*corresponding author

2023

Witman N, Zhou C, Häneke T, Xiao Y, Huang X, Rohner E, Sohlmér J, Grote Beverborg N, Lehtinen ML, Chien KR, Sahara M*. Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development. Nat Commun. 14: 5435, 2023

Sahara M*. Recent advances in generation of in vitro cardiac organoids. Int J Mol Sci. 24: 6244, 2023.

Meier AB, Zawada D, Santamaria G, de Angelis MT, Dorn T, Zhang F, Tian Q, Sahara M, Lipp P, Laugwitz KL, Goedel A, Moretti A. Epicardioid single-cell genomics uncover principles of human epicardium biology in heart development and disease. Nat Biotechnol. 41: 1787-1800, 2023.

Zhou C, Häneke T, Rohner E, Sohlmér J, Kameneva P, Artemov A, Adameyko I, Sahara M*. STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development. Cardiovasc Res. 119: 1202-1217, 2023.

2022

Häneke T, Sahara M*. Progress in Bioengineering Strategies for Heart Regenerative Medicine. Int J Mol Sci. 23: 3482, 2022.

Kogan PS, Wirth F, Tomar A, Darr J, Teperino R, Lahm H, Dreßen M, Puluca N, Zhang Z, Neb I, Beck N, Luzius T, de la Osa de la Rosa L, Gärtner K, Hüls C, Zeidler R, Ramanujam D, Engelhardt S, Wenk C, Holdt LM, Mononen M, Sahara M, Cleuziou J, Hörer J, Lange R, Krane M, Doppler S. Uncovering the Molecular Identity and the Cellular Origin of Cardiosphere-Derived Cells (CDCs) by Single Cell RNA Sequencing. Basic Res Cardiol. 117: 11, 2022.

Tang CSM, Mononen M, Lam WY, Jin SC, Zhuang X, Garcia-Barcelo MM, Li Q, Yang Y, Sahara M, Eroglu E, Chien KR, Hong H, Tam PKH, Gruber PJ. Whole genome sequencing of a Chinese cohort reveals clustering of de novo mutations in myogenic heart progenitors as a cellular pathway for Tetralogy of Fallot. JCI Insight. 7: e152198, 2022.

2021

Krane M, Dreßen M, Santamaria G, My I, Schneider C, Dorn T, Mastantuono E, Berutti R, Rawat H, Laue S, Gilsbach R, Schneider P, Lahm H, Schwarz S, Doppler S, Paige S, Puluca N, Doll S, Neb I, Brade T, Zhang Z, Abou-Ajram C, Northoff B, Holdt L, Sudhop S, Sahara M, Goedel A, Dendorfer A, Tjong F, Rijlaarsdam M, Cleuziou J, Lang N, Kupatt C, Bezzina C, Lange R, Bowles N, Mann M, Gelb B, Crotti L, Hein L, Meitinger T, Wu S, Sinnecker D, Gruber P, Laugwitz KL, Moretti A. Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome. Circulation. 144: 1409-1428, 2021.

Rohner E, Witman N, Sohlmér J, De Genst E, Louch WE, Sahara M*, Chien KR. An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation. Mol Med. 27: 102, 2021.

Santoro F, Chien KR, Sahara M*. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis. STAR Protoc. 2: 100339, 2021.

2020

Xu J, Zhou C, Foo KS, Yang R, Xiao Y, Bylund K, Sahara M, Chien KR. Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors. Stem Cells. 38: 741-755, 2020.

Witman N, Zhou C, Grote Beverborg N, Sahara M*, Chien KR. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. Semin Cell Dev Biol. 100: 29-51, 2020.

2019

Goedel A, Grote Beverborg N, Sahara M, Chien KR. In search of the next super models. EMBO Mol Med. 11: e11502, 2019.

Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, Chien KR. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 310: 103-114, 2019.

Sahara M*, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract. Dev Cell. 48: 475-490, 2019.

2018

Sahara M, Eroglu E, Chien KR. Lnc'ed in to cardiogenesis. Cell Stem Cell. 22: 787-789, 2018.

Witman N, Sahara M*. Cardiac stem/progenitor cells in basics and regenerative medicine. Stem Cells Int. 2018: 8283648, 2018.

2017

Ikutomi M, Minami Y, Sahara M*. Response to "Comment to the article 'Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation". J Mol Cell Cardiol. 103: 137-138, 2017.

2016

Witman N, Sahara M*. Expansion of cardiac progenitors from reprogrammed fibroblasts as potential novel cardiovascular therapy. Stem Cell Investig. 3: 34, 2016.

2015

Santoro F, Sahara M*. A specified therapeutic window for neuregulin-1 to regenerate neonatal heart muscle. Ann Transl Med. 3: 249, 2015.

Ikutomi M, Sahara M*, Nakajima T, Minami Y, Morita T, Hirata Y, Komuro I, Nakamura F, Sata M. Diverse Contribution of Bone Marrow-derived Late-outgrowth Endothelial Progenitor Cells to Vascular Repair under Pulmonary Arterial Hypertension and Arterial Neointimal Formation. J Mol Cell Cardiol. 86: 121-135, 2015.

Minami Y, Nakajima T, Ikutomi M, Morita T, Komuro I, Sata M, Sahara M*. Angiogenic Potential of Early and Late Outgrowth Endothelial Progenitor Cells is Dependent on the Time of their Emergence. Int J Cardiol. 186: 305-314, 2015.

Sahara M*, Santoro F, Chien KR. Programming and Reprogramming a Human Heart Cell. EMBO J. 34: 710-738, 2015.

2014

Sahara M*, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives efficient formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 24: 820-841, 2014.

Sahara M*, Ikutomi M, Morita T, Minami Y, Nakajima T, Hirata Y, Nagai R, Sata M. Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation. Cardiovasc Res. 101: 236-246, 2014.

2013

Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 23: 1172-1186, 2013.

Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol. 15: 1098-1106, 2013.

2003-2012

Sahara M*, Sata M, Morita T, Hirata Y, Nagai R. Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension. PLoS One. 7: e33367, 2012.

Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M. The ATP-binding cassette transporter subfamily G member 2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. Arterioscler Thromb Vasc Biol. 32: 654-661, 2012.

Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M. The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function. Arterioscler Thromb Vasc Biol. 30: 2128-2135, 2010.

Sahara M*, Sata M, Morita T, Nakajima T, Hirata Y, Nagai R. A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway. Arterioscler Thromb Vasc Biol. 30: 1315-1324, 2010.

Sugiyama H, Sahara M, Imai Y, Ono M, Okamoto K, Kikuchi K, Nagai R. Infective endocarditis by Bartonella quintana masquerading as antineutrophil cytoplasmic antibody-associated small vessel vasculitis. Cardiology. 114: 208-211, 2009.

Sahara M, Sata M, Morita T, Nakamura K, Hirata Y, Nagai R. Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation. Circulation. 115: 509-517, 2007.

Sahara M*, Takahashi T, Imai Y, Nakajima T, Yao A, Morita T, Hirata Y, Nagai R. New insights in the treatment strategy for pulmonary arterial hypertension. Cardiovasc Drugs Ther. 20: 377-386, 2006.

Sahara M, Sata M, Matsuzaki Y, Tanaka K, Morita T, Hirata Y, Okano H, Nagai R. Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury. Stem Cells. 23: 874-8, 2005.

Sahara M*, Kirigaya H, Oikawa Y, Yajima J, Nagashima K, Hara H, Ogasawara K, Aizawa T. Soft plaque detected on intravascular ultrasound is the strongest predictor of in-stent restenosis: an intravascular ultrasound study. Eur Heart J. 25: 2026-33, 2004.

Ogasawara K, Mashiba S, Wada Y, Sahara M, Uchida K, Aizawa T, Kodama T. A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease. Atherosclerosis. 174: 349-56, 2004.

Sahara M*, Kirigaya H, Oikawa Y, Yajima J, Ogasawara K, Satoh H, Nagashima K, Hara H, Nakatsu Y, Aizawa T. Arterial remodeling patterns before intervention predict diffuse in-stent restenosis: an intravascular ultrasound study. J Am Coll Cardiol. 42: 1731-8, 2003.