Smart Maneuver: Epstein-Barr Virus Hijacks Host Genome Boosting Nasopharyngeal Carcinoma
Mar 26, 2024
Researchers unravel the mechanisms of Epstein-Barr virus (EBV) and host chromatin interactions in nasopharyngeal cancer cells
Nasopharyngeal cancer (NPC) is a rare cancer of the nasopharynx and is associated with an accompanying Epstein-Barr virus (EBV) infection. EBV is known to alter the host genome and activate latent genes promoting tumor formation. However, EBV-host epigenomic interactions and alterations in NPC are not well understood. In a recent study now, researchers from Japan and Singapore have revealed that EBV hijacked host enhancers to rewire the host genome and dysregulate gene expression, thus promoting NPC progression.
Reference
Title：
Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma
Journal：
eBioMedicine
DOI：
