000000000000698

Paparelli A, Iwata K, Wakuda T, Iyegbe C, Murray RM, Takei N. Perinatal asphyxia in rat alters expression of novel schizophrenia risk genes. Frontiers in Molecular Neuroscience. 2017 Oct 27; 10:341. Doi: https://doi.org/10.3389/fnmol.2017.00341

Cherepanov SM, Akther S, Nishimura T, Shabalova AA, Mizuno A, Ichinose W, Shuto S, Yamamoto Y, Yokoyama S, Higashida H. Effects of Three Lipidated Oxytocin Analogs on Behavioral Deficits in CD38 Knockout Mice. Brain Sciences. 2017 Oct 16; 7(10):132. Doi: https://doi.org/10.3390/brainsci7100132

Balan S, Yamada K, Iwayama Y, Hashimoto T, Toyota T, Shimamoto C, Maekawa M, Takagai S, Wakuda T, Kameno Y, Kurita D, Yamada K, Kikuchi M, Hashimoto T, Kanahara N, Yoshikawa T. Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia. Schizophrenia Research. 2017 Jul; 185:33-40. Doi: https://doi.org/10.1016/j.schres.2017.01.003

Makinodan M, Iwata K, Yamashita Y, Yamamuro Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Yoshino H, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Matsuzaki H, Kishimoto T. Tumor necrosis factor alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder. Neurochemistry International. 2017 Mar; 104:1-5. Doi: https://doi.org/10.1016/j.neuint.2016.12.005

Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro Y, Kimoto S, Toritsuka M, Yamauchi T, Fukami S, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matuszaki H, Kamba S. Microglia-derived neuregulin expression in psychiatric disorders. Brain, Behavior & Immunity. 2017 Mar; 61:375-385. Doi: https://doi.org/10.1016/j.bbi.2017.01.003

Kawai E, Takagai S, Takei N, Itoh H, Kanayama N, Tsuchiya KJ. Maternal postpartum depressive symptoms predict delay in non-verbal communication in 14-month-old infants. Infant Behavior and Development. 2017 Feb; 46:33-45. Doi: https://doi.org/10.1016/j.infbeh.2016.11.006


Kameno Y, Suzuki K, Takagai S, Iwata K, Matsuzaki H, Takahashi K, Wakuda T, Iwata Y, Magata Y, Mori N. Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats. Acta Neuropsychiatrica. 2016 Dec; 28(6):352-356. Doi: https://doi.org/10.1017/neu.2016.24

Mundalil Vasu M, Anitha A, Takahashi T, Thanseem I, Iwata K, Asakawa T, Suzuki K. Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines. PLoS One. 2016 Oct 7; 11(10):e0164425. Doi: https://doi.org/10.1371/journal.pone.0164425

Asano R, Tsuchiya KJ, Harada T, Kugizaki Y, Nakahara R, Nakayasu C, Okumura A, Suzuki Y, Takagai S, Mori N, Takei N. Season of Birth Predicts Emotional and Behavioral Regulation in 18-Month-Old Infants: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). Frontiers in Public Health. 2016 Jul 25; 4:152. Doi: https://doi.org/10.3389/fpubh.2016.00152

Sato R, Tsuchiya KJ, Matsuzaki H, Takei N, Itoh H, Kanayama N, Suda T, Watanabe H, Ohashi T, Tanaka M, Nishimura S, Maekawa M. Fetal Environment and Glycosylation Status in Neonatal Cord Blood: A Comprehensive Mass Spectrometry-based Glycosylation Analysis. Medicine (Baltimore). 2016 Apr; 95(14):e3219. Doi: https://doi.org/10.1097/MD.0000000000003219

Nishimura T, Takei N, Tsuchiya KJ, Asano R, Mori N. Identification ofneurodevelopmental trajectories in infancy and of risk factors affecting deviant development: a longitudinal birth cohort study. International Journal of Epidemiology. 2016 Apr; 45(2):543-53. Doi: https://doi.org/10.1093/ije/dyv363

Takagai S, Tsuchiya KJ, Itoh H, Kanayama N, Mori N, Takei N; HBC Study Team..Cohort Profile: Hamamatsu Birth Cohort for Mothers and Children (HBC Study). International Journal of Epidemiology. 2016 Apr;45(2):333-42. Doi: https://doi.org/10.1093/ije/dyv290

Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya KJ, Mori N, Katayama T,Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H. Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. Molecular Autism. 2016 Mar 23; 7:19. Doi: https://doi.org/10.1186/s13229-016-0083-y