Articles and Publications

298.Rahman MF, Islam A, Islam MM, Mamun MA, Xu L, Sakamoto T, Sato T, Takahashi Y, Kahyo T, Aoyagi S, Kaibuchi K, Setou M.

Mass Spectrometry Imaging Combined with Sparse Autoencoder Method Reveals Altered Phosphorylcholine Distribution in Imipramine Treated Wild-Type Mice Brains.
Int J Mol Sci. 2024 Jul 21;25(14):7969. doi: 10.3390/ijms25147969.

297.Islam MS, Ema S, Nabi MM, Rahman MM, Waliullah ASM, Yan J, Ferdous R, Sakamoto T, Takahashi Y, Kato A, Sato T, Kahyo T, Setou M.

Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration.
PLoS One. 2024 Jul 19;19(7):e0299757. doi: 10.1371/journal.pone.0299757. eCollection 2024.

296.Yan J, Kahyo T, Zhang H, Ping Y, Zhang C, Jiang S, Ji Q, Ferdous R, Islam MS, Oyama S, Aramaki S, Sato T, Mimi MA, Hasan MM, Setou M.

Alpha-Synuclein Interaction with UBL3 Is Upregulated by Microsomal Glutathione S-Transferase 3, Leading to Increased Extracellular Transport of the Alpha-Synuclein under Oxidative Stress.
Int J Mol Sci. 2024 Jul 4;25(13):7353. doi: 10.3390/ijms25137353.

295.Rahman MM, Islam A, Mamun MA, Afroz MS, Nabi MM, Sakamoto T, Sato T, Kahyo T, Takahashi Y, Okino A, Setou M.

Low-Temperature Plasma Pretreatment Enhanced Cholesterol Detection in Brain by Desorption Electrospray Ionization-Mass Spectrometry Imaging.
J Am Soc Mass Spectrom. 2024 Jun 5;35(6):1227-1236. doi: 10.1021/jasms.4c00045. Epub 2024 May 22.

294.Takanashi Y, Kahyo T, Sekihara K, Kawase A, Setou M, Funai K.

Prognostic potential of lipid profiling in cancer patients: a systematic review of mass spectrometry-based studies.
Lipids Health Dis. 2024 May 25;23(1):154. doi: 10.1186/s12944-024-02121-0.

293.Islam MM, Rahman MF, Islam A, Afroz MS, Mamun MA, Rahman MM, Maniruzzaman M, Xu L, Sakamoto T, Takahashi Y, Sato T, Kahyo T, Setou M.

Elucidating Gender-Specific Distribution of Imipramine, Chloroquine, and Their Metabolites in Mice Kidney Tissues through AP-MALDI-MSI.
Int J Mol Sci. 2024 Apr 29;25(9):4840. doi: 10.3390/ijms25094840.

292.Xu L, Zhang C, Oyama S, Machida M, Kahyo T, Setou M.

Coarse-graining of perplexity for the spatial distribution of molecules.
Phys Rev E. 2024 Jan;109(1-1):014402. doi: 10.1103/PhysRevE.109.014402.

291.Ishibashi T, Waliullah A.S.M. , Aramaki S, Kamiya M, Kahyo T, Nakamura K, Tasaki E, Takata M, Setou M, Matsuura K.

Plastic brain structure changes associated with the division of labor and aging in termites.
Development, Growth & Differentiation.2023 Jun 25;65(7)371-428.doi/10.1111/dgd.12873.

290.Li W, Zhang C, Aramaki S, Xu L, Tsuge S, Sakamoto T, Mamun MA, Islam A, Hayakawa T, Takanashi Y, Dubail M, Konishi K, Sato T, Kahyo T, Fouillade C, Nakamura K, Setou M.

Lipid Polyunsaturated Fatty Acid Chains in Mouse Kidneys Were Increased within 5 min of a Single High Dose Whole Body Irradiation.
Int J Mol Sci. 2023 Aug 4;24(15):12439. doi: 10.3390/ijms241512439.

289.Arihisa W, Kondo T, Yamaguchi K, Matsumoto J, Nakanishi H, Kunii Y, Akatsu H, Hino M, Hashizume Y, Sato S, Sato S, Niwa SI, Yabe H, Sasaki T, Shigenobu S, Setou M.

Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia.
Neuropsychopharmacol Rep. 2023 Jul 27. doi: 10.1002/npr2.12368. Online ahead of print.

288.Yamashita T, Takanashi Y, Uebayashi A, Oka M, Mizuno K, Kawase A, Oyama S, Kitamoto T, Kondo M, Omori S, Tao H, Takahashi Y, Sakamoto T, Kahyo T, Sugimura H, Setou M, Shiiya N, Funai K.

Lung adenocarcinoma and squamous cell carcinoma difficult for immunohistochemical diagnosis can be distinguished by lipid profile.
Sci Rep. 2023 Jul 26;13(1):12092. doi: 10.1038/s41598-023-37848-w.

287.Kato D, Aoyama Y, Nishida K, Takahashi Y, Sakamoto T, Takeda I, Tatematsu T, Go S, Saito Y, Kunishima S, Cheng J, Hou L, Tachibana Y, Sugio S, Kondo R, Eto F, Sato S, Moorhouse AJ, Yao I, Kadomatsu K, Setou M, Wake H.

Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning.
Glia. 2023 Jul 20. doi: 10.1002/glia.24441.

286.Tasaki E, Mitaka Y, Takahashi Y, Waliullah ASM, Tamannaa Z, Sakamoto T, Islam A, Kamiya M, Sato T, Aramaki S, Kikushima K, Horikawa M, Nakamura K, Kahyo T, Takata M, Setou M, Matsuura K.

The royal food of termites shows king and queen specificity.
PNAS Nexus. 2023 Jul 4;2(7):pgad222. doi: 10.1093/pnasnexus/pgad222. eCollection 2023 Jul.

285.Chen B, Hasan MM, Zhang H, Zhai Q, Waliullah ASM, Ping Y, Zhang C, Oyama S, Mimi MA, Tomochika Y, Nagashima Y, Nakamura T, Kahyo T, Ogawa K, Kaneda D, Yoshida M, Setou M.

UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib
Biomedicines. 2023 Jun 10;11(6):1685. doi: 10.3390/biomedicines11061685.

284.Ishibashi T, Waliullah ASM, Aramaki S, Kamiya M, Kahyo T, Nakamura K, Tasaki E, Takata M, Setou M, Matsuura K.

Plastic brain structure changes associated with the division of labour and ageing in termites
Dev Growth Differ. 2023 Jun 25. doi: 10.1111/dgd.12873.

283.Mamun MA, Rahman MM, Sakamoto T, Islam A, Oyama S, Nabi MM, Sato T, Kahyo T, Takahashi Y, Setou M.

Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 μm Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope.
J Am Soc Mass Spectrom. 2023 Jun 12. doi: 10.1021/jasms.3c00149.

282.Ping Y, Ohata K, Kikushima K, Sakamoto T, Islam A, Xu L, Zhang H, Chen B, Yan J, Eto F, Nakane C, Takao K, Miyakawa T, Kabashima K, Watanabe M, Kahyo T, Yao I, Fukuda A, Ikegami K, Konishi Y, Setou M.

Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain
Biomolecules. 2023 May 1;13(5):784. doi: 10.3390/biom13050784.

281.Aramaki S, Tsuge S, Islam A, Eto F, Sakamoto T, Oyama S, Li W, Zhang C, Yamaguchi S, Takatsuka D, Hosokawa Y, Waliullah ASM, Takahashi Y, Kikushima K, Sato T, Koizumi K, Ogura H, Kahyo T, Baba S, Shiiya N, Sugimura H, Nakamura K, Setou M.

Lipidomics-based tissue heterogeneity in specimens of luminal breast cancer revealed by clustering analysis of mass spectrometry imaging: A preliminary study.
PLoS One. 2023 May 10;18(5):e0283155. doi: 10.1371/journal.pone.0283155. eCollection 2023.

280.Sano F, Kikushima K, Benner S, Xu L, Kahyo T, Yamasue H, Setou M.

Associations between prefrontal PI (16:0/20:4) lipid, TNC mRNA, and APOA1 protein in schizophrenia: A trans-omics analysis in post-mortem brain
Front Psychiatry. 2023 Apr 18;14:1145437. doi: 10.3389/fpsyt.2023.1145437. eCollection 2023.

279.Muraki R, Morita Y, Ida S, Kitajima R, Furuhashi S, Takeda M, Kikuchi H, Hiramatsu Y, Takanashi Y, Hamaya Y, Sugimoto K, Ito J, Kawata K, Kawasaki H, Sato T, Kahyo T, Setou M, Takeuchi H.

Phosphatidylcholine in bile-derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma.
Cancer Med. 2023 Apr 25. doi: 10.1002/cam4.5973. Online ahead of print.

278.Xu L, Kikushima K, Sato S, Islam A, Sato T, Aramaki S, Zhang C, Sakamoto T, Eto F, Takahashi Y, Yao I, Machida M, Kahyo T,Setou M.

Spatial distribution of the Shannon entropy for mass spectrometry imaging.
PLoS One. 2023 Apr 6;18(4):e0283966. doi: 10.1371/journal.pone.0283966. eCollection 2023.

277.Waliullah ASM, Sakamoto T, Uchiyama T , Itai E , Naru E, Inomata K, Mamun MA, Hasan MM, Fukui R, Sato T, Takahashi Y , Honda T, Kahyo T, Setou M.

Detection of highly abundant small molecules in the stratum corneum of healthy young women using desorption electrospray ionization-mass spectrometry imaging.
Medical Mass Spectrometry. 2023 June; 7(1). doi: 10.24508/mms.2023.06.001. Epub 2022 Oct 11.

276.Takanashi Y, Kahyo T, Hayakawa T, Sekihara K, Kawase A, Kondo M, Kitamoto T, Takahashi Y, Sato T, Sugimura H, Shiiya N, Setou M, Funai K.

Lipid biomarkers that reflect postoperative recurrence risk in lung cancer patients who smoke: a case-control study.
Lipids Health Dis. 2023 Jan 28;22(1):15. doi: 10.1186/s12944-023-01778-3.

275.Zhai Q, Islam A, Chen B, Zhang H, Chi DH, Mamun MA, Takahashi Y, Sato N, Yamasue H, Nakajima Y, Nagashima Y, Sano F, Sato T, Kahyo T, Setou M.

Endocannabinoid 2-Arachidonoylglycerol Levels in the Anterior Cingulate Cortex, Caudate Putamen, Nucleus Accumbens, and Piriform Cortex Were Upregulated by Chronic Restraint Stress.
Cells. 2023 Jan 21;12(3):393. doi: 10.3390/cells12030393.

274.Zhang H, Chen B, Waliullah ASM, Aramaki S, Ping Y, Takanashi Y, Zhang C, Zhai Q, Yan J, Oyama S, Kahyo T, Setou M.

A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins-UBL3.
Int J Mol Sci. 2023 Jan 8;24(2):1231. doi: 10.3390/ijms24021231.

273.Kurihara M, Mano T, Eto F, Yao I, Sato K, Ohtomo G, Bannai T, Shibata S, Ishiura H, Ikemura M, Matsubara T, Morishima M, Saito Y, Murayama S, Toda T, Setou M, Iwata A.

Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease.
Neurobiol Dis. 2023 Feb;177:105989. doi: 10.1016/j.nbd.2023.105989. Epub 2023 Jan 5.

272.Zhang C, Xu Li, Endo M, Kahyo T, Kikushima K, Horikawa M, Murakami M, Waliullah ASM, Hasan MM, Sakamoto T, Takahashi Y, Aramaki S, Ozawa T, Setou M

Blue light alters cellular lipidome--Light-induced lipidomic changes can be modulated by optogenetically engineered cPLA2α.
Journal of Photochemistry and Photobiology. 2022 Dec;12. doi: 10.1016/j.jpap.2022.100150. Epub 2022 Oct 27.

Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease.
Neurobiol Dis. 2023 Feb;177:105989. doi: 10.1016/j.nbd.2023.105989. Epub 2023 Jan 5.

271.Zhang C, Kikushima K, Endo M, Kahyo T, Horikawa M, Matsudaira T, Tanaka T, Takanashi Y, Sato T, Takahashi Y, Xu L, Takayama N, Islam A, Mamun MA, Ozawa T, Setou M.

Imaging and Manipulation of Plasma Membrane Fatty Acid Clusters Using TOF-SIMS Combined Optogenetics.
Cells. 2022 Dec 20;12(1):10. doi: 10.3390/cells12010010.

270.Kurosu K, Islam A, Sato T, Kahyo T, Banno T, Sato N, Matsuyama Y, Setou M.

Expression and Kinetics of Endogenous Cannabinoids in the Brain and Spinal Cord of a Spare Nerve Injury (SNI) Model of Neuropathic Pain.
Cells. 2022 Dec 19;11(24):4130. doi: 10.3390/cells11244130.

269.Islam A, Sakamoto T, Zhai Q, Rahman MM, Mamun MA, Takahashi Y, Kahyo T, Setou M.

Application of AP-MALDI Imaging Mass Microscope for the Rapid Mapping of Imipramine, Chloroquine, and Their Metabolites in the Kidney and Brain of Wild-Type Mice.
Pharmaceuticals (Basel). 2022 Oct 25;15(11):1314. doi: 10.3390/ph15111314.

268.Yan J, Sakamoto T, Islam A, Ping Y, Oyama S, Fuchino H, Kawakami H, Yoshimatsu K, Kahyo T, Setou M.

Cinnamomum verum J. Presl Bark Contains High Contents of Nicotinamide Mononucleotide.
Molecules. 2022 Oct 19;27(20):7054. doi: 10.3390/molecules27207054.

267.Yamada H, Xu L, Eto F, Takeichi R, Islam A, Mamun MA, Zhang C, Yao I, Sakamoto T, Aramaki S, Kikushima K, Sato T, Takahashi Y, Machida M, Kahyo T, Setou M.

Changes of Mass Spectra Patterns on a Brain Tissue Section Revealed by Deep Learning with Imaging Mass Spectrometry Data.
J Am Soc Mass Spectrom. 2022 Sep 7;33(9):1607-1614. doi: 10.1021/jasms.2c00080. Epub 2022 Jul 26.

266.Mamun MA, Nabi MM, Sato T, Aramaki S, Takanashi Y, Sakamoto T, Hizume K, Mori C, Yasue M, Ozaki M, Islam A, Kahyo T, Horikawa M, Takahashi Y, Okazaki S, Ohishi K, Nagashima Y, Seno K, Hotta Y, Setou M.

Coenzyme Q10 in the eye isomerizes by sunlight irradiation.
Sci Rep. 2022 Jul 15;12(1):12104. doi: 10.1038/s41598-022-16343-8.

265.Ijaz F, Nakazato R, Setou M, Ikegami K.

A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution.
Sci Rep. 2022 Jul 8;12(1):11681. doi: 10.1038/s41598-022-15776-5.

264.Hiraide T, Morita Y, Horikawa M, Sugiyama E, Sato T, Kahyo T, Furuhashi S, Takeda M, Kikuchi H, Hiramatsu Y, Sakaguchi T, Konno H, Setou M, Takeuchi H.

Saturated Fatty Acids in Cell Membrane Lipids Induce Resistance to 5-Fluorouracil in Colorectal Cancer Cells.
Anticancer Res. 2022 Jul;42(7):3313-3324. doi: 10.21873/anticanres.15819.PMID: 35790250

263.Zhang C, Horikawa M, Kahyo T, Matsudaira T, Tanaka T, Xu L, Takei S, Setou M.

Glutaraldehyde and Uranyl Acetate Dual Fixation Combined Sputtering/Unroofing Enables Intracellular Fatty Acids TOF-SIMS Imaging with Organelle-Corresponding Subcellular Distribution.
Microscopy (Oxf). 2022 Jun 28:dfac034. doi: 10.1093/jmicro/dfac034. Online ahead of print.PMID: 35762441

262.Nabi MM, Sakamoto T, Mamun MA, Islam A, Waliullah ASM, Aramaki S, Hasan MM, Ema S, Kato A, Takahashi Y, Kahyo T, Setou M, Sato T.

A convenient online desalination tube coupled with mass spectrometry for the direct detection of iodinated contrast media in untreated human spent hemodialysates.
PLoS One. 2022 Jun 6;17(6):e0268751. doi: 10.1371/journal.pone.0268751. eCollection 2022.PMID: 35666735 Free PMC article.

261.Kondo N, Sakurai Y, Takata T, Kano K, Kume K, Maeda M, Takai N, Suzuki S, Eto F, Kikushima K, Wanibuchi H, Miyatake SI, Kajihara T, Oda S, Setou M, Aoki J, Suzuki M.

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
Sci Rep. 2022 May 24;12(1):8718. doi: 10.1038/s41598-022-12293-3.PMID: 35610277 Free PMC article.

260.Katsumata M, Fujisawa T, Kamiya Y, Tanaka Y, Kamiya C, Inoue Y, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Maekawa M, Setou M, Watanabe H, Ikegami K, Suda T.

Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium.
BMC Pulm Med.2022 May 8;22(1):186. doi: 10.1186/s12890-022-01983-3.

259.Akita K, Kikushima K, Ikoma T, Islam A, Sato T, Yamamoto T, Kahyo T, Setou M, Maekawa Y.

The association between the clinical severity of heart failure and docosahexaenoic acid accumulation in hypertrophic cardiomyopathy.
BMC Res Notes.2022 Apr 14;15(1):139. doi: 10.1186/s13104-022-06023-1.

258.Islam A, Takeyama E, Nabi MM, Zhai Q, Fukushima M, Watanabe N, Al Mamun M, Kikushima K, Kahyo T, Setou M.

Stress upregulates 2-arachidonoylglycerol levels in the hypothalamus, midbrain, and hindbrain, and it is sustained by green nut oil supplementation in SAMP8 mice revealed by DESI-MSI.
Biochem Biophys Res Commun.2022 Jun 18;609:9-14. doi: 10.1016/j.bbrc.2022.04.004. Epub 2022 Apr 4.

257.Takanashi Y, Kahyo T, Kamamoto S, Zhang H, Chen B, Ping Y, Mizuno K, Kawase A, Koizumi K, Satou M, Funai K, Shiiya N, Setou M.

Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles.
Cell Struct Funct.2022;47(1):1-18. doi: 10.1247/csf.21078.

256.Chi DH, Kahyo T, Islam A, Hasan MM, Waliullah ASM, Mamun MA, Nakajima M, Ikoma T, Akita K, Maekawa Y, Sato T, Setou M.

NAD+ Levels Are Augmented in Aortic Tissue of ApoE-/- Mice by Dietary Omega-3 Fatty Acids.
Arterioscler Thromb Vasc Biol. 2022 Feb 10:ATVBAHA121317166. doi:10.1161/ATVBAHA.121.317166.

255.Hino M, Kondo T, Kunii Y, Matsumoto J, Wada A, Niwa SI, Setou M, Yabe H.

Tubulin/microtubules as novel clozapine targets.
Neuropsychopharmacol Rep. 2022 Mar;42(1):32-41. doi: 10.1002/npr2.12221. Epub 2021 Dec 28.

254.Yamada T, Horikawa M, Sato T, Kahyo T, Takanashi Y, Ushirozako H, Kurosu K, Al Mamun M, Mihara Y, Oe S, Arima H, Banno T, Yosida G, Hasegawa T, Yamato Y, Matsuyama Y, Setou M.

Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with abnormal accumulation of specific lipids.
Sci Rep. 2021 Dec 6;11(1):23515. doi:10.1038/s41598-021-02818-7.

253.Takanashi Y, Funai K, Eto F, Mizuno K, Kawase A, Tao H, Kitamoto T, Takahashi Y, Sugimura H, Setou M, Kahyo T, Shiiya N.

Decreased sphingomyelin (t34:1) is a candidate predictor for lung squamous cell carcinoma recurrence after radical surgery: a case-control study.
BMC Cancer. 2021 Nov 17;21(1):1232. doi:10.1186/s12885-021-08948-5.

252.Ito TK, Sato T, Takanashi Y, Tamannaa Z, Kitamoto T, Odagiri K, Setou M.

A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NADþ levels in healthy subjects.
Translational Medicine of Aging. 5 (2021) 43-51.

251.Takeda R, Islam A, Sato T, Kurita H, Kahyo T, Urano T, Setou M.

The stability of the metabolic turnover of arachidonic acid in human unruptured intracranial aneurysmal walls is sustained.
Clin Neurol Neurosurg. 2021 Sep;208:106881. doi: 10.1016/j.clineuro.2021.106881. Epub 2021 Aug 8.

250.Kikushima K, Terao Y, Miyazaki H, Nagae M, Ohnuki K, Satou D, Shimizu K, Ohnuki K.

Improvement of Cognitive Functions by Taking Supplement Containing Panax ginseng -A Randomized, Placebo-controlled, Double-blind, Clinical Study -
Jpn Pharmacol Ther（薬理と治療）vol.49, no.7 pp1149-1156.

248.Mamun MA, Islam A, Hasan MM, Waliullah ASM, Tamannaa Z, Huu Chi D, Sato T, Kahyo T, Kikushima K, Takahashi Y, Naru E, Sakata O, Yamanoi M, Kobayashi E, Izumi K, Honda T, Tokura Y, Setou M.

The human vermilion surface contains a rich amount of cholesterol sulfate than the skin.
J Dermatol Sci. 2021 Jul 27:S0923-1811(21)00174-2. doi: 10.1016/j.jdermsci.2021.07.008. Online ahead of print.

247.Pham PT, Fukuda D, Nishimoto S, Kim-Kaneyama JR, Lei XF, Takahashi Y, Sato T, Tanaka K, Suto K, Kawabata Y, Yamaguchi K, Yagi S, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Shimada K, Kanematsu Y, Takagi Y, Shimabukuro M, Setou M, Barber GN, Sata M.

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases.
Eur Heart J. 2021 Jul 6:ehab249. doi: 10.1093/eurheartj/ehab249. Online ahead of print.

246.Matsumoto T, Takiyama M, Sakamoto T, Kaifuchi N, Watanabe J, Takahashi Y, Setou M.

Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice.
J Ethnopharmacol. 2021 Jun 12;279:114332. doi: 10.1016/j.jep.2021.114332. Online ahead of print.

245.Umbarawan Y, Enoura A, Ogura H, Sato T, Horikawa M, Ishii T, Sunaga H, Matsui H, Yokoyama T, Kawakami R, Maeno T, Setou M, Kurabayashi M, Iso T.

FABP5 Is a Sensitive Marker for Lipid-Rich Macrophages in the Luminal Side of Atherosclerotic Lesions.
Int Heart J. 2021 May 29;62(3):666-676. doi: 10.1536/ihj.20-676. Epub 2021 May 15.

244.Matsuo T, Isosaka T, Hayashi Y, Tang L, Doi A, Yasuda A, Hayashi M, Lee CY, Cao L, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu Q, Kobayakawa R, Kobayakawa K.

Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.
Nat Commun. 2021 Apr 6;12(1):2074. doi: 10.1038/s41467-021-22205-0.

243.Nabi M, Mamun A, Islam A, Hasan M, Waliullah ASM, Tamannaa Z, Sato T, Kahyo T, Setou M.

Mass spectrometry in the lipid study of cancer.
Expert Rev Proteomics. 2021 Mar;18(3):201-219. doi: 10.1080/14789450.2021.1912602. Epub 2021 May 3.

242.Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M and Takeuchi H.

Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.
ANTICANCER RESEARCH,2021 Apr;41(4):1733-1744. doi: 10.21873/anticanres.14938.

241.Nakamizo S, Honda T, Sato T, Mamun MA, Chow Z, Duan K, Lum J, Tan KJ, Tomari K, Sato R, Kitoh A, Tay ASL, Common JEA, Guan NL, Setou M, Ginhoux F, Kabashima K.

High-fat diet induces follicular hyperkeratinization and predisposes to develop neutrophilic folliculitis in mice
J Allergy Clin Immunol. 2021 Mar 10:S0091-6749(21)00363-8. doi: 10.1016/j.jaci.2021.02.032. Online ahead of print.

240.Hasan MM, Eto F, Mamun MA, Sato S, Islam A, Waliullah ASM, Chi DH, Takahashi Y, Kahyo T, Naito Y, Kotani M, Ohmura T, Setou M.

Desorption ionization using through‐hole alumina membrane offers higher reproducibility than 2,5‐dihydroxybenzoic acid, a widely used matrix in Fourier transform ion cyclotron resonance mass spectrometry imaging analysis.
Rapid Commun Mass Spectrom. 2021 Mar 2:e9076. doi: 10.1002/rcm.9076. Online ahead of print.

239.Adachi K, Kato D, Kahyo T, Konishi T, Sato T, Madokoro Y, Mizuno M, Akatsu H, Setou M, Matsukawa N.

Possible correlated variation of GABA A receptor α3 expression with hippocampal cholinergic neurostimulating peptide precursor protein in the hippocampus
Biochem Biophys Res Commun. 2021 Jan 24;542:80-86. doi: 10.1016/j.bbrc.2021.01.010. Online ahead of print

238.Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T.

Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium.
Respir Res. 2020 Oct 27;21(1):282. doi: 10.1186/s12931-020-01555-1.

237.Eto F, Sato S, Setou M, Yao I and Sato K.

Mass spectrometry imaging reveals glycine distribution in the developing mouse brain.
J Chem Neuroanat. 2020 Dec;110:101869. doi:10.1016/j.jchemneu.2020.101869. Epub 2020 Oct 21.

236.Takanashi Y, Funai K, Sato S, Kawase A, Tao H, Takahashi Y, Sugimura H, Setou M, Kahyo T, Shiiya N.

Sphingomyelin(d35:1) as a novel predictor for lung adenocarcinoma recurrence after a radical surgery: a case-control study.
BMC Cancer. 2020 Aug 24;20(1):800. doi: 10.1186/s12885-020-07306-1.

235.Ito TK, Sato T,Hakamata A, Onoda Y, Sato S, Yamazaki F, Horikawa M,Takahashi Y, Kitamoto T, Suzuki M, Uchida S, Odagiri K, Setou M.

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NADþ levels in healthy subjects.
Translational Medicine of Aging. 4(2020):45-54.

234.Sano M, Hirakawa S, Suzuki M, Sakabe JI, Ogawa M, Yamamoto S, Hiraide T, Sasaki T, Yamamoto N, Inuzuka K, Tanaka H, Saito T, Sugisawa R, Katahashi K, Yata T, Kayama T, Urano T, Tokura Y, Sato K, Setou M, Takeuchi H, Konno H, Unno N.

Potential role of transforming growth factor-beta 1/Smad signaling in secondary lymphedema after cancer surgery.
Cancer Sci. 2020 Jul;111(7):2620-2634. doi: 10.1111/cas.14457. Epub 2020 Jun 9.

233.Lan H, Suzuki H, Nagatake T, Hosomi K, Ikegami K, Setou M, Kunisawa J.

Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine.
Int Immunol. 2020 Jul 28;32(8):559-568. doi: 10.1093/intimm/dxaa029.

232.Matsumoto T, Ikarashi Y, Takiyama M, Watanabe J & Setou M.

Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis.
Scientific Reports. 2020 Apr 29;10(1):7293. doi: 10.1038/s41598-020-63474-x.

231.Eto F, Sato S, Setou M, and Yao I.

Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain.
Scientific Reports. 2020 May 4;10(1):7435. doi: 10.1038/s41598-020-64277-w.

230.Islam A, Takeyama E, Mamun MA, Sato T, Horikawa M, Takahashi Y, Kikushima K, Setou M.

Green Nut Oil or DHA Supplementation Restored Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia.
Metabolites. 2020 Apr 16;10(4):153. doi: 10.3390/metabo10040153.

229.Mamun MA, Sato S, Naru E, Sakata O, Hoshikawa E, Suzuki A, Islam A, Kahyo T, Sato T, Ito TK, Horikawa M, Fukui R, Izumi K, Setou M.

Higher Accumulation of Docosahexaenoic Acid in the Vermilion of the Human Lip than in the Skin.
Int J Mol Sci.　2020 Apr 17;21(8):2807. doi: 10.3390/ijms21082807.

228.Furuhashi S, Sakaguchi T, Murakami T, Fukushima M, Morita Y, Ikegami K, Kikuchi H, Setou M, Takeuchi H.

Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma.
Pancreas. 2020 Mar;49(3):442-454. doi: 10.1097/MPA.0000000000001506.

227.Nakashima Y, Eto F, Ishihara K, Yamazaki F, Sato S, Sakurai T, Kahyo T, Setou M.

Development of sheet enhanced technique (Set) method for MALDI-IMS.
Rapid Commun Mass Spectrom. 2019 Dec 15:e8703. doi: 10.1002/rcm.8703. [Epub ahead of print].

226.Takeyama E, Islam A, Watanabe N, Tsubaki H, Fukushima M, Mamun MA, Sato S, Sato T, Eto F, Yao I, Ito TK, Horikawa M, Setou M.

Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery.
Nutrients. 2019 Oct 4;11(10). pii: E2371. doi: 10.3390/nu11102371.

225.Sugiyama E, Matteo MG, Honda K, Hattori Y, Abe M, Patrik K, Per EA, Tanaka KF, Setou M, Sidonia F, Suematsu M, Sugiura Y.

Detection of a high turnover serotonin circuit in the mouse brain using mass spectrometry imaging.
iScience, 2019 Oct 25;20:359-372. doi: 10.1016/j.isci.2019.09.036. Epub 2019 Sep 27..

224.Nampei M, Horikawa M, Ishizu K, Yamazaki F, Yamada H, Kahyo T, Setou M.

Unsupervised machine learning using an imaging mass spectrometry dataset automatically reassembles grey and white matter.
Scientific Reports, 2019 Sep 13;9(1):13213.doi: 10.1038/s41598-019-49819-1.

223.Hino K, Kaneko S, Harasawa T, Kimura T, Takei S, Shinohara M, Yamazaki F, Morita SY, Sato S, Kubo Y, Kono T, Setou M, Yoshioka M, Fujino J, Sugihara H, Kojima H, Yamada N, Udagawa J.

Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats.
J Neurosci.2019 Sep 25;39(39):7689-7702. doi: 10.1523/JNEUROSCI.2721-18.2019. Epub 2019 Aug 7.

222.Sato T, Horikawa M, Takei S, Yamazaki F, Ito TK, Kondo T, Sakurai T, Kahyo T, Ikegami K, Sato S, Sato R, Jinno Y, Kawano H, Naoe S, Arita M, Kashiwagi Y, Setou M.

Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques.
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1802-1816. doi: 10.1161/ATVBAHA.119.313093. Epub 2019 Aug 1.

221.Mamun MA, Valdes Gonzalez-T, Islam A, Sato T,Sato S, Ito KT, Horikawa M, Yamazaki Fm Alarcon RC, Ido T, Setou M.

Analysis of potential anti-aging beverage Pru, a traditional Cuban refreshment, by desorption electrospray innization-mass spectrometry and FTICR tandem mass spectrometry.
Journal of Food and Drug Analysis, 2019 Oct;27(4):833-840. doi: 10.1016/j.jfda.2019.05.004. Epub 2019 Jun 27.

220.Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T.

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Cell. 2019 Jun 27;178(1):261. doi: 10.1016/j.cell.2019.06.015. No abstract available.

219.Nakashima Y, Sato H, Shioda H, Setou M.

Pilot study of measurement method of skin transparency using smartphone camera.
Skin Res Technol. 2019 May 22. doi: 10.1111/srt.12723. [Epub ahead of print]

218.Aizawa F, Sato S, Yamazaki F, Yao I, Yamashita T, Nakamoto K, Kasuya F, Setou M, Tokuyama S.

N-3 fatty acids modulate repeated stress-evoked pain chronicity.
Brain Res. 2019 Jul 1;1714:218-226. doi: 10.1016/j.brainres.2019.03.001. Epub 2019 Mar 2.

217.Saito Y, Eto F, Takei S, Yao I, Setou M.

Imaging mass spectrometry reveals sodium lauryl sulfate-induced changes in skin lipoquality, principally affecting sphingomyelin.
Medical Mass3 Spectrometry. 2019 June 11;3(1):35-42.doi: 10.24508/mms.2019.06.004.

216.Tamura K, Horikawa M, Sato S, Miyake H and Setou M.

Discovery of lipid biomarkers correlated with disease progression in clear cell renal cell carcinoma using desorption electrospray ionization imaging mass spectrometry.
Oncotarget. 2019 Mar 1;10(18):1688-1703. doi: 10.18632/oncotarget.26706. eCollection 2019 Mar 1.

215.Mori N, Mochizuki T, Yamazaki F, Takei S, Mano H, Matsugi T, Setou M.

MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration.
PLoS One. 2019 Jan 25;14(1):e0211376. doi: 10.1371/journal.pone.0211376. eCollection 2019.

214.Katoh TA, Ikegami K, Uchida N, Iwase T, Nakane D, Masaike T, Setou M, Nishizaka T.

Three-dimensional tracking of microbeads attached to the tip of single isolated tracheal cilia beating under external load.
Sci Rep. 2018 Oct 22;8(1):15562. doi: 10.1038/s41598-018-33846-5.

213.Mihara Y, Horikawa, Sato S, Eto F, Hanada M, Banno T, Arima H, Ushirozako H, Yamada T, Xu D, Okamoto A, Yamazaki F, Takei S, Omura T, Yao I, Matsuyama Y, Setou M.

Lysophosphatidic acid precursor levels decrease and an arachidonic acid-containing phosphatidylcholine level increases in the dorsal root ganglion of mice after peripheral nerve injury.
Neuroscience Letters.2018 Dec 26;698:69-75. doi: 10.1016/j.neulet.2018.12.035. [Epub ahead of print]

212.Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.

UBL3 modification influences protein sorting to small extracellular vesicles.
Nat Commun. 2018 Sep 26;9(1):3936. doi: 10.1038/s41467-018-06197-y.

211.Takeda M, Sakaguchi T, Hiraide T, Shibasaki Y, Morita Y, Kikuchi H, Ikegami K, Setou M, Konno H, Takeuchi H.

Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease.
Cancer Sci. 2018 Aug;109(8):2401-2411. doi: 10.1111/cas.13659. Epub 2018 Jul 7.

210.Kimura Y, Tsutsumi K, Konno A, Ikegami K, Hameed S, Kaneko T, Kaplan OI, Teramoto T, Fujiwara M, Ishihara T, Blacque OE, Setou M.

Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway.
Sci Rep. 2018 May 30;8(1):8392. doi: 10.1038/s41598-018-26694-w.

209.Nakashima Y,Setou M.

Distribution of antisense oligonucleotides in rat eyeballs using MALDI imaging mass spectrometry and spatial scale of analysis.
Mass Spectrom (Tokyo). 2018;7(1):A0070. doi: 10.5702/massspectrometry.A0070. Epub 2018 Sep 11.

208.Sato S, Horikawa M, Kondo T, Sato T, Setou M.

A power law distribution of metabolite abundance levels in mice regardless of the time and spatial scale of analysis.
Sci Rep. 2018 Jul 9;8(1):10315. doi: 10.1038/s41598-018-28667-5.

207.Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J.

Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.
Sci Rep. 2018 Feb 13;8(1):2904. doi: 10.1038/s41598-018-21120-7.

206.Russo D, Della Ragione F, Rizzo R, Sugiyama E, Scalabrì F, Hori K, Capasso S, Sticco L, Fioriniello S, De Gregorio R, Granata I, Guarracino MR, Maglione V, Johannes L, Bellenchi GC, Hoshino M, Setou M, D'Esposito M, Luini A, D'Angelo G.

Glycosphingolipid metabolic reprogramming drives neural differentiation.
EMBO J. 2018 Apr 3;37(7). pii: e97674. doi: 10.15252/embj.201797674. Epub 2017 Dec 27.

205.Shibasaki Y, Horikawa M, Ikegami K, Kiuchi R, Takeda M, Hiraide T, Morita Y, Konno H, Takeuchi H, Setou M, Sakaguchi T.

The stearate-to-palmitate ratio modulates endoplasmic reticulum stress and cell apoptosis in non-B non-C hepatoma cells.
Cancer Sci. 2018 Apr;109(4):1110-1120. doi: 10.1111/cas.13529. Epub 2018 Mar 6.

204.Hama K, Fujiwara Y, Morita M, Yamazaki F, Nakashima Y, Takei S, Takashima S, Setou M, Shimozawa N, Imanaka T and Yokoyama K.

Profiling and imaging of phospholipids in brain of Abcd1-deficient mice
Lipids. 2018 Jan;53(1):85-102. doi: 10.1002/lipd.12022. Epub 2018 Feb 22.

203.Sugiyama E, Yao I, Setou M.

Visualization of Local Phosphatidylcholine Synthesis within Hippocampal Neurons Using a Compartmentalized Culture System and Imaging Mass Spectrometry
Biochemical and Biophysical Research Communications, 2017 Nov 21. pii: S0006-291X(17)32287-8. doi: 10.1016/j.bbrc.2017.11.108. Epub 2017 Nov 21.

202.Ikedo T, Minami M, Kataoka H, Hayashi K, Nagata M, Fujikawa R, Yamazaki F, Setou M, Yokode M, Miyamoto S.

Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms.
Biochem Biophys Res Commun. 2017 Oct 27. pii: S0006-291X(17)32118-6. doi: 10.1016/j.bbrc.2017.10.133. Epub 2017 Oct 27.

201.Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M.

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.
Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017.

200.Hosokawa Y, Masaki N, Takei S, Horikawa M, Matsushita S, Sugiyama E, Ogura H, Shiiya N, Setou M.

Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues.
PLoS One. 2017 Aug 23;12(8):e0183724. doi: 10.1371/journal.pone.0183724. eCollection 2017.

199.Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N.

Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.

J Vasc Res. 2017 Jul 6;54(4):200-208. doi: 10.1159/000473879. Epub 2017 Jul 6.

198. Nishio T, Kurabe N, Goto-Inoue N, Nakamura T, Sugimura H, Setou M, Maekawa M.

Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), a candidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ.
Clin Chim Acta.2017 Aug;471:276-282. doi: 10.1016/j.cca.2017.06.011. Epub 2017 Jun 13.

197. Banno T, Omura T, Masaki N, Arima H, Xu D, Okamoto A, Costigan M,Latremoliere A, Matsuyama Y,Setou M.

Arachidonic acid containing phosphatidylcholine increases due to microglial activation in ipsilateral spinal dorsal horn following spared sciatic nerve injury.
Plos One, 2017 May 24;12(5):e0177595. doi: 10.1371/journal.pone.0177595. eCollection 2017.

196. Ishikawa S, Tateya I, Hayasaka T, Shinriki S, Masaki N, Hirano S, Kitamura M, Muto M, Morita S, Setou M, Ito J.

The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma.
Biomed Res Int. 2017;2017:5387913. doi: 10.1155/2017/5387913. Epub 2017 Mar 8.

195. Shintani-Domoto Y, Hayasaka T, Maeda D, Masaki N, Ito TK, Sakuma K, Tanaka M, Kabashima K, Takei S, Setou M, Fukayama M.

Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients.
Biochim Biophys Acta. 2017 Mar 21. pii: S1570-9639(17)30048-1. doi: 10.1016/j.bbapap.2017.03.006. Epub 2017 Mar 21.

194. Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.

Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
Sci Rep. 2017 Mar 23;7:45050. doi: 10.1038/srep45050.

193. Koga K, Yao I, Setou M, Zhuo M.

SCRAPPER selectively contributes to spontaneous release and presynaptic long-term potentiation in the anterior cingulate cortex.
J Neurosci. 2017 Apr 5;37(14):3887-3895. doi: 10.1523/JNEUROSCI.0023-16.2017.

192. Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N.

Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside.
Gene. 2017 May 30;614:49-55. doi: 10.1016/j.gene.2017.03.004. Epub 2017 Mar 14.

191. Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa S, Yabe H, Terasaki T, Setou M and Ohtsuki S.

Downregulation of GNA13-ERK network in prefrontal cortex of
schizophrenia brain identified by combined focused and targeted
quantitative proteomics.
Journal of Proteomics, 2017 Mar 31;158:31-42. doi: 10.1016/j.jprot.2017.02.009.

190. Matsumoto T, Kushida H, Matsushita S, Oyama Y, Suda T, Watanabe J, Kase Y, Setou M.

Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto.
Scientific reports. 2017 Mar 8;7:44098. doi: 10.1038/srep44098.

189. Tanaka H, Yamamoto N, Suzuki M, Mano Y, Sano M, Zaima N, Sasaki T, Setou M, Unno N.

Insufficient Lymph Drainage Causes Abnormal Lipid Accumulation and Vein Wall Degeneration.
Ann Vasc Dis. 2016;9(4):277-284. doi: 10.3400/avd.oa.16-00122.

188. Ijaz F, Hatanaka Y, Hatanaka T, Tsutsumi K, Iwaki T, Umemura K, Ikegami K, Setou M.

Proper cytoskeletal architecture beneath the plasma membrane of red blood cells requires Ttll4.
Mol Biol Cell. 2017 Feb 15; 28(4):535-544. doi: 10.1091/mbc.E16-02-0089.

187. Matsushita S, Masaki N, Sato K, Hayasaka T, Sugiyama E, Hui SP, Chiba H, Mase N, Setou M.

Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometry.
Anal Bioanal Chem. 2017;409(6):1475-1480. doi:10.1007/s00216-016-0119-3.

186. Vu HT, Akatsu H, Hashizume Y, Setou M, Ikegami K.

Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Sci Rep. 2017 Jan 9;7:40205. doi: 10.1038/srep40205.

185. Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T.

Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.
Sci Rep. 2016 Aug 8;6:31268. doi: 10.1038/srep31268.

184. Hiraide T, Ikegami K, Sakaguchi T, Morita Y, Hayasaka T, Masaki N, Waki M, Sugiyama E, Shinriki S, Takeda M, Shibasaki Y, Miyazaki S, Kikuchi H, Okuyama H, Inoue M, Setou M, Konno H.

Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer.
Sci Rep. 2016 Jul 20;6:29935. doi: 10.1038/srep29935.

183. Konno A, Ikegami K, Konishi Y, Yang HJ, Abe M, Yamazaki M, Sakimura K, Yao I, Shiba K, Inaba K and Setou M.

Doublet 7 shortening, doublet 5-preferential poly-Glu reduction, and beating stall of sperm flagella in <I>Ttll9</I><SUP>-/-</SUP> mice.
Journal of Cell Science. 2016 Jul 15;129(14):2757-66. doi: 10.1242/jcs.185983.

182. Xu D, Omura T, Masaki N, Arima H, Banno T, Okamoto A, Hanada M, Takei S, Matsushita S, Sugiyama E, *Setou M, Matsuyama Y.

Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.
Scientific Reports, 2016 May 23;6:26427. doi:10.1038/srep26427.

181. Kurabe N, Igarashi H, Ohnishi I, Tajima S, Inoue Y, Takahashi Y, Setou M, Sugimura H.

Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry.
World J Gastrointest Pathophysiol. 2016 May 15;7(2):235-41. doi: 10.4291/wjgp.v7.i2.235.

180. Kitakaze K, Mizutani Y, Sugiyama E, Tasaki C,Tsuji D, Maita N, Hirokawa T, Asanuma D, Kamiya M,Sato K, Setou M, Urano Y, Togawa T, Otaka A, SakurabaH, Itoh K.

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
J Clin Invest. 2016 May 2;126(5):1691-703. doi:10.1172/JCI85300. Epub 2016 Mar 28.

179. Miyawaki S, Imai H, Hayasaka T, Masaki N, Ono H, Ochi T, Ito A, Nakatomi H, Setou M and Saito.

Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after
transient global ischemia
Neuroscience. 2016 (in press)

178. Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Konno H, Urano T, Setou M, Unno N.

Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms.
J Atheroscler Thromb. 2015 Dec 14. [Epub ahead of print]

177. Akiyoshi T, Ota H, Iijima K, Son BK, Kahyo T, Setou M, Ogawa S, Ouchi Y, Akishita M.

A novel organ culture model of aorta for vascular calcification.
Atherosclerosis. 2016 Jan;244:51-8. doi:10.1016/j.atherosclerosis.2015.11.005. Epub 2015 Nov 10.

176. Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M.

Mechanical Stimulation by Postnasal Drip Evokes Cough.
PLoS One. 2015 Nov 18;10(11):e0141823. doi: 10.1371/journal.pone.0141823. eCollection 2015.

175. Senoo N, Miyoshi N, Goto-Inoue N, Minami K, Yoshimura R, Morita A, Sawada N, Matsuda J, Ogawa J, Setou M, Kamei Y, Miura S.

PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle.
J Lipid Res. 2015 Oct 5. pii: jlr.M060533. [Epub ahead of print]

174. Yamazaki K, Masaki M, Kohmura-Kobayashi Y, Chizuko Y, Hayasaka T, Itoh H, Setou M, Kanayama N.

Decrease in Sphingomyelin (d18:1/16:0) in Stem Villi and Phosphatidylcholine (16:0/20:4) in Terminal Villi of Human Term Placentas with Pathohistological Maternal Malperfusion.
PLos One, 2015 Nov 16;10(11):e0142609. doi: 10.1371/journal.pone.0142609. eCollection 2015.

173. Hirano-Sakamaki W, Sugiyama E, Hayasaka T, Ravid R, Setou M, Taki T.

Alzheimer's disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus.
FEBS Lett. 2015 Nov 30;589(23):3611-6. doi: 10.1016/j.febslet.2015.09.033. Epub 2015 Oct 17.

172. Sugiyama E, Masaki N, Matsushita S, Setou M.

Ammonium sulfate improves detection of hydrophilic quaternary ammonium compounds through decreased ion suppression in matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Chem. 2015 Nov 17;87(22):11176-81. doi: 10.1021/acs.analchem.5b02672. Epub 2015 Nov 6.

171. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M, Kiyono H.

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1.
Cell Rep. 2015 Oct 6;13(1):122-31. doi: 10.1016/j.celrep.2015.08.063. Epub 2015 Sep 24.

170. Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.

Imaging mass spectrometry reveals a unique distribution of triglycerides in abdominal aortic aneurysmal wall.
J Vasc Res. 2015;52(2):127-35. doi: 10.1159/000439169. Epub 2015 Sep 9.

169. Hameed S, Ikegami K, Sugiyama E, Matsushita S, Kimura Y, Hayasaka T, Sugiura Y, Masaki N, Waki M, Ohta I, Hossen MA, Setou M.

Direct profiling of the phospholipid composition of adult Caenorhabditis elegans using whole-body imaging mass spectrometry.
Anal Bioanal Chem. 2015 Oct;407(25)7589-602. doi:10.1007/s00216-015-8932-7. Epub 2015 Aug 27.

168. Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T, Inuzuka K, Hayasaka T,Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.

Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.
PLoS One. 2015 Aug 26;10(8):e0134386. doi: 10.1371/journal.pone.0134386.eCollection 2015.

167. Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.

Collection: Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye.
PLos One. 2015 Aug 19;10(8): e0135619. doi: 10.1371/journal.pone.0135619.

166. Sumpownon C, Engsusophon A, Siangcham T, Sugiyama E, Soonklang N, Meeratana P, Wanichanon C, Hanna PJ, Setou M, Sobhon P.

Variation of prostaglandin E2 concentrations in ovaries and its effects on ovarian maturation and oocyte proliferation in the giant fresh water prawn, Macrobrachium rosenbergii.
Gen Comp Endocrinol. 2015 May 8. pii: S0016-6480(15)00131-8. doi: 10.1016/j.ygcen.2015.04.019. [Epub ahead of print]

165. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H,Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H.

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
Sci Rep. 2015 Jun 11;5:9750. doi: 10.1038/srep9750.

164. Masaki N, Ishizaki I, Hayasaka T, Fisher GL, Sanada N, Yokota H, Setou M.

Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry.
Sci Rep. 2015 May 11;5:10000. doi: 10.1038/srep10000.

163. Hossen MA, Nagata Y, Waki M, Ide Y, Takei S, Fukano H, Romero-Perez GA, Tajima S, Yao I, Ohnishi K, Setou M.

Decreased level of phosphatidylcholine (16:0/20:4) in multiple myeloma cells compared to plasma cells: A single-cell MALDI-IMS approach.
Anal Bioanal Chem. 2015 Jul;407(18):5273-80. doi:10.1007/s00216-015-8741-z. Epub 2015 May 10.

162. Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H,Kadomatsu K, Matsushita Y, Setou M.

Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model.
Neuroscience. 2015 Jun 25;297:127-136. doi:10.1016/j.neuroscience.2015.03.060. Epub 2015 Apr 2.

161. Siangcham T, Chansela P, Hayasaka T, Masaki N, Sroyraya M, Poljaroen J, Suwansa-ard S, Engsusophon A, Hanna PJ, Sobhon P, Setou M.

Changes of Phosphatidylcholine and Fatty Acids in Germ Cells during Testicular Maturation in Three Developmental Male Morphotypes of Macrobrachium rosenbergii Revealed by Imaging Mass Spectrometry.
PLoS ONE. 2015 Mar 17;10(3)e0120412. doi: 10.1371/journal.pone.0120412. eCollection2015.

160. Nagata Y, Ishizaki I, Waki M, Ide Y, Hossen MA, Ohnishi K, Miyayama T, Setou M.

Palmitic acid, verified by lipid profiling using secondary ion mass spectrometry, demonstrates anti-multiple myeloma activity.
Leuk Res. 2015 Jun;39(6):638-45. doi: 10.1016/j.leukres.2015.02.011. Epub 2015 Mar 18.

159. Yuki D, Sugiura Y, Zaima N, Akatsu H, Takei S, Yao I, Maesako M, Kinoshita A, Yamamoto T, Kon R, Sugiyama K, Setou M.

DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
Sci Rep. 2014 Nov 20;4:7130. doi: 10.1038/srep07130.

158. Uehara T,Kikuchi H,Miyazaki S,Iino I,Setoguchi T,Hiramatsu Y,Ohta M,Kamiya K,Morita Y,Tanaka H,Baba S,Hayasaka T,Setou M,Konno H.

Overexpression of lysophosphatidylcholine acyltransferase 1 and concomitant lipid alterations in gastric cancer.
Ann Surg Oncol. 2015 Mar 10. [Epub ahead ofprint]

157. Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N.

Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm.
PLoS One. 2014 Mar 20;9(3):e89830. doi: 10.1371/journal.pone.0089830. eCollection 2014.

156. Waki M, Ide Y, Ishizaki I, Nagata Y, Masaki N, Sugiyama E, Kurabe N, Nicolaescu D, Yamazaki F, HayasakaT, Ikegami K, Kondo T, Shibata K, Hiraide T, Taki Y, Ogura H, Shiiya N, Sanada N, Setou M.

Single-cell time-of-flight secondary ion mass spectrometry reveals that human breast cancer stem cells have significantly lower content of palmitoleic acid compared to their counterpart non-stem cancer cells.
Biochimie. 2014 Dec;107 Pt A:73-7. doi: 10.1016/j.biochi.2014.10.003. Epub 2014 Oct 13.

155. Shibasaki Y, Sakaguchi T, Hiraide T, Morita Y, Suzuki A, Baba S, Setou M, Konno H.

Expression of indocyanine green-related transporters in hepatocellular carcinoma.
J Surg Res. 2015 Feb:193(2):567-76. doi:10.1016/j.jss.2014.07.055. Epub 2014 Jul 31.

154. Ikeda Y, Zaima N, Hirano K, Mano M, Kobayashi K, Yamada S, Yamaguchi S, Suzuki A, Kanzaki H, Hamasaki T, Kotani J, Kato S, Nagasaka H, Setou M, Ishibashi-Ueda H.

Coronary triglyceride deposition in contemporary advanced diabetics.
Pathol Int. 2014 Jul;64(7):325-35. doi: 10.1111/pin.12177.

153. Furuichi Y, Goto-Inoue N, Manabe Y, Setou M, Masuda K, Fujii NL.

Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles.
Biochim Biophys Acta. 2014 Oct;1837(10):1699-706. doi:10.1016/j.bbabio.2014.05.356. Epub 2014 May 29.

152. Matsushita S, Sugiyama E, Hayasaka T, Masaki N, Setou M.

Atmospheric pressure MALDI-IMS using p-nitroaniline matrix at high spatial resolution in positive and negative ion modes.
J. Mass Spectrom Soc. Jpn.2014 Aug 1;62(4):29-36. doi:10.5702/massspec.14-57

151. He Q, Takizawa Y, Hayasaka T, Noritaka M, Kusama Y, Su J, Mineta H, Setou M.

Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor.
Anal Bioanal Chem. 2014 Sep:406(24):5815-25. doi:10.1007/s00216-014-7890-9. Epub 2014 Jun 1.

150. Hayasaka T, Goto-Inoue N, Masaki N, Ikegami K, Setou M.

Application of 2,5-dihydroxyacetophenone with sublimation provides more efficientionization of lipid species by atmospheric pressure matrix-assisted laser desorption/ionization imaging mass spectrometry.
Surf Interface Anal. 2014 Jun 27;46(12-13):1219-22.doi:10.1002/sia.5592. [Epub ahead of print]

149. Arima H, Hanada M, Hayasaka T, Masaki N, Omura T, Xu D, Hasegawa T, Togawa D, Yamato Y, Kobayashi S, Yasuda T, Matsuyama Y, Setou M.

Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containingphosphatidylcholine levels in a mouse model of spinal cord injury.
Neuroscience. 2014 Jun 6;269:1-10. doi: 10.1016/j.neuroscience.2014.03.012.
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148. Ide Y, Waki M, Ishizaki I, Nagata Y, Yamazaki F, Hayasaka T, Masaki N, Ikegami K, Kondo T, Shibata K, Ogura H, Sanada N, Setou M.

Single Cell Lipidomics of SKBR-3 Breast Cancer Cells by Using Time-of-Flight Secondary-Ion Mass Spectrometry.
Surf Interface Anal. 2014 Apr 30;46(S1):181-4. doi: 10.1002/sia.5523.

147. Nagata Y, Ishizaki I, Waki M, Ide Y, Hossen A, Ohnishi K, Sanada N, Setou M.

Glutaraldehyde Fixation Method for Single-Cell Lipid Analysis by Time-of-Flight Secondary Ion-Mass Spectrometry.
Surf Interface Anal. 2014 Apr 30;46(S1):185-8. doi: 10.1002/sia.5522.

146.Lu J, Yao I, Shimojo M, Katano T, Uchida H, Setou M, Ito S.

Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry.
Anal Bioanal Chem. 2014 Feb;406(5):1387-96. doi: 10.1007/s00216-013-7535-4. Epub 2014 Jan 23.

145.Kim TW, Cho HM, Choi SY, Suguira Y, Hayasaka T, Setou M, Koh HC, Hwang EM, Park JY, Kang SJ, Kim HS, Kim H, Sun W.

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
Cell Death Dis. 2013 Nov 14;4:e919. doi: 10.1038/cddis.2013.447.

144. Goto-Inoue N, Yamada K, Inagaki A, Furuichi Y, Ogino S, Manabe Y, Setou M, Fujii NL.

Lipidomics analysis revealed the phospholipid compositional changes in muscle by chronic exercise and high-fat diet.
Sci Rep. 2013 Nov 20;3:3267. doi: 10.1038/srep03267.

143.Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD.

Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin.
J Biol Chem. 2013 Oct 18;288(42):30445-53. doi:10.1074/jbc.M113.497917. Epub 2013 Sep 10.

142.Suzuki T, Shimoda M, Ito K, Hanai S, Aizawa H, Kato T, Kawasaki K, Yamaguchi T, Ryoo HD, Goto-Inoue N, Setou M, Tsuji S, Ishida N.

Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye.
PLoS One. 2013 Aug 2;8(8):e69147. doi:10.1371/journal.pone.0069147.

141.Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A.

Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations.
Cardiovasc Res. 2013 Aug 1;99(3):382-94. doi: 10.1093/cvr/cvt106. Epub 2013 Apr 30.

140.Kurabe N, Hayasaka T, Ogawa M, Masaki N, Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H.

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
Cancer Sci. 2013 Oct; 104(10):1295-302. doi: 10.1111/cas. 12221. Epub 2013 Jul 30.

139. Hirano H, Masaki N, Hayasaka T, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M.

Matrix-assisted laser desorption/ionization imaging mass spectrometry revealed traces of dental problem associated with dental structure.
Anal Bioanal Chem. 2014 Feb;406(5):1355-63. doi: 10.1007/s00216-013-7075-y. Epub 2013 Jun 2.

138. Uchiyama Y, Hayasaka T, Masaki N, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M.

Imaging mass spectrometry distinguished the cancer and stromal regions of oral squamous cell carcinoma by visualizing phosphatidylcholine (16:0/16:1) and phosphatidylcholine (18:1/20:4).
Anal Bioanal Chem. 2014 Feb;406(5):1307-16. doi: 10.1007/s00216-013-7062-3. Epub 2013 Jun 1.

137.Kurabe N, Hayasaka T, Igarashi H, Mori H, Sekihara K, Tao H, Yamada H, Kahyo T, Onishi I, Tsukui H, Kawase A, Matsuura S, Inoue Y, Shinmura K, Funai K, Setou M, Sugimura H.

Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry.
Pathol Int. 2013 Apr;63(4):195-200. doi: 10.1111/pin.12050.

136.Nakajima K, Terao M, Takaishi M, Kataoka S, Goto-Inoue N, Setou M, Horie K, Sakamoto F, Ito M, Azukizawa H, Kitaba S, Murota H, Itami S, Katayama I, Takeda J, Sano S.

Barrier Abnormality Due to Ceramide Deficiency Leads to Psoriasiform Inflammation in a Mouse Model.
J Invest Dermatol. 2013 Nov;133(11):2555-65. doi: 10.1038/jid.2013.199. Epub 2013 Apr 30.

135. Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y, Ogura H, Shiiya N, Setou M.

Human Breast Cancer Tissues Contain Abundant Phosphatidylcholine(36:1) with High Stearoyl-CoA Desaturase-1 Expression.
PLoS One. 2013 Apr 16;8(4):e61204. doi:10.1371/journal.pone.0061204. Print 2013.

134. Tanaka H, Zaima N, Ito H, Hattori K, Yamamoto N, Konno H, Setou M, Unno N.

Cilostazol inhibits accumulation of triglycerides in a rat model of carotid artery ligation.
J Vasc Surg. 2013 Nov;58(5):1366-74. doi: 10.1016/j.jvs.2013.01.033. Epub 2013 Apr 6.

133. Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Inaba K, Murakami M, Setou M, Konno H.

Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
J Hepatol. 2013 Aug;59(2):292-9. doi: 10.1016/j.jvs. 2013.01.030. Epub 2013 Apr 6.

132. Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N.

Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.
PLoS One. 2013;8(2):e57398. doi: 10.1371/journal.pone.0057398. Epub 2013 Feb 27.

131. Onishi S, Tatsumi Y, Wada K, Yang HJ, Sugiura Y, Setou M, Yoshikawa H.

Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry.
Med Mol Morphol. 2013 Feb 16. [Epub ahead of print]

130. Iino I, Kikuchi H, Miyazaki S, Hiramatsu Y, Ohta M, Kamiya K, Kusama Y, Baba S, Setou M, Konno H.

Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis.
Cancer Sci. 2013 May;104(5):624-30. doi: 10.1111/cas.12122. Epub 2013 Mar 13.

129. Takagi H, Setou M, Ito S, Yao I.

SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses.
Neural Plast. 2012;2012:352829. doi: 10.1155/2012/352829. Epub 2012 Dec 20.

128. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M.

Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.
PLoS One. 2012;7(11):e49519. doi: 10.1371/journal.pone.0049519. Epub 2012 Nov 15.

127. Ishikawa S, Tateya I, Hayasaka T, Masaki N, Takizawa Y, Ohno S, Kojima T, Kitani Y, Kitamura M, Hirano S, Setou M, Ito J.

Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer.
PLoS One. 2012;7(11):e48873. doi: 10.1371/journal.pone.0048873. Epub 2012 Nov 6.

126. Sugiura Y, Zaima N, Setou M, Ito S, Yao I.

Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry.
Anal Bioanal Chem. 2012 Jun;403(7):1851-61. Epub 2012 Apr 19.

125. Chansela P, Goto-Inoue N, Zaima N, Hayasaka T, Sroyraya M, Kornthong N, Engsusophon A, Tamtin M, Chaisri C, Sobhon P, Setou M.

Composition and Localization of Lipids in Penaeus merguiensis Ovaries during the Ovarian Maturation Cycle as Revealed by Imaging Mass Spectrometry.
PLoS One. 2012;7(3):e33154. Epub 2012 Mar 14.

124. Hanada M, Sugiura Y, Shinjo R, Masaki N, Imagama S, Ishiguro N, Matsuyama Y, Setou M.

Spatiotemporal alteration of phospholipids and prostaglandins in a rat model of spinal cord injury.
Anal Bioanal Chem. 2012 Jun;403(7):1873-84. Epub 2012 Mar 14.

123. Goto-Inoue N, Manabe Y, Miyatake S, Ogino S, Morishita A, Hayasaka T, Masaki N, Setou M, Fujii L. N.

Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Bioanal Chem. 2012 Jun;403(7):1863-71. Epub 2012 Feb 17.

122.Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias P. M., Sano S, Maeda Y.

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.
J Invest Dermatol. 2012 Aug;132(8):2019-25. doi: 10.1038/jid.2012.100. Epub 2012 May 10.

121.Yoshimura Y, Enomoto H, Moriyama T, Kawamura Y, Setou M, Zaima N.

Visualization of anthocyanin species in rabbiteye blueberry Vaccinium ashei by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Bioanal Chem 2012 Jun;403(7):1885-95. Epub 2012 Mar 8.

120. Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, Marsh SE, Olvera J, Brancati F, Iannicelli M, Ikegami K, Schlossman AM, Merriman B, Attié-Bitach T, Logan CV, Glass IA, Cluckey A, Louie CM, Lee JH, Raynes HR, Rapin I, Castroviejo IP, Setou M, Barbot C, Boltshauser E, Nelson SF, Hildebrandt F, Johnson CA, Doherty DA, Valente EM, Gleeson JG.

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.
Nat Genet. 2012 Jan 15 ;44(2):193-9 doi: 10.1038/ng.1078.

119. Ota H, Akishita M, Akiyoshi T, Kahyo T, Setou M, Ogawa S, Iijima K, Eto M, Ouchi Y.

Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 mice: Protective role of eNOS and SIRT1.
PLoS One. 2012;7(1):e29598. Epub 2012 Jan 4.

118. Yang H, Sugiura Y, Ikegami K, Konishi Y, Setou M.

Axonal Gradient of Arachidonic Acid-containing Phosphatidylcholine and Its Dependence on Actin Dynamics.
J Biol Chem. 2012 Feb 17;287(8):5290-300. Epub 2011 Dec 29. doi: 10.1074/jbc.M111.316877.

117.Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD.

Cytosolic Carboxypeptidase 1 Is Involved in processing α-tubulin and β-tubulin.
J Biol Chem. 2012 Feb 24;287(9):6503-17. Epub 2011 Dec 14.

116. Yamada M, Yao I, Hayasaka T, Ushijima M, Matsuura M, Takada H, Shikata N, Setou M, Kwon KH, Ito S.

Identification of oligosaccharides from histopathological sections by MALDI imaging mass spectrometry.
Anal Bioanal Chem. 2012 Feb;402(5):1921-30. Epub 2011 Dec 13.

115. Goto-Inoue N,Hayasaka T, Zaima N, Setou M.

Imaging mass spectrometry reveals changes of metabolites distribution in mouse testis during testicular maturation.
Surf Interface Anal. 2011 Nov 21. doi: 10.1002/sia.3869

114. Waki ML, Onoue K, Takahashi T, Goto K, Saito Y, Inami K, Makita I, Angata Y, Suzuki T, Yamashita M, Sato N, Nakamura S, Yuki D, Sugiura Y, Zaima N, Goto-Inoue N, Hayasaka T, Shimomura Y, Setou M.

Investigation by imaging mass spectrometry of biomarker candidates for aging in the hair cortex.
PLoS One. 2011;6(10):e26721. Epub 2011 Oct 24.

113. Tanaka H, Zaima N, Sasaki T, Yamamoto N, Sano M, Konno H, Setou M, Unno N.

Loss of lymphatic vessels and regional lipid accumulation is associated with incompetent great saphenous vein incompetence.
J Vasc Surg. 2012 May;55(5):1440-8. Epub 2012 Jan 4.

112. Valdes-Gonzalez T, Goto-Inoue N, Hayasaka T, Ishiyama H, Setou M, Taki T.

Imaging Technology of Complex Lipid Molecular Species by a Combination of TLC-Blot and MALDI-TOF -Special Reference to Human Brain Ganglioside Molecular Species.
J Glycom Lipidom. 2011 Jul;1(2):104.

111. Asakawa H, Ikegami K, Setou M, Watanabe N, Tsukada M, Fukuma T.

Submolecular-scale imaging of α-helices and C-terminal domains of tubulins by frequency modulation Aaomic force microscopy in liquid.
Biophys J. 2011 Sep 7;101(5):1270-6.

110. Shrivas K, Hayasaka T, Sugiura Y, Setou M.

Method for Simultaneous Imaging of Endogenous Low Molecular Weight Metabolites in mouse brain using TiO(2) nanoparticle in nanoparticle-assisted laser desorption/ionization-imaging Mmass spectrometry.
Anal Chem. 2011 Oct 1;83(19):7283-9. Epub 2011 Sep 6.

109. Kaneko Y, Obata Y, Nishino T, Kakeya H, Miyazaki Y, Hayasaka T, Setou M, Furusu A, Kohno S.

Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys.
Exp Mol Pathol. 2011 Oct;91(2):614-21. Epub 2011 Jul 23.

108. Yuki D, Sugiura Y, Zaima N, Akatsu H, Hashizume Y, Yamamoto T, Fujiwara M, Sugiyama K, Setou M.

Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex.
Neuroscience.2011 Oct 13;193:44-53. Epub 2011 Jul 28.

107. Beck G, Sugiura Y, Shinzawa K, Kato S, Setou M, Sakoda S, Sumi-Akamaru H.

Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes.
J.Neurosci. 2011 Aug 3;31(31):11411-11420.

106. Kubo A, Ohmura M, Wakui M, Harada T, Kajihara S, Ogawa K, Suemizu H, Nakamura M, Setou M, Suematsu M.

Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice.
Anal Bioanal Chem. 2011 Jun;400(7):1895-904. Epub 2011 Apr 10.

105. Zaima N, Sasaki T, Tanaka T, Cheng XW, Onoue K, Hayasaka T, Goto-Inoue N, Enomoto H, Unno N, Kuzuya M, Setou M.

Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions.
Atherosclerosis. 2011 Aug;217(2):427-32. Epub 2011 Apr 9.

104. Koizumi S, Hayasaka T, Goto-Inoue N, Doi K, Setou M, Namba H.

Imaging mass spectrometry evaluation of the effects of vaious irrigation fluids in a rat model of postoperative cerebral edema.
World Neuroserg.2012 Jan;77(1):153-9. Epub 2011 Nov 17. doi: 10.1016/j.wneu.2011.03.039

103.Zaima N, Goto-Inoue N, Hayasaka T, Enomoto H, Setou M.

Authenticity assessment of beef origin by principal component analysis of matrix-assisted laser desorption/ionization mass spectrometric data.
Anal Bioanal Chem. 2011 Jun;400(7):1865-71. Epub 2011 Mar 1.

102.Miyamura N, Nakamura T, Goto-Inoue N, Zaima N, Hayasaka T, Yamasaki T, Terai S, Sakaida I, Setou M, Nishina H.

Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver.
Biochem Biophys Res Commun. 2011 Apr 29;408(1):120-5. Epub 2011 Apr 2.

101.Chansela P, Goto-Inoue N, Zaima N,Sroyraya M, Sobhon P, Setou M.

Visualization of neuropeptides in paraffin-embedded tissue sections of the central nervous system in the decapod crustacean, Penaeus monodon, by imaging mass spectrometry.
Peptides. 2012 Mar;34(1):10-8. Epub 2011 Apr 1.

100.Enomoto H, Sugiura Y, Setou M, Zaima N.

Visualization of phosphatidylcholine, lysophosphatidylcholine and sphingomyelin in mouse tongue body by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Bioanal Chem. 2011 Jun;400(7):1913-21. Epub 2011 Apr 7.

99.Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N,Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa SI.

Abnormal phospholipids distribution in theprefrontal cortex from a patient withschizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Anal Bioanal Chem. 2011 Jun;400(7):1933-43. Epub 2011 Apr 2.

98.Sakao Y, Kato A, Tsuji T, Yasuda H, Togawa A, Fujigaki Y, Kahyo T, Setou M, Hishida A.

Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney.
Clin Exp Nephrol. 2011 Jun;15(3):363-72. Epub 2011 Mar 18.

97.Sugiura Y, Taguchi R, Setou M.

Visualization of Spatiotemporal Energy Dynamics of Hippocampal Neurons
by Mass Spectrometry during a Kainate-induced Seizure.
PLoS ONE. 2011 Mar 22;6(3):e17952.

96.Tanaka H, Zaima N, Yamamoto N, Suzuki M, Mano Y, Konno H, Unno N, Setou M.

Distribution of phospholipid molecular species in autogenous
access grafts for hemodialysis analyzed using imaging mass spectrometry.
Anal Bioanal Chem. 2011 Jun.;400(7):1873-80. Epub 2011 Mar 16.

95.Hayasaka T, Goto-Inoue N, Ushijima M, Yao I, Yuba-Kubo A, Wakui M, Kajihara S, Matsuura M, Setou M.

Development of imaging mass spectrometry (IMS) dataset extractor software, IMS Convolution.
Anal Bioanal Chem. 2011 Jul;401(1):183-93. Epub 2011 Mar 17.

94.Yao I, Takao K, Miyakawa T, Ito S, Setou M

Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning; Extensive
Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing
Mutant Mice
PLoS ONE. 2011 Feb 24;6(2):e17317.

93.Katagiri YU, Sato B, Yamatoya K, Taki T, Goto-Inoue N, Setou M, OkitaH, Fujimoto J, Ito C, Toshimori K, Kiyokawa N.

GalNAcβ1,3-linked paragloboside carries the epitope of a spermmaturation-related glycoprotein that is recognized by the monoclonalantibody MC121.
Biochem Biophys Res Commun. 2011 Mar 18;406(3):326-31. Epub 2011 Feb 17.

92.Zaima N, Goto-Inoue N, Setou M.

Selective analysis of lipids by thin-layer chromatography blot matrix-assisted laser desorption/ionization imaging mass spectrometry.
J Oleo Sci. 2011;60(2):93-8.

91.Setoguchi T, Kikuchi H, Yamamoto M, Baba M, Ohta M, Kamiya K, Tanaka T, Baba S, Goto-Inoue N, Setou M, Sasaki T, Mori H, Sugimura H, Konno H.

Microarray analysis indentifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors.
Cancer Sci. 2011 Apr;102(4):883-9. doi: 10.1111/j.1349-7006.2011.01872.x. Epub 2011 Feb 24.

90.Valdes-Gonzalez T, Goto-Inoue N, Hirano W, Ishiyama H, Hayasaka T, Setou M, Taki T.

New approach for glyco- and lipidomics -molecular scanning of human brain gangliosides by TLC-Blot and MALDI-QIT-TOF MS-.
J Neurochem. 2011 Mar;116(5):678-83. doi: 10.1111/j.1471-4159.2010.07152.x. Epub 2011 Jan 19.

89.Roy MC, Nakanishi H, Takahashi K, Nakanishi S, Kajihara S, Hayasaka T, Setou M, Ogawa K, Taguchi R, Naito T.

Salamander retina phospholipids and their localization by MALDI imaging mass spectrometry at cellular size resolution.
J Lipid Res. 2011 Mar;52(3):463-70. Epub 2010 Dec 13.

88.Onoue K, Zaima N, Sugiura Y, Isojima T, Okayama S, Horii M, Akai Y, Uemura S, Takemura G, Sakuraba H, Sakaguchi Y, Setou M, Saito Y.

Imaging mass spectrometry to accurately diagnose Fabry's disease.
Circ J. 2010 Dec 24;75(1):221-3. Epub 2010 Nov 28.

87.Shrivas K, Hayasaka T, Goto-Inoue N, Zaima N, Setou M.

Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections.
Anal Chem. 2010;82(21):8800-06.

86.Yang HJ, Sugiura Y, Ishizaki I., Sanada N, Ikegami K, Zaima N, Shrivas K, Setou M.

Imaging of lipids in culturedmammalian neurons by matrix assisted laser/desorption ionization and secondary ion mass spectrometry.
Surf.Interface Anal. 2010 Jun 28 ;42(10):1606-11.

85.Takizawa Y, Mizuta K, Hayasaka T, Nakanishi H, Okamura J, Mineta H, Setou M.

Specific localization of five phosphatidylcholine species in the cochlea by using mass microscopy.
Audiol Neurootol. 2011;16(5):315-22. Epub 2010 Dec 15.

84.Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y.

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway.
Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2205-11. Epub 2010 Aug 12.

83.Kaplan O, Herman AM, Cevik S, Ghossoub R, Kida K, Kimura Y, Jenkins P, Martens J, Setou M, Benmerah A, Blacque OE.

AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans neuronal ciliary membrane transport.
J Cell Sci. 2010 Nov 15;123(Pt 22):3966-77.

82.Goto-Inoue N, Hayasaka T, Zaima N, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.

The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles.
J Am Soc Mass Spectrom. 2010 Nov;21(11):1940-3. Epub 2010 Aug 10.

81.Tanaka H, Zaima N, Yamamoto N, Sagara D, Suzuki M, Nishiyama M, Mano Y, Sano M, Hayasaka T, Goto-Inoue N, Sasaki T, Konno H, Unno N, Setou M.

Imaging Mass Spectrometry Reveals Unique Lipid Distribution in Primary Varicose Veins.
Eur J Vasc Endovasc Surg. 2010 Nov;40(5):657-63.

80.Zaima N, Goto-Inoue N, Hayasaka T, Setou M.

Application of imaging mass spectrometry for analysis of rice Oryza sativa.
Rapid Commun Mass Spectrom. 2010 Sep;24(18):2723-9.

79.Asai-Akieda S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.

SIRT1 regulates TSH release by enhancing PIP5Kγ activity through deacetylation.
PloS One. 2010 Jul 23;5(7):e11755.

78.Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M.

Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry.
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5. Epub 2010 May 24.

77.Goto-Inoue N, Setou M, Zaima N.

Visualization of Spatial Distribution of γ-Aminobutyric Acid in Eggplant (Solanum Melongena) by Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry.
Anal Sci. 2010;26(7):821-5.

76.Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M.

Identification of Tubulin Deglutamylase among Caenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)
J Biol Chem. 2010 Jul 23;285(30):22936-41. Epub 2010 Jun 2.

75.Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.

Imaging Mass Spectrometry with Silver Nanoparticles Reveals the Distribution of Fatty Acids in Mouse Retinal Sections.
J Am Soc Mass Spectrom. 2010 Aug;21(8):1446-54. Epub 2010 Apr 24.

74.Kono S, Nishio T, Takahashi Y, Goto-Inoue N, Kinoshita M, Zaima N, Suzuki H, Fukutoku-Otsuji A, Setou M, Miyajima H.

Dominant-negative effects of a novel mutation in the filamin myopathy.
Neurology. 2010 Aug 10;75(6):547-54.

73.Sroyraya M, Goto-Inoue N, Zaima N, Hayasaka T, Chansela P, Tanasawet S, Shrivas K, Sobhon P, Setou M.

Visualization of biomolecules in the eyestalk of the blue swimming crab, Portunus pelagicus, by imaging mass spectrometry using the atmospheric-pressure mass microscope.
Surf Interface Anal. 2010 Oct-Nov;42(10-11):1589-92.

72.Koizumi S, Yamamoto S, Hayasaka T, Konishi Y, Yamaguchi-Okada M, Goto-Inoue N, Sugiura Y, Setou M, Namba H.

Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain.
Neuroscience. 2010 Jun 16;168(1):219-25. Epub 2010 Apr 1.

71.Ageta H, Ikegami S, Miura M, Masuda M, Migishima R, Hino T, Takashima N, Murayama A, Sugino H, Setou M, Kida S, Yokoyama M, Hasegawa Y, Tsuchida K, Aosaki T, Inokuchi K.

Activin plays a key role in the maintenance of long-term memory and late-LTP.
Learn Mem. 2010 Mar 23;17(4):176-85. Print 2010 Apr.

70.Kobayashi Y, Hayasaka T, Setou M, Itoh H, Kanayama N.

Comparison of Phospholipid Molecular Species between Terminal and Stem Villi of Human Term Placenta by Imaging Mass Spectrometry.
Placenta. 2010 Mar;31(3):245-8. Epub 2010 Jan 29.

69.Tada H, Okano HJ, Takagi H, Shibata S, Matsumoto M, Yao I, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H.

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
J Biol Chem. 2010 Feb 5;285(6):3840-9. Epub 2009 Dec 7.

68.Yang HJ, Ishizaki I, Sanada N, Zaima N, Sugiura Y, Yao I, Ikegami K, Setou M.

Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time of flight-secondary ion mass spectrometry.
Med Mol Morphol. 2010 Sep;43(3):158-64. Epub 2010 Sep 21.

67.Koizumi S, Hayasaka T, Goto-Inoue N, Setou M, Namba H.

Application of multiple-stage tandem imaging mass spectrometry to molecular imaging in a rat brain C6 glioma model.
CI. 2010;32(1):33-41.

66.Morita Y, Ikegami K, Goto-Inoue N, Hayasaka T, Zaima N, Tanaka H, Uehara T, Setoguchi T, Sakaguchi T, Igarashi H, Sugimura H, Setou M, Konno H.

Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray.
Cancer Sci. Jan 1;101(1):267-73. Epub 2009 Oct 8.

65.Goto-Inoue N, Hayasaka T, Taki T, Gonzalez TV. G, Setou M.

A new lipidomics approach by thin-layer chromatography-blot-matrix-assisted laser desorption/ionization imaging mass spectrometry for analyzing detailed patterns of phospholipid molecular species.
J Chromatogr A. 2009 Oct 16;1216(42):7096-101. Epub 2009 Aug 27.

64.Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M.

Visualization of volatile substances in different organelles with an atmospheric-pressure Mass Microscope.
Anal Chem. 2009 Nov 1;81(21):9153-7.

63.Sugiura Y, Setou M.

Selective imaging of positively charged polar and nonpolar lipids by optimizing matrix solution composition.
Rapid Commun Mass Spectrom. 2009 Oct 30;23(20):3269-78.

62.Hayasaka T. Goto-Inoue N. Zaima N. Kimura Y. Setou M.

Organ-Specific Distributions of Lysophosphatidylcholine and Triacylglycerol in Mouse Embryo. Lipids. 2009 Sep;44(9):837-48. Epub 2009 Aug 15.

61.Goto-Inoue N. Hayasaka T. Zaima N. Setou M.

The specific localization of seminolipid molecular species on mouse testis during testicular maturation revealed by imaging mass spectrometry.
Glycobiology. 2009 sep:19(9):950-7.

60.Sugiura Y, Konishi Y, Zaima N, Kajihara S, Nakanishi H, Taguchi R, Setou M.

Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry.
J Lipid Res. 2009 Sep;50(9):1776-88. Epub 2009 May 5.

59.Ikegami K, Setou M.

TTLL10 can perform tubulin glycylation when co-expressed with TTLL8.
FEBS Lett. 2009 Jun 18;583(12):1957-63. Epub 2009 May 8.

58.Konishi Y, Setou M.

Tubulin tyrosination navigates the kinesin-1 motor domain to axons.
Nat Neurosci. 2009 May;12(5):559-67. Epub 2009 Apr 19.

57.Zaima N, Hayasaka T, Goto-Inoue N, Setou M.

Imaging of metabolites by MALDI mass spectrometry.
J Oleo Sci. 2009;58(8):415-9.

56.Zaima N, Matsuyama Y, Setou M.

Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver.
J Oleo Sci. 2009;58(5):267-73.

55.Mukai M, Ikegami K, Sugiura Y, Takeshita K, Nakagawa A, Setou M.

Recombinant mammalian tubulin polyglutamylase TTLL7 performs both initiation and elongation of polyglutamylation on β-tubulin through a random sequential pathway.
Biochemistry. 2009 Feb 10;48(5):1084-93..

54.Moritake S, Taira S, Sugiura Y, Setou M, Ichiyanagi Y.

Magnetic Nanoparticle-based Mass Spectrometry for the Detection of Biomolecules in Cultured Cells.
J Nanosci Nanotechnol. 2009 Jan;9(1):169-76.

53.Ageta H, Asai S, Sugiura Y, Goto-Inoue N, Zaima N, Setou M.

Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass spectrometry.
Med Mol Morphol. 2009 March;42(1):16-23. Epub 2009 Mar 18.

52.Nishiguchi M, Ueno Y, Toyoda M, Setou M.

Design of a new multi-turn ion optical system "IRIS" for a time-of-flight mass spectrometer.
J Mass Spectrom. 2009 May;44(5):594-604.

51.Ohkawa N, Sugisaki S, Tokunaga E, Fujitani K, Hayasaka T, Setou M, Inokuchi K.

N-acetyltransferase ARD-NAT1 regulates neuronal dendritic development.
Genes Cells. 2008 Nov;13(11):1171-83.

50.Setou M, Hayasaka T, Shimma S, Sugiura Y, Matsumoto M.

Protein denaturation improves enzymatic digestion efficiency for direct tissue analysis using mass spectrometry. Applied Surface Science. 2008;255:1555-9.

49.Kahyo T, Ichikawa S, Hatanaka T, Yamada M, Setou M.

A novel chalcine polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J Pharmacol Sci. 2008 Nov 21;108(3):364-71. Epub 2008 Nov 13.

48.Yamada M, Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, Mimori-Kiyosue Y, Nakamura T, Itoh K, Fushiki S, Setou M, Wynshaw-Boris A, Torisawa T, Toyoshima YY, Hirotsune S.

LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.
EMBO J. 2008 Oct 8;27(19):2471-83. Epub 2008 Sep 11.

47.Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Nakanishi H, Ohishi K, Nakanishi S, Naito T, Taguchi R, Setou M.

MALDI-QIT-TOF-based imaging mass spectrometry reveals layered distribution of phospholipid molecular species in mouse retina.
Rapid Commun Mass Spectrom. 2008 Oct 7;22(21):3415-26.

46.Sugiura Y, Shimma S, Konishi Y, Yamada M, Setou M.

Imaging Mass Spectrometry technology and the application on ganglioside study; Visualization of Age-dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus.
PLoS ONE. 2008 Sep 18;3(9):e3232.

45.Yao I, Sugiura Y, Matsumoto M, Setou M.

In situ proteomics with imaging mass spectrometry and principal component analyses in the Scrappper-Knockout mouse brain.
Proteomics. 2008 Sep 9;8(18):3692-701.

44.Yamada M, Konishi Y, Kakinoki B, Ikegami K, Setou M.

Enhancement of Trk signaling pathways by a cholestane amide conjugate, MCC-257
J Pharmacol Sci. 2008 Sep;108(1):131-4. Epub 2008 Aug 30.

43.Yang HJ, Takagi H, Konishi Y, Ageta H, Ikegami K, Yao I, Satou S, Hatanaka K, Inokuchi K, Seog D-H, Setou M.

Transmembrane and Ubiquitin-like Domain-containing Protein 1 (Tmub1/HOPS) Facilitates Surface Expression of GluR2-containing AMPA Receptors.
PLoS ONE. 2008 Jul 30;3(7):e2809.

42.Kahyo T, Mostoslavsky R, Goto M, Setou M.

Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.
FEBS Lett. 2008 Jul 23;582(17):2479-83. Epub 2008 Jun 25.

41.Hosokawa N, Sugiura Y, Setou M.

Spectrum Normalization Method Using an External Standard in Mass Spectrometric Imaging.
J Mass Spectrom Soc. 2008;56(3):77-81.

40.Goto-Inoue N, Hayasaka T, Sugiura Y, Taki T, Li Y-T, Matsumoto M, Setou M.

High-Sensitivity Analysis of Glycosphingolipids by Matrix-Assisted Laser Desorption/Ionization Quadrupole Ion Trap Time-of-Flight Imaging Mass Spectrometry on Transfer Membranes.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 1;870(1):74-83. Epub 2008 Jun 6.

39.Taira S, Sugiura Y, Moritake S, Shimma S, Ichiyanagi Y, Setou M.

Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution.
Anal Chem. 2008 Jun 15;80(12):4761-6. Epub 2008 May 14.

38.Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor GR, Setou M.

TTLL10 is a protein polyglycylase that can modify mucleosome assembly protein 1
FEBS Lett. 2008 Apr 2;582(7):1129-34. Epub 2008 Mar 10.

37.Asai S, Takamura K, Suzuki H, Setou M.

Real-time single-cell imaging of c-fos expression in rat primary hippocampal cells using a luminescence microscope.
Neurosci Lett. 2008 Apr 4;434(3):289-92.

36.Shimma S, Sugiura Y, Hayasaka T, Zaima N, Matsumoto M, Setou M.

Mass imaging and identification of biomolecules with MALDI-QIT-TOF-based system.
Anal Chem. 2008;80(3):878-85. Epub 2008 Jan 1.

35.Ichiyanagi Y, Moritake S, Taira S, Setou M.

Functional magnetic nanoparticles for medical application.
J Magnetism and Magnetic Materials. 2007 Mar;310(2): 2877-9.

34.Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, MacGregor GR, Tanaka K, Setou M.

SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
Cell. 2007 Sep 7;130(5):943-57.

33.Shimma S, Setou M.

Mass microscopy revealed the distinct localization of heme B(m/z 616) in colon cancer liver metastasis.
J Mass Spectrom Soc Jpn. 2007;55(3):145-8.

32.Moritake S, Taira S, Hatanaka T, Setou M, Ichiyanagi Y.

Preparation of Amino Acid Conjugated Nano-Magnetic Particles for Delivery Systems.
e-J Surf Sci Nanotech. 2007;5:60-6.

31.Taira S, Hatanaka T, Moritake S, Kai Y, Ichiyanagi Y, Setou M.

Cellular Recognition of Functionalized with Folic acid Nanoparticles.
e-J Surf Sci Nanotech. 2007;5: 23-8.

30.Ikegami K, Robb L. Heier, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Patrick K. Campbell, Yuasa S, Carsten Janke, Grant R. MacGregor, Setou M.

Loss of Alpha Tubulin Polyglutamylation in ROSA22 Mice is Associated with Abnormal Targeting of KIF1A and Modulated Synaptic Function.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3213-8. Epub 2007 Feb 20.

29.Shimma S, Sugiura Y, Hayasaka T, Hoshikawa Y, Noda T, Setou M.

MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug;855(1):98-103. Epub 2007 Feb 28.

28.Matsumoto M, Setou M, Inokuchi K.

Transcriptome analysis reveals the population of dendritic RNAs and their redistribution by neural activity.
Neurosci Res. 2007 Mar;57(3):411-23. Epub 2006 Dec 16.

27.Moritake S, Taira S, Ichiyanagi Y, Morone N, Si-Young Song, Hatanaka T, Yuasa S, Setou M.

Functionalized Nano-Magnetic Particles for an In Vivo Delivery System.
J Nanosci Nanotechnol. 2007 Mar;7(3):937-44.

26.Shimma S, Furuta M, Ichimura K, Yoshida Y, Setou M.

Direct MS/MS analysis in mammalian tissue sections using MALDI-QIT-TOFMS and chemical inkjet technology.
Surf Int Anal. 2006;38:1712-4.

25.Sugiura Y, Shimma S, Setou M.

Two-Step Matrix Application Technique To Improve Ionization Efficiency for Matrix-Assisted Laser Desorption/Ionization in Imaging Mass Spectrometry.
Anal Chem. 2006 Dec 15;78(24):8227-35.

24.Hatanaka T, Hatanaka Y, Tsuchida J.-I., Ganapathy V, Setou M.

Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes.
J Biol Chem. 2006 Dec 22;281(51):39273-84. Epub 2006 Oct 18.

23.Setou M, Radostin D, Atsuzawa K., Yao I, Fukuda Y, Usuda N, Nagayama K.

Mammalian cell nano structures visualized by cryo Hilbert differential contrast transmission electron microscopy.
Med Mol Morphol. 2006 Dec;39(4):176-80. Epub 2006 Dec 21.

22.Hatanaka T, Hatanaka Y, Setou M.

Regulation of amino acid transporter ATA2 by ubiquitin ligase NEDD4-2.
J Biol Chem. 2006 Nov 24;281(47):35922-30. Epub 2006 Sep 26.

21.Hatanaka K, Ikegami K, Takagi H, Setou M.

Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL 5.
Biochem Biophys Res Commun. 2006 Nov 24;350(3):610-5.

20.Ikegami K, Mukai M, Tsuchida JI, Heier RL, Macgregor GR, Setou M.

TTLL7 is a mammalian beta -tubulin polyglutamylase required for growth of MAP2-positive neurites.
J Biol Chem. 2006 Oct 13;281(41):30707-16. Epub 2006 Aug 9.

19.Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y.

SAD: a Novel Presynaptic Kinase Associated with Synaptic Vesicles and the Active Zone Cytomatorix that Regulates Neurotransmitter Release.
Neuron. 2006 Apr 20;50(2):261-75.

18.Shimma S, Furuta M, Ichimura K, Yoshida Y, Setou M.

A Novel Approach to In Situ Proteome Analysis Using a Chemical Inkjet Printing Technology and MALDI-QIT-TOF Tandem Mass Spectrometer.
J Mass Spectrom Soc Jpn. 2006;54:133-40.

17.Fukuda Y, Kawano Y, Tanikawa Y, Oba M, Koyama M, Takagi H, Matsumoto M, Nagayama K, Setou M.

In Vivo imaging of the dendritic arbors of layer V pyramidal cells in the cerebral cortex using a laser scanning microscope with a stick-type objective lens.
Neurosci Lett. 2006 May 29;400(1-2):53-7. Epub 2006 Mar 10.

16.Sugiura Y, Shimma S, Setou M.

Thin sectioning improves the peak intensity and signal-to-noise ratio in direct tissue mass spectrometry.
J Mass Spectrom Soc Jpn. 2006;54:45-8.

15.Schriml LM, Hill DP, Blake JA, Bono H, Wynshaw-Boris A, Pavan WJ, Ring BZ, Beisel K, Setou M, Okazaki Y; RIKEN GER Group; GSL Members.

Human disease genes and their cloned mouse orthologs: exploration of the FANTOM2 cDNA sequence data set.
Genome Res. 2003 Jun;13(6B):1496-500.

14.Miki H, Setou M, Hirokawa N; RIKEN GER Group; GSL Members.

Kinesin superfamily proteins (KIFs) in the mouse transcriptome.
Genome Res. 2003 Jun;13(6B):1455-65.

13.Guillaud L, Setou M, Hirokawa N.

KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons.
J Neurosci. 2003 Jan 1;23(1):131-40.

12.Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P.

CREM-dependent transcription in male germ cells controlled by a kinesin.
Science. 2002 Dec 20;298(5602):2388-90.

11.Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y; FANTOM Consortium; RIKEN Genome Exploration Research Group Phase I & II Team.

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Nature. 2002 Dec 5;420(6915):563-73.

10.Wong RW, Setou M, Teng J, Takei Y, Hirokawa N.

Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice.
Proc Natl Acad Sci U S A. 2002 Oct 29;(22):14500-5.

9.Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N.

Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.
Nature. 2002 May 2;417(6884): 83-7.

8.Nakajima K, Takei Y, Tanaka Y, Nakagawa T, Nakata T, Noda Y, Setou M, Hirokawa N.

Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.
Mol Cell Biol. 2002 Feb ;22(3): 866-73.

7.Noda Y, Okada Y, Saito N, Setou M, Xu Y, Zhang Z, Hirokawa N.

KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes.
J Cell Biol. 2001 Oct;155(1):77-88.

6.Setou M, Kurauchi T, Tsuzuku T, Kaga K.

Binaural interaction of bone-conducted auditory brainstem responses.
Acta Otolaryngol. 2001 Jun;121(4):486-9.

5.Miki H, Setou M, Kaneshiro K, Hirokawa N.

All kinesin superfamily protein, KIF, genes in mouse and human.
Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7004-11.

4.Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N.

Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Cell. 2001 Jun 1;105(5): 587-97.

3.Kaga K, Setou M, Nakamura M.

Bone-conducted sound lateralization of interaural time difference and interaural intensity difference in children and a young adult with bilateral microtia and atresia of the ears.
Acta Otolaryngol. 2001 Jan;121(2): 274-7.

2.Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N.

A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.
Cell. 2000 Nov 10;103(4):569-81.

1.Setou M, Nakagawa T, Seog DH, Hirokawa N.

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
Science. 2000 Jun 9;288(5472):1796-802.

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