教授　椙村春彦

• Publication list（2018年1月20日現在） (146.9KB)

1. Yamada, H., Shinmura, K., Ito, H., Kasami, M., Sasaki, N., Shima, H., Ikeda, M., Tao, H., Goto, M., Ozawa, T., Tsuneyoshi, T., Tanioka, F., and Sugimura, H., Germline alterations of the CDH1 gene in familial gastric cancer in the Japanese population. Cancer Sci, 2011. 102(10): 1782-88.
2. Tamaki, Y., Honda, M., Muroi, Y., Arai, T., Sugimura, H., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N., and Hiratsuka, M., Novel Single Nucleotide Polymorphism of the CYP2A13 gene in Japanese individuals. Drug Metab Pharmacokinet, 2011. 26(5): 544-547.
3. Tamaki, Y., Arai, T., Sugimura, H., Sasaki, T., Honda, M., Muroi, Y., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N., and Hiratsuka, M., Association between Cancer Risk and Drug Metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Japanese Cases of Lung Cancer. Drug Metab Pharmacokinet, 2011. 26(5): 516-522.
4. Sugimura, H., Tao, H., Suzuki, M., Mori, H., Tsuboi, M., Matsuura, S., Goto, M., Shinmura, K., Ozawa, T., Tanioka, F., Sato, N., Matsushima, Y., Kageyama, S., Funai, K., Chou, P.H., and Matsuda, T., Genetic susceptibility to lung cancer. Front Biosci (Schol Ed), 2011. 3: 1463-77.
5. Shinmura, K., Igarashi, H., Goto, M., Tao, H., Yamada, H., Matsuura, S., Tajima, M., Matsuda, T., Yamane, A., Funai, K., Tanahashi, M., Niwa, H., Ogawa, H., and Sugimura, H., Aberrant Expression and Mutation-Inducing Activity of AID in Human Lung Cancer. Ann Surg Oncol, 2011. 18(7): 2084-92
6. Shinmura, K., Goto, M., Suzuki, M., Tao, H., Yamada, H., Igarashi, H., Matsuura, S., Maeda, M., Konno, H., Matsuda, T., and Sugimura, H., Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer. J Pathol, 2011. 225(3): 414-23.
7. Setoguchi, T., Kikuchi, H., Yamamoto, M., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Baba, S., Goto-Inoue, N., Setou, M., Sasaki, T., Mori, H., Sugimura, H., and Konno, H., Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors. Cancer Sci, 2011. 102(4): 883-9.
8. Saeki, N., Saito, A., Choi, I.J., Matsuo, K., Ohnami, S., Totsuka, H., Chiku, S., Kuchiba, A., Lee, Y.S., Yoon, K.A., Kook, M.C., Park, S.R., Kim, Y.W., Tanaka, H., Tajima, K., Hirose, H., Tanioka, F., Matsuno, Y., Sugimura, H., Kato, S., Nakamura, T., Nishina, T., Yasui, W., Aoyagi, K., Sasaki, H., Yanagihara, K., Katai, H., Shimoda, T., Yoshida, T., Nakamura, Y., Hirohashi, S., and Sakamoto, H., A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title: MUC1is a gastric cancer susceptibility gene. Gastroenterology, 2011. 140(3): 892-902.
9. Kawahara, N., Sugimura, H., Nakagawara, A., Masui, T., Miyake, J., Akiyama, M., Wahid, I.A., Hao, X., and Akaza, H., The 6th Asia Cancer Forum: What Should We Do to Place Cancer on the Global Health Agenda? Sharing Information Leads to Human Security. Jpn J Clin Oncol, 2011.
10. Kawahara, N., Roh, J.K., Akaza, H., Inoue, H., Shibuya, K., Iwasaki, M., Tsuji, T., Nishiyama, M., Nakagawara, A., Watanabe, K., Nozaki, S., Inoue, M., Sugimura, H., Miyake, J., and Li, F., The 7th Asia Cancer Forum: From the Perspective of Human Security, How Can We Collaborate as Asians in Order to Place Cancer on the Global Health Agenda? How Can We Fill in the Gaps that Exist Among Us Jpn J Clin Oncol, 2011.
11. Kahyo, T., Iwaizumi, M., Shinmura, K., Matsuura, S., Nakamura, T., Watanabe, Y., Yamada, H., and Sugimura, H., A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Oncogene, 2011. 30(44): 4453-63.
12. Ikematsu, Y., Tamura, H., Nakata, Y., Hayashi, T., Kanai, T., Hirayama, K., Mori, H., Ozawa, T., Hasegawa, S., Okawada, T., Kageyama, S., Sugimura, H., and Nishiwaki, Y., Metachronous multiple adenocarcinomas of the pancreas. Int J Clin Oncol, 2011.
13. Funai, K., Sugimura, H., Morita, T., Shundo, Y., Shimizu, K., and Shiiya, N., Lymphatic Vessel Invasion is a Significant Prognostic Indicator in Stage IA Lung Adenocarcinoma. Ann Surg Oncol, 2011.
14. Wang, J., Dong, Y., Wang, X., Ma, H., Sheng, Z., Li, G., Lu, G., Sugimura, H., and Zhou, X., Expression of EphA1 in gastric carcinomas is associated with metastasis and survival. Oncol Rep, 2010. 24(6): 1577-84.
15. Tsuboi, M., Mori, H., Bunai, T., Kageyama, S., Suzuki, M., Okudela, K., Takamochi, K., Ogawa, H., Niwa, H., Shinmura, K., and Sugimura, H., Secreted form of EphA7 in lung cancer. Int J Oncol, 2010. 36(3): 635-40.
16. Toyoshima, M., Chida, K., Kono, M., Kaida, Y., Nakamura, Y., Suda, T., and Sugimura, H., IgG4-related lung disease in a worker occupationally exposed to asbestos. Intern Med, 2010. 49(12): 1175-8.
17. Tao, H., Shinmura, K., Yamada, H., Maekawa, M., Osawa, S., Takayanagi, Y., Okamoto, K., Terai, T., Mori, H., Nakamura, T., and Sugimura, H., Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis. BMC Res Notes, 2010. 3(1): 305.
18. Sugimura, H., Wang, J.D., Mori, H., Tsuboi, M., Nagura, K., Igarashi, H., Tao, H., Nakamura, R., Natsume, H., Kahyo, T., Shinmura, K., Konno, H., Hamaya, Y., Kanaoka, S., Kataoka, H., and Zhou, X.J., EPH-EPHRIN in human gastrointestinal cancers. World J Gastrointest Oncol, 2010. 2(12): 421-8.
19. Sugimura, H., Mori, H., Nagura, K., Kiyose, S., Hong, T., Isozaki, M., Igarashi, H., Shinmura, K., Hasegawa, A., Kitayama, Y., and Tanioka, F., Fluorescence in situ hybridization analysis with a tissue microarray: 'FISH and chips' analysis of pathology archives. Pathol Int, 2010. 60(8): 543-50.
20. Sugimoto, M., Nishino, M., Kodaira, C., Yamade, M., Ikuma, M., Tanaka, T., Sugimura, H., Hishida, A., and Furuta, T., Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole. J Clin Pharmacol, 2010. 50(3): 320-30.
21. Shinmura, K., Tao, H., Nagura, K., Goto, M., Matsuura, S., Mochizuki, T., Suzuki, K., Tanahashi, M., Niwa, H., Ogawa, H., and Sugimura, H., Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer, 2010.
22. Shinmura, K., Kageyama, S., Igarashi, H., Kamo, T., Mochizuki, T., Suzuki, K., Takahashi, M., Niwa, H., Ogawa, H., and Sugimura, H., EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung canrcinomas. Experimental and therapeutic medicine, 2010. 1: 271-275.
23. Sato, N., Kageyama, S., Chen, R., Suzuki, M., Tanioka, F., Kamo, T., Shinmura, K., Nozawa, A., and Sugimura, H., Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese. Psychiatr Genet, 2010. 20(3): 135-6.
24. Sato, N., Kageyama, S., Chen, R., Suzuki, M., Mori, H., Tanioka, F., Yamada, H., Kamo, T., Tao, H., Shinmura, K., Nozawa, A., and Sugimura, H., Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. J Hum Genet, 2010. 55(11): 755-60.
25. Nishino, M., Sugimoto, M., Kodaira, C., Yamade, M., Uotani, T., Shirai, N., Ikuma, M., Tanaka, T., Sugimura, H., Hishida, A., and Furuta, T., Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers. J Clin Pharmacol, 2010.
26. Morita, Y., Ikegami, K., Goto-Inoue, N., Hayasaka, T., Zaima, N., Tanaka, H., Uehara, T., Setoguchi, T., Sakaguchi, T., Igarashi, H., Sugimura, H., Setou, M., and Konno, H., Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray. Cancer Sci, 2010. 101(1): 267--273.
27. Kawahara, N., Sugimura, H., Nakagawara, A., Masui, T., Miyake, J., Akiyama, M., Wahid, I.A., Hao, X., and Akaza, H., The 6th Asia cancer forum: what should we do to place cancer on the global health agenda? Sharing information leads to human security. Jpn J Clin Oncol, 2010. 41(5): 723-9.
28. Goto, M., Shinmura, K., Tao, H., Tsugane, S., and Sugimura, H., Three novel NEIL1 promoter polymorphisms in gastric cancer patients. World Journal of Gastrointestinal Oncology, 2010. 2(2): 117-120.
29. Goto, M., Shinmura, K., Nakabeppu, Y., Tao, H., Yamada, H., Tsuneyoshi, T., and Sugimura, H., Adenine DNA glycosylase activity of 14 Human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer. Hum Mutat, 2010. 31: E1881-74.
30. Chou, P.H., Kageyama, S., Matsuda, S., Kanemoto, K., Sasada, Y., Oka, M., Shinmura, K., Mori, H., Kawai, K., Kasai, H., Sugimura, H., and Matsuda, T., Detection of lipid peroxidation-induced DNA adducts caused by 4-oxo-2(E)-nonenal and 4-oxo-2(E)-hexenal in human autopsy tissues. Chem Res Toxicol, 2010. 23(9): 1442-8.
31. Akieda-Asai, S., Zaima, N., Ikegami, K., Kahyo, T., Yao, I., Hatanaka, T., Iemura, S., Sugiyama, R., Yokozeki, T., Eishi, Y., Koike, M., Ikeda, K., Chiba, T., Yamaza, H., Shimokawa, I., Song, S.Y., Matsuno, A., Mizutani, A., Sawabe, M., Chao, M.V., Tanaka, M., Kanaho, Y., Natsume, T., Sugimura, H., Date, Y., McBurney, M.W., Guarente, L., and Setou, M., SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One, 2010. 5(7): e11755.
32. Yamada, H., Shinmura, K., Yamamura, Y., Kurachi, K., Nakamura, T., Tsuneyoshi, T., Yokota, N., Maekawa, M., and Sugimura, H., Identification and characterization of a novel germline p53 mutation in a patient with glioblastoma and colon cancer. Int J Cancer, 2009. 125(4): 973-6.
33. Yamada, H., Shinmura, K., Goto, M., Iwaizumi, M., Konno, H., Kataoka, H., Yamada, M., Ozawa, T., Tsuneyoshi, T., Tanioka, F., and Sugimura, H., Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. Mol Cancer, 2009. 8(1): 63.
34. Takai, T., Kanaoka, S., Yoshida, K., Hamaya, Y., Ikuma, M., Miura, N., Sugimura, H., Kajimura, M., and Hishida, A., Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. Cancer Epidemiol Biomarkers Prev, 2009. 18(6): 1888-93.
35. Suzuki, M., Nagura, K., Igarashi, H., Tao, H., Midorikawa, Y., Kitayama, Y., and Sugimura, H., Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterations in human tumors. Pathol Int, 2009. 59(4): 218-28.
36. Seike, M., Goto, A., Okano, T., Bowman, E.D., Schetter, A.J., Horikawa, I., Mathe, E.A., Jen, J., Yang, P., Sugimura, H., Gemma, A., Kudoh, S., Croce, C.M., and Harris, C.C., MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A, 2009. 106(29): 12085-90.
37. Okudela, K., Yazawa, T., Woo, T., Sakaeda, M., Ishii, J., Mitsui, H., Shimoyamada, H., Sato, H., Tajiri, M., Ogawa, N., Masuda, M., Takahashi, T., Sugimura, H., and Kitamura, H., Down-Regulation of DUSP6 Expression in Lung Cancer --Its Mechanism and Potential Role in Carcinogenesis. Am J Pathol, 2009. 175(2): 867-881.
38. Okudela, K., Yazawa, T., Suzuki, T., Sugimura, H., and Kitamura, H., Role of 3'-phosphoinositides in oncogenic KRAS-induced modulation of shape and motility of airway epithelial cells. Pathol Int, 2009. 59(1): 28-37.
39. Okudela, K., Yazawa, T., Ishii, J., Woo, T., Mitsui, H., Bunai, T., Sakaeda, M., Shimoyamada, H., Sato, H., Tajiri, M., Ogawa, N., Masuda, M., Sugimura, H., and Kitamura, H., Down-Regulation of FXYD3 Expression in Human Lung Cancers. Its Mechanism and Potential Role in Carcinogenesis. Am J Pathol, 2009. 175(6): 2646-56.
40. Nishino, M., Sugimoto, M., Kodaira, C., Yamade, M., Shirai, N., Ikuma, M., Tanaka, T., Sugimura, H., Hishida, A., and Furuta, T., Relationship Between Low-Dose Aspirin-Induced Gastric Mucosal Injury and Intragastric pH in Healthy Volunteers. Dig Dis Sci, 2009.
41. Midorikawa, Y., Yamamoto, S., Tsuji, S., Kamimura, N., Ishikawa, S., Igarashi, H., Makuuchi, M., Kokudo, N., Sugimura, H., and Aburatani, H., Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis. Hepatology, 2009. 49(2): 513-22.
42. Iwaizumi, M., Shinmura, K., Mori, H., Yamada, H., Suzuki, M., Kitayama, Y., Igarashi, H., Nakamura, T., Suzuki, H., Watanabe, Y., Hishida, A., Ikuma, M., and Sugimura, H., Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut, 2009. 58(2): 249-60.
43. Goto, M., Shinmura, K., Igarashi, H., Kobayashi, M., Konno, H., Yamada, H., Iwaizumi, M., Kageyama, S., Tsuneyoshi, T., Tsugane, S., and Sugimura, H., Altered expression of the human base excision repair gene NTH1 in gastric cancer. Carcinogenesis, 2009. 30(8): 1345-52.
44. Dong, Y., Wang, J., Sheng, Z., Li, G., Ma, H., Wang, X., Zhang, R., Lu, G., Hu, Q., Sugimura, H., and Zhou, X., Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis. Mod Pathol, 2009. 22(1): 151-60.
45. Yamagata, N., Furuno, K., Sonoda, M., Sugimura, H., and Yamamoto, K., Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis. Biochem Biophys Res Commun, 2008. 376(3): 499-503.
46. Torisu, Y., Watanabe, A., Nonaka, A., Midorikawa, Y., Makuuchi, M., Shimamura, T., Sugimura, H., Niida, A., Akiyama, T., Iwanari, H., Kodama, T., Zeniya, M., and Aburatani, H., Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. Cancer Sci, 2008. 99(6): 1139-46.
47. Tao, H., Shinmura, K., Suzuki, M., Kono, S., Mibu, R., Tanaka, M., Kakeji, Y., Maehara, Y., Okamura, T., Ikejiri, K., Futami, K., Yasunami, Y., Maekawa, T., Takenaka, K., Ichimiya, H., Imaizumi, N., and Sugimura, H., Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population. Cancer Sci, 2008. 99(2): 355-60.
48. Suzuki, M., Kageyama, S., Shinmura, K., Okudela, K., Bunai, T., Nagura, K., Igarashi, H., Kiyose, S., Mori, H., Tao, H., Goto, M., Takamochi, K., Mochizuki, T., Suzuki, K., Ohashi, R., Ogawa, H., Yamada, T., Niwa, H., Tsuneyoshi, T., and Sugimura, H., Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and protein expression of EGFR in the carcinoma. J Surg Oncol, 2008. 98(6): 457-61.
49. Suzuki, A., Suzuki, S., Sakaguchi, T., Oishi, K., Fukumoto, K., Ota, S., Inaba, K., Takehara, Y., Sugimura, H., Uchiyama, T., and Konno, H., Colonic fistula associated with severe acute pancreatitis: report of two cases. Surg Today, 2008. 38(2): 178-83.
50. Sugimura, H., Detection of chromosome changes in pathology archives: an application of microwave-assisted fluorescence in situ hybridization to human carcinogenesis studies. Carcinogenesis, 2008. 29(4): 681-7.
51. Sugimura, H., [Familial aggregation of gastric cancer]. Gan To Kagaku Ryoho, 2008. 35(4): 551-6.
52. Sugimoto, M., Furuta, T., Shirai, N., Kodaira, C., Nishino, M., Yamade, M., Ikuma, M., Sugimura, H., Ishizaki, T., and Hishida, A., MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. Life Sci, 2008. 7-883(7-8): 301-4.
53. Sugimoto, M., Furuta, T., Kodaira, C., Nishino, M., Yamade, M., Ikuma, M., Sugimura, H., and Hishida, A., Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. J Gastroenterol, 2008. 43(10): 751-61.
54. Shinmura, K., Suzuki, M., Yamada, H., Tao, H., Goto, M., Kamo, T., Nagura, K., Kageyama, S., Kato, M., Ogawa, S., Maekawa, M., Takamochi, K., Suzuki, K., Nakamura, T., and Sugimura, H., Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient. Pathol Int, 2008. 58(11): 706-12.
55. Shinmura, K., Kageyama, S., Tao, H., Bunai, T., Suzuki, M., Kamo, T., Takamochi, K., Suzuki, K., Tanahashi, M., Niwa, H., Ogawa, H., and Sugimura, H., EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer, 2008. 61(2): 163-9.
56. Shinmura, K., Iwaizumi, M., Igarashi, H., Nagura, K., Yamada, H., Suzuki, M., Fukasawa, K., and Sugimura, H., Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol, 2008. 216(3): 365-74.
57. Sheng, Z., Wang, J., Dong, Y., Ma, H., Zhou, H., Sugimura, H., Lu, G., and Zhou, X., EphB1 is underexpressed in poorly differentiated colorectal cancers. Pathobiology, 2008. 75(5): 274-80.
58. Sakamoto, H., Yoshimura, K., Saeki, N., Katai, H., Shimoda, T., Matsuno, Y., Saito, D., Sugimura, H., Tanioka, F., Kato, S., Matsukura, N., Matsuda, N., Nakamura, T., Hyodo, I., Nishina, T., Yasui, W., Hirose, H., Hayashi, M., Toshiro, E., Ohnami, S., Sekine, A., Sato, Y., Totsuka, H., Ando, M., Takemura, R., Takahashi, Y., Ohdaira, M., Aoki, K., Honmyo, I., Chiku, S., Aoyagi, K., Sasaki, H., Yanagihara, K., Yoon, K.A., Kook, M.C., Lee, Y.S., Park, S.R., Kim, C.G., Choi, I.J., Yoshida, T., Nakamura, Y., and Hirohashi, S., Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet, 2008. 40(6): 730-40.
59. Ohnami, S., Sato, Y., Yoshimura, K., Sakamoto, H., Aoki, K., Ueno, H., Ikeda, M., Morizane, C., Shimada, K., Sakamoto, Y., Esaki, M., Saito, I., Hirose, H., Saito, D., Sugimura, H., Kosuge, T., Okusaka, T., and Yoshida, T., His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk. Gastroenterology, 2008. 135(2): 477-88.
60. Nakayama, R., Sato, Y., Masutani, M., Ogino, H., Nakatani, F., Chuman, H., Beppu, Y., Morioka, H., Yabe, H., Hirose, H., Sugimura, H., Sakamoto, H., Ohta, T., Toyama, Y., Yoshida, T., and Kawai, A., Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan. Cancer Sci, 2008. 99(2): 333-9.
61. Mori, H., Nagata, M., Nishijima, N., Nagura, K., Igarashi, H., Hamazaki, M., Ozono, S., and Sugimura, H., Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette: differentiation from neuroblastoma on repeating fluorescence in situ hybridization. Pathol Int, 2008. 58(8): 518-23.
62. Lee, K.M., Kang, D., Clapper, M.L., Ingelman-Sundberg, M., Ono-Kihara, M., Kiyohara, C., Min, S., Lan, Q., Le Marchand, L., Lin, P., Lung, M.L., Pinarbasi, H., Pisani, P., Srivatanakul, P., Seow, A., Sugimura, H., Tokudome, S., Yokota, J., and Taioli, E., CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. Cancer Epidemiol Biomarkers Prev, 2008. 17(5): 1120-6.
63. Kasami, M., Uematsu, T., Honda, M., Yabuzaki, T., Sanuki, J., Uchida, Y., and Sugimura, H., Comparison of estrogen receptor, progesterone receptor and Her-2 status in breast cancer pre- and post-neoadjuvant chemotherapy. Breast, 2008.
64. Kageyama, S., Shinmura, K., Yamamoto, H., Goto, M., Suzuki, K., Tanioka, F., Tsuneyoshi, T., and Sugimura, H., Fluorescence-labeled methylation-sensitive amplified fragment length polymorphism (FL-MS-AFLP) analysis for quantitative determination of DNA methylation and demethylation status. Jpn J Clin Oncol, 2008. 38(4): 317-22.
65. Goto, M., Shinmura, K., Yamada, H., Tsuneyoshi, T., and Sugimura, H., OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2'-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa. J Genet, 2008. 87(2): 181-6.
66. Arai, Y., Tsuchida, T., Tanioka, F., Sugimura, H., Watanabe, C., Hongo, T., and Tsutsui, Y., Congenital anaplastic astrocytoma differentiated into pilocytic astrocytoma: an autopsy case. Neuropathology, 2008. 28(4): 433-9.
67. Yamada, H., Shinmura, K., Okudela, K., Goto, M., Suzuki, M., Kuriki, K., Tsuneyoshi, T., and Sugimura, H., Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population. Carcinogenesis, 2007. 28(9): 2013-8.
68. Yamada, H., Shinmura, K., Ikeda, S., Tao, H., Otani, T., Hanaoka, T., Tsuneyoshi, T., Tsugane, S., and Sugimura, H., Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. Scand J Gastroenterol, 2007. 42(12): 1479-85.
69. Watanabe, Y., Shibata, K., Sugimura, H., and Maekawa, M., p53-dependent change in replication timing of the human genome. Biochem Biophys Res Commun, 2007. 364(2): 289-93.
70. Wang, J.D., Dong, Y.C., Sheng, Z., Ma, H.H., Li, G.L., Wang, X.L., Lu, G.M., Sugimura, H., Jin, J., and Zhou, X.J., Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis. Oncology, 2007. 73(3-4): 238-45.
71. Wang, J., Li, G., Ma, H., Bao, Y., Wang, X., Zhou, H., Sheng, Z., Sugimura, H., Jin, J., and Zhou, X., Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma. Hum Pathol, 2007. 38(11): 1649-56.
72. Takamochi, K., Suzuki, K., Sugimura, H., Funai, K., Mori, H., Bashar, A.H., and Kazui, T., Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation. Lung Cancer, 2007. 58(1): 149-55.
73. Suzuki, H., Sugimura, H., and Hashimoto, K., Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamous cell carcinoma. Br J Oral Maxillofac Surg, 2007. 45(2): 123-9.
74. Sugimoto, M., Furuta, T., Shirai, N., Nakamura, A., Xiao, F., Kajimura, M., Sugimura, H., and Hishida, A., Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol, 2007. 22(1): 51-9.
75. Sugimoto, M., Furuta, T., Shirai, N., Nakamura, A., Kajimura, M., Sugimura, H., and Hishida, A., Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. J Gastroenterol Hepatol, 2007. 22(9): 1443-9.
76. Sugimoto, M., Furuta, T., Shirai, N., Kodaira, C., Nishino, M., Ikuma, M., Sugimura, H., and Hishida, A., Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese. Carcinogenesis, 2007. 28(9): 2036-40.
77. Seike, M., Yanaihara, N., Bowman, E.D., Zanetti, K.A., Budhu, A., Kumamoto, K., Mechanic, L.E., Matsumoto, S., Yokota, J., Shibata, T., Sugimura, H., Gemma, A., Kudoh, S., Wang, X.W., and Harris, C.C., Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst, 2007. 99(16): 1257-69.
78. Okudela, K., Suzuki, M., Kageyama, S., Bunai, T., Nagura, K., Igarashi, H., Takamochi, K., Suzuki, K., Yamada, T., Niwa, H., Ohashi, R., Ogawa, H., Mori, H., Kitamura, H., Kaneko, T., Tsuneyoshi, T., and Sugimura, H., PIK3CA mutation and amplification in human lung cancer. Pathol Int, 2007. 57(10): 664-71.
79. Kikuchi, H., Yamamoto, M., Hiramatsu, Y., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Sugimura, H., Kitagawa, M., Kanai, T., Kitayama, Y., Kanda, T., Nishikura, K., and Konno, H., Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Cancer Sci, 2007. 98(11): 1734-9.
80. Ikeda, M., Hirabayashi, S., Fujiwara, N., Mori, H., Kawata, A., Iida, J., Bao, Y., Sato, Y., Iida, T., Sugimura, H., and Hata, Y., Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp Cell Res, 2007. 313(7): 1484-95.
81. Gao, C.M., Takezaki, T., Wu, J.Z., Chen, M.B., Liu, Y.T., Ding, J.H., Sugimura, H., Cao, J., Hamajima, N., and Tajima, K., CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. World J Gastroenterol, 2007. 13(43): 5725-30.
82. Yamashita, K., Igarashi, H., Kitayama, Y., Ozawa, T., Kiyose, S., Konno, H., Kazui, T., Ishikawa, S., Aburatani, H., Tanioka, F., Suzuki, M., and Sugimura, H., Chromosomal numerical abnormality profiles of gastrointestinal stromal tumors. Jpn J Clin Oncol, 2006. 36(2): 85-92.
83. Suzuki, H., Sugimura, H., and Hashimoto, K., p16INK4A in oral squamous cell carcinomas--a correlation with biological behaviors: immunohistochemical and FISH analysis. J Oral Maxillofac Surg, 2006. 64(11): 1617-23.
84. Sugimoto, M., Furuta, T., Shirai, N., Ikuma, M., Sugimura, H., and Hishida, A., Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan. Cancer Epidemiol Biomarkers Prev, 2006. 15(10): 1929-34.
85. Sano, T., Kitayama, Y., Igarashi, H., Suzuki, M., Tanioka, F., Chida, K., Okudela, K., and Sugimura, H., Chromosomal numerical abnormalities in early stage lung adenocarcinoma. Pathol Int, 2006. 56(3): 117-25.
86. Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J.M., Benhamou, S., Boffetta, P., Cote, M.L., Dialyna, I.A., Dolzan, V., Filiberti, R., Garte, S., Hirvonen, A., Husgafvel-Pursiainen, K., Imyanitov, E.N., Kalina, I., Kang, D., Kiyohara, C., Kohno, T., Kremers, P., Lan, Q., London, S., Povey, A.C., Rannug, A., Reszka, E., Risch, A., Romkes, M., Schneider, J., Seow, A., Shields, P.G., Sobti, R.C., Sorensen, M., Spinola, M., Spitz, M.R., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Tokudome, S., Yang, P., Yuan, J.M., Warholm, M., and Taioli, E., Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Am J Epidemiol, 2006. 164(11): 1027-42.
87. Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H., Chida, K., and Kitagawa, M., Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner. Biochem Biophys Res Commun, 2006. 340(1): 54-61.
88. Midorikawa, Y., Yamamoto, S., Ishikawa, S., Kamimura, N., Igarashi, H., Sugimura, H., Makuuchi, M., and Aburatani, H., Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays. Oncogene, 2006. 25(40): 5581-90.
89. Kitayama, Y., Igarashi, H., Kozu, T., Nagura, K., Ohashi, Y., and Sugimura, H., Repeated fluorescence in situ hybridization by a microwave-enhanced protocol. Pathol Int, 2006. 56(9): 490-3.
90. Kikuchi, H., Yamashita, K., Kawabata, T., Yamamoto, M., Hiramatsu, Y., Kondo, K., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Kitagawa, K., Kitagawa, M., Sugimura, H., and Konno, H., Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors: sequential analyses. Cancer Sci, 2006. 97(2): 127-32.
91. Kikuchi, H., Yamamoto, M., Hiramatsu, Y., Baba, M., Ohta, M., Kamiya, K., Tanaka, T., Suzuki, S., Sugimura, H., and Konno, H., [Manifestation of liver metastasis 13 years after gastrectomy for gastric GIST]. Nippon Shokakibyo Gakkai Zasshi, 2006. 103(9): 1055-60.
92. Kanaly, R.A., Hanaoka, T., Sugimura, H., Toda, H., Matsui, S., and Matsuda, T., Development of the adductome approach to detect DNA damage in humans. Antioxid Redox Signal, 2006. 8(5-6): 993-1001.
93. Yamada, H., Shinmura, K., Tsuneyoshi, T., and Sugimura, H., Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression. J Genet, 2005. 84(2): 131-6.
94. Wang, J., Kataoka, H., Suzuki, M., Sato, N., Nakamura, R., Tao, H., Maruyama, K., Isogaki, J., Kanaoka, S., Ihara, M., Tanaka, M., Kanamori, M., Nakamura, T., Shinmura, K., and Sugimura, H., Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene, 2005. 24(36): 5637-47.
95. Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., Yasuda, H., and Kitagawa, M., Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J, 2005. 24(1): 160-9.
96. Sugimoto, M., Furuta, T., Shirai, N., Nakamura, A., Kajimura, M., Sugimura, H., Hishida, A., and Ishizaki, T., Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection. Aliment Pharmacol Ther, 2005. 22(10): 1033-40.
97. Shinmura, K., Goto, M., Tao, H., Shimizu, S., Otsuki, Y., Kobayashi, H., Ushida, S., Suzuki, K., Tsuneyoshi, T., and Sugimura, H., A novel STK11 germline mutation in two siblings with Peutz-Jeghers syndrome complicated by primary gastric cancer. Clin Genet, 2005. 67(1): 81-6.
98. Shimamura, T., Ito, H., Shibahara, J., Watanabe, A., Hippo, Y., Taniguchi, H., Chen, Y., Kashima, T., Ohtomo, T., Tanioka, F., Iwanari, H., Kodama, T., Kazui, T., Sugimura, H., Fukayama, M., and Aburatani, H., Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci, 2005. 96(5): 265-73.
99. Raimondi, S., Boffetta, P., Anttila, S., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Dragani, T.A., Garte, S., Gsur, A., Haidinger, G., Hirvonen, A., Ingelman-Sundberg, M., Kalina, I., Lan, Q., Leoni, V.P., Le Marchand, L., London, S.J., Neri, M., Povey, A.C., Rannug, A., Reszka, E., Ryberg, D., Risch, A., Romkes, M., Ruano-Ravina, A., Schoket, B., Spinola, M., Sugimura, H., Wu, X., and Taioli, E., Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res, 2005. 592(1-2): 45-57.
100. Nakamura, R., Kataoka, H., Sato, N., Kanamori, M., Ihara, M., Igarashi, H., Ravshanov, S., Wang, Y.J., Li, Z.Y., Shimamura, T., Kobayashi, T., Konno, H., Shinmura, K., Tanaka, M., and Sugimura, H., EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci, 2005. 96(1): 42-7.
101. Maekawa, M., Taniguchi, T., Uramoto, T., Higashi, H., Horii, T., Takeshita, A., Sugimura, H., and Kanamori, M., Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes. Clin Chim Acta, 2005. 355(1-2): 181-4.
102. Kitayama, Y. and Sugimura, H., Nonrandom chromosomal numerical abnormality as a new molecular cytogenetic tumor marker--a retrospective study of 60 gastric cancer cases. Rinsho Byori, 2005. 53(10): 881-6.
103. Igarashi, H., Yamashita, K., Suzuki, M., Kitayama, Y., Isogaki, J., Maruyama, K., Sunayama, K., Tsuda, H., Ozawa, T., Kiyose, S., and Sugimura, H., Simultaneous imaging of membrane antigen and the corresponding chromosomal locus in pathology archives. Pathol Int, 2005. 55(12): 753-6.
104. Aoki, M., Yamamoto, K., Ohyama, S., Yamamura, Y., Takenoshita, S., Sugano, K., Minamoto, T., Kitajima, M., Sugimura, H., Shimada, S., Noshiro, H., Hiratsuka, M., Sairenji, M., Ninomiya, I., Yano, M., Uesaka, K., Matsuno, S., Maehara, Y., Aikou, T., and Sasazuki, T., A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. Biochem Biophys Res Commun, 2005. 335(2): 566-74.
105. Aoki, M., Yamamoto, K., Noshiro, H., Sakai, K., Yokota, J., Kohno, T., Tokino, T., Ishida, S., Ohyama, S., Ninomiya, I., Uesaka, K., Kitajima, M., Shimada, S., Matsuno, S., Yano, M., Hiratsuka, M., Sugimura, H., Itoh, F., Minamoto, T., Maehara, Y., Takenoshita, S., Aikou, T., Katai, H., Yoshimura, K., Takahashi, T., Akagi, K., Sairenji, M., Yamamura, Y., and Sasazuki, T., A full genome scan for gastric cancer. J Med Genet, 2005. 42(1): 83-7.
106. Watanabe, Y., Ikemura, T., and Sugimura, H., Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing. Genomics, 2004. 84(5): 796-805.
107. Tao, H., Shinmura, K., Hanaoka, T., Natsukawa, S., Shaura, K., Koizumi, Y., Kasuga, Y., Ozawa, T., Tsujinaka, T., Li, Z., Yamaguchi, S., Yokota, J., Sugimura, H., and Tsugane, S., A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus. Carcinogenesis, 2004. 25(10): 1859-66.
108. Tanaka, M., Ohashi, R., Nakamura, R., Shinmura, K., Kamo, T., Sakai, R., and Sugimura, H., Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J, 2004. 23(5): 1075-88.
109. Smits, K.M., Benhamou, S., Garte, S., Weijenberg, M.P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A.K., Muzi, G., Dolzan, V., Duzhak, T.G., Farker, K., Golka, K., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M.C., London, S., Manni, J.J., Maugard, C.M., Morgan, G.J., Morita, S., Nazar-Stewart, V., Kristensen, V.N., Oda, Y., Parl, F.F., Peters, W.H., Rannug, A., Rebbeck, T., Pinto, L.F., Risch, A., Romkes, M., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnett, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Zheng, W., Pedotti, P., and Taioli, E., Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Int J Cancer, 2004. 110(2): 266-70.
110. Shinmura, K., Tao, H., Yamada, H., Kataoka, H., Sanjar, R., Wang, J., Yoshimura, K., and Sugimura, H., Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. Hum Mutat, 2004. 24(3): 273-4.
111. Shinmura, K., Tao, H., Goto, M., Igarashi, H., Taniguchi, T., Maekawa, M., Takezaki, T., and Sugimura, H., Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. Carcinogenesis, 2004. 25(12): 2311-7.
112. Mori, H., Hirabayashi, S., Shirasawa, M., Sugimura, H., and Hata, Y., JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidney cells. Genes Cells, 2004. 9(9): 811-9.
113. Maekawa, M., Taniguchi, T., Higashi, H., Sugimura, H., Sugano, K., and Kanno, T., Methylation of mitochondrial DNA is not a useful marker for cancer detection. Clin Chem, 2004. 50(8): 1480-1.
114. Maekawa, M., Nagaoka, T., Taniguchi, T., Higashi, H., Sugimura, H., Sugano, K., Yonekawa, H., Satoh, T., Horii, T., Shirai, N., Takeshita, A., and Kanno, T., Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNA sequencing for mutation analysis of K-ras codons 12 and 13. Clin Chem, 2004. 50(8): 1322-7.
115. Kobayashi, K., Nishioka, M., Kohno, T., Nakamoto, M., Maeshima, A., Aoyagi, K., Sasaki, H., Takenoshita, S., Sugimura, H., and Yokota, J., Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo. Oncogene, 2004. 23(17): 3089-96.
116. Kikuchi, H., Konno, H., Kamiya, K., Baba, M., Ohta, M., Kondo, K., Hiramatsu, Y., Yamamoto, M., Tanaka, T., Sugimura, H., Ohashi, M., Kanda, T., and Nakamura, S., [Two cases of postoperative recurrence of gastric GIST treated by imatinib]. Gan To Kagaku Ryoho, 2004. 31(10): 1569-73.
117. Kataoka, H., Igarashi, H., Kanamori, M., Ihara, M., Wang, J.D., Wang, Y.J., Li, Z.Y., Shimamura, T., Kobayashi, T., Maruyama, K., Nakamura, T., Arai, H., Kajimura, M., Hanai, H., Tanaka, M., and Sugimura, H., Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Cancer Sci, 2004. 95(2): 136-41.
118. Kanaoka, S., Yoshida, K., Miura, N., Sugimura, H., and Kajimura, M., Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology, 2004. 127(2): 422-7.
119. Hiramatsu, Y., Konno, H., Kamiya, K., Baba, M., Ohta, M., Kondo, K., Yamamoto, M., Kikuchi, H., Tanaka, T., Sugimura, H., and Nakamura, S., [A case of gastric GIST treated preoperatively by imatinib mesylate]. Gan To Kagaku Ryoho, 2004. 31(8): 1219-23.
120. Gao, C.M., Takezaki, T., Wu, J.Z., Liu, Y.T., Ding, J.H., Li, S.P., Su, P., Hu, X., Kai, H.T., Li, Z.Y., Matsuo, K., Hamajima, N., Sugimura, H., and Tajima, K., Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. Asian Pac J Cancer Prev, 2004. 5(2): 133-8.
121. Furuta, T., Shirai, N., Xiao, F., El-Omar, E.M., Rabkin, C.S., Sugimura, H., Ishizaki, T., and Ohashi, K., Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy. Clin Gastroenterol Hepatol, 2004. 2(1): 22-30.
122. Wang, Y., Song, J.P., Ikeda, M., Shinmura, K., Yokota, J., and Sugimura, H., Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer. Jpn J Clin Oncol, 2003. 33(1): 17-20.
123. Vineis, P., Veglia, F., Benhamou, S., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Dolzan, V., Haugen, A., Hirvonen, A., Ingelman-Sundberg, M., Kihara, M., Kiyohara, C., Kremers, P., Le Marchand, L., Ohshima, S., Pastorelli, R., Rannug, A., Romkes, M., Schoket, B., Shields, P., Strange, R.C., Stucker, I., Sugimura, H., Garte, S., Gaspari, L., and Taioli, E., CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls. Int J Cancer, 2003. 104(5): 650-7.
124. Ueki, T., Tanaka, M., Yamashita, K., Mikawa, S., Qiu, Z., Maragakis, N.J., Hevner, R.F., Miura, N., Sugimura, H., and Sato, K., A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. J Neurosci, 2003. 23(37): 11732-40.
125. Tozawa, K., Hanai, H., Sugimoto, K., Baba, S., Sugimura, H., Aoshi, T., Uchijima, M., Nagata, T., and Koide, Y., Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice. J Gastroenterol Hepatol, 2003. 18(5): 578-87.
126. Tanioka, F., Tamashima, S., Shimizu, S., Kobayashi, H., Kobayashi, Y., and Sugimura, H., A case of primary plasma cell leukemia with hairy-cell morphology and lambda-type Bence-Jones protein. Immunohistochemical and molecular analysis. Jpn J Clin Oncol, 2003. 33(5): 232-7.
127. Tanaka, M., Kamo, T., Ota, S., and Sugimura, H., Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J, 2003. 22(4): 847-58.
128. Otsuki, Y., Tanaka, M., Kamo, T., Kitanaka, C., Kuchino, Y., and Sugimura, H., Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts. J Biol Chem, 2003. 278(7): 5132-40.
129. Nakamura, R. and Sugimura, H., [Molecular biology of colorectal cancer: The cell cycle and its regulation]. Nippon Rinsho, 2003. 61 Suppl 7: 91-4.
130. Nakamura, R., Song, J.P., Isogaki, J., Kitayama, Y., and Sugimura, H., Multiple (multicentric and multifocal) cancers in the ipsilateral breast with different histologies: profiles of chromosomal numerical abnormality. Jpn J Clin Oncol, 2003. 33(9): 463-9.
131. Maekawa, M., Taniguchi, T., Tatebayashi, C., Horii, T., Takeshita, A., Sugimura, H., Sugano, K., Yonekawa, H., Nagaoka, T., and Kanno, T., [Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system]. Rinsho Byori, 2003. 51(4): 306-12.
132. Maekawa, M., Taniguchi, T., Ishikawa, J., Sugimura, H., Sugano, K., and Kanno, T., Promoter hypermethylation in cancer silences LDHB, eliminating lactate dehydrogenase isoenzymes 1-4. Clin Chem, 2003. 49(9): 1518-20.
133. Li, Z., Tanaka, M., Kataoka, H., Nakamura, R., Sanjar, R., Shinmura, K., and Sugimura, H., EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence. J Cancer Res Clin Oncol, 2003. 129(12): 703-8.
134. Le Marchand, L., Guo, C., Benhamou, S., Bouchardy, C., Cascorbi, I., Clapper, M.L., Garte, S., Haugen, A., Ingelman-Sundberg, M., Kihara, M., Rannug, A., Ryberg, D., Stucker, I., Sugimura, H., and Taioli, E., Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States). Cancer Causes Control, 2003. 14(4): 339-46.
135. Kitayama, Y., Igarashi, H., Watanabe, F., Maruyama, Y., Kanamori, M., and Sugimura, H., Nonrandom chromosomal numerical abnormality predicting prognosis of gastric cancer: a retrospective study of 51 cases using pathology archives. Lab Invest, 2003. 83(9): 1311-20.
136. Yokota, N., Nishizawa, S., Ohta, S., Date, H., Sugimura, H., Namba, H., and Maekawa, M., Role of Wnt pathway in medulloblastoma oncogenesis. Int J Cancer, 2002. 101(2): 198-201.
137. Wang, Y., Ota, S., Kataoka, H., Kanamori, M., Li, Z., Band, H., Tanaka, M., and Sugimura, H., Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun, 2002. 296(1): 214-20.
138. Takezaki, T., Gao, C.M., Wu, J.Z., Li, Z.Y., Wang, J.D., Ding, J.H., Liu, Y.T., Hu, X., Xu, T.L., Tajima, K., and Sugimura, H., hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese. Int J Cancer, 2002. 99(4): 624-7.
139. Sunaga, N., Kohno, T., Yanagitani, N., Sugimura, H., Kunitoh, H., Tamura, T., Takei, Y., Tsuchiya, S., Saito, R., and Yokota, J., Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility. Cancer Epidemiol Biomarkers Prev, 2002. 11(8): 730-8.
140. Song, J.P., Kitayama, Y., Igarashi, H., Guo, R.J., Wang, Y.J., Kobayashi, T., Konno, H., Kataoka, H., Tanaka, M., and Sugimura, H., Centromere numerical abnormality in the papillary, papillotubular type of early gastric cancer, a further characterization of a subset of gastric cancer. Int J Oncol, 2002. 21(6): 1205-11.
141. Ohta, S., Nishizawa, S., Namba, H., and Sugimura, H., Bilateral cavernous sinus actinomycosis resulting in painful ophthalmoplegia. Case report. J Neurosurg, 2002. 96(3): 600-2.
142. Ohta, M., Konno, H., Tanaka, T., Baba, M., Kamiya, K., Mitsuoka, H., Unno, N., Sugimura, H., and Nakamura, S., Gastrojejunocolic fistula after gastrectomy with Billroth II reconstruction: report of a case. Surg Today, 2002. 32(4): 367-70.
143. Nakamura, T., Maruyama, K., Kashiwabara, H., Sunayama, K., Ohata, K., Fukazawa, A., Yasumi, K., Sugimura, H., and Nakamura, S., Diverticulitis causing a high serum level of carbohydrate antigen 19-9: report of a case. Surg Today, 2002. 32(3): 282-4.
144. Matsuda, H., Chida, K., Miwa, S., Nakano, H., Kuwata, H., Suzuki, K., Yokomura, K., Asada, K., Nakamura, Y., Inui, N., Suda, T., Nakamura, H., Naito, Y., and Sugimura, H., [An autopsy case of cor pulmonale due to a pulmonary tumor embolism as the first clinical manifestation of occult gastric cancer]. Nihon Kokyuki Gakkai Zasshi, 2002. 40(11): 910-4.
145. Li, Z., Wang, Y., Song, J., Kataoka, H., Yoshii, S., Gao, C., Zhou, J., Ota, S., Tanaka, M., and Sugimura, H., Genomic structure of the human beta-PIX gene and its alteration in gastric cancer. Cancer Lett, 2002. 177(2): 203-8.
146. Kobayashi, T., Sugimura, H., and Kimura, T., Total gastrectomy is not always necessary for advanced gastric cancer of the cardia. Dig Surg, 2002. 19(1): 15-21.
147. Kataoka, H., Tanaka, M., Kanamori, M., Yoshii, S., Ihara, M., Wang, Y.J., Song, J.P., Li, Z.Y., Arai, H., Otsuki, Y., Kobayashi, T., Konno, H., Hanai, H., and Sugimura, H., Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. J Cancer Res Clin Oncol, 2002. 128(7): 343-8.
148. Gao, C.M., Takezaki, T., Wu, J.Z., Li, Z.Y., Liu, Y.T., Li, S.P., Ding, J.H., Su, P., Hu, X., Xu, T.L., Sugimura, H., and Tajima, K., Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers: a case-control study of a high-incidence area in Jiangsu Province, China. Cancer Lett, 2002. 188(1-2): 95-102.
149. Gao, C., Takezaki, T., Wu, J., Li, Z., Wang, J., Ding, J., Liu, Y., Hu, X., Xu, T., Tajima, K., and Sugimura, H., Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese. Cancer Epidemiol Biomarkers Prev, 2002. 11(1): 29-34.
150. Furuta, T., Shirai, N., Takashima, M., Xiao, F., and Sugimura, H., Effect of genotypic differences in interleukin-1 beta on gastric acid secretion in Japanese patients infected with Helicobacter pylori. Am J Med, 2002. 112(2): 141-3.
151. Furuta, T., El-Omar, E.M., Xiao, F., Shirai, N., Takashima, M., and Sugimura, H., Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology, 2002. 123(1): 92-105.
152. Zhu, Y., Wang, D., and Sugimura, H., [Mutation analysis of tumor suppressor gene PTEN in bone and soft tissue tumors]. Zhonghua Yi Xue Za Zhi, 2001. 81(12): 715-8.
153. Yoshii, S., Tanaka, M., Otsuki, Y., Fujiyama, T., Kataoka, H., Arai, H., Hanai, H., and Sugimura, H., Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Mol Cell Biol, 2001. 21(20): 6796-807.
154. Wang, Y.J., Oba, S.M., Yoshii, S., Song, J.P., Wang, Y., Kanamori, M., Ota, S., Tanaka, M., and Sugimura, H., Genomic structure of human alpha-pix, and variable deletions in a poly (T) tract in gastric cancer tissue. Cancer Lett, 2001. 164(1): 69-75.
155. Takashima, M., Furuta, T., Hanai, H., Sugimura, H., and Kaneko, E., Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils. Gut, 2001. 48(6): 765-73.
156. Otsuki, Y., Tanaka, M., Yoshii, S., Kawazoe, N., Nakaya, K., and Sugimura, H., Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1. Proc Natl Acad Sci U S A, 2001. 98(8): 4385-90.
157. Oba, S.M., Wang, Y.J., Song, J.P., Li, Z.Y., Kobayashi, K., Tsugane, S., Hamada, G.S., Tanaka, M., and Sugimura, H., Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. Cancer Lett, 2001. 164(1): 97-104.
158. Nakamura, T., Ozawa, T., Kawasaki, T., Nakamura, H., and Sugimura, H., Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors. J Gastroenterol Hepatol, 2001. 16(12): 1402-8.
159. Hanaoka, T., Sugimura, H., Nagura, K., Ihara, M., Li, X.J., Hamada, G.S., Nishimoto, I., Kowalski, L.P., Yokota, J., and Tsugane, S., hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians. Cancer Lett, 2001. 170(1): 53-61.
160. Guo, R.J., Arai, H., Kitayama, Y., Igarashi, H., Hemmi, H., Arai, T., Hanai, H., and Sugimura, H., Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa. Pathol Int, 2001. 51(4): 240-7.
161. Garte, S., Gaspari, L., Alexandrie, A.K., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Benhamou, S., Boffetta, P., Bouchardy, C., Breskvar, K., Brockmoller, J., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Dell'Omo, M., Dolzan, V., Dresler, C.M., Fryer, A., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Kihara, M., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M.C., van Lieshout, E.M., London, S., Manni, J.J., Maugard, C.M., Morita, S., Nazar-Stewart, V., Noda, K., Oda, Y., Parl, F.F., Pastorelli, R., Persson, I., Peters, W.H., Rannug, A., Rebbeck, T., Risch, A., Roelandt, L., Romkes, M., Ryberg, D., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnet, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., and Taioli, E., Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev, 2001. 10(12): 1239-48.
162. Furuta, T., Shirai, N., Takashima, M., Xiao, F., Hanai, H., Sugimura, H., Ohashi, K., Ishizaki, T., and Kaneko, E., Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. Clin Pharmacol Ther, 2001. 69(3): 158-68.
163. Furuta, T., Shirai, N., Takashima, M., Xiao, F., Hanai, H., Nakagawa, K., Sugimura, H., Ohashi, K., and Ishizaki, T., Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin. Pharmacogenetics, 2001. 11(4): 341-8.
164. Endoh, A., Inoue, N., Katoh, T., Nakamura, T., Sugimura, H., and Ohzeki, T., A case of glycogen storage disease IA with multiple hepatic tumors managed by transcatheter arterial embolization and an acarbose diet. J Pediatr Gastroenterol Nutr, 2001. 33(3): 333-6.
165. Baba, M., Konno, H., Tanaka, T., Kamiya, K., Baba, S., Sugimura, H., and Nakamura, S., Relationship of p53 and Helicobacter pylori to clinicopathological features of human remnant stomach cancer after gastric surgery for primary gastric cancer. Oncol Rep, 2001. 8(4): 831-4.
166. Wang, D.Y., Xiang, Y.Y., Li, X.J., Hashimoto, M., Tanaka, M., and Sugimura, H., Mxi1 is a potential cellular target of carcinogens and frequently mutated in experimental rat tumors and tumor cell lines. Pathol Int, 2000. 50(5): 373-83.
167. Tanida, S., Tanioka, F., Inukai, M., Yoshioka, N., Saida, Y., Imai, K., Nakamura, T., Kitamura, H., and Sugimura, H., Ewing's sarcoma/peripheral primitive neuroectodermal tumor (pPNET) arising in the omentum as a multilocular cyst with intracystic hemorrhage. J Gastroenterol, 2000. 35(12): 933-40.
168. Shinmura, K., Kohno, T., Takeuchi-Sasaki, M., Maeda, M., Segawa, T., Kamo, T., Sugimura, H., and Yokota, J., Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells. Int J Oncol, 2000. 16(4): 701-7.
169. Saigusa, N., Kurahashi, T., Nakamura, T., Sugimura, H., Baba, S., Konno, H., and Nakamura, S., Functional outcome of stapled ileal pouch-anal canal anastomosis versus handsewn pouch-anal anastomosis. Surg Today, 2000. 30(7): 575-81.
170. Ohta, M., Konno, H., Kamiya, K., Suwa, D., Baba, M., Tanaka, T., Nakamura, T., Nishino, N., Sugimura, H., and Nakamura, S., Crohn's disease of the esophagus: report of a case. Surg Today, 2000. 30(3): 262-7.
171. Nishimura, T., Nozue, M., Suzuki, K., Imai, M., Suzuki, S., Sakahara, H., Nakamura, T., and Sugimura, H., Perianal mucinous carcinoma successfully treated with a combination of external beam radiotherapy and high dose rate interstitial brachytherapy. Br J Radiol, 2000. 73(870): 661-4.
172. Nishimoto, I.N., Hanaoka, T., Sugimura, H., Nagura, K., Ihara, M., Li, X.J., Arai, T., Hamada, G.S., Kowalski, L.P., and Tsugane, S., Cytochrome P450 2E1 polymorphism in gastric cancer in Brazil: case-control studies of Japanese Brazilians and non-Japanese Brazilians. Cancer Epidemiol Biomarkers Prev, 2000. 9(7): 675-80.
173. Matsushita, I., Hanai, H., Sato, Y., Arai, H., Iida, T., Hosoda, Y., Kaneko, E., Yasumi, K., and Sugimura, H., Protein-losing enteropathy caused by mesenteric venous thrombosis with protein C deficiency. J Clin Gastroenterol, 2000. 30(1): 94-7.
174. Koda, K., Yoshino, G., Honda, S., Watanabe, F., and Sugimura, H., Adenocarcinoma of the rectum with various grades of atypia in association with Crohn's disease: a case report and immunohistochemistry of p53 and Ki-67. Pathol Int, 2000. 50(4): 318-26.
175. Kobayashi, K., Kitayama, Y., Igarashi, H., Yoshino, G., Kobayashi, T., Kazui, T., and Sugimura, H., Intratumor heterogeneity of centromere numerical abnormality in multiple primary gastric cancers: application of fluorescence in situ hybridization with intermittent microwave irradiation on paraffin-embedded tissue. Jpn J Cancer Res, 2000. 91(11): 1134-41.
176. Kitayama, Y., Igarashi, H., and Sugimura, H., Initial intermittent microwave irradiation for fluorescence in situ hybridization analysis in paraffin-embedded tissue sections of gastrointestinal neoplasia. Lab Invest, 2000. 80(5): 779-81.
177. Kitayama, Y., Igarashi, H., and Sugimura, H., Different vulnerability among chromosomes to numerical instability in gastric carcinogenesis: stage-dependent analysis by FISH with the use of microwave irradiation. Clin Cancer Res, 2000. 6(8): 3139-46.
178. Kitayama, Y., Honda, S., and Sugimura, H., Epstein-Barr virus-related gastric pseudolymphoma in infectious mononucleosis. Gastrointest Endosc, 2000. 52(2): 290-1.
179. Igarashi, H., Nagura, K., and Sugimura, H., Trypan blue as a slow migrating dye for SSCP detection in polyacrylamide gel electrophoresis. Biotechniques, 2000. 29(1): 42-4.
180. Hashimoto, M., Wang, D.Y., Kamo, T., Zhu, Y., Tsujiuchi, T., Konishi, Y., Tanaka, M., and Sugimura, H., Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung. Am J Pathol, 2000. 157(1): 21-7.
181. Dragani, T.A., Hirohashi, S., Juji, T., Kawajiri, K., Kihara, M., Ono-Kihara, M., Manenti, G., Nomoto, T., Sugimura, H., Genka, K., Yokota, J., Takahashi, T., Mitsudomi, T., and Nagao, M., Population-based mapping of pulmonary adenoma susceptibility 1 locus. Cancer Res, 2000. 60(18): 5017-20.
182. Ando, H., Nishimura, T., Nakamura, T., Sugimura, H., and Nakamura, S., Chemoradiation therapy for squamous cell carcinoma of anal canal cancer: report of a case. Radiat Med, 2000. 18(3): 199-203.
183. Yuan, X., Ishibashi, S., Hatakeyama, S., Saito, M., Nakayama, J., Nikaido, R., Haruyama, T., Watanabe, Y., Iwata, H., Iida, M., Sugimura, H., Yamada, N., and Ishikawa, F., Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells, 1999. 4(10): 563-72.
184. Yoshii, S., Tanaka, M., Otsuki, Y., Wang, D.Y., Guo, R.J., Zhu, Y., Takeda, R., Hanai, H., Kaneko, E., and Sugimura, H., alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Oncogene, 1999. 18(41): 5680-90.
185. Ueda, M., Wang, Y., Sugimura, H., Tamura, S., Kondoh, M., and Ichihashi, M., A case of multiple sebaceous epithelioma: analysis of microsatellite instability. J Dermatol, 1999. 26(3): 178-82.
186. Suzuki, K., Kazui, T., Yoshida, M., Uno, T., Kobayashi, T., Kimura, T., Yoshida, T., and Sugimura, H., Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro. Jpn J Clin Oncol, 1999. 29(7): 323-31.
187. Sugimura, H., Kohno, T., Wakai, K., Nagura, K., Genka, K., Igarashi, H., Morris, B.J., Baba, S., Ohno, Y., Gao, C., Li, Z., Wang, J., Takezaki, T., Tajima, K., Varga, T., Sawaguchi, T., Lum, J.K., Martinson, J.J., Tsugane, S., Iwamasa, T., Shinmura, K., and Yokota, J., hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev, 1999. 8(8): 669-74.
188. Shinmura, K., Kohno, T., Takahashi, M., Sasaki, A., Ochiai, A., Guilford, P., Hunter, A., Reeve, A.E., Sugimura, H., Yamaguchi, N., and Yokota, J., Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. Carcinogenesis, 1999. 20(6): 1127-31.
189. Nakamura, T., Ozawa, T., Kawasaki, T., Yasumi, K., Wang, D.Y., Kitagawa, M., Takehira, Y., Tamakoshi, K., Yamada, M., Kida, H., Sugie, H., Nakamura, H., and Sugimura, H., Case report: Hepatocellular carcinoma in type 1a glycogen storage disease with identification of a glucose-6-phosphatase gene mutation in one family. J Gastroenterol Hepatol, 1999. 14(6): 553-8.
190. Li, X.J., Wang, D.Y., Zhu, Y., Guo, R.J., Wang, X.D., Lubomir, K., Mukai, K., Sasaki, H., Yoshida, H., Oka, T., Machinami, R., Shinmura, K., Tanaka, M., and Sugimura, H., Mxi1 mutations in human neurofibrosarcomas. Jpn J Cancer Res, 1999. 90(7): 740-6.
191. Kobayashi, T., Suzuki, K., Arai, T., and Sugimura, H., Angiomyofibroblastoma arising from the fallopian tube. Obstet Gynecol, 1999. 94(5 Pt 2): 833-4.
192. Kitayama, Y., Igarashi, H., and Sugimura, H., Amplification of FISH signals using intermittent microwave irradiation for analysis of chromosomal instability in gastric cancer. Mol Pathol, 1999. 52(6): 357-9.
193. Isogaki, J., Shinmura, K., Yin, W., Arai, T., Koda, K., Kimura, T., Kino, I., and Sugimura, H., Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers. Cancer Detect Prev, 1999. 23(3): 204-14.
194. Hosoda, Y., Hanai, H., Arai, H., Sato, Y., Kajimura, M., Sugimura, H., and Kaneko, E., Early gastric cancer exhibiting the features of submucosal tumor: report of a case. Endoscopy, 1999. 31(2): S11.
195. Arai, H., Hanai, H., Furuta, T., Sato, Y., Yamada, M., Kaneko, E., Baba, S., and Sugimura, H., A patient who survived total colonic type ulcerative colitis complicated by toxic megacolon, disseminated intravascular coagulation, methicillin-resistant Staphylococcus aureus infection and bilateral femoral phlebothrombosis. J Gastroenterol, 1999. 34(3): 395-9.
196. Yasumi, K., Guo, R.J., Hanai, H., Arai, H., Kaneko, E., Konno, H., Takenoshita, S., Hagiwara, K., and Sugimura, H., Transforming growth factor beta type II receptor (TGF beta RII) mutation in gastric lymphoma without mutator phenotype. Pathol Int, 1998. 48(2): 134-7.
197. Wang, Y., Shinmura, K., Guo, R.J., Isogaki, J., Wang, D.Y., Kino, I., and Sugimura, H., Mutational analyses of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability. Jpn J Cancer Res, 1998. 89(12): 1284-91.
198. Uchida, H., Ando, H., Maruyama, K., Kobayashi, H., Toda, H., Ogawa, H., Ozawa, T., Matsuda, Y., Sugimura, H., Kanno, T., and Baba, S., Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum. Jpn J Cancer Res, 1998. 89(3): 299-306.
199. Tanaka, M., Wang, D.Y., Kamo, T., Igarashi, H., Wang, Y., Xiang, Y.Y., Tanioka, F., Naito, Y., and Sugimura, H., Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development. Oncogene, 1998. 17(12): 1509-16.
200. Takashima, M., Hanai, H., Sato, Y., Arai, H., Furuta, T., Shirakawa, K., Chida, K., Sato, A., Sugimura, H., Baba, S., and Kaneko, E., Association of Crohn's ileitis with pulmonary and cutaneous sarcoidosis in a Japanese patient. Gastrointest Endosc, 1998. 48(6): 637-9.
201. Sugimura, H., Wakai, K., Genka, K., Nagura, K., Igarashi, H., Nagayama, K., Ohkawa, A., Baba, S., Morris, B.J., Tsugane, S., Ohno, Y., Gao, C., Li, Z., Takezaki, T., Tajima, K., and Iwamasa, T., Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa. Cancer Epidemiol Biomarkers Prev, 1998. 7(5): 413-7.
202. Shinmura, K., Tani, M., Isogaki, J., Wang, Y., Sugimura, H., and Yokota, J., RER phenotype and its associated mutations in familial gastric cancer. Carcinogenesis, 1998. 19(2): 247-51.
203. Shinmura, K., Kohno, T., Kasai, H., Koda, K., Sugimura, H., and Yokota, J., Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn J Cancer Res, 1998. 89(8): 825-8.
204. Naito, Y., Ohori, K., Tanaka, M., Kamo, T., Baba, S., Hori, T., Hashizume, K., and Sugimura, H., Collagen and elastin synthesis by desmoid tumor in vitro. Pathol Int, 1998. 48(8): 603-10.
205. Konno, H., Arai, T., Tanaka, T., Baba, M., Matsumoto, K., Kanai, T., Nakamura, S., Baba, S., Naito, Y., Sugimura, H., Yukita, A., Asano, M., and Suzuki, H., Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm. Jpn J Cancer Res, 1998. 89(9): 933-9.
206. Kohno, T., Shinmura, K., Tosaka, M., Tani, M., Kim, S.R., Sugimura, H., Nohmi, T., Kasai, H., and Yokota, J., Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene, 1998. 16(25): 3219-25.
207. Kobayashi, T., Kimura, T., Takabayashi, N., and Sugimura, H., Two synchronous solid and cystic tumors of the pancreas. J Gastroenterol, 1998. 33(3): 439-42.
208. Kiyokawa, E., Hashimoto, Y., Kurata, T., Sugimura, H., and Matsuda, M., Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. J Biol Chem, 1998. 273(38): 24479-84.
209. Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T., and Matsuda, M., Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev, 1998. 12(21): 3331-6.
210. Kitayama, Y., Sugimura, H., and Nakamura, S.I., Gastric plasmacytoma coexistent with plasma cell granuloma in a patient with gastric cancer. J Gastroenterol, 1998. 33(1): 80-5.
211. Guo, R.J., Wang, Y., Kaneko, E., Wang, D.Y., Arai, H., Hanai, H., Takenoshita, S., Hagiwara, K., Harris, C.C., and Sugimura, H., Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer. Carcinogenesis, 1998. 19(9): 1539-44.
212. Yin, J., Kong, D., Wang, S., Zou, T.T., Souza, R.F., Smolinski, K.N., Lynch, P.M., Hamilton, S.R., Sugimura, H., Powell, S.M., Young, J., Abraham, J.M., and Meltzer, S.J., Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Hum Mutat, 1997. 10(6): 474-8.
213. Xiang, Y.Y., Wang, D.Y., Tanaka, M., Suzuki, M., Kiyokawa, E., Igarashi, H., Naito, Y., Shen, Q., and Sugimura, H., Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa. Int J Cancer, 1997. 74(1): 1-6.
214. Wang, Y., Shinmura, K., and Sugimura, H., [Microsatellite instability in gastric cancer with varied structure]. Rinsho Byori, 1997. 45(7): 651-5.
215. Wang, S., Souza, R.F., Kong, D., Yin, J., Smolinski, K.N., Zou, T.T., Frank, T., Young, J., Flanders, K.C., Sugimura, H., Abraham, J.M., and Meltzer, S.J., Deficient transforming growth factor-beta1 activation and excessive insulin-like growth factor II (IGFII) expression in IGFII receptor-mutant tumors. Cancer Res, 1997. 57(13): 2543-6.
216. Souza, R.F., Yin, J., Smolinski, K.N., Zou, T.T., Wang, S., Shi, Y.Q., Rhyu, M.G., Cottrell, J., Abraham, J.M., Biden, K., Simms, L., Leggett, B., Bova, G.S., Frank, T., Powell, S.M., Sugimura, H., Young, J., Harpaz, N., Shimizu, K., Matsubara, N., and Meltzer, S.J., Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors. Cancer Res, 1997. 57(12): 2350-3.
217. Simms, L.A., Zou, T.T., Young, J., Shi, Y.Q., Lei, J., Appel, R., Rhyu, M.G., Sugimura, H., Chenevix-Trench, G., Souza, R.F., Meltzer, S.J., and Leggett, B.A., Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers. Oncogene, 1997. 14(21): 2613-8.
218. Shinmura, K., Yin, W., Isogaki, J., Saitoh, K., Kanazawa, K., Koda, K., Yokota, J., Kino, I., Arai, T., and Sugimura, H., Stage-dependent evaluation of microsatellite instability in gastric carcinoma with familial clustering. Cancer Epidemiol Biomarkers Prev, 1997. 6(9): 693-7.
219. Shinmura, K., Kasai, H., Sasaki, A., Sugimura, H., and Yokota, J., 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity. Mutat Res, 1997. 385(1): 75-82.
220. Kasami, M., Yoshida, M., Isogaki, J., Ogawa, H., Shinmura, K., Endo, Y., Kiyokawa, E., Naito, Y., Arai, T., Kimura, T., Inoue, R., and Sugimura, H., Bilateral breast tumors, malignant phyllodes tumor and invasive lobular carcinoma in a 46,XX/46,XY mosaic female with family history of breast cancer. Pathol Int, 1997. 47(2-3): 147-54.
221. Kanai, T., Konno, H., Maruyama, K., Baba, M., Tanaka, T., Maruo, Y., Nishino, N., Nakamura, S., Baba, S., and Sugimura, H., p53 overexpression and proliferative activity do not correlate with lymph node metastasis in early gastric cancer. Eur Surg Res, 1997. 29(1): 35-41.
222. Inoue, R., Ushijima, T., Fukutomi, T., Fukami, A., Sugimura, H., Inoue, S., Okonogi, H., Sugimura, T., Matsumoto, Y., and Nagao, M., BRCA2 germline mutations in Japanese breast cancer families. Int J Cancer, 1997. 74(2): 199-204.
223. Arai, T., Maruyama, K., Kamo, T., and Sugimura, H., Origin of intraepithelial apoptotic cells in human colorectal adenomas. Pathol Int, 1997. 47(5): 333-5.
224. Yokota, N., Aruga, J., Takai, S., Yamada, K., Hamazaki, M., Iwase, T., Sugimura, H., and Mikoshiba, K., Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. Cancer Res, 1996. 56(2): 377-83.
225. Xiang, Y.Y., Wang, D.Y., Tanaka, M., Igarashi, H., Naito, Y., Ohtawara, Y., Shen, Q., and Sugimura, H., Expression of structure-specific recognition protein mRNA in fetal kidney and Fe-nitrilotriacetate-induced renal carcinoma in the rat. Cancer Lett, 1996. 106(2): 271-8.
226. Wang, D.Y., Xiang, Y.Y., Tanaka, M., Shen, Q., and Sugimura, H., Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Cancer Lett, 1996. 108(1): 119-27.
227. Souza, R.F., Appel, R., Yin, J., Wang, S., Smolinski, K.N., Abraham, J.M., Zou, T.T., Shi, Y.Q., Lei, J., Cottrell, J., Cymes, K., Biden, K., Simms, L., Leggett, B., Lynch, P.M., Frazier, M., Powell, S.M., Harpaz, N., Sugimura, H., Young, J., and Meltzer, S.J., Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet, 1996. 14(3): 255-7.
228. Saigusa, N., Maruyama, K., Sugimura, H., Endoh, Y., and Baba, S., [The results of p53 immunostaining in colorectal adenomas, early cancers, advanced cancers and their hepatic metastasis]. Gan To Kagaku Ryoho, 1996. 23 Suppl 2: 159-63.
229. Masui, T., Takahashi, M., Sugimura, H., Isoda, H., Mochizuki, T., Kaneko, M., and Nishizawa, S., Pituitary prolactinoma mimicking tumor originating from the sphenoid sinus or clivus. Radiat Med, 1996. 14(4): 189-91.
230. Masui, T., Kurosawa, Y., Iwase, T., Sugimura, H., Isoda, H., Takahashi, M., Mochizuki, T., and Takinami, M., Meningeal hemangiopericytoma metastatic to the heart. Radiat Med, 1996. 14(2): 91-4.
231. Maruyama, K., Tanaka, T., Baba, S., Nakamura, S., Endo, Y., and Sugimura, H., p53 accumulation in colorectal cancer with hepatic metastasis. Jpn J Cancer Res, 1996. 87(4): 368-76.
232. Iwase, T., Nishimura, M., Sugimura, H., Igarashi, H., Ozawa, F., Shinmura, K., Suzuki, M., Tanaka, M., and Kino, I., Localization of Menkes gene expression in the mouse brain; its association with neurological manifestations in Menkes model mice. Acta Neuropathol, 1996. 91(5): 482-8.
233. Xiang, Y.Y., Wang, D.Y., Tanaka, M., Igarashi, H., Kamo, T., Shen, Q., Sugimura, H., and Kino, I., Efficient and specific induction of esophageal tumors in rats by precursors of N-nitrososarcosine ethyl ester. Pathol Int, 1995. 45(6): 415-21.
234. Sugimura, H., Yamamoto, H., Watabiki, H., Ogawa, H., Harada, H., Saitoh, I., Miyamura, T., Inoue, M., Tajima, K., and Kino, I., Correlation of detectability of hepatitis C virus genome in saliva of elderly Japanese symptomatic HCV carriers with their hepatic function. Infection, 1995. 23(5): 258-62.
235. Sugimura, H., Hamada, G.S., Suzuki, I., Iwase, T., Kiyokawa, E., Kino, I., and Tsugane, S., CYP1A1 and CYP2E1 polymorphism and lung cancer, case-control study in Rio de Janeiro, Brazil. Pharmacogenetics, 1995. 5 Spec No: S145-8.
236. Shinmura, K., Sugimura, H., Naito, Y., Shields, P.G., and Kino, I., Frequent co-occurrence of mutator phenotype in synchronous, independent multiple cancers of the stomach. Carcinogenesis, 1995. 16(12): 2989-93.
237. Oda, H., Nakatsuru, Y., Imai, Y., Sugimura, H., and Ishikawa, T., A mutational hot spot in the p53 gene is associated with hepatoblastomas. Int J Cancer, 1995. 60(6): 786-90.
238. Kitayama, Y., Sugimura, H., Tanaka, M., Nakamura, S., and Kino, I., Expression of p53 and flow cytometric DNA analysis of isolated neoplastic glands of the stomach: an application of the gland isolation method. Virchows Arch, 1995. 426(6): 557-62.
239. Kitayama, Y., Sugimura, H., Arai, T., Nagamatsu, K., and Kino, I., Primary osteosarcoma arising from cirrhotic liver. Pathol Int, 1995. 45(4): 320-5.
240. Kitayama, Y., Nakamura, S., Sugimura, H., and Kino, I., Cytophotometric and flow cytometric DNA content of isolated glands in gastric neoplasia. Gut, 1995. 36(4): 516-21.
241. Iwase, T., Nishizawa, S., Baba, S., Hinokuma, K., Sugimura, H., Nakamura, S., Uemura, K., Shirasawa, H., and Kino, I., Intrasellar neuronal choristoma associated with growth hormone-producing pituitary adenoma containing amyloid deposits. Hum Pathol, 1995. 26(8): 925-8.
242. Hamada, G.S., Sugimura, H., Suzuki, I., Nagura, K., Kiyokawa, E., Iwase, T., Tanaka, M., Takahashi, T., Watanabe, S., Kino, I., and et al., The heme-binding region polymorphism of cytochrome P450IA1 (CypIA1), rather than the RsaI polymorphism of IIE1 (CypIIE1), is associated with lung cancer in Rio de Janeiro. Cancer Epidemiol Biomarkers Prev, 1995. 4(1): 63-7.
243. Endo, Y., Sugimura, H., and Kino, I., Monoclonality of normal human colonic crypts. Pathol Int, 1995. 45(8): 602-4.
244. Baba, S., Masago, S.A., Takahashi, T., Kasama, T., Sugimura, H., Tsugane, S., Tsutsui, Y., and Shirasawa, H., A novel allelic variant of serum amyloid A, SAA1 gamma: genomic evidence, evolution, frequency, and implication as a risk factor for reactive systemic AA-amyloidosis. Hum Mol Genet, 1995. 4(6): 1083-7.
245. Xiang, Y.Y., Tanaka, M., Suzuki, M., Igarashi, H., Kiyokawa, E., Naito, Y., Ohtawara, Y., Shen, Q., Sugimura, H., and Kino, I., Isolation of complementary DNA encoding K-cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma. Cancer Res, 1994. 54(11): 3034-41.
246. Wang, D.Y., Xiang, Y.Y., Tanaka, M., Li, X.R., Li, J.L., Shen, Q., Sugimura, H., and Kino, I., High prevalence of p53 protein overexpression in patients with esophageal cancer in Linxian, China and its relationship to progression and prognosis. Cancer, 1994. 74(12): 3089-96.
247. Takai, S., Tanaka, M., Sugimura, H., Yamada, K., Naito, Y., Kino, I., and Matsuda, M., Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization. Hum Genet, 1994. 94(5): 549-50.
248. Sugimura, H., Suzuki, I., Hamada, G.S., Iwase, T., Takahashi, T., Nagura, K., Iwata, H., Watanabe, S., Kino, I., and Tsugane, S., Cytochrome P-450 lA1 genotype in lung cancer patients and controls in Rio de Janeiro, Brazil. Cancer Epidemiol Biomarkers Prev, 1994. 3(2): 145-8.
249. Kiyokawa, E., Takai, S., Tanaka, M., Iwase, T., Suzuki, M., Xiang, Y.Y., Naito, Y., Yamada, K., Sugimura, H., and Kino, I., Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Cancer Res, 1994. 54(14): 3645-50.
250. Kato, S., Shields, P.G., Caporaso, N.E., Sugimura, H., Trivers, G.E., Tucker, M.A., Trump, B.F., Weston, A., and Harris, C.C., Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol Biomarkers Prev, 1994. 3(6): 515-8.
251. Igarashi, H., Sugimura, H., Maruyama, K., Kitayama, Y., Ohta, I., Suzuki, M., Tanaka, M., Dobashi, Y., and Kino, I., Alteration of immunoreactivity by hydrated autoclaving, microwave treatment, and simple heating of paraffin-embedded tissue sections. APMIS, 1994. 102(4): 295-307.
252. Dobashi, Y., Sugimura, H., Sakamoto, A., Mernyei, M., Mori, M., Oyama, T., and Machinami, R., Stepwise participation of p53 gene mutation during dedifferentiation of human thyroid carcinomas. Diagn Mol Pathol, 1994. 3(1): 9-14.
253. Arai, T., Sugimura, H., Suzuki, M., Iwase, T., Sakuramachi, S., Kimura, T., Harada, Y., and Kino, I., Benign schwannoma of the esophagus: report of two cases with immunohistochemical and ultrastructural studies. Pathol Int, 1994. 44(6): 460-5.
254. Suzuki, M., Tanaka, M., Iwase, T., Naito, Y., Sugimura, H., and Kino, I., Over-expression of HOX-8, the human homologue of the mouse Hox-8 homeobox gene, in human tumors. Biochem Biophys Res Commun, 1993. 194(1): 187-93.
255. Shiseki, M., Nishikawa, R., Yamamoto, H., Ochiai, A., Sugimura, H., Shitara, N., Sameshima, Y., Mizoguchi, H., Sugimura, T., and Yokota, J., Germ-line p53 mutation is uncommon in patients with triple primary cancers. Cancer Lett, 1993. 73(1): 51-7.
256. Shields, P.G., Caporaso, N.E., Falk, R.T., Sugimura, H., Trivers, G.E., Trump, B.F., Hoover, R.N., Weston, A., and Harris, C.C., Lung cancer, race, and a CYP1A1 genetic polymorphism. Cancer Epidemiol Biomarkers Prev, 1993. 2(5): 481-5.
257. Iwase, T., Tanaka, M., Suzuki, M., Naito, Y., Sugimura, H., and Kino, I., Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. Biochem Biophys Res Commun, 1993. 194(2): 698-705.
258. Dobashi, Y., Sugimura, H., Sato, A., Hirabayashi, T., Kanda, H., Kitagawa, T., Kawaguchi, N., Imamura, T., and Machinami, R., Possible association of p53 overexpression and mutation with high-grade chondrosarcoma. Diagn Mol Pathol, 1993. 2(4): 257-63.
259. Dobashi, Y., Sakamoto, A., Sugimura, H., Mernyei, M., Mori, M., Oyama, T., and Machinami, R., Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma. Am J Surg Pathol, 1993. 17(4): 375-81.
260. Weston, A., Caporaso, N.E., Perrin, L.S., Sugimura, H., Tamai, S., Krontiris, T.G., Trump, B.F., Hoover, R.N., and Harris, C.C., Relationship of H-ras-1, L-myc, and p53 polymorphisms with lung cancer risk and prognosis. Environ Health Perspect, 1992. 98: 61-7.
261. Shields, P.G., Sugimura, H., Caporaso, N.E., Petruzzelli, S.F., Bowman, E.D., Trump, B.F., Weston, A., and Harris, C.C., Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism. Environ Health Perspect, 1992. 98: 191-4.
262. Kato, S., Shields, P.G., Caporaso, N.E., Hoover, R.N., Trump, B.F., Sugimura, H., Weston, A., and Harris, C.C., Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk. Cancer Res, 1992. 52(23): 6712-5.
263. Caporaso, N.E., Shields, P.G., Landi, M.T., Shaw, G.L., Tucker, M.A., Hoover, R., Sugimura, H., Weston, A., and Harris, C.C., The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype. Environ Health Perspect, 1992. 98: 101-5.
264. Weston, A., Vineis, P., Caporaso, N.E., Krontiris, T.G., Lonergan, J.A., and Sugimura, H., Racial variation in the distribution of Ha-ras-1 alleles. Mol Carcinog, 1991. 4(4): 265-8.
265. Sugimura, H., Weston, A., Caporaso, N.E., Shields, P.G., Bowman, E.D., Metcalf, R.A., and Harris, C.C., Biochemical and molecular epidemiology of cancer. Biomed Environ Sci, 1991. 4(1-2): 73-92.
266. Sugimura, H., Fukazawa, T., Saitoh, M., Nakamura, K., Shimada, H., and Ohtsubo, K., The histopathology of the liver in older patients with hepatitis B virus surface antigenaemia. Virchows Arch A Pathol Anat Histopathol, 1991. 419(5): 409-15.
267. Tamai, S., Sugimura, H., Caporaso, N.E., Resau, J.H., Trump, B.F., Weston, A., and Harris, C.C., Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. Int J Cancer, 1990. 46(3): 411-5.
268. Sugimura, H., Tsugane, S., Watanabe, S., Nanri, S., and Ishii, H., Hepatitis B virus markers in Japanese immigrants and their descendants in Bolivia and native Bolivians. Gastroenterol Jpn, 1990. 25(3): 335-8.
269. Sugimura, H., Caporaso, N.E., Shaw, G.L., Modali, R.V., Gonzalez, F.J., Hoover, R.N., Resau, J.H., Trump, B.F., Weston, A., and Harris, C.C., Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls. Carcinogenesis, 1990. 11(9): 1527-30.
270. Sugimura, H., Caporaso, N.E., Modali, R.V., Hoover, R.N., Resau, J.H., Trump, B.F., Longergan, J.A., Krontiris, T.G., Mann, D.L., Weston, A., and et al., Association of rare alleles of the Harvey ras protooncogene locus with lung cancer. Cancer Res, 1990. 50(6): 1857-62.
271. Harris, C.C., Weston, A., Sugimura, H., Iman, D., Shows, T., Stanbridge, E., Kaighn, E., and McMenamin, M., Tumor suppression studies of human lung cancer. Prog Clin Biol Res, 1990. 340D: 21-31.
272. Harris, C.C., Reddel, R., Modali, R., Lehman, T.A., Iman, D., McMenamin, M., Sugimura, H., Weston, A., and Pfeifer, A., Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. Basic Life Sci, 1990. 53: 363-79.
273. Weston, A., Willey, J.C., Modali, R., Sugimura, H., McDowell, E.M., Resau, J., Light, B., Haugen, A., Mann, D.L., Trump, B.F., and et al., Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. Proc Natl Acad Sci U S A, 1989. 86(13): 5099-103.
274. Ikeda, H. and Sugimura, H., Fv-4 resistance gene: a truncated endogenous murine leukemia virus with ecotropic interference properties. J Virol, 1989. 63(12): 5405-12.
275. Tsugane, S., Watanabe, S., Sugimura, H., Otsu, T., Tobinai, K., Shimoyama, M., Nanri, S., and Ishii, H., Infectious states of human T lymphotropic virus type I and hepatitis B virus among Japanese immigrants in the Republic of Bolivia. Am J Epidemiol, 1988. 128(5): 1153-61.
276. Wakabayashi, T., Mori, S., Pastolero, J., and Sugimura, H., Bile ductal and ductular changes of the livers in the renal allografted patients. Acta Pathol Jpn, 1987. 37(8): 1223-36.
277. Tsugane, S., Watanabe, S., Sugimura, H., Urano, Y., and Matsubara, S., Recent trends in different histological types of lung cancer in Tokyo based on pathological autopsy records. Jpn J Cancer Res, 1987. 78(2): 162-9.
278. Tsugane, S., Watanabe, S., Sugimura, H., Arimoto, H., Shimosato, Y., and Suemasu, K., Smoking, occupation and family history in lung cancer patients under fifty years of age. Jpn J Clin Oncol, 1987. 17(4): 309-17.
279. Sugimura, H., Watanabe, S., Tsugane, S., Morinaga, S., and Yoneyama, T., Case-control study on histologically determined multiple primary lung cancer. J Natl Cancer Inst, 1987. 79(3): 435-41.
280. Konishi, F., Wyse, N.E., Muto, T., Sawada, T., Morioka, Y., Sugimura, H., and Yamaguchi, K., Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature. Dis Colon Rectum, 1987. 30(10): 790-9.
281. Kawasaki, H., Shimada, H., Nakura, H., Sugimura, H., and Tomonaga, M., Peculiar pattern of glial fibrillary acidic protein production in extracranial metastatic tumor cells of malignant astrocytoma. Acta Neuropathol, 1987. 74(1): 89-91.
282. Urano, Y., Ohmori, H., Sugimura, H., and Fukushima, T., [Behcet's disease with Budd-Chiari syndrome. Apropos of a case. Review of cases autopsied in Japan and of the literature]. Ann Pathol, 1986. 6(3): 192-6.
283. Sugimura, H., Tange, T., Yamaguchi, K., and Mori, W., Systemic hemangiomatosis. Acta Pathol Jpn, 1986. 36(7): 1089-98.
284. Sugimura, H., Mohri, N., Urano, Y., Yamamoto, E., Kawana, T., and Hagino, Y., A case report of mixed mesodermal tumor of the uterine cervix (mixed, heterologous and homologous sarcoma of the uterine cervix). Jpn J Clin Oncol, 1986. 16(4): 391-6.
285. Sugimura, H., Shiga, J., Urano, Y., and Mori, W., [Distribution of hepatitis B surface antigen in the liver]. Nippon Shokakibyo Gakkai Zasshi, 1985. 82(11): 2769-74.

助教　華表友暁 †

1. A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth inHEK293T cells. Kahyo T, Ichikawa S, Hatanaka T, Yamada KM, Setou M. Journal ofPharmacological Sciences, 108, 364-371, 2008.
2. Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.Kahyo T, Mostoslavsky R, Goto M, Setou M. FEBS Letters, 582, 2479-83, 2008.
3. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synapticvesicle release. Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T,Morone N, Yuasa S, Inokuchi K, Ohtsuka T, Macgregor GR, Tanaka K, Setou M. Cell, 130,943-57, 2007.
4. Interactions between pias proteins and Sox9 result in an increase in the cellularconcentrations of Sox9. Hattori T, Eberspaecher H, Lu J, Zhang R, Nishida T, Kahyo T,Yasuda H, de Crombrugghe B. The Journal of Biological Chemistry, 281, 14417-28,2006.
5. Yeast Ull1/Siz1 Is a Novel SUMO1/Smt3 Ligase for Septin Components and Functions asan Adaptor between Conjugation Enzyme and Substrates. *Takahashi Y, *Kahyo T,Toh-E A, Yasuda H, Kikuchi Y. (*equal contributed authors) The Journal of BiologicalChemistry, 276, 48973-48977, 2001.
6. Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53.Kahyo T, Nishida T, Yasuda H. Molecular Cell, 8, 713-718, 2001.

特任研究員　夏目宏子 †

1. Nishiyama K, Baba S., Yamada T., Matsushita A., Natsume H., Nakano K.,Sasaki S., Nakamura H., Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha 1 in mice. Endocr J. 50(5): 561-70, 2003, Oct
2. Natsume H., Sasaki S., Kitagawa M., Kashiwabara Y., Matsushita A., Nakano K., Nishiyama K., Nagayama K., Misawa H., Masuda H., Nakamura H. Beta-catenin/Tcf-1-mediated transactivation of cyclin D1 promoter is negatively regulated by thyroid hormone. Biochem Biophys Res Commun Sep 19; 309(2): 408-13, 2003, Sep19
3. Gemma R., Miura K., Mikami T., Natsume H., Nishiyama K., Nakamura H., Histological changes of thyroid tissues in patients with liver cirrhosis. Endocr J. 48 (5): 535-42, 2001, Oct
4. Nishiyama K., Kitahara A., Natsume H., Matsushita A., Nakano K., Sasaki S., Genma R., Yamamoto Y., Nakamura H., Malignant hyperthermia in patient with Graves' disease during subtotal thyroidectomy. Endocr J. 48(2); 227-32, 2001, Apr
5. Matsushita A., Misawa H., Andoh S., Natsume H., Nishiyama K., Sasaki S., Nakamura H. Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT. J. Endocrinol. 167(3):493-503, 2000, Dec
6. Nishiyama K., Matsushita A., Natsume H., Mikami T., Genma R., Sasaki S., Nakamura H. Differences between the silencing related properties of the extreme carboxyl terminal regions of thyroid hormone receptors alpha 1 and beta 1. J. Endocrinol. 167(2):219-27, 2000, Nov
7. Mikami T., Genma R., Nishiyama K., Ando S., Kitahara A., Natsume H., Yoshimi T., Horiuchi R., Nakamura H. Alterations in the enzyme activity and protein contents of protein disulfide isomerase in rat tissue during fasting and refeeding. Metabolism. 47(9):1083-8, 1998, Sep
8. Nakamura H., Genma R., Mikami T., Kitahara A., Natsume H., Andoh H., Nagasawa S., Nishiyama K., Chida K., Sato A., Yoshimi T. High incidence of positive autiantibodies against thyroid peroxidase and thyroglobulin in patients with sarcoidosis. Clin Endocrinol (Oxf). 46(4):467-472, 1997, Apr
9. Ando S., Nakamura H., Sasaki S., Nishiyama K., Kitahara A., Nagasawa S., Mikami T., Natsume H., Genma R., Yoshimi T., Introducing a point mutation identified in a patient with pituitary resistance to thyroid hormone (Arg338 to Trp) into other mutant thyroid hormone receptors weakens their dominant negative activities. J Endocrinol. 151(2): 293-300, 1996, Nov
10. Nakamura H., Mori T., Genma R., Suzuki Y., Natsume H., Andoh S., Kitahara R., Nagasawa S., Nishiyama K., Yoshimi T. Urinary excretion of pyridinoline and deoxypyridinoline measured by immunoassay in hypothyroidism. Clin Endocrinol (Oxf). 44(4):447-51, 1996, Apr